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围手术期应用生长激素对肠外营养病人肠粘膜通透性、细胞免疫功能及预后的影响

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中国临床营养杂志 2001年第2期9卷 77-80页

作者：刘卫蒋朱明王秀荣舒红崔巍 wilmore dw 中国医学科学院北京协和医院外科中国医学科学院北京协和医院检验科美国哈佛医学院Brigham&Women医院外科

目的　观察围手术期应用重组人生长激素 (rHGH)对肠外营养病人肠粘膜通透性、小肠粘膜形态、细胞免疫功能和预后的影响。　方法　前瞻性、随机、双盲、安慰剂对照的临床研究。 2 0例因胃肠道疾病行手术治疗的病人进入本研究。术前 3天... 详细信息

目的　观察围手术期应用重组人生长激素 (rHGH)对肠外营养病人肠粘膜通透性、小肠粘膜形态、细胞免疫功能和预后的影响。　方法　前瞻性、随机、双盲、安慰剂对照的临床研究。 2 0例因胃肠道疾病行手术治疗的病人进入本研究。术前 3天至术后第 7天 ,研究组病人接受rHGH(0 .3IU·kg-1·d-1,皮下注射 )治疗 ,对照组接受安慰剂。从术前 1天至术后第 6天 ,两组病人接受等氮等热卡的肠外营养 (2 0Kcal·kg-1·d-1,N 0 .15 g·kg-1·d-1)。观察指标包括 :肠粘膜通透性、小肠粘膜形态、外周血淋巴细胞亚群和预后。　结果　 (1)rHGH治疗显著提高了研究组病人血浆GH和IGF 1浓度 (P =0 .0 0 93～ 0 .0 2 9) ,而对照组血浆GH和IGF 1浓度较术前无变化 (P =0 .2 5～ 0 .6 9)。(2 )手术后对照组肠粘膜通透性较术前明显升高 (P =0 .0 1) ,研究组升高不明显 (P =0 .0 8)。研究组小肠粘膜厚度和绒毛高度与对照组比较无显著差别 (P =0 .5 4,P =0 .6 6 )。 (3)对照组病人术后CD4+淋巴细胞比例及CD4+/CD8+淋巴细胞比值较术前下降 (P =0 .0 3) ,研究组术后无明显变化 (P =0 .0 9～ 0 .49) ,两组间变化差值比较有显著性差异 (P =0 .0 2 )。 (4)临床未见与rHGH治疗有关的严重不反应。rHGH治疗后研究组空腹血糖较治疗前有升高趋?

关键词：生长激素肠外营养肠粘膜屏障细胞免疫预后围手术期

单用静脉大豆油脂肪乳剂对比联合应用鱼油脂肪乳剂的肠外营养对消化道肿瘤术后患者结局影响的随机、对照、双盲、多中心临床研究(摘要)

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中华临床营养杂志 2011年第2期19卷 118-118页

作者：蒋朱明 wilmore dw 王秀荣韦军民张忠涛顾倬云王杉韩少梅江华于康中国医学科学院北京协和医学院北京协和医院基本外科肠外肠内营养中心哈佛医学院布莱根妇女医院外科卫生部北京医院普外科首都医科大学附属北京友谊医院普外科解放军总医院普通外科北京大学人民医院普通外科中国医学科学院北京协和医学院基础医学研究所流行病及统计学系四川省医学科学院四川省人民医院城东病区创伤代谢组多学科实验室

部分回顾性临床研究观察到在营养液配方中添加特异的药理营养素可能降低术后并发症,缩短术后恢复时间,但仍缺乏较大样本、前瞻性、多中心、随机对照临床研究的证据。近年来,药理营养素在肿瘤患者综合治疗中可能发挥的作用逐渐受到重视... 详细信息

部分回顾性临床研究观察到在营养液配方中添加特异的药理营养素可能降低术后并发症,缩短术后恢复时间,但仍缺乏较大样本、前瞻性、多中心、随机对照临床研究的证据。近年来,药理营养素在肿瘤患者综合治疗中可能发挥的作用逐渐受到重视。本研究前瞻性观察了静脉用鱼油脂肪乳剂对消化道肿瘤术后患者结局和免疫功能的影响。

关键词：脂肪乳剂大豆油鱼油肠外营养消化道肿瘤

Correction of TOPEX altimeter data error and its preliminary results in application

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Chinese Science Bulletin 1997年第17期42卷 1451-1455页

作者： Zheng, dw Wu, HQ Shanghai Observatory Chinese Academy of Sciences Shanghai China

TOPEX/POSEIDON is an altimetric satellite mission jointly conducted by NASA, the US

关键词： ocean satellite altimeter instrument drift correction sea-level change.

Polar motion and the North Atlantic Oscillation

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Chinese Science Bulletin 1997年第11期42卷 927-931页

作者： Zhou, YH Zheng, dw Chao, BF Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai China NASA Goddard Space Flight Center USA

THE motion of earth’s instantaneous rotation pole with respect to the earth crust or the mean pole of the epoch is briefly referred to as the polar *** polar motion is mainly charac-terized by the annual and Chandler polar *** data accumulation and promotion ofthe observation accuracy after the 1980s,people have extended researches of only annual

关键词： polar motion the North Atlantic Oscillation excitation function interannual time scale.

SURFACE　INTEGRAL　OF　THREE－DIMENSIONAL　VELOCITY　FIELD　FOR　SQUARE　BAR　DRAWING　THROUGH　CONICAL　DIE

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中国有色金属学会会刊：英文版 1996年第3期6卷 131-135页

作者： Zhao, dw Guo, CW Liu, XH Fang, YK NORTHEASTERN UNIV ROLLING TECHNOL & TANDEM ROLLING AUTOMAT NATL KEY SHENYANG 110006 PEOPLES R CHINA UNIV FREIBURG INST ANGEW MATH D-7800 FREIBURG GERMANY

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ＳＵＲＦＡＣＥＩＮＴＥＧＲＡＬＯＦＴＨＲＥＥ－ＤＩＭＥＮＳＩＯＮＡＬＶＥＬＯＣＩＴＹＦＩＥＬＤＦＯＲＳＱＵＡＲＥＢＡＲＤＲＡＷＩＮＧＴＨＲＯＵＧＨＣＯＮＩＣＡＬＤＩＥ￥ＺｈａｏＤｅｗｅｎ；ＧｕｏＣｈａｎｇｗｕ；ＬｉｕＸｉａｎｇｈｕａ（ＲｏｌｌｉｎｇＴ...

关键词： square bar drawing three dimensional velocity field surface integral

Perimeter-Area Relation and Fractal Dimension of Fracture Surfaces

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Journal of Materials Science & Technology 1997年第5期13卷 416-420页

作者： Shi, dw Jiang, J Tian, EK Lung, CW International Centre for Materials Physics Institute of Metal Research Chinese Academy of Sciences Shenyang 110015 China

We have theoretically analysed the perimeter-area relation and simulated its application to measuring the fractal dimension of fracture surfaces. It is proved that the fractal dimension D obtained by slit island method (SIM) is related to the dependence of measured area A(delta) of the slit island on yardstick delta. So in some cases, the dimension D obtained by SIM is dependent on yardstick and in other cases independent on yardstick delta. But in all cases, when delta-->0 the dimension D obtained by SIM approaches the real fractal dimension (similar dimension) of 'coastline' of the island. We analysed some experimental data and found some new and interesting characteristics of crack propagation in steels.

关键词： Steel

High-level expression of human calmodulin in *** and its effects on cell proliferation

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World Journal of Gastroenterology 2000年第4期6卷 588-592页

作者： Li XJ Wu JG Si JL Guo dw Xu JP Nanjing Gen Hosp Nanjing Command Ctr Lab Med Sci Dept ImmunolPLA Nanjing 210002 Jiangsu Prov Peoples R China

Calmodulin (CaM), widely distributed in almost all eukaryotic cells, is a major intracellular calcium receptor responsible for mediating the Ca2 + signal to a multitude of different enzyme systems and is thought to play a vital role in the regulation of cell proliferative cycle[1，2]. Recently, many studies showed that CaM is also present in extracellular fluid such as cell culture media and normal body fluid and has been reported to stimulate proliferation in a range of normal and neoplastic cells, apparently acting as an autocrine growth factor[3-11]. In 1988, Crocker et al reported for the first time that addition of extracellular pure pig brain CaM could promote DNA synthesis and cell [7]proliferation in K562 human leukaemic lymphocytes[7].After that, more and more research was done on extracellular CaM and evidences demonstrated that extracellular CaM could also stimulate cell proliferation in normal human umbilical vein endothelial cells[5], keratinocytes[4], suspension-cultured cells of Angelica Dahurica, etc[6]. CaM is a monomeric protein of 148 amino acids that contains four homologous Ca2 + -binding domains. CaM has been highly conserved throughout the evolution. Only 1 out of 148 amino acids of human CaM is different from that of fish CaM. Complementary DNAs encoding rat, eel, chicken, human, and trypanosome CaM have been cloned.

关键词： calmodulin gene expression biological activity Escherichia coli cell proliferation trifluoperazine polymerase chain reaction monoclonal antibodies

Photochemistry of phenothiazine in benzene and cyclohexane

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Chinese Science Bulletin 1997年第12期42卷 998-1000页

作者： Wang, SH Chen, dw Gou, JX Wang, H Institute of Chemistry Chinese Academy of Sciences Beijing China

IN the last few years phenothiazine(PTH)and its derivatives have captured much attention inthe fields of medicines,biology,and microelectronic materials due to their ability to ef-ficiently photosensitize acid production in the presence of vicinal dibromides and hence tochange the solubilization of polymer *** photophysical and photochemical properties re-lated to the processes have been *** Barra et *** that the triplet

关键词： photochemistry ESR nitroxyl radical cation radical.

Fractal Microstructure of Fracture Surfaces and Fracture Energy of Metals

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Journal of Materials Science & Technology 1997年第6期13卷 495-498页

作者： Shi, dw Jiang, J Lung, CW Liu, HZ Lou, TP Liu, HB Chinese Acad Sci Inst Met Res Int Ctr Mat Phys Shenyang 110015 Peoples R China Chinese Acad Sci Inst Met Res State Key Lab RSA Shenyang 110015 Peoples R China

Using a fractal model, we give a new interpretation of the reversed sigmoidal curves of fracture surface profile length obtained in some experiments. It is pointed out that a single parameter (fractal dimension D) is not sufficient to characterize a fractal curve completely. It is shown that the initiator length L-0 is also important to characterize a fractal curve. We have derived a formula which correlate the fracture energy with the fractal parameters of the fracture surfaces and analyzed some experimental data.

关键词： Fracture