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意义是我最珍贵的珠宝

新潮（芭珠甄选） 2024年第3期 44-53页

作者：陈谦 win Tam(摄影) 不详

江南女子,云淡风轻。《庆余年》里的“鸡腿姑娘”与她的外表不谋而合,却似而不同。李沁在演员生涯中,跟随角色一步步成长。可贵的是,她始终不忘投人生活柔软的怀抱,不怕慢,也不怕远,为自己扎扎实实的每一步注入闪闪发光的意义。

关键词：云淡风轻扎扎实实意义

Study on the Establishment of Demonstration Site for Peatland Conservation through Integrated Management and Sustainable Utilization of Non-timber Forest Products(NTFPs)

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Journal of Agricultural Science and Technology(A) 2024年第2期14卷 93-106页

作者： Sann Lwin Mya win Myint Myint Khaing Tin Maung Htun Soe Min Ye Wunna Soe Forest Resource Environment Development and Conservation Association(FREDA)

A participatory action research was conducted in 2022,with the“Establishment of Demonstration Site for Peatland Conservation through Integrated Management and Sustainable Utilization of Non-Timber Forest Products(NTFPs)”to give recommendation on the development of guidelines on Sustainable Utilization of Non-Timber Forest Products(NTFPs)and peatland *** to the peat soil assessment,it was found that peat soil content was very low and top soil was thin under the mangrove forest,and Payena paralleloneura-Kan Zaw bearing forest in March *** material might be pressed by trespasser to collect Kan Zaw seed,to conduct horticulture and mining near the Kan Zaw bearing forest,or organic material might be damaged by burning with controlled fire in the previous years,under Kan Zaw trees to collect *** material might have been carried to the downwards with running water due to the heavy rainfall,with 4,700 mm/*** forest and Kan Zaw bearing evergreen forest can be assumed as“the major source of coastal peatland formation,with peat deposits eroded seawards”.It is assumed that the organic material will accumulate on top of the sands and it will lead to the formation of the peatland at coastal *** can be assumed that the accumulation of organic material found in mangrove forest and evergreen forests will promote the soil carbon storage,if we can adopt the ASEAN Policy on Zero Burning,which reflect ASEAN's commitment to controlling fires and haze,offering techniques,benefits,requirements,and challenges for implementing zero burning practices[1].Sustainable utilization of NTFP including peat and Kan Zaw-Payena paralleloneura Kurz seed was studied at demonstration sites,and it is recommended to make a trial on silvicultural system at mangrove forest and apply suitable silvicultural system such as Clear-Felling(in blocks or in alternate strips)system,Selection System,and Shelter Wood System to ensure the sustainable utilization of NTFP

关键词： Silvicultural system mangrove forest moist evergreen forest peat soil Kan Zaw-Payena paralleloneura Kurz seed

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肢端黑色素瘤的认知和早期检测

中国现代医学杂志 2024年第16期34卷 39-44页

作者： Ei Thae Mon win 粟娟鲁丽霞中南大学湘雅医院皮肤科湖南长沙410008

肢端黑色素瘤(AM)是黑色素瘤的一种亚型,病变分布于手掌、足底和甲床区域。不同人群AM的患病率存在差异,该亚型在白种人群中罕见,而在西班牙、非洲及亚洲人群中较为常见。研究表明,AM约占所有黑色素瘤患者的2%~3%。由于早期AM的临床诊... 详细信息

肢端黑色素瘤(AM)是黑色素瘤的一种亚型,病变分布于手掌、足底和甲床区域。不同人群AM的患病率存在差异,该亚型在白种人群中罕见,而在西班牙、非洲及亚洲人群中较为常见。研究表明,AM约占所有黑色素瘤患者的2%~3%。由于早期AM的临床诊断具有挑战性,且对早期AM缺乏认知这就导致AM患者在诊断时往往处于较晚期。因此,了解早期AM诊断的最新进展至关重要。AM与其他亚型皮肤黑色素瘤相比预后较差,对该疾病的早期认识也有助于制订治疗策略。该综述总结了AM的流行病学的特点、临床、皮肤镜和组织病理学特征,以期优化早期AM的检测策略提高患者的预后。

关键词：肢端黑色素瘤流行病学临床特征皮肤镜组织病理学

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立体绒织物的三维虚拟设计

染整技术 2024年第4期46卷 41-47页

作者：王靓靓 Kyaw win Moe 陈敏之浙江理工大学服装学院浙江杭州310018 浙江理工大学国际教育学院浙江杭州310018

为了提高立体绒织物在数字时尚方面的设计效率,针对其外观效果还原的复杂性与软件设置参数调整的盲目性,提出了一种基于参数转化和图像处理的虚拟绒织物设计方法。在建立织物外观特征参数与软件设置参数对照表的基础上,构建软件设置参... 详细信息

为了提高立体绒织物在数字时尚方面的设计效率,针对其外观效果还原的复杂性与软件设置参数调整的盲目性,提出了一种基于参数转化和图像处理的虚拟绒织物设计方法。在建立织物外观特征参数与软件设置参数对照表的基础上,构建软件设置参数与绒毛结构参数的转化量表。根据织物外观特征及转化量表,利用纹理叠加、模糊处理等计算机图像技术完成二维贴图的快速生成与修改,通过style3D所拥有的毛皮渲染模块对立体绒织物进行三维建模与变化应用。结果表明:该方法利用二维贴图使立体绒织物数字化模型的外观凹凸效果更加显著,并能够快速完成模型重构,操作简易方便,准确清晰地模拟高度差明显的立体绒织物。

关键词：立体绒织物三维虚拟设计计算机图像技术纹理叠加二维贴图

Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung Choi Susan win Yoo Jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,win S,Lee YJ and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

Is prostate cancer a Lynch syndrome cancer？

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Asian Journal of Andrology 2013年第5期15卷 588-589页

作者： Aung Ko win Centre for Molecular Environmental Genetic andAnalytic Epidemiology Melbourne School of Populationand G oba Heath Parkv e Vc. 3010 Austra a

The question of whether men with an inherited genetic condition called Lynch syndrome have an increased risk of developing prostate cancer has been controversial. It is important to answer this question, for understanding the role of DNA mismatch repair in carcinogenesis of prostate as well as for clinical implications for screening.

关键词： prostate cancer Lynch syndrome cancer

MOF负载Weel抑制剂实现p53突变胆囊癌的合成致死靶向治疗

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Science Bulletin 2024年第9期69卷 1286-1301页

作者：郦仕杰 Sarun Juengpanich win Topatana 谢天傲侯丽丹朱怡远陈佳东单煜凯韩依纳陆子毅陈天恩 Charlie Topatana 张斌曹佳胜胡家豪严加费陈迎鑫顾臻俞计成蔡秀军陈鸣宇 Department of General Surgery Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Medicine Zhejiang UniversityHangzhou 310058China National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China School of Materials Science and Engineering Zhejiang UniversityHangzhou 310058China Department of Chemistry Zhejiang UniversityHangzhou 310016China Department of Pathology Sir Run-Run Shaw HospitalZhejiang UniversityHangzhou 310016China International College Zhejiang UniversityHangzhou 310058China Institute of Advanced Magnetic Materials and International Research Center for EM Metamaterials College of Materials&Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018China Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Liangzhu Laboratory Zhejiang UniversityHangzhou 311121China Jinhua Institute of Zhejiang University Jinhua 321299China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Adavosertib(ADA)is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer(GBC).However,drug resistance due to DNA damage response compensation pathways and high toxicity limits further ***,estrone-targeted ADA-encapsulated metal–organic frameworks(ADA@MOF-EPL)for GBC synthetic lethal treatment by inducing conditional factors are *** high expression of estrogen receptors in GBC enables ADA@MOF-EPL to quickly enter and accumulate near the cell nucleus through estrone-mediated endocytosis and release ADA to inhibit WEE1 upon entering the acidic tumor *** irradiation induces ADA@MOF-EPL to generate reactive oxygen species(ROS),which leads to a further increase in DNA damage,resulting in a higher sensitivity of p53-mutated cancer cells to WEE1 inhibitor and promoting cell death via conditional synthetic *** conditional factor induced by ADA@MOF-EPL further enhances the antitumor efficacy while significantly reducing systemic ***,ADA@MOF-EPL demonstrates similar antitumor abilities in other p53-mutated solid tumors,revealing its potential as a broad-spectrum antitumor drug.

关键词： Synthetic lethality Nanomedicine Sonodynamic therapy Gallbladder cancer Metal-organic frameworks DNA damage response

Effects of platinum content on tribological properties of platinum/nitrogen doped diamond-like carbon thin films deposited via magnetron sputtering

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Friction 2014年第1期2卷 64-72页

作者： Nay win KHUN Erjia LIU School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Platinum(Pt)and nitrogen(N)were co-incorporated in diamond-like carbon(DLC)thin films using a magnetron sputtering system to form PtN-DLC thin films for tribological *** Pt content in the PtN-DLC films prepared on Si substrates was controlled by varying RF power applied to a Pt target at a fixed N2 flow *** tribological properties of the PtN-DLC films were investigated with respect to the Pt content in the *** uncoated Si substrate surface tested against a steel ball of 6 mm in diameter had significant abrasive and fatigue wear,while no significant wear was found on the N-DLC coated sample surface,indicating that the N-DLC film effectively prevented its underlying Si substrate from ***,the incorporation of Pt in the N-DLC films reduced the wear resistance of the films by degrading sp3-bonded cross-linking structures of the films so that significant wear tracks were found on the surfaces of the PtN-DLC ***,the increased radio frequency(RF)power applied to the Pt target decreased the wear resistance of the PtN-DLC films as a result of the increased Pt content.

关键词： diamond-like carbon(DLC)film Pt and N doping friction wear

Tribological properties of platinum/ruthenium/nitrogen doped diamond-like carbon thin films deposited with different negative substrate biases

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Friction 2014年第4期2卷 317-329页

作者： Nay win KHUN Erjia LIU School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

The platinum/ruthenium/nitrogen doped diamond‐like carbon(PtRuN‐DLC)thin films were deposited on Si substrates via DC magnetron sputtering by varying negative substrate *** tribological performance of the PtRuN‐DLC films was systematically investigated using ball‐on‐disc microtribological *** Raman results showed that the increased negative substrate bias significantly increased the number of sp3 bonds in the PtRuN‐DLC films as a result of the increased kinetic energies of impinging *** adhesion strength of the PtRuN‐DLC films apparently decreased with increased negative substrate bias due to the promoted residual stress in the *** tribological results clearly revealed that the increased negative substrate bias decreased the friction and wear of the PtRuN‐DLC films by improving the sp3 bonded cross‐linking structures of the *** can be concluded that the PtRuN‐DLC films could effectively prevent their underlying Si substrates from wear as the negative substrate bias had a significant influence on the tribological properties of the PtRuN‐DLC films.

关键词： DC magnetron sputtering PtRuN‐DLC film adhesion friction wear