检索结果-南通市图书馆

Modeling process-structure-property relationships for additive manufacturing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Mechanical Engineering 2018年第4期13卷 482-492页

作者： Wentao YAN Stephen LIN Orion L. KAFKA Cheng YU Zeliang liu Yanping LIAN Sarah WOLFF Jian CAO Gregory J. WAGNER wing Kam liu Department of Mechanical Engineering Northwestern University Evanston IL 60201 USA

This paper presents our latest work on comprehensive modeling of process-structure-property relationships for additive manufacturing （AM） materials, including using data-mining techniques to close the cycle of design-predict-optimize. To illustrate the process- structure relationship, the multi-scale multi-physics pro- cess modeling starts from the micro-scale to establish a mechanistic heat source model, to the meso-scale models of individual powder particle evolution, and finally to the macro-scale model to simulate the fabrication process of a complex product. To link structure and properties, a high- efficiency mechanistic model, self-consistent clustering analyses, is developed to capture a variety of material response. The model incorporates factors such as voids, phase composition, inclusions, and grain structures, which are the differentiating features of AM metals. Furthermore, we propose data-mining as an effective solution for novel rapid design and optimization, which is motivated by the numerous influencing factors in the AM process. We believe this paper will provide a roadmap to advance AM fundamental understanding and guide the monitoring and advanced diagnostics of AM processing.

关键词： additive manufacturing thermal fluid flow data mining material modeling

Rational design of platinum(Ⅱ)complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2023年第10期66卷 2878-2884页

作者： Yeye Ai Zherui Zhang Yuexuan Fei Ruirong Ye Angela Sin-Yee Law Zong-Wan Mao Junqiu liu Yongguang Li Vivian wing-Wah Yam Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong KongChina School of Chemistry Sun Yat-Sen UniversityGuangzhou 510275China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China

The mitochondria are essential for tumorigenesis and have been regarded as important targets in cancer ***,the mitochondria-targeted platinum(Ⅱ)complexes have been *** introduction of the triazole group with larger steric hindrance through post-click reaction converts the hybridization of carbon from sp to sp^(2),endowing the complexes with an orthogonally oriented ligand with restricted rotation and emission enhancement *** of the triazolyl ligand has led to platinum(Ⅱ)complexes that can efficiently enter cancer cells and selectively accumulate in mitochondria,leading to significant enhancement in *** vivo anti-cancer investigations have demonstrated their distinct antitumor efficacy in substantial inhibition of tumor growth in breast cancer mice through dissipation of mitochondrial membrane potential,inducing apoptosis of tumor cell with negligibly systemic cytotoxicity.

关键词： platinum(Ⅱ)complexes post-click reaction emission enhancement mitochondria-targeting antitumor

Long-term clinical outcomes of drug-eluting stents ***-metal stents in Chinese geriatric patients

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2013年第4期10卷 330-335页

作者： Pak-Hei Chan Sha-Sha liu Hung-Fat Tse wing-Hing Chow Man-Hong Jim Hee-Hwa HO Chung Wah Siu Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong 102 Pokfulam Rd Hong Kong China Cardiac Medical Unit Grantham Hospital 125 Wong Chuk Hang Rd Aberdeen Hong Kong China

BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P <0.05)。 No significant differences were found in the three-year cumulative rate for target lesion revascularization (6.3% vs4.6%, P =0.61) or stent thrombosis (3.6% vs2.3%, P =0.70)。 Likewise, there were no statistically significant differences in the cumulative rate for intracranial hemorrhage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。

关键词： Bare-metal stents Drug-eluting stents Geriatric patients Percutaneous coronary intervention

A facile design for multifunctional AIEgen based on tetraaniline derivatives

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2019年第6期62卷 732-738页

作者： Beibei liu Wei He Hao Lu Kun Wang Mingming Huang Ryan Tsz kin Kwok Jacky wing Yip Lam Longcheng Gao Jiping Yang Benzhong Tang Key laboratory of Aerospace Advanced Materials and Performance Ministry of Education School of Materials Science and EngineeringBeihang University Department of Chemistry HKUST Jockey Club Institute for Advanced Study Institute of Molecular Functional Materials Division of Biomedical Engineering State Key Laboratory of Molecular Neuroscience Division of Life Science The Hong Kong University of Science and Technology Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education Key Laboratory of Beijing Energy School of Chemistry and Environment Beihang University

Aniline oligomers have been widely used in many fields due to their excellent physicochemical properties. Owing to strong intermolecular interactions, their emission is always weakened or quenched when they are in high concentration or aggregated state, which greatly limits their fluorescent applications. Inspired by the concept of aggregation-induced emission(AIE), herein we introduced large steric groups onto the aniline oligomer to prevent the formation of packing structure. In particular, diphenyl vinyl group was bonded with oligomeric tetraaniline by a facile synthetic procedure with high yield. The obtained aniline oligomer derivative exhibited typical AIE features, which was also confirmed by density functional theoretical calculation. More importantly, this AIE oligomer was able to detect Fe^(3+) ions selectively and quantitatively. The fluorescence intensity decreased linearly along with the increment of Fe^(3+) concentration. Moreover, we demonstrated that this AIE oligomer could stain live bacteria, such as E. coli and S. aureus efficiently. All these results suggest that such a readily accessible and multifunctional tetraaniline derivative provides a new platform for the construction of fluorescent materials.

关键词： tetraaniline aggregation-induced emission Fe3+ ion detection bacteria imaging

RiceENCODE:A comprehensive epigenomicdatabase as a rice Encyclopedia of DNA Elements

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2021年第10期14卷 1604-1606页

作者： Liang Xie Minghao liu Lun Zhao Kai Cao Peng Wang Wenhao Xu wing-kin Sung Xingwang Li Guoliang Li National Key Laboratory of Crop Genetic Improvement Hubei HongshanLaboratoryHuazhong Agricultural University1 Shizishan StreetHongshanDistrictWuhan 430070HubeiChina Agricultural Bioinformatics Key Laboratory of Hubei Province and HubeiEngineering Technology Research Center of Agricultural Big Data 3DGenomics Research CenterHuazhong Agricultural University1 ShizishanStreetHongshan DistrictWuhan 430070HubeiChina Department of Computer Science National University of SingaporeSingapore 117417Singapore Department of Computational and Systems Biology Genome Institute ofSingaporeSingapore 138672Singapore

Dear Editor,Rice(Oryza sativa)is one of the most important crops in the worldand a common model plant for genomic *** genomesofXian/IndicaandGeng/Japonicahave been completelysequenced and annotated with accurate genome *** the past few years,epigenomic information,including DNAmethylation,histone modification,and chromatin accessibility,has been characterized in theXian/IndicaandGeng/Japonicage-nomes(Zhao et al.,2020).Quite a few rice three-dimensionalgenome studies have been published in the meantime(Zhaoet al.,2019).However,it is still a big challenge for many groupsthat lack dedicated bioinformatic personnel or sufficientcomputational resources to utilize such epigenetic data.

关键词： sativa Oryza crops

Avascular necrosis of the first metatarsal head in a young female adult:A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第25期9卷 7445-7452页

作者： Ronald wing Hei Siu Jeremy Ho Pak liu Gene Chi Wai Man Michael Tim Yun Ong Patrick Shu Hang Yung Department of Orthopaedics and Traumatology Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China The Lui Che Woo Institute of Innovative Medicine Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China

BACKGROUND This case study describes an atypical presentation of avascular necrosis(AVN)of the first metatarsal head,which is largely unfounded in the *** SUMMARY A healthy 24-year-old female initially presented with pain at the first metatarsophalangeal joint(MTPJ)and was diagnosed with AVN by physical examination and magnetic resonance *** patient demonstrated atypically poor progress in recovery,despite being in otherwise good health and being of young age,with no history of corticosteroid or alcohol *** patient also did not have any history or clinical features of autoimmune disease or vasculitis,such as systemic lupus *** patient was managed with conservative treatment for 18 mo,which allowed for gradual return of full range of motion of the first MTPJ and subsiding pain,permitting the patient to return to highintensity sports training and full *** her recovery,many differential diagnoses were ruled out through specific investigations leading to further reinforcement of the diagnosis of AVN of the 1st metatarsal *** Atypical AVN may occur with no predisposing risk *** is mainly conservative,with unclear guidelines in literature on management.

关键词： Avascular necrosis Osteonecrosis Metatarsal head Atypical Avascular necrosis Young Female Foot and ankle Sports medicine Case report

Microstructure and mechanical properties of 7075 aluminum alloy during complex thixoextrusion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2020年第12期30卷 3173-3182页

作者： Jian liu Yuan-sheng CHENG Sin wing Norman CHAN Daniel SUNG National Key Laboratory for Precision Hot Processing of Metal Harbin Institute of TechnologyHarbin 150001China KaShui Technology(Huizhou)Co. Ltd.Huizhou 516000China

7075 aluminum alloy was used to obtain elbow parts by complex thixoextrusion and the microstructure evolution and mechanical properties during this process were studied by SEM,TEM and other analytical *** results show that different parts in 7075 aluminum alloy show quite different *** microstructure of the thin walls formed by back-extrusion is stratified,and the bottom of the parts formed by angular extrusion is obviously *** forces contribute to the crushing of grains and the coarse second *** main strengthening phases in the material areηphase and E phase,whose amounts greatly decrease during heating to semi-solid and *** heat treatment,they can precipitate evenly to improve the mechanical properties of the *** average tensile strength of whole part after thixoextrusion and heat treatment is 485.49 MPa,while the average elongation is 5.49%.

关键词： 7075 aluminum alloy thixoextrusion semi-solid forming elbow parts mechanical properties

Data-Driven Microstructure and Microhardness Design in Additive Manufacturing Using a Self-Organizing Map

在线全文

学校读者我要写书评

暂无评论

Engineering 2019年第4期5卷 730-735页

作者： Zhengtao Gan Hengyang Li Sarah J.Wolff Jennifer L.Bennett Gregory Hyatt Gregory J.Wagner Jian Cao wing Kam liu Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA DMG MORI Hoffman EstatesIL 60192USA

To design microstructure and microhardness in the additive manufacturing(AM)of nickel(Ni)-based superalloys,the present work develops a novel data-driven approach that combines physics-based models,experimental measurements,and a data-mining *** simulation is based on a computational thermal-fluid dynamics(CtFD)model,which can obtain thermal behavior,solidification parameters such as cooling rate,and the dilution of solidified *** on the computed thermal information,dendrite arm spacing and microhardness are estimated using well-tested mechanistic *** microstructure and microhardness are determined and compared with the simulated values for *** visualize process-structure-properties(PSPs)linkages,the simulation and experimental datasets are input to a data-mining model-a self-organizing map(SOM).The design windows of the process parameters under multiple objectives can be obtained from the visualized *** proposed approaches can be utilized in AM and other data-intensive ***-driven linkages between process,structure,and properties have the potential to benefit online process monitoring control in order to derive an ideal microstructure and mechanical properties.

关键词： Additive manufacturing Data science Multiphysics modeling Self-organizing map Microstructure Microhardness Ni-based superalloy

Large-diameter indium antimonide microwire based broadband and robust optical switch

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2023年第2期66卷 68-78页

作者： Fei Lou Xiangpeng Cui Xinyue Sheng Chunyan Jia Shuaiyi Zhang Xia Wang Vladislav Khayrudinov Baitao Zhang Shande liu wing Yim Tam Harri Lipsanen He Yang Jingliang He Shandong Advanced Optoelectronic Materials and Technologies Engineering Laboratory of Qingdao School of Mathematics and PhysicsQingdaoUniversityof Scienceand TechnologyQingdao266061China School of Instrumenation and Optoeletronic Engineering Beihang University Beijing 100191China Department of Electronics and Nanoengineering Aalto Universiy EspooFl-0o076Finland State Key Laboratory of Crystal Materials Institute of Novel Semiconductors Shandong University.Jinan 250100China College of Electronic and Information Engineering Shandong University of Science and TechnologyQingdao 266590China Depariment of Physics and Wiliam Mong Institute of Nano Science and Technology Hong Kong University of Science and Technology.HongKongChina

Various nanophotonic devices based on semiconductor wires with a diameter of several ten nanometers have been ***,studying the optoelectronics properties and performance of such devices based on large-diameter wires is interesting and ***,we successfully grew the micronsized indium antimonide(InSb) wires,and examined their nonlinear optical properties by Z-scan and I-scan(power-dependent) methods within the wavelength range of 0.8-2.8 μ***,we demonstrated InSb micro wires(MWs) working as an effective and robust optical switch within 1-2.8 μm *** findings can open possibilities for research on more large-diameter MWs made from other semiconductor materials for photonic and electronic devices.

关键词： optical antimonide InSb