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Kinematics ofmandibular advancement devices(MADs):Why do some MADs move the lower jaw backward duringmouth opening?

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Bio-Design and Manufacturing 2024年第5期7卷 637-650页

作者： Juan a.cabrera Alex Bataller Sergio Postigo Marcos García Mechanical Engineering Department University of Malaga29071 MalagaSpain

Mandibular advancement devices(MADs)are widely used treatments for obstructive sleep *** function by advancing the lower jaw to open the upper *** increase patient comfort,most patients allow the mouth to be ***,not all systems maintain the lower jaw in a forward position during mouth opening,which results in the production of a retrusion that favors the collapse of the upper ***,the kinematic behavior of the mechanism formed by the mandible-device assembly depends on jaw *** means that,during mouth opening,some devices cause lower jaw protrusion in some patients,but cause its retraction in *** this study,we report the behavior of well-known devices currently on *** do so,we developed a kinematic model of the lower jawdevice *** validated for all devices analyzed using a high-resolution camera *** results show that some of the devices analyzed here did not produce the correct behavior during patient mouth opening.

关键词： Mandibular advancement devices Lower jaw kinematics Sleep apnea

The Public Role of the Social and Human Sciences After the Crisis of Modernity

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Fudan Journal of the Humanities and Social Sciences 2019年第1期12卷 15-26页

作者： Miguel a.cabrera University of La Laguna Ap.45638200 La LagunaTenerifeSpain

The current crisis of modernity has far-reaching implications for the public role of the social and human *** crisis has made it clear that the central theoretical premises and concepts used by social scientists until now are not reflections of phenomena and processes which really exist,but components of the modern imaginary or *** a consequence,social scientists5 ambition of being experts and guides of human practice has been seriously undermined and their social function should be completely reconsidered and *** now on,the function of social scientists cannot be to provide people with an objective knowledge about *** a situation marked by the theoretical and epistemological disenchantment of modernity,their public role should be to help denaturalize and deconstruct any statement,practice,institution,or power relation with claims of being objectively founded.

关键词： Social scientists,role Crisis of modernity Knowledge Modern imaginary Deconstruction

uFSHh、pFSH和rFSH在体外受精与卵胞浆内单精子注射妊娠结局的回顾性分析

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宁夏医学杂志 2006年第2期28卷 83-85页

作者：徐仙赵淑梅 Rafael a.cabrera 宁夏医学院附属医院宁夏银川750004 美国弗吉尼亚Jones生殖医学研究院弗吉尼亚诺福克23507

目的探讨基因重组和尿卵泡刺激素在体外受精(IVF)和卵胞浆内单精子注射(ICSI)的妊娠结局。方法在促性腺激素释放激素激动剂(GnRHa)长或短方案下,分别应用尿卵泡刺激素(uFSH)、高纯度尿卵泡刺激素(hpFSH)和基因重组卵泡刺激素(rFSH)促排... 详细信息

目的探讨基因重组和尿卵泡刺激素在体外受精(IVF)和卵胞浆内单精子注射(ICSI)的妊娠结局。方法在促性腺激素释放激素激动剂(GnRHa)长或短方案下,分别应用尿卵泡刺激素(uFSH)、高纯度尿卵泡刺激素(hpFSH)和基因重组卵泡刺激素(rFSH)促排卵,回顾性分析1049例实施IVF和ICSI的治疗周期。结果无论在GnRHa长或短方案中,uFSH组和hpFSH组ICSI的受精率较IVF显著降低(P<0.0001),但在rFSH组两者无明显差异;而且各组之间IVF和ICSI的种植率或妊娠率亦无统计学差异。结论在IVF和ICSI周期治疗中,uFSH、hpFSH与rFSH具有等同的胚胎种植率和临床妊娠率。

关键词：卵泡刺激素体外受精卵胞浆内单精子注射种植妊娠

On the installation of an in situ large-scale vertical SEALing (VSEAL) experiment on bentonite pellet-powder mixture

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第9期15卷 2388-2401页

作者： Nadia Mokni Justo cabrera Frédéric Deleruyelle Institut de Radioprotection et de SûretéNucléaire(IRSN) PSE-ENV/SEDRE/LETISFontenay-aux-Roses92260France

Recently,the Institute for Radiological protection and Nuclear Safety(IRSN)has launched VSEAL(Vertical SEALing)project to investigate the impact of gas migration on the long-term performance of bentonite based vertical sealing systems(VSS).The first VSEAL in situ test was emplaced in IRSN’s Underground Research Laboratory(URL)in Tournemire(France)in 2019 and was equipped with 76 wired and wireless *** test is still in progress,but the collected set of data provides already valuable information of the hydro-mechanical behavior of VSS during *** swelling core consists of a mixture of highdensity pellets and powder of MX80 bentonite in a ratio of 80/20(in dry mass).An innovative method was adopted to drill a 1-m diameter and w10-m deep shaft in order to minimize the rock perturbation at the *** a specific protocol was adopted to install the bentonite mixture together with a careful characterization of the core during construction,VSEAL 1 constitutes the unique in situ sealing test with a well-known initial structural distribution of the pellets and the *** heterogeneities occurred within the experiment during the installation process:a damaged zone developed around the shaft walls due to the interruption of the installation operations caused by COVID19 lockdown in France;a technological gap with a variable thickness between the last pellets layer and the top confining lid and a heterogeneous distribution of the bentonite powder at some layers inducing large inter pellets voids close to the bentonite-rock *** injected water volume,relative humidity,water content and swelling pressure in both radial and axial directions were *** of the results showed that the presence of installation-induced heterogeneities led to the generation of preferential flow paths that influenced the swelling pressure evolution at radial and axial directions.

关键词： Bentonite pellet-powder mixture Heterogeneities Technological gap Seals In situ test

Re-engineering artificial muscle with microhydraulics

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Microsystems & Nanoengineering 2017年第1期3卷 278-285页

作者： Jakub Kedzierski Eric Holihan Rafmag cabrera Isaac Weaver Massachusetts Institute of Technology Lincoln Laboratory LexingtonMA 02420USA

We introduce a new type of actuator,the microhydraulic stepping actuator(MSA),which borrows design and operational concepts from biological muscle and stepper *** offer a unique combination of power,efficiency,and scalability not easily achievable on the *** actuator works by integrating surface tension forces produced by electrowetting acting on scaled droplets along the length of a thin *** muscle,MSAs have liquid and solid functional components and can displace a large fraction of their *** 100μm pitch MSA presented here already has an output power density of over 200 W kg^(−1),rivaling the most powerful biological muscles,due to the scaling of surface tension forces,MSA’s power density grows quadratically as its dimensions are reduced.

关键词： artificial muscle electrowetting linear actuator microactuator microsystem microhydraulic stepping actuator

Nodal user’s demand response based on incentive based programs

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Journal of Modern Power Systems and Clean Energy 2017年第1期5卷 79-90页

作者： Nestor GONZáLEZ-cabrera Guillermo GUTIéRREZ-ALCARAZ Instituto Tecnolo´gico Superior de Irapuato Irapuato 36620Mexico Instituto Tecnolo´gico de Morelia Morelia 58120Me´xico

This paper describes a practical approach to identify nodal price compensation payment for nodal consumers willing to reduce their energy consumption(consumers’ demand response). The implementation of a nodal reliability service pricing is based on contingency assessment of N-2 order for transmission lines. A representative annualized demand curve is used to reflect the system’s operation condition by seasons. Such curve is used to access the nodal reliability impact trough a whole year in order to determine back-payments(incentive payment) to users for service interruption. The IEEE_RTS 24 nodes system is used to implement the proposed approach.

关键词： Nodal demand response Demand side management Reliability assessment Incentive based programs(IBP)

Using single cell transcriptomics to study the complexity of human retina

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Neural Regeneration Research 2020年第11期15卷 2045-2046页

作者： Daniel Urrutia.cabrera Raymond Ching-Bong Wong Centre for Eye Research Australia Department of Surgery(Ophthalmology)University of MelbourneMelbourneAustralia

The human retina is a specialized multilayered structure composed of numerous cell *** process of vision relies on a robust network integrated by rod photoreceptors,cone photoreceptors,bipolar cells,horizontal cells,amacrine cells and retinal ganglion cells,which detect,process and relay the visual information to the ***,structural and metabolic support is provided by Muller glia,retinal astrocytes and *** 200 genes have been implicated in inherited retinal diseases(RetNet:https://***/retnet/).However,in many cases,the retinal cell types that express these disease-associated genes remain to be *** complexity of the human retina represents a major challenge for the molecular profiling of all retinal cell *** previous studies utilised bulk RNA-seq to profile the whole human adult retina,which only analysed the averaged gene expression levels across all retinal cell *** such,knowledge of the transcriptome profile in specific cell types within the retina would help us to unravel the heterogeneity of retinal cells,advance understanding of the pathogenesis of inherited retinal diseases,and to develop gene therapies that could improve treatment options.

关键词： diseases specialized retina

Assisted Natural Remediation of a Trace Element-Contaminated Acid Soil:An Eight-Year Field Study

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Pedosphere 2015年第2期25卷 250-262页

作者： Jian XIONG Paula MADEJON Engracia MADEJON Francisco cabrera Instituto de Recursos Naturales y Agrobiologia de SevillaIRNAS CSICAvenida Reina Mercedes10P.O.Box 1052Seville 41080 Spain

There are many remediation techniques for organic contaminated soils,but relatively few of them are applicable to trace elementcontaminated soils.A field experiment was carried out to investigate assisted natural remediation(ANR) of an acid soil contaminated by As,Cd,Cu,Zn and Pb using one inorganic amendment,sugar beet lime(SL),and two organic amendments,biosolid compost(BC)and leonardeite(LE).The experiment was arranged in a completely randomized block design with four treatments in three replicates:1) a non-amended control(NA);2) SL amended at 30 Mg ha^(-1) year^(-1);3) BC amended at 30 Mg ha^(-1) year^(-1) and 4) LE amended at 20 Mg ha^(-1) year^(-1) plus SL amended at 10 Mg ha^(-1) year^(-1)(LESL).The amended plots received two doses of each amendment(DO2):one in October 2002 and another in October *** plots were then divided in half into two subpolts and one subplot received another two doses of the same amendments(DO4) in October 2005 and October *** 2011,the pH values of the amended soils were greater than that of the NA soil,with the SL-amended soil showing the highest *** organic carbon(TOC) was also greater in the amended soil,and greater with DO4 than with *** reduced the concentrations of 0.01 mol L^(-1) CaCl_2-extractable Cd,Cu and Zn,especially in the SL-amended *** cover of colonizing vegetation was enhanced by amendments,but was independent of amendment *** in soil properties from 2003 to 2011 showed that the first amendment application of DO2 caused a high differentiation between all the amendment treatments and the NA *** the second application of DO2,soil pH and TOC continued increasing *** two applications of amendments(DO4) caused differences only in the organic *** cover increased over time in all the treatments including *** could be concluded that the slow and steady natural remediation of this soil could be enhanced by amendment application(ANR).

关键词： amendment application CaCl2 extraction colonizing vegetation plant cover soil contamination soil property

Dipole and generalized oscillator strength derived electronic properties of an endohedral hydrogen atom embedded in a Debye-Huckel plasma

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Matter and Radiation at Extremes 2018年第5期3卷 227-242页

作者： C.Martínez-Flores R.cabrera-Trujillo Instituto de Ciencias Físicas Universidad Nacional Autonoma de MexicoAp.Postal 43-8CuernavacaMorelos62251Mexico

We report electronic properties of a hydrogen atom encaged by an endohedral cavity under the influence of a weak plasma interaction. Weimplement a finite-difference approach to solve the Schrodinger equation for a hydrogen atom embedded in an endohedral cavity modeled by theWoods-Saxon potential with well depth V0, inner radius R0, thickness D, and smooth parameter g. The plasma interaction is described by aDebye-Hu¨ckel screening potential that characterizes the plasma in terms of a Debye screening length lD. The electronic properties of theendohedral hydrogen atom are reported for selected endohedral cavity well depths, V0, and screening lengths, lD, that emulate differentconfinement and plasma conditions. We find that for low screening lengths, the endohedral cavity potential dominates over the plasma interaction by confining the electron within the cavity. For large screening lengths, a competition between both interactions is observed. We assessand report the photo-ionization cross section, dipole polarizability, mean excitation energy, and electronic stopping cross section as function of lD and V0. We find a decrease of the Generalized Oscillator Strength (GOS) when the final excitation is to an s state as the plasma screeninglength decreases. For a final excitation into a p state, we find an increase in the GOS as the endohedral cavity well-depth increases. For the caseof the electronic stopping cross section, we find that the plasma screening and endohedral cavity effects are larger in the low-to-intermediateprojectile energies for all potential well depths considered. Our results agree well to available theoretical and experimental data and are afirst step towards the understanding of dipole and generalized oscillator strength dependent properties of an atom in extreme conditions encagedby an endohedral cavity immersed in a plasma medium.

关键词： Oscillator strengths Debye-Huckel plasma Cavities Endohedral Energy loss Stopping power