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Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes

Bone Research 2014年第2期2卷 121-130页

作者： Fengjie Zhang Qiling He wing Pui Tsang w Timothy Garvey wai yee Chan Chao wan Ministry of Education Key Laboratory for Regenerative Medicine School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong School of Biomedical Sciences Core Laboratory Institute of Stem Cell Genomics and Translational Research Shenzhen Research Institute The Chinese University of Hong Kong Departments of Microbiology and Pathology University of Alabama at Birmingham AL USA Department of Nutrition Sciences University of Alabama at Birmingham AL USA

Insufficient insulin production or action in diabetic states is associated with growth retardation and impaired bone healing, while the underling mechanisms are unknown. In this study, we sought to define the role of insulin signaling in the growth plate. Insulin treatment of embryonic metatarsal bones from wild-type mice increased chondrocyte proliferation. Mice lacking insulin receptor （IR） selectively in chondrocytes （CartIR-/-） had no discernable differences in total femoral length compared to control littermates. However, CartIR-/- mice exhibited an increase in chondrocyte numbers in the growth plate than that of the controls. Chondrocytes lacking IR had elevated insulin-like growth factor （IGF）-IR mRNA and protein levels. Subsequently, IGF-1 induced phosphorylafion of Akt and ERK was enhanced, while this action was eliminated when the cells were treated with IGF-1R inhibitor Picropodophyllin. Deletion of the IR impaired chondrogenic differentiation, and the effect could not be restored by treatment of insulin, but partially rescued by IGF-1 treatment. Intriguingly, the size of hypertrophic chondrocytes was smaller in CartIR-/- mice when compared with that of the control littermates, which was associated with upregnlation of tuberous sclerosis complex 2 （TSC2）. These results suggest that deletion of the IR in chondrocytes sensitizes IGF-1R signaling and action, IR and IGF-1R coordinate to regulate the proliferation, differentiation and hypertrophy of growth plate chondrocytes.

关键词： IGF-1 independent actions in growth plate chondrocytes Insulin exerts direct

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Vampyroteuthis pseudoinfernalis ***.:the second extant widespread deep sea squid species of Vampyromorpha(Cephalopoda:Coleoidea)

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Zoological Systematics 2024年第3期49卷 246-257页

作者： Dajun Qiu Bilin Liu yupei Guo wijesooriya A.S.w.Lakmini yehui Tan Gang Li Zhixin Ke Kaizhi Li Liangmin Huang CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China University of Chinese Academy of Sciences Beijing 100049China College of Marine Sciences Shanghai Ocean UniversityShanghai 200090China

The vampire squid,Vampyroteuthis infernalis Chun,1903,is currently the only extant species in the family Vampyroteuthidae Chun,***,specimens from the Gulf of Guinea,Africa,and California suggested the possibility of additional ***,we report the second species of Vampyroteuthis,collected from the South China Sea,China,which differs from *** by its tail shape,lower beak,photophores position,and the phylogenetic analysis of mitochondrial COI and nuclear large subunit ribosomal DNA(LSU)sequences:*** present by the lacking of the tail,photophores located approximately one-third of the points between the fins and end,and the lower beak with a broad,short wing;*** Qiu,Liu&Huang,*** by an acuate tail,a pair of photophores located at the midpoints between the fins and tail,and a lower beak with a broad,elongate wing.

关键词： Nuclear gene mitochondrial COI phylogeny morphology South China Sea

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Attitudes of visitors at adult intensive care unit toward organ donation and organ support

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Chinese Medical Journal 2019年第3期132卷 373-376页

作者： nga-wing Tsai yee-Man Leung Pauline yeung ng Ting Liong Sui-Fong Lee Chun-wai ngai wai-Ching Sin Jenny Koo wai-Ming Chan Adult Intensive Care Unit Queen Mary HospitalHong Kong 999077China Intensive Care Unit United Christian HospitalHong Kong 999077China Intensive Care Unit Kwong Wah HospitalHong Kong 999077China Central Nursing Department Queen Mary HospitalHong Kong 999077China

The concept of brain death was 1st introduced in the 1960s, providing an essential conceptual change to medical practice,[1] and its diagnosis is based on demonstrating the complete, irreversible cessation of brainste... 详细信息

关键词： brain death toward organ donation organ support

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Modeling the causal regulatory network by integrating chromatin accessibility and transcriptome data

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National Science Review 2016年第2期3卷 240-251页

作者： yong wang Rui Jiang wing Hung wong Department of Statistics Department of Biomedical Data ScienceBio-X ProgramStanford University Academy of Mathematics and Systems Science National Center for Mathematics and Interdisciplinary SciencesChinese Academy of Sciences MOE Key Laboratory of Bioinformatics Bioinformatics Division and Center for Synthetic and Systems BiologyTNLISTDepartment of AutomationTsinghua University

Cell packs a lot of genetic and regulatory information through a structure known as chromatin,*** is wrapped around histone proteins and is tightly packed in a remarkable *** express a gene in a specific coding region,the chromatin would open up and DNA loop may be formed by interacting enhancers and ***,the mediator and cohesion complexes,sequence-specific transcription factors,and RNA polymerase Ⅱ are recruited and work together to elaborately regulate the expression *** is in pressing need to understand how the information,about when,where,and to what degree genes should be expressed,is embedded into chromatin structure and gene regulatory *** to large consortia such as Encyclopedia of DNA Elements(ENCODE) and Roadmap Epigenomic projects,extensive data on chromatin accessibility and transcript abundance are available across many tissues and cell *** rich data offer an exciting opportunity to model the causal regulatory ***,we will review the current experimental approaches,foundational data,computational problems,interpretive frameworks,and integrative models that will enable the accurate interpretation of regulatory ***,we will discuss the efforts to organize,analyze,model,and integrate the DNA accessibility data,transcriptional data,and functional genomic regions *** believe that these efforts will eventually help us understand the information flow within the cell and will influence research directions across many fields.

关键词： gene regulatory network open chromatin DNA accessibility transcription factor colocalization statistical model data integration

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Enriched reproducing kernel particle method for fractional advection–diffusion equation

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Acta Mechanica Sinica 2018年第3期34卷 515-527页

作者： yuping ying yanping Lian Shaoqiang Tang wing Kam Liu Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics College of Engineering Peking University Department of Mechanical Engineering Northwestern University HEDPS CAPT and LTCS Peking University

The reproducing kernel particle method （RKPM） has been efficiently applied to problems with large deformations, high gradients and high modal density. In this paper, it is extended to solve a nonlocal problem modeled by a fractional advectiondiffusion equation （FADE）, which exhibits a boundary layer with low regularity. we formulate this method on a moving least-square approach. Via the enrichment of fractional-order power functions to the traditional integer-order basis for RKPM, leading terms of the solution to the FADE can be exactly reproduced, which guarantees a good approximation to the boundary layer. Numerical tests are performed to verify the proposed approach.

关键词： Meshfree method Fractional calulus Enriched reproducing kernel Advection-diffusion equation Fractional-order basis

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Brain MRI of hippocampal volumetry in patients with refractory temporal lobe epilepsy

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Chinese Medical Journal 2000年第3期 62-64页

作者： Ka Kui Philip ng, Kwok wing Tang, yuk Ling James Cheung and Patrick Chung Ki Li

Objective To detect for hippocampal sclerosis presurgically in a group of patients with refractory temporal lobe epilepsy Methods Eighty four consecutive patients with refractory temporal lobe epilepsy were subjected to brain MRI of hippocampal volumetry A ratio of smaller to larger hippocampal volume was determined and unilateral hippocampal atrophy (HA) was diagnosed if the ratio is less than 0 91 Results Unilateral HA was diagnosed in 42 patients (50%) and bilateral HA in 1 patient Other MRI abnormalities were detected in 18 patients with or without coexisting HA Conclusions Hippocampal sclerosis can be detected presurgically in many patients by brain MRI Additional abnormalities not detected by brain CT can also be demonstrated

关键词： temporal lobe epilepsy · hippocampal sclerosis · MRI · volumetry

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The Dark Side of the Genome： Revealing the Native Transposable Element/Repeat Content of Eukaryotic Genomes

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Molecular Plant 2016年第12期9卷 1664-1666页

作者： Dario Copetti Rod A. wing Arizona Genomics Institute BIO5 Institute and School of Plant Sciences University of Arizona Tucson AZ 85721 USA International Rice Research Institute T.T. Chang Genetic Resources Center Los Baños Laguna 63108 Philippines

Dear Editor,The majority of genome assemblies to date fail to represent the true structure of native genomes. This lack of completeness is largely due to the inability to assemble the variable （often significant） fraction of nuclear genomes that is composed primarily of repeated sequences （with either a structural function such as satellite DNA and simple sequence repeats or ＂selfish DNA＂ such as high-copy transposable elements [TEs]）, herein defined as the ＂dark side of the genome.＂

关键词： Specialized Metabolites Flavonol

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Remarks on two theorems of Qi-Keng Lu

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Science China Mathematics 2008年第4期51卷 773-776页

作者： CHEUng wing-Sum wOng Bun Department of Mathematics University of Hong Kong Department of Mathematics University of California

Two alternate arguments in the framework of intrinsic metrics and measures respectively of part of the proof of a famous theorem due to Qi-Keng Lu on Bergman metric with constant negative holomorphic sectional curvature are presented.A relationship between the Lu constant and the holo- morphic sectional curvature of the Bergman metric is *** recent progress of the yau’s porblem on the characterization of domain of holomorphy on which the Bergman metric is K(?)hler-Einstein is described.

关键词： Bergman metric holomorphic sectional curvature intrinsic metrics and measures Qi-Keng Lu theorem 32F45 32Q05 32w20

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SOME DISCRETE NONLINEAR INEQUALITIES AND APPLICATIONS TO DIFFERENCE EQUATIONS

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Acta Mathematica Scientia 2008年第2期28卷 417-430页

作者： Cheung wing-Sum Ma Qing-Hua Josip Pecaric Department of Mathematics University of Hong Kong Hong Kong Faculty of Information Science and Technology Guangdong University of Foreign Studies Guangzhou 510420 China Faculty of Textile Technology University of Zagreb Pierottijeva 6 1000 Zagreb Croatia

In this article, the authors establish some new nonlinear difference inequalities in two independent variables, which generalize some existing results and can be used as handy tools in the study of qualitative as well... 详细信息

关键词： Discrete Gronwll-Bellman-Ou-Iang type inequalities a Priori bound difference equation boundary value problems

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Nodal peripheral T-cell lymphomas in the new classification systems

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Cancer Biology & Medicine 2023年第12期20卷 922-926页

作者： Catalina Amador wing C.Chan Department of Pathology University of Miami Miller School of MedicineMiamiFL 33136USA Department of Pathology City of Hope National Medical CenterDuarteCA 91010USA

Peripheral T-cell lymphomas(PTCLs)encompass a biologically diverse group of non-Hodgkin lymphomas derived from mature *** PTCLs present as nodal diseases and include several subtypes characterized by distinct clinical and pathologic features,and will be the focus of this *** PTCL group presenting as rare distinctive extranodal diseases will not be *** T-cell neoplasms,like B-cell lymphomas,recapitulate stages of normal differentiation,the biology is notably intricate and exhibits remarkable plasticity.

关键词： lymphoma neoplasms diseases

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