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more evidence intratumoral DHT synthesis drives castration-resistant prostate cancer

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Asian Journal of Andrology 2014年第1期16卷 99-100页

作者： Elizabeth m wilson Laboratories for Reproductive Biology Department of Pediatrics Lineberger Comprehensive Cancer Center Department of Biochemistry and Biophysics University of North Carolina

Again-of-function stabilizing somatic mutation in 3β-hydroxysteroiddehydrogenase type 1 （3βHSDI, HSD3B1） was reported in castration-resistant prostate cancer. The A-C nucleotide polymorphism replaced asparagine-367 with threonine （3βHSD1-N367T） as a homozygous somatic mutation in a subset of castration-resistant prostate cancers by loss of heterozygosity of the wild-type allele. Increased stability of 3[HSD I-N367T was associated with decreased ubiquitin-mediated degradation and higher levels of dihydrotestosterone （DHT）. The studies suggest that genetic instability in castration-resistant prostate cancer favors the more stable 313HSD I-N367T mutant that contributes to drug resistance. A somatic mutation in a steroid metabolic enzyme required for DHT synthesis provides further support for intratumoral androgen synthesis contributing to prostate cancer progression.

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Iron Oxides and Their Relations to Colors in Some Soilsof Southern China

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Pedosphere 1998年第1期8卷 53-58页

作者： ZHANGmINGKUI m．J．wilson 等 DepartmentofSoilScienceandWaterResource ZhejiangAgriculturalUniversityHangzhou310029（CHina） Soilsand

Iron oxides from 33 samples of 25 soils derived from various parent materials in the southern China were studied using NaOH selective dissolution technique and X-ray diffraction (XRD). Goethite and hematite were the only two crystalline Fe oxides occurring in a significant quantity. The goethite / (goethite + hematie )ratios ranged from 0 to 1, being the highest in yellow soil, some yellow-red soils and saprolite samples and the lowest in soils derived from purple sandstone where only hematite was present. Al substitution in goethite ranged from 6.6 to 29.9 mol % with a mean value of 16.7 mol %, while substitution of Al in hematite ranged from 0 to 12.1 mol %. The values of Al substitution of hematite in coexisting goethite and hematite were closely related with corresponding values of goethite (r=0.7292, Pmount of hematite (r=0.8109, Pmate hematite contents of soils.

关键词： Al substitution color iron oxides southern China

Protection in the eye room:minimising risks of COVID-19 transmission during eye examinations in the emergency department

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Emergency and Critical Care medicine 2022年第1期2卷 5-6页

作者： matthew m.wilson C/O Royal Victorian Eye and Ear Hospital 32 Gisborne StreetEast MelbourneVictoria 3002Australia

Ocular examinations in the emergency department(ED)provide an increased risk of coronavirus disease 2019(COVID-19)transmission due to the close-proximity to the patient and inability to physical *** this article,I dis... 详细信息

关键词： COVID-19 Ocular examination Ophthalmology Respiratory droplet

Ribozymes and the mechanisms that underlie RNA catalysis

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Frontiers of Chemical Science and Engineering 2016年第2期10卷 178-185页

作者： Timothy J. wilson Yijin Liu David m. J. Lilley Cancer Research UK Nucleic Acid Structure Research Group MSI/WTB Complex The University of Dundee Dundee DD1 5EH UK

Ribozymes are widespread, and catalyze some extremely important reactions in the cell. mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozymes fall into the latter class, mostly using nucleobases. A sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozymes are still being discovered at regular intervals and we can speculate on the potential existence of ribozymes that catalyze chemistry beyond phosphoryl transfer reactions, perhaps using small-molecule coenzymes.

关键词： RNA catalysis RNA structure catalytic mechanism

Dupilumab-associated ulcerative keratitis

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 1020-1022页

作者： matthew m wilson Philipp K Roberts mark Daniell Corneal Service Royal Victorian Eye and Ear HospitalEast MelbourneVictoria 3002Australia medical University of Vienna Vienna 1090Austria Department of Surgery(Ophthalmology) University of MelbourneParkvilleVIC 3013Australia Surgical Research Unit Centre for Eye Research Australia(CERA)University of MelbourneMelbourneVIC 3013Australia

Dear Editor,We present a case of a healthy 32-year-old man who developed bilateral corneal ulceration 3 wk after commencing dupilumab for atopic dermatitis. Dupilumab is a recently introduced systemic monoclonal antibody used in the treatment of moderate-to-severe atopic dermatitis, showing efficacy in clinical trials;. Several publications have reported ocular surface complications associated with dupilumab.

关键词： dermatitis clinical keratitis

Genesis of the Gentio metagranitoid: Post-Collisional High-K Plutonism within the mineiro Belt, S?o Francisco Craton, Brazil

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Journal of Earth Science 2021年第6期32卷 1374-1396页

作者： marize m.da Silva Ciro A.Ávila Felipe m.Tavares Natali S.Barbosa wilson Teixeira Programa de Pós-graduação em Geologia Universidade Federal do Rio de Janeiro21.949-900Rio de JaneiroRJBrazil museu Nacional Universidade Federal do Rio de Janeiro20940-040Rio de JaneiroRJBrazil Serviço Geológico do Brasil Divisão de Geologia Econômica22290-255Rio de JaneiroBrazil Instituto de Geociências Universidade Federal da Bahia40170-110SalvadorBABrazil

The Gentio metagranitoid presents equigranular and porphyritic facies, modal composition ranging from tonalite to monzogranite with calculated T_(Zr)6 wt.%). Zircon analyses by LA-ICP-mS and SHRImP yielded a concordia... 详细信息

The Gentio metagranitoid presents equigranular and porphyritic facies, modal composition ranging from tonalite to monzogranite with calculated T_(Zr)most samples. Its mineralogy is dominated by quartz and feldspar(77% to 95%), biotite is the only mafic mineral present(2% to 18%) and, titanite, zircon, apatite, allanite are important accessory phases. These rocks range from metaluminous to weakly peraluminous, and have large variation in major and trace elements, and high alkali contents(>6 wt.%). Zircon analyses by LA-ICP-mS and SHRImP yielded a concordia age of 2 119±10 ma for the porphyritic facies and an upper intercept age of 2 111±15 ma for the equigranular facies. The whole-rock Sm-Nd T_(Dm) ages vary from 2.4 to 2.8 Ga with ε_(Nd)(2.1) values between -0.7 and-5.3, indicating crustal derivation from distinct and/or heterogeneous protoliths. Field observations indicate that the Gentio metagranitoid was formed through different pulses of magma. Individual batches were subject to little or even no fractionation process after its emplacement. Although the Gentio metagranitoid crosscuts metamafic and metaultramafic rocks akin to an oceanic arc setting, this pluton is likely originated by partial melting of a more evolved quartz-feldspathic crustal igneous rock in a post-collisional environment, after the accretion of the arcs from the mineiro belt and rocks of the mantiqueira Complex.

关键词： high-K granites mineiro belt post-collisional Sao Francisco Craton U-Pb geochronology

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Branched hybridization chain reaction-using highly dimensional DNA nanostructures for label-free,reagent-less,multiplexed molecular diagnostics

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microsystems & Nanoengineering 2019年第1期5卷 316-322页

作者： Gaolian Xu mingliang Lai Rab wilson Andrew Glidle Julien Reboud Jonathan m.Cooper Division of Biomedical Engineering James Watt School of EngineeringUniversity of GlasgowOakfield AvenueGlasgow G128LTUK

The specific and multiplexed detection of DNA underpins many analytical methods,including the detection of microorganisms that are important in the medical,veterinary,and environmental *** achieve such measurements generally requires enzyme-mediated amplification of the low concentrations of the target nucleic acid sequences present,together with the precise control of temperature,as well as the use of enzyme-compatible *** inevitably leads to compromises between analytical performance and the complexity of the *** hybridization chain reaction(HCR)provides an attractive alternative,as a route to enzyme-free DNA *** date,the linear nucleic acid products,produced during amplification,have not enabled the development of efficient multiplexing strategies,nor the use of label-free ***,we show that by designing new DNA nanoconstructs,we are able,for the first time,to increase the molecular dimensionality of HCR products,creating highly branched amplification products,which can be readily detected on label-free *** show that this new,branching HCR system offers a route for enzyme-free,label-free DNA detection,we demonstrate the multiplexed detection of a target sequence(as the initiator)in whole *** the future,this technology will enable rapid point-of-care multiplexed clinical analysis or in-the-field environmental monitoring.

关键词： reagent attractive branching

Exploitation of symmetry in periodic Self-Consistent-Field ab initio calculations: application to large three-dimensional compounds

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Science China Chemistry 2014年第10期57卷 1418-1426页

作者： DE LA PIERRE marco ORLANDO Roberto FERRABONE matteo ZICOVICH-wilson Claudio m. DOVESI Roberto Dipartimento di Chimica Università di Torino and NIS Nanostructured Interfaces and Surfaces Centre of Excellence Via P. Giuria 7 10125 Torino Italy Nanochemistry Research Institute Department of Chemistry Curtin University GPO Box U1987 Perth WA 6845 Australia Facultad de Ciencias Universidad Autónoma del Estado de Morelos Av. Universidad 1001 Col. Chamilpa 62209 Cuernavaca (Morelos) Mexico

Symmetry can dramatically reduce the computational cost （running time and memory allocation） of Self-Consistent-Field ab initio calculations for crystalline systems. Crucial for running time is use of symmetry in the evaluation of one- and two-electron integrals, diagonalization of the Fock matrix at selected points in reciprocal space, reconstruction of the density matrix. As regards memory allocation, full square matrices （overlap, Fock and density） in the Atomic Orbital （AO） basis are avoided and a direct transformation from the packed AO to the SACO （Symmetry Adapted Crystalline Orbital） basis is per- formed, so that the largest matrix to be handled has the size of the largest sub-block in the latter basis. We here illustrate the effectiveness of this scheme, following recent advancements in the CRYSTAL code, concerning memory allocation and direct basis set transformation. Quantitative examples are given for large unit cell systems, such as zeolites （all-silica faujasite and silicalite mF1） and garnets （pyrope）. It is shown that the full SCF of 3D systems containing up to 576 atoms and 11136 Atomic Orbitals in the cell can be run with a hybrid functional on a single core PC with 500 mB RAm in about 8 h.

关键词： point symmetry Symmetry Adapted Crystalline Orbitals Fock matrix density matrix CPU time memory allocation quantum-mechanical calculations CRYSTAL code

Thermal and photoperiodic requirements of the seedling stage of three tropical forest species

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Journal of Forestry Research 2023年第1期34卷 209-220页

作者： Fabrina Bolzan martins mábele de Cássia Ferreira Flávia Fernanda Azevedo Fagundes Gabriel wilson Lorena Florêncio Natural Resource Institute Federal University of ItajubáItajubáMinas Gerais 37500-903Brazil

Air temperature and photoperiod play an important role in the seedling development for tropical forest *** variables are sensitive to climate,and so evaluating thermal and photoperiodic effects on seedling development is fundamental,especially for climate change *** to quantify thermal time and the energy required for plants to reach a development stage include air temperature and cardinal *** photoperiod will also affect physiological reactions of a plant and thus its *** we evaluated the six thermal time methods widely used to compute thermal requirement,and identified the influence of the photoperiod from the 2015 and2016 growing seasons and 12 sowing dates in Itajubá,minas Gerais state,Brazil,on seedling development of three native tropical forest species Psidium guajava L.(myrtaceae),Citharexylum myrianthum Cham.(Verbenaceae),and Bixa orellana L.(Bixaceae).The method used to quantify thermal time influenced the analytical results of seedling development;the one that considered three cardinal temperatures and compared them with the mean air temperature(method5)performed better in computing thermal *** influence of photoperiod on seedling development was inconclusive for the three species,but all three developed better in mild temperatures(between 13.3℃and 26.9℃)with a photoperiod shorter than 13 h.

关键词： Phyllochron Thermal time Day length Seedling stage Phenology