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The MKK3–MPK7 cascade phosphorylates ERF4 and promotes its rapid degradation to release seed dormancy in Arabidopsis

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Molecular Plant 2023年第11期16卷 1743-1758页

作者： Xi Chen Qiujia Li Ling Ding Shengnan Zhang Siyao Shan Xiong Xiong Wenhui Jiang Bo Zhao Liying Zhang Ying Luo Yiming Lian Xiuqin Kong Xiali Ding Jun Zhang Chunli Li wim J.J.Soppe Yong Xiang Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Center for Crop Science College of AgronomyQingdao Agricultural UniversityQingdao 266109China School of Petrochemical Engineering Lanzhou University of TechnologyLanzhou 730050China Hou Ji Laboratory in Shanxi Province Academy of AgronomyShanxi Agricultural UniversityTaiyuan 030031China State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqing 400715China Rijk Zwaan 2678 ZG De Lierthe Netherlands

Seeds establish dormancy to delay germination until the arrival of a favorable growing *** this study,we identify a fate switch comprised of the MKK3–MPK7 kinase cascade and the ethylene response factor ERF4 that is responsible for the seed state transition from dormancy to *** show that dormancy-breaking factors activate the MKK3–MPK7 module,which affects the expression of some a-EXPANSIN(EXPA)genes to control seed ***,we identify a direct downstream substrate of this module,ERF4,which suppresses the expression of these EXPAs by directly binding to the GCC boxes in their exon *** activated MKK3–MPK7 module phosphorylates ERF4,leading to its rapid degradation and thereby releasing its inhibitory effect on the expression of these ***,our work identifies a signaling chain consisting of protein phosphorylation,degradation,and gene transcription,by which the germination promoters within the embryo sense and are activated by germination signals from ambient conditions.

关键词： seed dormancy dormancy breaking seed germination MKK3 MPK7 ERF4 phosphorylation protein degradation DNA binding

人类CD标志单克隆抗体与恒河猴白细胞的反应性

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单克隆抗体通讯 1992年第2期8卷 84-86页

作者： Margreet Jonker wim Slingerland 沈德诚

恒河猴是一种常用的临床前研究实验动物,尤其是在骨髓和器官移植、自身免疫病以及新近的艾滋病研究上。在所有这些研究领域中,免疫系统起着中枢的作用。在免疫学研究中,识别白细胞分化抗原CD标志的单克隆抗体(单抗)是重要的工具。荷兰TN... 详细信息

恒河猴是一种常用的临床前研究实验动物,尤其是在骨髓和器官移植、自身免疫病以及新近的艾滋病研究上。在所有这些研究领域中,免疫系统起着中枢的作用。在免疫学研究中,识别白细胞分化抗原CD标志的单克隆抗体(单抗)是重要的工具。荷兰TNO灵长类动物中心曾参加过四届(1982、1984、1986和1989)

关键词：单克隆抗体恒河猴白细胞

Influence of a Liquid Nutritional Supplement on Water Intake in Experimental Beagle Dogs

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Open Journal of Veterinary Medicine 2016年第4期6卷 69-74页

作者： Christelle Rotat Estelle Lhoest Anaelle Rauw Marjorie Dequenne wim Van Kerkhoven Marianne Diez Nutrition Unit Department of Animal Production Faculty of Veterinary Medicine University of Liège Liège Belgium Viyo International NV Ijzerenpoortkaai Antwerpen Belgium

The objectives were to evaluate the effects of a liquid nutritional supplement formulated for dogs on water intakes and urine output. A liquid nutritional supplement was tested by way of a cross-over design in 8 experimental healthy Beagle dogs (4 males and 4 females, aged 9.3 years). The supplement (87 percent water, 2.7 percent protein, 2.6 percent fat, 0.4 percent crude fiber) was added to water and tested at 2 incorporation rates (50 or 70 ml/day/dog—D50 or D70) versus the control placebo (CO-water only). The dogs were kept in a controlled environment;water intakes and urine output were measured. Individual water intakes were characterised by large variations. Mean water intake increased significantly by 28 percent in dogs receiving the liquid nutritional supplement, in both genders, irrespectively of the dosage. Urine output was also increased, by 55 percent. Faeces scores remained unchanged. It was concluded that the liquid supplement increased water intake and urine output in a safe way, without increasing dramatically the daily dietary sodium chloride intake. The recommended dosage of the manufacturer—50 ml/day for dogs weighing 10 - 20 kg BW is efficient. Increasing the dosage had no advantage, nor adverse effects. Increased water intake and urine output is of interest for dogs suffering from urolithiasis.

关键词： Dog Water Intake Liquid Supplement Urine Output

Bayesian Model Calibration with Interpolating Polynomials based on Adaptively Weighted Leja Node

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Communications in Computational Physics 2020年第1期27卷 33-69页

作者： Laurent van den Bos Benjamin Sanderse wim Bierbooms Gerard van Bussel Centrum Wiskunde&Informatica P.O.Box 940791090 GBAmsterdamThe Netherlands Delft University of Technology P.O.Box 52600 AADelftThe Netherlands

An efficient algorithm is proposed for Bayesian model calibration,which is commonly used to estimate the model parameters of non-linear,computationally expensive models using measurement *** approach is based on Bayesian statistics:using a prior distribution and a likelihood,the posterior distribution is obtained through application of Bayes’*** novel algorithm to accurately determine this posterior requires significantly fewer discrete model evaluations than traditional Monte Carlo *** key idea is to replace the expensive model by an interpolating surrogate model and to construct the interpolating nodal set maximizing the accuracy of the *** determine such a nodal set an extension to weighted Leja nodes is introduced,based on a new weighting *** prove that the convergence of the posterior has the same rate as the convergence of the *** the convergence of the posterior is measured in the Kullback–Leibler divergence,the rate *** algorithm and its theoretical properties are verified in three different test cases:analytical cases that confirm the correctness of the theoretical findings,Burgers’equation to show its applicability in implicit problems,and finally the calibration of the closure parameters of a turbulence model to show the effectiveness for computa-tionally expensive problems.

关键词： Bayesian model calibration interpolation Leja nodes surrogate modeling

联合国建议的固体氧化物燃烧测试方法的研究(英文)

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安全与环境学报 2002年第1期2卷 32-35页

作者：古积博间杉健二 wim Mak 日本消防研究所日本海事检定协会荷兰应用科学研究组织(TNO)PrinsMaurite研究所

由于日本消防法中固体氧化物的燃烧试验方法 ,与联合国黄皮书中所建议的试验方法有所不同 ,在实际应用中经常出现矛盾。因此 ,本文对其中的一些不同之处进行了重新的研究考察。并与日本海事检定协会和代表联合国标准测试方法的荷兰应用... 详细信息

由于日本消防法中固体氧化物的燃烧试验方法 ,与联合国黄皮书中所建议的试验方法有所不同 ,在实际应用中经常出现矛盾。因此 ,本文对其中的一些不同之处进行了重新的研究考察。并与日本海事检定协会和代表联合国标准测试方法的荷兰应用科学研究组织进行合作 ,对比研究了联合国建议的关于固体氧化物燃烧试验的方法。并就其中发现的问题提出了相应的改进意见。具体有以下 4方面的措施 :(1 )纤维素种类对于燃烧时间的影响 ;(2 )环境湿度及纤维素含水量对燃烧时间的影响 ;(3)导火线材料与导火线破裂方式出现的问题 ;(4)联合国建议中的举例数据。

关键词：固体氧化物联合国建议燃烧测试方法

Femtojoule electro-optic modulation using a silicon– organic hybrid device

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Light(Science & Applications) 2015年第1期4卷 483-490页

作者： Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos Institute of Photonics and Quantum Electronics(IPQ)and Institute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)76131 KarlsruheGermany Now with:Institute of Electromagnetic Fields Swiss Federal Institute of Technology(ETH)ZurichSwitzerland University of Washington Department of ChemistrySeattleWA 98195-1700USA Now with:Massachusetts Institute of Technology Research Lab of Electronics(RLE)CambridgeMA 02139USA Now with:Infinera Corporation SunnyvaleCAUSA Ghent University–IMEC Photonics Research GroupDepartment of Information TechnologyGentBelgium Now with:Department of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027China

Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such ***,the performance of all-silicon devices is limited by intrinsic material *** particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces ***–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular *** this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error *** power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material *** is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular *** device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1).

关键词： electro-optic materials electro-optic modulation nonlinear organic materials silicon-organic hybrid

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高分辨率的电子印刷

丝网印刷 2013年第3期 14-18页

作者： wim Zoomer

随着电子元件的微型化，电子印刷越来越精细，如电路板、触摸屏、生物传感器、RFID天线、原电池指纹照相等。印刷的线条愈细，则意味着对其边缘清晰度的要求就愈高。

关键词：电子印刷高分辨率生物传感器电子元件 RFID 微型化电路板触摸屏

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认识建筑部门促进可持续发展的潜力

生态毒理学报 2004年第2期26卷 9-12页

作者： wim Bakens Secretary General International Council for Research and Innovation in Building and Construction (CIB) Postbox 1837 3000 BV Rotterdam The Netherlands

要支持续建筑和建造部门的合作,必须对这个部门的组成、谁是主要的利益相关者以及必须解决的主要问题有一致的定义.确定术语有助于确定为了实现可持续发展的总体目标可以采取的各种措施.如果不同的参与者要采取包含非传统形式合作的行动... 详细信息

要支持续建筑和建造部门的合作,必须对这个部门的组成、谁是主要的利益相关者以及必须解决的主要问题有一致的定义.确定术语有助于确定为了实现可持续发展的总体目标可以采取的各种措施.如果不同的参与者要采取包含非传统形式合作的行动,他们必须承认他们是同一个利益相关者的团体的一部分,属于同一个部门,不管这个部门是如何定义的.《21世纪可持续建筑议程》和《21世纪发展中国家可持续建筑议程》两份刊物和欧盟CRISP计划可以作为包括SBC各个方面的概念框架和术语的基础.

关键词：可持续建筑可持续发展利益相关者发展中国家总体目标议程术语概念框架传统形式组成团体欧盟刊物建造基础措施

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峰回路转见真功

电子产品世界 2004年第2B期11卷 19-20页

作者： wim Roelandts Xilinx公司

赛灵思(Xilinx)公司总裁兼首席执行官wim Roelandts最近在接受我刊结盟出版物Electronic News采访时,纵论成功经验和错过的机会、不断上升的ASIC开发成本,以及推动无生产线半导体业务模式(fabless model)继续发展的因素.下面是内容摘要.

关键词：赛灵思公司 ASIC开发成本半导体业务模式市场及功能正电子制造业