检索结果-南通市图书馆

Sample preference for colorectal cancer screening tests: Blood or stool?

Open Journal of Preventive medicine 2012年第3期2卷 326-331页

作者： Joanne m. Osborne Carlene wilson Vivienne moore Tess Gregory Ingrid Flight Graeme P. Young CSIRO Preventative Research Flagship Adelaide Australia Discipline of Public Health University of Adelaide Adelaide Australia Flinders Centre for Cancer Prevention and Control Flinders University of South Australia Adelaide Australia

Objective: Despite the high prevalence of CRC and the proven benefits of faecal sampling tests, participation rates in CRC screening are suboptimal. Literature has identified a number of barriers to participation, including faecal aversion. Emerging test technologies suggest blood-based molecular markers might provide an alternative, more acceptable option, for CRC screening tests. We aim to determine preference for blood compared to faeces as the sample for the screening test. methods: A survey was mailed to 956 South Australians aged 50 to 74 years. Data were collected on sample preference, demographic variables, and ratings of screening test convenience and comfort. Results: The survey yielded a 43% response rate. The majority of participants preferred to provide a blood sample (78% v 22%, p men were more likely to prefer blood than men (82% vs 74%, p = 0.05). Sample experience influenced preferences, with a significantly higher preference for faeces among participants with experience in faecal sampling (27% vs 17% with no experience, p mple rated it significantly more convenient (p more comfortable (p more acceptable (p mpling. Conclusions: Survey participants overwhelmingly indicate a preference for the idea of a blood sample over a faecal sample for CRC screening. Preference was influenced by gender, experience with sampling method and the individual’s perception of sampling convenience, sampling comfort and sample acceptability. Our results suggest population participation rates are likely to improve with blood-based screening tests.

关键词： Colon Cancer Screening Faecal Occult Blood Test Sample Preference Stool Sampling Blood Sampling Participation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Target-based approach for osteoarthritis treatment

引用

World Journal of Orthopedics 2020年第6期11卷 278-284页

作者： Gustavo C de Campos Antonio m Tieppo Cyro S de Almeida Jr Paulo C Hamdan wilson m Alves márcia U de Rezende Department of Orthopedics and Traumatology Hospital de Clínicas da Universidade Estadual de CampinasCampinasSP 13083-887Brazil Department of Physiatrics Faculdade de Ciências Médicas da Santa Casa de São PauloSão PauloSP 01221-020Brazil Departamento de medicina Esportiva Universidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-901Brazil Ortopedia Pontifícia Universidade Católica de CampinasCampinasSP 13087-571Brazil Instituto de Ortopedia e Traumatologia da Faculdade de medicina da Universidade de São Paulo São PauloSP 05403-010Brazil

There is still no definitive treatment for knee osteoarthritis(OA). We are certainly far from a consensus on the best form of treatment or on an effective treatment recommendation. There are reasons for the current equivocal treatment recommendations in the face of this very serious health problem. The greatest of these reasons, undoubtedly, is the great complexity of the factors involved in the development and progression of knee OA and the complex pathophysiology including mechanical, inflammatory, metabolic, post-traumatic, molecular,genetic, and psychological changes. For several years, an attempt has been made to correlate different patient phenotypes to different patterns of response to treatment, thus creating the possibility of developing specific treatments for certain groups of patients and theoretically allowing better treatment ***, in practice we still find totally different responses and evolutions even in individuals belonging to the same phenotype. Thus, classification by phenotypes, despite being an advance, is not sufficient. The present article proposes a fragmented look at each of the many factors or targets involved in the genesis and evolution of OA. Therefore, we propose not the treatment of OA per se but the management of an individual set of targets to achieve personalized OA management. We believe that, paradoxically, by fragmenting the view of the disease we will be able to treat our patients more holistically in an individualized way.

关键词： Osteoarthritis Knee osteoarthritis Cartilage Treatment Target Pain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

眼内炎的病因及其预防

引用

国际眼科纵览 1988年第2期 107-111页

作者： Fred m wilson Ⅱ 曾平

严格地说,眼内炎是指眼球壁的一层或层膜及相邻眼内腔的炎症。但在临床上,本术语常指视网膜、脉络膜和玻璃体腔的潜在性破坏性炎症。本文从病因和预防这两个方面,对外源感染性、内源感染性和非感染性等各类眼内炎进行论述。一、眼内炎... 详细信息

严格地说,眼内炎是指眼球壁的一层或层膜及相邻眼内腔的炎症。但在临床上,本术语常指视网膜、脉络膜和玻璃体腔的潜在性破坏性炎症。本文从病因和预防这两个方面,对外源感染性、内源感染性和非感染性等各类眼内炎进行论述。一、眼内炎的病因 (一)外源感染性眼内炎的病因外源性感染多由需氧菌引起,偶尔也可由厌氧菌或真菌导致。 1.术后眼内炎术后培养呈阳性的眼内炎病例,革兰氏阳性需氧菌约占90％,革兰氏阴性细菌约占7％,真菌39％。20～50％的病例,致病菌是表皮葡萄球菌。其它可致术后眼内炎的革兰氏阳性需氧菌,有金黄色葡萄球菌、肺炎链球菌、绿色链球菌、酿脓链球菌和棒状杆菌属。另外,还曾分离出革兰氏阳性厌氧菌-胨链球菌、疮疱丙酸杆菌和梭状芽孢杆菌属。虽然还有别的致病菌,如变形杆菌,流感嗜血杆菌,肺炎克雷伯氏杆菌,埃希氏大肠杆菌和产气肠杆菌等,但引起细菌性眼内炎最常

关键词：眼内炎感染性人工晶体内源感染晶体皮质术前检查白内障囊外摘出术滤过泡

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chitosan Biopolymers for Analysis of Organic Acids in Aquatic Environments of Treatment Wetlands

引用

Journal of Geoscience and Environment Protection 2017年第6期5卷 214-225页

作者： mohamed H. mohamed Kerry m. Peru John V. Headley Lee D. wilson Department of Chemistry University of Saskatchewan Saskatoon Canada Water Science and Technology Directorate Environment and Climate Change Canada Saskatoon Canada

Herein, we report on the use of chitosan-based engineered materials for the sequestration of naphthenic acid fraction compounds (NAFCs) and other species (matrix) in oil sands process-affected water (OSPW) in order to improve monitoring of NAFCs after phytoremediation. Chitosan pellets (CPs) were cross linked with glutaraldehyde (GLU) at variable feed ratios and characterized using thermogravimetric analysis (TGA). Sorption studies at equilibrium and kinetic conditions were carried on OSPW extract, raw and treated wetland samples. The materials were shown to have similar sorption capacity for NAFCs but with variable selectivity of the species in the complex mixture. As well, the matrix uptake varied according to the type of OSPW. Overall, CP in its native form outperformed the cross linked CP pellets, as evidenced by a reduction in matrix effects.

关键词： Chitosan Adsorbent Organic Acid Contaminants Sorption matrix Effects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent Advances on Photodynamic Therapy

Recent Advances on Photodynamic Therapy

引用

中国光学学会2006年学术大会

作者： Brian C wilson Division of Biophysics and Bioimaging Ontario Cancer InstituteUniversity of TorontoTorontoOntarioCanadaM5G2M9

Photodynamic therapy (PDT) has been known for over a hundred years, but is only becoming widely accepted and used at present in that the understanding of theoretical mechanism for PDT has been tremendously enhanced over the past few years. This review updates the advances on photosensitizers, lasers and non-laser light sources, dosimetry and potential applications of PDT in cancer and other diseases. Firstly, the photosensitizers used in PDT with regulatory approval and clinical trials, as well as under developing

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

供细菌性脂多糖检测的新方法

引用

肉品卫生 1993年第5期 30-31页

作者： wilson,m 吴信法

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

瑞典花岗岩和早元古代地壳的演化——从 Sm-Nd、U-Pb 和 O 同位素体系获得的证据

引用

地球与环境 1986年第4期 71-79页

作者： m.R.wilson 胡霭琴

引言瑞典的前寒武系为研究1.9—1.6Ga 期间的地壳演化过程提供了一个良好的机会。这部分元古界包括斯维科卡雷尔带(1.9—1.7Ga)和随后的后斯维科卡雷尔带(1.75—1.65Ga)。wilson(1982)根据已发表的花岗岩类地球化学和同位素数据提出,岩... 详细信息

引言瑞典的前寒武系为研究1.9—1.6Ga 期间的地壳演化过程提供了一个良好的机会。这部分元古界包括斯维科卡雷尔带(1.9—1.7Ga)和随后的后斯维科卡雷尔带(1.75—1.65Ga)。wilson(1982)根据已发表的花岗岩类地球化学和同位素数据提出,岩浆的产生可能与板块构造运动有关,先是约1.9Ga 出现的与俯冲有关的岩浆作用早期相,接着是约1.75Ga 产生了主要为地壳源的岩浆。沿新的斯维科卡雷尔变质带的边缘出现的俯冲作用的另一个阶段,可能

关键词：花岗岩类卡雷尔维科上地壳 U-Pb Nd 同位素瑞典北欧

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Periconceptional growth hormone treatment alters early uterine environment

引用

Open Journal of Animal Sciences 2013年第2期3卷 121-126页

作者： Jill m. Koch Caleb O. Lemley Ronald R. magness matthew E. wilson Department of medicine Section of Cardiovascular Medicine University of Wisconsin-Madison Madison USA Division of Animal and Nutritional Sciences Davis College of Agriculture Natural Resources and Design West Virginia University Morgantown Morgantown USA Perinatal Research Labs Departments of Obstetrics and Gynecology and Department of Animal Science University of Wisconsin Madison USA

We have shown that an injection of sustained release growth hormone (GH), given just prior to breeding, results in lambs that are 25% heavier at birth, with an altered body composition as evidenced by an increased abdominal girth, but no difference in crown rump length. The mechanisms by which these differences occur from a single periconceptional injection are not yet known. Therefore, the objective of this experiment was to determine the effect of an injection of GH given prior to breeding on the composition of the uterine luminal environment and the embryo at the time of blastocyst. Ewes were synchronized with two injections of prostaglandin F2α given eight days apart. On the day of the second injection, ewes were randomly assigned to be given an injection of sustained release GH or remain as controls and penned with a ram. On day 6.5 following breeding embryos were collected. Prior to surgery a jugular blood sample was taken to determine plasma progesterone and urea concentration. The uterine content of urea, prostaglandin F2α, prostaglandin E2, transforming growth factor β-1 (TGF β), and nitric oxide metabolites were measured. Collected embryos were differentially stained to calculate a trophectoderm to inner cell mass ratio. The concentration of progesterone in maternal plasma was greater in the treated group compare to controls, but blood urea nitrogen was not different between groups. The uterine content of urea in the GH group was lower than that of the control group. There was a trend for TGF β to be increased in the GH treated group compared to control (P = 0.07). There was no difference (P > 0.05) in the total uterine content prostaglandin F2α, prostaglandin E2 or nitric oxide metabolites. The trophectoderm to inner cell mass ratio was not different between treatment groups. Thus, we suggest that the observed difference in fetal development following periconceptional growth hormone administration just prior to breeding may be the result of an alteration

关键词： Growth Hormone Uterine Environment Embryo

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

脂多糖在内毒素诱导的淋巴细胞增殖和软骨细胞胶原酶合成中的作用

引用

宁夏医科大学学报 1988年第4期 147-148页

作者： m. wilson 沈冰

单核细胞因子IL-1是一种有效的结缔组织损伤因子,在慢性炎症中起主要作用。结缔组织损伤和慢性炎症是慢性炎症性牙周病(CIPD)的一个特征。在CIPD中,来自牙斑的细菌产物是如何造成损伤的还不清楚。现已证明至少有一种成伤胞壁二肽具IL—... 详细信息

单核细胞因子IL-1是一种有效的结缔组织损伤因子,在慢性炎症中起主要作用。结缔组织损伤和慢性炎症是慢性炎症性牙周病(CIPD)的一个特征。在CIPD中,来自牙斑的细菌产物是如何造成损伤的还不清楚。现已证明至少有一种成伤胞壁二肽具IL—1样作用。本文作者研究了其它细菌胞壁成伤也具有IL—1样活性的可能性;比较了IL—1活性测定的两种方法:淋巴细胞激

关键词：脂多糖淋巴内毒素胶原酶梭菌肽酶A 蛋白酶

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism

引用

Genes & Diseases 2022年第4期9卷 1129-1142页

作者： Brendan P.Norman Andrew S.Davison Juliette H.Hughes Hazel Sutherland Peter J.m.wilson Neil G.Berry Andrew T.Hughes Anna m.milan Jonathan C.Jarvis Norman B.Roberts Lakshminarayan R.Ranganath George Bou-Gharios James A.Gallagher Institute of Life Course and medical Sciences University of LiverpoolWilliam Henry Duncan Building6 West Derby StreetLiverpoolL78TXUK Department of Clinical Biochemistry&metabolic medicine Liverpool Clinical LaboratoriesRoyal Liverpool University HospitalPrescot StreetLiverpoolL78XPUK School of Sport&Exercise Sciences Liverpool John Moores UniversityTom Reilly BuildingByrom StreetLiverpoolL33AFUK Department of Chemistry University of LiverpoolCrown StreetLiverpoolL697ZDUK

Alkaptonuria (AKU) is an inherited disorder of tyrosine metabolism caused by lack of active enzyme homogentisate 1,2-dioxygenase (HGD). The primary consequence of HGD deficiency is increased circulating homogentisic acid (HGA), the main agent in the pathology of AKU disease. Here we report the first metabolomic analysis of AKU homozygous Hgd knockout (Hgd−/−) mice to model the wider metabolic effects of Hgd deletion and the implication for AKU in humans. Untargeted metabolic profiling was performed on urine from Hgd−/− AKU (n = 15) and Hgd+/− non-AKU control (n = 14) mice by liquid chromatography high-resolution time-of-flight mass spectrometry (Experiment 1). The metabolites showing alteration in Hgd−/− were further investigated in AKU mice (n = 18) and patients from the UK National AKU Centre (n = 25) at baseline and after treatment with the HGA-lowering agent nitisinone (Experiment 2). A metabolic flux experiment was carried out after administration of 13C-labelled HGA to Hgd−/−(n = 4) and Hgd+/−(n = 4) mice (Experiment 3) to confirm direct association with HGA. Hgd−/− mice showed the expected increase in HGA, together with unexpected alterations in tyrosine, purine and TCA-cycle pathways. metabolites with the greatest abundance increases in Hgd−/− were HGA and previously unreported sulfate and glucuronide HGA conjugates, these were decreased in mice and patients on nitisinone and shown to be products from HGA by the 13C-labelled HGA tracer. Our findings reveal that increased HGA in AKU undergoes further metabolism by mainly phase II biotransformations. The data advance our understanding of overall tyrosine metabolism, demonstrating how specific metabolic conditions can elucidate hitherto undiscovered pathways in biochemistry and metabolism.

关键词： Alkaptonuria Biotransformation metabolism metabolomics mice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：