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The Global Stratotype Section and Point （GSSP） for the base of the Holocene Series/Epoch （Quaternary System/Period） in the NGRIP ice core

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Episodes 2008年第2期31卷 264-267页

作者： Mike Walker Sigfus johnsen Sune Olander Rasmussen jorgen-Peder Steffensen Trevor Popp Philip Gibbard wim Hoek john Lowe john Andrews Svante Bjorck Les Cwynar Konrad Hughen Peter Kershaw Bernd Kromer Thomas Litt David j. Lowe Takeshi Nakagawa Rewi Newnham jakob Schwander Department of Archaeology and Anthropology University of Wales Lampeter Wales SA48 7ED UK. Centre for Ice and Climatel The Niels Bohr Institute University of Copenhagen Juliane Maries Vej 30 DK2100 Copenhagen Denmark. Stable Isotope Laboratory Institute of Arctic and Alpine Research University of Colorado Boulder Co 80302 USA. Department of Geography University of Cambridge Downing Place Cambridge CB2 3EN UK. Department-of Physical Geography University of Utrecht Heidelberglaan 2 3508 TC Utrecht The Netherlands. Department of Geography Royal Holloway University of London Egham Surrey TW20 0EX UK. Institute for Arctic and Alpine Research University of Colorado Campus Box 450 Boulder Co 80309 USA. GeoBiosphere Science Centre Quaternary Sciences Lund University S/51veg 12 SE-223 62 Lund Sweden. Department of Biology University of New Brunswick Fredericton New Brunswick Canada E3B 6E1. Department of Marine Chemistry and Geochemistry Woods Hole Oceanographic Institution Woods Hole MA 02543 USA. School of Geography and Environmental Science Monash University Victoria 3800 Australia. Heidelberg Academy of Sciences University of Heidelberg 1NF 229 D-69120 Heidelberg Germany. Institute for Palaeontology University of Bonn Nussallee 8 D-53115 Bonn Germany. Department of Earth and Ocean Sciences University of Waikato Private Bag 3105 Hamilton New Zealand. Department of Geography University of Newcastle Newcastle-upon-Tyne NE 1 7RU UK. School of Geography University of Plymouth Drake Circus Plymouth PIA 8AA UK. Climate and Environmental Physics Physics Institute University of Bern Sidlerstrasse 5 CH-3012 Bern Switzerland.

The Greenland ice core from NorthGRIP (NGRIP) contains a proxy climate record across the Pleistocene-Holocene boundary of unprecedented clarity and resolution. Analysis of an array of physical and chemical parameters within the ice enables the base of the Holocene, as reflected in the first signs of climatic warming at the end of the Younger Dryas/ Greenland Stadial 1 cold phase, to be located with a high degree of precision. This climatic event is most clearly reflected in an abrupt shift in deuterium excess values, accompanied by more gradual changes in δ18O, dust concentration, a range of chemical species, and annual layer thickness. A timescale based on multi-parameter annual layer counting provides an age of 11,700 yr b2k (before AD2000) for the base of the Holocene, with an estimated 2σ uncertainty of 99 yr. It is proposed that an archived core from this unique sequence should constitute the Global Stratotype Section and Point (GSSP) for the base of the Holocene Series/Epoch (Quaternary System/Period).

关键词：地球全新世第四纪地质时代周期

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金属表面硅烷处理技术

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电镀与涂饰 2009年第10期28卷 67-71页

作者：朱丹青 wim j.van Ooij 王一建陆国建沈泉飞支波美国依科技术公司杭州五源科技实业有限公司浙江杭州310000

根据金属腐蚀及涂层防腐原理,研究了金属表面硅烷处理工艺技术及处理后的功能特性,分别进行了中性盐雾、铜加速醋酸盐雾、电偶腐蚀、大气暴露和海水浸泡试验。结果表明,金属表面硅烷处理工艺技术可以取代涂装前磷化及铬化处理。该技术... 详细信息

根据金属腐蚀及涂层防腐原理,研究了金属表面硅烷处理工艺技术及处理后的功能特性,分别进行了中性盐雾、铜加速醋酸盐雾、电偶腐蚀、大气暴露和海水浸泡试验。结果表明,金属表面硅烷处理工艺技术可以取代涂装前磷化及铬化处理。该技术具有常温处理、无毒性无污染的特点,可广泛应用于涂装前处理与防腐领域。

关键词：硅烷防腐盐雾试验电偶腐蚀大气暴露海水浸泡涂装

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金属表面硅烷处理技术

金属表面硅烷处理技术

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2017浙江省腐蚀与防护学术与技术发展论坛——现代表面...

作者：朱丹青 wim j.van Ooij 王一建陆国建沈泉飞支波美国依科技术公司杭州五源科技实业有限公司

根据金属腐蚀及涂层防腐原理,研究了金属表面硅烷处理工艺技术及处理后的功能特性,分别进行了中性盐雾、铜加速醋酸盐雾、电偶腐蚀、大气暴露和海水浸泡试验.结果表明,金属表面硅烷处理工艺技术可以取代涂装前磷化及铬化处理.该技术具... 详细信息

根据金属腐蚀及涂层防腐原理,研究了金属表面硅烷处理工艺技术及处理后的功能特性,分别进行了中性盐雾、铜加速醋酸盐雾、电偶腐蚀、大气暴露和海水浸泡试验.结果表明,金属表面硅烷处理工艺技术可以取代涂装前磷化及铬化处理.该技术具有常温处理、无毒性无污染的特点,可广泛应用于涂装前处理与防腐领域。

关键词：硅烷防腐盐雾试验电偶腐蚀大气暴露海水浸泡涂装

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Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion

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World journal of Gastroenterology 2016年第9期22卷 2760-2770页

作者： joep Grootjans Kaatje Lenaerts wim A Buurman Cornelis HC Dejong joep PM Derikx Department of Surgery NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Center Brigham and Women’s Hospital Harvard Medical School NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University Medical Center

Intestinal ischemia is a frequently observed phenomenon. Morbidity and mortality rates are extraordinarily high and did not improve over the past decades. This is in part attributable to limited knowledge on the pathophysiology of intestinal ischemia-reperfusion(IR) in man, the paucity in preventive and/or therapeutic options and the lack of early diagnostic markers for intestinal ischemia. To improve our knowledge and solve clinically important questions regarding intestinal IR, we developed a human experimental intestinal IR model. With this model, we were able to gain insight into the mechanisms that allow the human gut to withstand short periods of IR without the development of severe inflammatory responses. The purpose of this review is to overview the most relevant recent advances in our understanding of the pathophysiology of human intestinal IR, as well as the(potential) future clinical implications.

关键词： Small intestinal ischemia Colon ischemia Epithelial lining Ischemia-reperfusion Human models

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海葵毒素致小鼠长QT综合征中窦房结功能紊乱及雷诺嗪对其防治作用

海葵毒素致小鼠长QT综合征中窦房结功能紊乱及雷诺嗪对其防治作用

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中华医学会第11次心血管病学术会议

作者：吴晶晶程龙献 wim j Lammers Lin Wu john Shryock Xin Wang Luiz Belardinelli 雷鸣华中科技大学同济医学院附属协和医院心内科 Cardiovascular Group School of Clinical and Laboratory SCIencesThe University of ManchesterGrafton StreetManchesterM139NT UK Department of Physiology Faculty of MediCIne and Health SCIencesUAE UniversityP.O.Box 17666 AI AinUnited Arab Emirates Pharmacological SCIences CV TherapeutiesInc.Palo AltoCaliforniaUSA. Section Ⅱ Faculty of Life SCIencesthe University of ManchesterGrafton StreetManchesterM13 9NTUK

目的在于说明晚钠电流诱导小鼠窦性心律失常。海葵毒素和雷诺嗪分别用来增强或抑制晚钠电流。方法海葵毒素灌流小鼠离体心脏,构建长QT综合征模型,记录心电图和单相动作电位,并与加用雷诺嗪后结果比较。并分离窦房结组织,利用64导mappin...

目的在于说明晚钠电流诱导小鼠窦性心律失常。海葵毒素和雷诺嗪分别用来增强或抑制晚钠电流。方法海葵毒素灌流小鼠离体心脏,构建长QT综合征模型,记录心电图和单相动作电位,并与加用雷诺嗪后结果比较。并分离窦房结组织,利用64导mapping研究以上药物对窦房结起搏功能的影响。结果予1～10 nmol/L海葵毒素后,小鼠离体心脏(n=

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0.18微米嵌入式快闪存储器技术及其应用

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电子设计技术 2000年第7期 54-54,56+58页

作者： Frans j.List Rob Verhaar Chris Schaeffer wim doedel 飞利浦公司飞利浦公司飞利浦公司飞利浦公司

快闪存储器最初是在PC中用作BIOS存储器,如今已广泛地用于GSM电话,数字照相机、CD-ROM、智能卡等产品。在需要经常更新软件以提供新服务的应用,都广泛地使用快闪存储器。它能够以电写入的方式在现场更新存储内容,因此颇受欢迎。

关键词：快闪存储器 NOR 存储单元仪表组合单元擦除

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Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease: Results from the Cosmic Study

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Open journal of Respiratory Diseases 2012年第3期2卷 63-72页

作者： Marie-Kathrin Breyer Eric P. A. Rutten Martijn A. Spruit wim C. j. Hop Dirkje S. Postma Emiel F. M. Wouters Department of Biostatistics Erasmus Medical Center Rotterdam The Netherlands Department of Pulmonology and Tuberculosis GRIAC Research Institute University Medical Center GroningenUniversity of Groningen Groningen The Netherlands Department of Respiratory Medicine Maastricht University Medical Center (MUMC) Maastricht The Netherlands Department of Respiratory Medicine Maastricht University Medical Center (MUMC) Maastricht The Netherlands Program Development Center Center of Expertise for Chronic Organ Failure Horn The Netherlands Department of Respiratory Medicine Maastricht University Medical Center (MUMC) Maastricht The Netherlands Program Development Center Center of Expertise for Chronic Organ Failure Horn The NetherlandsDepartment of Respiratory & Critical Care Medicine & Ludwig Boltzmann Institute for COPD and Pulmonary Epidemiology Otto Wagner Hospital Vienna Austria

Objective: The study aims to elucidate the association of host-related factors on systemic inflammation in COPD patients. Methods: In 295 clinically stable and optimally treated COPD patients from 39 outpatient centers, age, gender, and body composition (body mass index, BMI;fat-free mass index, FFMI;fat mass index, FMI) were related to inflammatory biomarkers: CRP, fibrinogen, TNFα, and its soluble receptors (s)TNFαR1 and sTNFαR2. Furthermore, forced expiratory volume in the first second (FEV1), BMI, FFMI, and FMI were stratified by quartiles to elucidate the influence on inflammatory biomarkers. Monovariate and multivariate regression analyses were performed for associations between inflammatory biomarkers. Results: Positive correlations were found for FFMI with sTNFαR1, FMI with CRP and age with TNFα, sTNFαR1 and sTNFαR2 (p < 0.01). FEV1 was not correlated with body composition and inflammatory markers. Mono- and multivariate analysis showed weak correlations between the acute phase markers and the TNFα system after correcting for multiple co-variants. Conclusions: This study highlights the modest role of age and body composition on levels of systemic inflammatory biomarkers in COPD. Results show the degree of airflow limitation does not affect systemic inflammation. Last, a weak relationship between acute phase markers and markers of the TNFα system is present in COPD.

关键词： Adipokines Body Composition CRP Fibrinogen Obesity TNFα

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犬猫病后术后营养支持

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畜牧产业 2021年第10期 54-61页

作者：米雁(译) 叶茜(译) Ronald j.Corbee1 wim j.S.Van Kerkhoven 吉宠(上海)国际贸易有限公司唯优国际(Viyo International 不详

犬猫术后或病后给予早期营养支持可降低死亡率,缩短住院时间。首选的饲喂方式取决于患者的具体身体状况。如果没有禁忌症,每个患者都必须获得营养支持,至少要符合静息能量需求(RER)。在疾病或手术的康复过程中,有几种营养素可能发挥作用... 详细信息

犬猫术后或病后给予早期营养支持可降低死亡率,缩短住院时间。首选的饲喂方式取决于患者的具体身体状况。如果没有禁忌症,每个患者都必须获得营养支持,至少要符合静息能量需求(RER)。在疾病或手术的康复过程中,有几种营养素可能发挥作用,但这些营养素对危重患宠的作用效果还需要进一步的研究证实。

关键词：康复食品补充营养营养素

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THREE-DIMENSIONAL STRUCTURE OF CHOLERATOXIN’S B PENTAMER IN COMPLEX WITH ITS PENTASACCHARIDE RECEPTOR AND COMPARISON WITH THE STRUCTURE OF THE RELATED ENTEROTOXIN FROM ***

THREE-DIMENSIONAL STRUCTURE OF CHOLERATOXIN’S B PENTAMER IN...

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Sixteenth Congress of the International Union of Crystallography

作者： Ethan Merrit Tita K.Sixma Focco van den Akker Steve Sarfaty Stewart Turley Kor H.Kalk Ingeborg Feil wim G.j.Hol The Biomolecular Structure Program Department of Biological StructureSM-20University of WashingtonSchool of MedicineSeattleWashington 98195 U.S.A.

＜正＞Choleratoxin（CT） and heat-labile enterotoxin of ***（LT） are two closely related major virulence factors of two bacterial species responsible for the death of hundreds of thousands of people annually,in particular,young children in third world *** toxins are heterohexamers with a B pentamer responsible for binding to the carbohydrate moieties of the gut epithelial *** single enzymatic A subunit carries out an ADP-ribosylation of Gsα,causing

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Fighting neglected infectious diseases:Medicinal Structure Genomics of Pathogenic Protozoa

Fighting neglected infectious diseases:Medicinal Structure G...

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中国化学会第二十五届学术年会

作者： Tracy Arakaki Erica Boni juergen Bosch Fred Buckner wim Hol Ethan Merritt Natascha Mueller Alberto j Napuli jenni Ross Sayaka Shibata Wesley Van Voorhis Christophe Verlinde Frank Zucker Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA

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