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Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang Zheng-De Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-Zhao Feng Wei Liu Yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary wing-kin Wong Zheng-yan Zhao Xing-Wang Li Yong-Hong yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

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非线性变参数无人船艏向H_∞鲁棒控制

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控制与决策 2024年第5期39卷 1507-1516页

作者：黄宴委黄鹏福州大学电气工程与自动化学院福州350116

针对水流冲击引起无人船(unmanned surface vehicle,USV)转艏呈现非线性特点,建立基于转艏运动的非线性变参数(nonlinear parameter-varying,NPV) USV模型,并提出一种NPV H_∞艏向控制方法,以提高艏向调节的快速性和鲁棒性.首先,考虑低... 详细信息

针对水流冲击引起无人船(unmanned surface vehicle,USV)转艏呈现非线性特点,建立基于转艏运动的非线性变参数(nonlinear parameter-varying,NPV) USV模型,并提出一种NPV H_∞艏向控制方法,以提高艏向调节的快速性和鲁棒性.首先,考虑低展弦比机翼理论能较好地描述船体受水流冲击的特点,建立基于水动力阻尼的非线性Fossen模型.通过忽略横荡速度和横流阻力将动力学模型简化为操纵动力学模型,并引入艏向角,建立NPV艏向模型.其次,构造与艏向控制系统状态和纵荡速度变参相关的Lyapunov函数,推导出满足艏向闭环控制系统H_∞鲁棒稳定的非线性控制器求解条件,该条件是一个非线性矩阵不等式(nonlinear matrix inequality,NLMI).由于NLMI难以求解,根据平方和(sums of squares,SOS)理论,用多项式矩阵代替NLMI中的非线性矩阵,并将NLMI转化为可使用SOS工具求解的多项式线性矩阵不等式.仿真结果表明,NPV H_∞控制器在艏向调节时具有较快的系统响应和更高的准确性.

关键词：无人船艏向控制水动力阻尼非线性变参数 H_∞鲁棒控制平方和

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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho wing yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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Performance analysis of reconfigurable intelligent surface assisted systems under channel aging

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Intelligent and Converged Networks 2022年第1期3卷 74-85页

作者： yan Zhang Jiayi Zhang Derrick wing Kwan Ng Huahua Xiao Bo Ai School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Electrical Engineering and Telecommunications University of New South WalesSydney 2052Australia. ZTE Corporation and State Key Laboratory of Mobile Network and Mobile Multimedia TechnologyShenzhen 518057China State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing 100044China

Reconfigurable intelligent surfaces(RISs)have attracted significant attention due to their capability in customizing wireless communication environments to improve system *** this study,we investigate the performance of an RIS-assisted multi-user multiple-input single-output wireless communication system,considering the impact of channel aging caused by users’relative *** particular,first,we propose a model incorporating the joint effects of channel aging and channel estimation errors to investigate the performance of the RIS-assisted ***,we derive novel closed-form expressions for characterizing the sum spectral efficiency with zero-forcing *** our analysis,we unveil that an increase in the temporal channel correlation coefficient,the number of base station antennas,and the received power at the users could help improve system ***,increasing the number of reflecting elements M of the RIS generally yields a good system performance,but with a diminishing return when M is sufficiently ***,simulation results are presented to validate the accuracy of the analytical results.

关键词： reconfigurable intelligent surface(RIS) channel aging spectral efficiency

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Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era

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世界胃肠病学杂志:英文版 2023年第33期29卷 4942-4961页

作者： Joyce wing yan Mak Alvin wing Hin Law Kimmy Wan Tung Law Rita Ho Carmen Ka Man Cheung Man Fai Law Department of Medicine and Therapeutics Prince of Wales HospitalHong Kong 852China West Island School Hong Kong 852China Department of Medicine North District HospitalHong Kong 852China

Hepatitis due to hepatitis B virus(HBV)reactivation can be serious and potentially fatal,but is *** reactivation is most commonly reported in patients receiving chemotherapy,especially rituximab-containing therapy for hematological malignancies and those receiving stem cell *** with inactive and even resolved HBV infection still have persistence of HBV genomes in the *** expression of these silent genomes is controlled by the immune *** or ablation of immune cells,most importantly B cells,may lead to reactivation of seemingly resolved HBV ***,all patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core *** found to be positive for HBsAg should be given prophylactic antiviral *** patients with resolved HBV infection,there are two *** first is pre-emptive therapy guided by serial HBV DNA monitoring,and treatment with antiviral therapy as soon as HBV DNA becomes *** second approach is prophy-lactic antiviral therapy,particularly for patients receiving high-risk therapy,especially anti-CD20 monoclonal antibody or hematopoietic stem cell *** and tenofovir are the preferred antiviral *** new effective therapies for hematological malignancies have been introduced in the past decade,for example,chimeric antigen receptor(CAR)-T cell therapy,novel monoclonal antibodies,bispecific antibody drug conjugates,and small molecule inhibitors,which may be associated with HBV *** there is limited evidence to guide the optimal preventive measures,we recommend antivi-ral prophylaxis in HBsAg-positive patients receiving novel treatments,including Bruton’s tyrosine kinase inhibitors,B-cell lymphoma 2 inhibitors,and CAR-T cell *** studies are needed to determine the risk o

关键词： Hepatitis B Hematologic neoplasms Chimeric antigen receptor-T cell therapy Monoclonal antibodies Bruton’s tyrosine kinase inhibitors Antiviral agents

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Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing-Fantasy or reality?

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慢性疾病与转化医学:英文版 2023年第3期9卷 191-199页

作者： Juan Du Xuelai Liu Carol wing yan Wong Kenneth Kak Yuen Wong Zhixin Yuan Diabetic Foot Diagnosis and Treatment Centre Jilin Province People HospitalChangchunJilinChina Department of Surgery Capital Institute of Pediatrics Affiliated Children HospitalBeijingChina Department of Surgery Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Department of Emergency Surgery Jilin Province People HospitalChangchunJilinChina

Induced pluripotent stem cell(iPSC)technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent *** have attracted wide attention as the first cell line used for differentiation into *** have found that fibroblasts can be induced into different types of cells in variable mediums or *** indicates the potential“stem”characteristics of fibroblasts in terms of direct cellular reprogramming compared with the iPSC *** this review,we described the morphology and biological function of *** stem cell characteristics and activities of fibroblasts,including transdifferentiation into myofibroblasts,osteogenic cells,chondrogenic cells,neurons,and vascular tissue,are *** biological values of fibroblasts are then briefly ***,we discussed the potential applications of fibroblasts in clinical practice.

关键词： direct cellular reprogramming fibroblast wound healing

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Changes in segment coordination variability and the impacts of the lower limb across running mileages in half marathons:Implications for running injuries

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Journal of Sport and Health Science 2022年第1期11卷 67-74页

作者： Tony Lin-Wei Chen Duo Wai-Chi Wong yan Wang Qitao Tan wing-Kai Lam Ming Zhang Department of Biomedical Engineering Faculty of EngineeringHong Kong Polytechnic UniversityHong Kong SAR 999077China Li Ning Sports Science Research Center Li Ning(China)Sports Goods Co.LtdBeijing 101111China Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057China Department of Kinesiology Shenyang Sports InstituteShenyang 110102China

Background:Segment coordination variability(CV)is a movement pattern associated with running-related *** can also be adversely affected by a prolonged ***,research on this topic is currently *** purpose of this study was to investigate the effects of a prolonged run on segment CV and vertical loading rates during a treadmill half ***:Fifteen healthy runners ran a half marathon on an instrumental treadmill in a biomechanical *** kinematic and kinetic data were collected every 2 km(from 2 km until 20 km),and the data were processed by musculoskeletal *** CVs were computed from the angle-angle plots of selected pelvis-thigh,thigh-shank,and shank-rearfoot couplings using a modified vector coding *** loading rate of vertical ground reaction force was also calculated.A one-way MANOVA with repeated measures was performed on each of the outcome variables to examine the main effect of running ***:Significant effects of running mileage were found on segment CVs(p≤0.010)but not on loading rate(p=0.881).Notably,during the early stance phase,the CV of pelvis frontal thigh frontal was significantly increased at 20 km compared with the CV at 8 km(g=0.59,p=0.022).The CV of shank transverse *** frontal decreased from 2 km to 8 km(g=0.30,p=0.020)but then significantly increased at both 18 km(g=0.05,p<0.001)and 20 km(g=0.36,p<0.001).Conclusion:At the early stance,runners maintained stable CVs on the sagittal plane,which could explain the unchanged loading rate throughout the half ***,increased CVs on the frontal/transverse plane may be an early sign of fatigue and indicative of possible injury *** studies are necessary for conclusive statements in this regard.

关键词： Coupling angle Endurance running Motion capture analysis Musculoskeletal modeling Vector coding technique

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Determination of urine catecholamines and metanephrines by reversed-phase liquid chromatography-tandem mass spectrometry

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色谱 2017年第10期35卷 1042-1047页

作者： CHEUK Man-Yung LO Yun-Chuen poon wing-Tat Department of Pathology Pamela Youde Nethersole Eastern Hospital

The measurement of urine catecholamine and metanephrine concentrations is important for biochemical screening and diagnosis of *** goal of this work was to develop a simple liquid chromatography-tandem mass spectrometry(LC-MS/MS)method for determining catecholamines and metanephrines in urine to replace an existing liquid chromatographic method using electrochemical *** samples were prepared using Oasis weak-cation-exchange *** eluate was analyzed on an Agilent ZORBAX Eclipse Plus Phenyl-Hexyl column in 3 ***,noradrenaline,dopamine,metanephrine,normetanephrine,and their deuterated internal standards were monitored in positive electrospray ionization mode by multiple reaction monitoring(MRM).No evidence of ion suppression was *** assay was linear up to 5μmol/L for adrenaline,5μmol/L for noradrenaline,6.1μmol/L for dopamine,5.6μmol/L for metanephrine,and 34.6μmol/L for normetanephrine,with lower limits of quantification of 5,5,12,6 and 7nmol/L,*** intra-day and inter-day precisions for all analytes ranged from 0.59%to 4.64%and1.98%to 4.80%,*** quality assurance samples were assayed and showed excellent agreement with the target *** simple method provides an improved assay for determining urine catecholamines and metanephrines.

关键词： liquid chromatography-tandem mass spectrometry (LC-MS/MS) metanephrines catecholamines pheochromocytoma urine

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升力翼列车通过隧道的气动效应研究

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Journal of Central South University 2024年第3期31卷 1003-1016页

作者：王田天黄大飞王军彦施方成朱彦张雷高广军 College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China Key Laboratory of Traffic Safety on Track of Ministry of Education School of Traffic&Transportation EngineeringCentral South UniversityChangsha 410075China CRRC Changchun Railway Vehicles Co. LtdChangchun 130062China

升力翼列车是一种通过增加升力翼来提升气动升力的新概念列车,可等效降低自身重力,有效减少轮轨磨损。本研究基于RNG k−ε湍流模型,采用滑移网格模拟方法,研究了不同攻角升力翼列车通过隧道的气动效应,并通过动模型实验数据对数值计算... 详细信息

升力翼列车是一种通过增加升力翼来提升气动升力的新概念列车,可等效降低自身重力,有效减少轮轨磨损。本研究基于RNG k−ε湍流模型,采用滑移网格模拟方法,研究了不同攻角升力翼列车通过隧道的气动效应,并通过动模型实验数据对数值计算方法的精度进行验证。研究结果表明:升力翼列车进入隧道后列车升力增大,相较于明线,隧道内平均升力增加了33.3%;在进入隧道时攻角由12.5°减小为7.5°,可以较好地减小进入隧道时的升力波动,同时也可减小列车和隧道表面的压力峰值,有利于列车平稳通过隧道。通过对比有、无升力翼的列车可发现,车体前端主要受到升力翼增加车隧阻塞比的影响,而压力上升;车体后端主要受到升力翼尾流的影响,压力降低。本研究结果可为升力翼列车平稳通过隧道提供技术支持。

关键词：升力翼列车升力翼攻角列车升力压力隧道

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高速水洞中超空泡稳定性与通气率定量试验研究

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船舶力学 2024年第4期28卷 479-484页

作者：李鹏陈炜烨王志张珂颜开中国船舶科学研究中心水动力学全国重点实验室江苏无锡214082

超空泡航行体通气规律对空泡形态控制具有重要意义。本文描述了在高速水洞中建立水下航行体通气率对超空泡形态及稳定性影响的一种试验研究方法。基于不同空化器和模型攻角条件下的空泡形态及通气率测量试验结果,总结得到无量纲通气率... 详细信息

超空泡航行体通气规律对空泡形态控制具有重要意义。本文描述了在高速水洞中建立水下航行体通气率对超空泡形态及稳定性影响的一种试验研究方法。基于不同空化器和模型攻角条件下的空泡形态及通气率测量试验结果,总结得到无量纲通气率计算的经验表达式。通过对有、无尾翼条件下的通气率试验进行比较,初步获得尾翼对超空泡泄气的影响规律。研究结果表明,通气率需要保持在一定范围内方可获得形状稳定、边界清晰的通气超空泡。依据试验结果给出了超空泡稳定性的判别方法。

关键词：通气超空泡圆盘空化器通气率水洞试验

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