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Histological and Morphological Study of the Intestines of Wistar Rat Fetuses in a Modified Gastroschisis Experimental Model

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Surgical Science 2016年第2期7卷 72-81页

作者： André Luis Hecht Sartori Marina Ferreira Rosa de Vilhena Gabriela Samaha frança willy marcus frança Faculty of Medical Science and Health Catholic University of S&atildeo Paulo (FCMS PUC/SP) S&atildeo Paulo Brazil São Paulo City University S&atildeo Paulo Brazil Pediatric Surgeon Laboratory of Surgery Technique and Experimental Surgery FCMS PUC/SP S&atildeo Paulo Brazil

In gastroschisis (G), the lesion degree of exposed intestinal segments is related to the time of its contact with the amniotic fluid (AF) and exposure to meconium which is the cause of intestinal morphological and histological alterations. The outcome of these alterations is intestinal hypoperistalsis and nutrient absorption deficiency, which contribute to increased morbidity and high medical-hospital costs. In this study, morphological and histological intestine alterations were identified at two different contact occasions with AF. Experimental gastroschisis (G) was performed on Wistar rat fetuses at a single gestational age on day 18.5th. The fetuses were removed on the 20.5th (G-1) and 21.5th days (G-2). Fetuses of both groups were divided in 3 sub-groups: control (C), gastroschisis (G) and sham (S). Measurements were taken of the Whole Set including fetus, placenta and membranes with AF (WS), fetus body weight (BW), intestinal weight (IW) and their diameters (DI). The objective of the present study is to test a new gastroschisis experimental model and identify differences in morphological and histological alterations in these two gestational periods that may be directly related to intestinal motility disorders in G. The WS and BW presented no significant statistical difference when compared G1 and G2. The results of the intestine average weight of G2 fetuses were significantly higher when compared to G1 fetuses in all subgroups (C: p = 0.02;G: p = 0.01;S: p = 0.02, Mann Whitney). The results of the intestinal average diameters (D/d) in G1 and G2 presented significant statistical difference only in G subgroup (p Kruskal Wallis). When compared intestinal average diameters, there was significant statistical difference of G fetuses in G1 and G2 (p Mann Whitney). In conclusion, the present experimental G model was adequate to reproduce G in rat fetuses. All G fetuses presented significant statistical difference when compared to other

关键词： Gastroschisis Intestinal Damage Intestinal Motility Early Delivery

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Comparative Study of Bovine Pericardium and Gore-Tex in Tissual Interaction with Wistar Rats Diaphragm

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Surgical Science 2016年第9期7卷 381-389页

作者： Artur Fracassi Guerra Mauro Razuk Filho Neil Ferreira Novo willy marcus frança Medical Science and Health Faculty Catholic University of Sao Paulo Sao Paulo Brazil Department of Medicine—Service of Statistical Studies Sao Paulo Brazil Department of Medicine Catholic University of Sao Paulo Sao Paulo Brazil

Introduction: Simple suture isn’t always possible in large congenital diaphragmatic hernia (cdh) defects. Synthetic materials are used for correction such as Silastic®, Gore-Tex® (GT), Teflon® or biological, such as autologous muscle patches. It was shown that bovine pericardium (bp) was effective to correct those large defects with many positive outcomes when compared with syntactic materials. Aim: This study aims to establish an experimental model of correction for large diaphragmatic defect with PB and GT patches to compare histologically the tissue interaction between them and diaphragm in young Wistar rats. Materials & Methods: 15 wistar rats were divided in 3 groups: Rats that used BP was named G1;Rats that used GT was named G2;and rats with only scraping in the diphragm, named G3 (control). Animals were submited to a laparotomy and fixed pathces to diaphragms and harvested 3 weeks later. Area between normal diaphragm and patches were isolated and separated for histological analysis, such as lymphocytic infiltration (inflammation), neovascularization and fibrosis. Results: G1 presented inflammation between BP and Diaphragm In 5 Samples. G2 Presented Neovascularization In 5 Samples, But No inflammation. Fibrotic tissue overlapping GT patches occurred in 3 samples in G2. Comparing G1 with G2 there was a significant statistical difference concerning inflammation (P = 0.0079), in G1. Comparing neovascularization there is no significant statistical difference (P = 0.4444), despite a slight higher incidence in G2. Fibrosis in both groups presented no significant statistical difference (P = 0.4444), despite a slight higher incidence in G2. There were no alterations in G3. Discussion: Despite the statistical difference in the inflammatory process was more frequent in G1 (P = 0.0079), neovascularization and fibrosis were more frequent in G2. Conclusion: The proposed experimental model was satisfactory to reproduce suture of patches in the diaphragm. These resu

关键词： Diaphragm Hernia Bovine Pericardium Gore-Tex Tissue Interaction and Wistar Rat

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Gigantic Abdominal Pseudocyst: An Unusual Evolution of the Ventriculoperitoneal Shunt

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Open Journal of Modern Neurosurgery 2021年第4期11卷 252-257页

作者： Alícia de Oliveira Mendes Fernanda Aquino Freres Silva Luiza Kohmann Salvoni willy marcus frança Medical Science and Health Faculty PUC/SP (FCMS PUC/SP) Campus Sorocaba Sorocaba Brazil Laboratory of Surgery Technique and Experimental Surgery of FCMS PUC/SP Campus Sorocaba Sorocaba Brazil

Background: The ventriculoperitoneal (VPS) shunt is the most common procedure in the treatment of hydrocephalus in children. Abdominal cerebrospinal fluid pseudocysts are a rare complication of the ventriculoperitoneal shunt with an incidence ranging from less than 1% to 10% and are more prevalent in children. The malfunction of the ventriculoperitoneal shunt can cause headaches, nausea, vomiting, altered level of consciousness and abdominal pain due to the accumulation of cerebrospinal fluid. There is no consensus on which type of treatment is better in this case, but there are several available methods. Aim: To report an unusual case of a giant abdominal cerebrospinal fluid pseudocyst as a complication of the VPS. Case Presentation: Female 1 y/3 months old patient, less than 7 kg, that has been diagnosed with hydrocephalus prenatally, confirmed postnatally associated with an esophageal atresia and distal tracheoesophageal fistula (AE/FTE, Gross III), was admitted to our service with progressive abdominal distention without obstructive intestinal signs or peritoneal inflammatory signs. The CT scan of the abdomen showed a large liquid collection (estimated volume of 600 ml), centered on the umbilical region, diagnosed as a giant abdominal cerebrospinal fluid (CSF) pseudocyst from the VPS. All of data and infor

关键词： Abdominal Cerebrospinal Fluid Pseudocysts Ventriculoperitoneal Shunt

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Epidemiological Study of Pediatric Surgery at Regional Hospital of Sorocaba between 2008 and 2012 by a Single Surgeon

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Surgical Science 2017年第8期8卷 375-383页

作者： Raíssa Teixeira Rosalino Natália Iwakura Martelli Neil F. Novo willy marcus franç a Medical Science and Health Faculty Pontifical Catholic University of S&atilde o Paulo (PUC-SP) S&atilde o Paulo Brazil Department of Medicine Service of Statistical Studies of Pontifical Catholic University of S&atilde o Paulo (PUC-SP) S&atilde o Paulo Brazil Medical Science and Health Faculty Pontifical Catholic University of S&atilde o Paulo (PUC-SP) S&atilde o Paulo Brazil

Introduction: volume increase of Pediatric Surgery (PedSur) due to factors not yet fully clarified contrast with the scarcity of pediatric surgeons in Brazil and globally. Geographic distribution, surgical care costs, and graduation period might contribute to this dearth. In Brazil, vacancy occupation rate in PedSur is below 43% (162 vacancies/year). Aim: analyze the volume of procedures performed on 0 - 12 year-old patients in PedSur by a single Specialist at Hospital Regional (HR);compare with the literature and propose the outset of a PedSur Medical Residence program. Material & Method: 1912 attendances were fulfilled on 986 children who were submitted to surgical procedures between 2008 and 2012 at HR by a single specialist. Results: Surgical procedures were performed on 1137 children, an average of 227/year or 197 children per year. Surgery was carried out in 667 (68%) boys and 319 (32%) girls. Hernias, appendectomies and circumcisions were the most frequent external surgeries. 437 (44%) patients were discharged on the same day and, 549 (56%) were hospitalized. In the Pediatric ICU and in the Neonatal ICU 181 procedures were performed (18%). Conclusion: It was possible to make evident the distribution of surgeries on children, the degree of complexity and a sufficient number of subjects for training in this Specialty. The obtained data allow the development of a study with regards to the inception of a Medical Residence in PedSur at HR for training and retaining the professional in the region.

关键词： Patient Care Pediatric Surgery Epidemiology Resident Education

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Preduodenal Portal Vein (PDPV): A Very Rare Cause of Duodenum Obstruction

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Surgical Science 2017年第12期8卷 493-498页

作者： Beatriz Dinamarco Elsner Gonzaga willy marcus franç a Pedro Luis Escher Parron Patrícia Junqueira Mais Soares Medical Science and Health Faculty PUC/SP (FCMS PUC/SP) Sorocaba Brazil Pediatric Surgeon the Medical Science and Health Faculty PUC/SP the Laboratory of Surgery Technique and Experimental Surgery of FCMS PUC/SP Sorocaba Brazil

Congenital duodenal obstruction (CDO) is one of the most common anomalies presented in the neonatal period of intestinal obstruction, with an incidence of 1:10,000, and Preduodenal Portal Vein (PDPV) is a rare extrinsic cause of CDO. PDPV leads to CDO with a persistent vomiting, impairment of the oral feeding and weight loss, but other publications state an asymptomatic disease that may requires late surgical correction. Prenatal diagnosis of CDO, including PDPV, is evidenced by association of polyhydramnios with a dilated fluid-filled gastric and duodenum and a double-bobble image in the ultrasonography and permits a proper management of associated malformation, delivery, surgery and allows family counseling. PDPV is commonly associated to other intestinal obstruction such as extrinsic (annular pancreas, adhesive bands, malrotation, peritoneal bands, intestinal duplication), and intrinsic (atresia, web and stenosis), and also associated with cardiovascular anomalies, situs inversus, Down’s syndrome and polysplenia. This is full term 5 days old newborn, 2865 g girl, without prenatal diagnosis of CDO. It was not still established PDPV until surgery procedure such as Duodenoduodenostomy (Diamond-Shape) and can guide Paediatric Surgeons that face high intestinal obstruction in the neonate with or without prenatal diagnosis. In the ambulatory follow up after 4 months, baby has developed very well, in breast-feeding associated with formula-feeding with a normal weight gain (average of 550 g/month).

关键词： Duodenal Obstruction Preduodenal Portal Vein Polysplenia Ultrasonography

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Comparative Study of Histological Alterations in Intravascular Catheter Region with and without the Use of Local Corticosteroid

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Surgical Science 2017年第4期8卷 175-183页

作者： Carolina Utsunomiya Muniz Maíra Stathourakis Sampaio Amaral Neil Ferreira Novo Juliana Abeche Fermozelli willy marcus franç a Medical Science and Health Faculty Sao Paulo Brazil Department of Medicine-Service of Statistical Studies Sao Paulo Brazil Department of Morphology & Pathology Sao Paulo Brazil Department of Medicine and Pediatric Surgeon Sao Paulo Brazil

Introduction: Central venous access is one of the most common procedures in pediatric surgery worldwide for infusion of antibiotics, electrolytes, chemotherapy, total parenteral nutrition, etc. Local regional complications due the permanence of venous catheters are described most frequently as: thrombosis, infection, edema and local cellulites, mobilization and catheter loss. As a result, the catheter must be prematurely removed. The use of local corticosteroid (Betamethasone) can be an alternative to lengthen the catheter maintenance. Aim: This study objective is to analyze perivascular inflammatory alterations in phlebotomies with polytetrafluoroethylene (20 GA) catheter in two periods of permanence 15 and 30 days with or without local Corticosteroid. Material & Method: 32 New Zealand adult rabbits were submitted to catheterization of the External Right Jugular Vein(RJV) and were divided in 4 groups: G1: with 8 rabbits’ catheters collected in the 15th day, without corticosteroid use;G2: with 8 rabbits’ catheters collected in the 15th day, with corticosteroid use;G3: with 8 rabbits’ catheters collected in the 30th day, without corticosteroid use;G4: with 8 rabbits’ catheters collected in the 30th day, with corticosteroid use;G5: Control was the contralateral vein of the rabbit itself. Results: G2 presented lower inflammatory incidence when compared to G1, despite this difference was not statistically significant (p = 0.7333). G4 also displayed lower inflammatory incidence than G3, however it was not statistically significant (p = 0.3571). When G1 and G3 were compared with G2 and G4, there was also lower incidence of the inflammatory process in those subjects using Betamethasone, although this difference was not statistically significant (p = 0.3202). Conclusion: Betamethasone used in the vascular catheters insertion areas through phlebotomy can lessen local inflammatory manifestations of venous catheterizations.

关键词： Experimental Surgery Central Venous Catheter Venous Thrombosis Phlebitis Corticosteroid

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The role of super-spreaders in modeling of SARS-CoV-2

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Infectious Disease Modelling 2022年第4期7卷 778-794页

作者： françois Rousse marcus Carlsson MagnusÖgren Benjamin Kalischer Wellander School of Science and Technology Örebro University70182ÖrebroSweden Centre for Mathematical Sciences Lund UniversityBox 11822100LundSweden Hellenic Mediterranean University P.O.Box 1939GR-71004HeraklionGreece Centrum för forskning och utveckling(CFUG)Region Gävleborg Sweden

In stochastic modeling of infectious diseases,it has been established that variations in infectivity affect the probability of a major outbreak,but not the shape of the curves during a major outbreak,which is predicted by deterministic models(Diekmann et al.,2012).However,such conclusions are derived under idealized assumptions such as the population size tending to infinity,and the individual degree of infectivity only depending on variations in the infectiousness *** this paper we show that the same conclusions hold true in a finite population representing a medium size city,where the degree of infectivity is determined by the offspring distribution,which we try to make as realistic as possible for *** particular,we consider distributions with fat tails,to incorporate the existence of *** also provide new theoretical results on convergence of stochastic models which allows to incorporate any offspring distribution with a finite variance.

关键词： COVID-19 Compartmental models SEIR SIR Offspring distribution for SARS-CoV-2

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Nucleosynthesis in the little bang

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Nuclear Science and Techniques 2024年第8期35卷 1-4页

作者： marcus Bleicher Institute for Theoretical Physics Goethe-University FrankfurtMax‑von‑Laue‑Str.160438 FrankfurtGermany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI HelmholtzzentrumCampusFrankfurtGermany

A new approach based on relativistic kinetic equations is proposed to solve the long-standing puzzle of light cluster formation, also called nucleosynthesis, in high-energy heavy-ion collisions. This method addresses the tension between STAR data and previous studies relying on either statistical equilibrium or coalescence approaches.

关键词： synthesis relativistic cluster

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Small scale adeno-associated virusvector production for preclinical gene delivery based on chloroform precipitation

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Neural Regeneration Research 2022年第1期17卷 99-100页

作者： marcus Davidsson Andreas Heuer Molecular Neuromodulation Department of Experimental Medical SciencesLund UniversityLundSweden Behavioural Neuroscience Laboratory Department of Experimental Medical SciencesLund UniversityLundSweden

Gene therapy aims to introduce genetic information into a cell-type of interest to replace,correct,silence,or modify defective *** therapy in its broadest sense can theoretically prevent,halt,or cure any condition that affects *** addition to that,the introduction and/or manipulation of genes is one of the major research areas in biological sciences,aimed to deepen our knowledge on how biological systems *** advances have made it possible to induce changes ranging from manipulations of large stretches of the genome to the change of single *** gold-standard vehicles to bring this genetic information into the target cells are viral vectors.

关键词： replace Small mankind

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Evaluation of a Modified Scleral Contact Lens as a Riboflavin Delivery Device for Corneal Collagen Crosslinking

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Open Journal of Ophthalmology 2017年第4期7卷 273-280页

作者： Ricardo Torres Soares Neil F.Novo willy marcus franca Faculty of Medical and Health Science Catholic University of Sao PauloSao PauloBrazil

Introduction: Keratoconus is a complex corneal disease that reduces visual acuity by progressively modifying the corneal shape and thickness, usually producing myopia and irregular astigmatism. Corneal collagen crosslinking with riboflavin + ultraviolet-A radiation (CXL) has become a widely accepted treatment for progressive keratoconus. During CXL, riboflavin administration is performed by repeated manual instillation of solution drops on the cornea for 30 minutes, a procedure that is often uncomfortable for many patients and that consumes surgical facilities and staff resources. In this study, especially modified scleral contact lenses (MSCL) were employed for delivering riboflavin to the cornea during CXL. Objective: The study aimed at evaluating the safety and efficacy of MSCL as a drug delivery system, verifying if anterior chamber flare confirms riboflavin penetration and describes the impact on patient comfort and optimization of surgical staff and facility resources. Material and Method: This study included 8 eyes of 6 patients aged 16 - 25 years old with history of progressive keratoconus. After mechanical removal of corneal epithelium, the concave surface of the modified scleral contact lens was filled with riboflavin solution and the lens was placed on the patient’s eye during 30 minutes. The lens design allows the formation of a riboflavin layer between the lens and the exposed corneal stroma to facilitate riboflavin penetration. Patients with lens were allowed to stand up and wait for the second UVA phase outside the surgical room. Riboflavin diffusion was confirmed by biomicroscopic examination of the corneal stroma and anterior chamber with the lens in place. Patients returned and the lens was removed before UV-A irradiation at 3 mW/cm2 for 30 minutes. Statistical analysis was performed by comparing the following parameters of each patient pre- and post-CXL: Spherical equivalent (***.), Mean simulated keratometry (SimK-m) and corrected distance vis

关键词： Keratoconus Riboflavin UVA Rigid Contact Lens Cross-Linking

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