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Effect of stress-dependent microannulus aperture on well leakage

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1967-1976页

作者： Meng Meng Luke P.Frash J.william Carey Mohamed Mehana Wenfeng Li Bailian Chen Earth and Environmental Sciences Los Alamos National LaboratoryLos AlamosNMUSA

Debonding at the cement-casing interface is recognized as a principal failure mechanism leading to CO_(2) leakage in *** detachment gives rise to a microannulus,which notably possesses greater permeability than undamaged cement,undermining its sealing ***,the permeability of the microannulus is regarded as a uniform value throughout the ***,fundamentally,a microannulus is one type of fracture,and its gap or aperture size is affected by the effective *** this work,we developed a unique experimental *** equipment facilitates the curing of cement inside a steel casing,the formation of a microannulus between the casing and the cement,and the investigation of the fluid flow dynamics along the microannulus under laboratory-replicated in situ *** microannulus was formed by injecting fluid from one end of the setup,and receiving similar amount of fluid on the other end signified the development of the leakage ***,strain gauges affixed to the casing’s external surface yielded key information on the microannulus’s opening and *** observed a noticeable decline in microannulus hydraulic aperture(or permeability)in relation to effective stress and an exponential equation fits their *** findings also indicate a distinct behavior when comparing liquid CO_(2) with ***,it is easier for liquid CO_(2) to create the ***,the hydraulic aperture range for this microannulus(0.7-6 mm)is considerably smaller than that created by water flow(2-17 mm).Finally,we integrated the stressdependent microannulus aperture size into the combined analysis of well mechanical integrity and well *** outcomes consistently demonstrated that when factoring in the stress-dependent aperture sizes,the leakage rates are 3e5 times compared to a fixed aperture *** traditional assumption of a constant aperture significantly underestimates fluid leakage risks.

关键词： Microannulus Leakage assessment Aperture size Triaxial experiment Carbon sequestration

The Use of Biologic Treatments for Osteoarthritis: A Review

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Open Journal of Regenerative Medicine 2024年第2期13卷 21-40页

作者： william Thornton Sion Glyn-Jones Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences University of Oxford Oxford UK

Background: The number of people presenting with osteoarthritis is increasing due, largely, to an ageing population and advances in medical treatments. This is driving the demand for new clinical solutions and treatments for the disease. Biologic therapies have been touted as an adjunct, or even alternative to established treatments for osteoarthritis. The term “biologics” refers to protein-based therapeutics that are derived from the proteins of living organisms. These treatments include, but are not limited to: autologous blood products such as platelet rich plasma (PRP), cell therapies such as autologous chondrocyte implantation (ACI) and mesenchymal stem cells, growth factors and cytokines, gene therapy. Aim: This study aims to provide a clear definition of these technologies and describe the evidence supporting their clinical efficacy to treat osteoarthritis. This is to provide clarity to both clinicians and patients on the range of technologies available. Method: Literature databases Embase and PubMed were searched for keywords such as “biologic”, “osteoarthritis”. Results: The literature identified 4 primary categories of biologic treatments for osteoarthritis: stem cell therapy, somatic cell therapy, protein therapy and gene therapy. The evidence level varied in its quality from treatment to treatment, as did the conclusions of published studies. Conclusion: Autologous chondrocyte therapy had the most convincing evidence to support its use as a treatment for osteoarthritis, however, current methods of use produced variable results. Other treatments such as platelet rich plasma and bone marrow derived stem cells show promise as potential future therapies, with more refinement, but evidence does not support their use currently. Other treatments including autologous stem cells should be avoided until there is a greater quantity and quality of evidence supporting their use.

关键词： Osteoarthritis Biologics Gene Therapy Stem Cell Protein Therapy

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Chlorantraniliprole exposure aggravates high-fat diet-induced metabolic disorders in mice by regulating gut microbiota and its metabolites

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Food Science and Human Wellness 2024年

作者： Ting Gu Jie Lin Jiani Yang william Mumby Quancai Sun Ye Peng Faculty of Medicine Macau University of Science and Technology School of Food and Biological Engineering Jiangsu University Department of Health Nutrition and Food Sciences Florida State University

Food contaminants， particularly insecticides， are important factors contributing to obesity and other adverse effects. As the most widely used diamide insecticide worldwide， chlorantraniliprole (CP) is ubiquitous in food and the environment. However， the influence of CP on obesity and the gut microbiota remains unknown. In this study， we administered CP/carboxymethyl cellulose sodium to C57BL/6J mice with a high-fat diet (HFD) via gavage for 13 weeks. The CP exposure induced significant increases in body weight gain， fat mass， serum total cholesterol (TC)， and low-density lipoprotein cholesterol (LDL-C). Moreover， CP aggravated the imbalance in the gut microbiota by increasing the relative abundance of obesity-associated bacteria and reducing the relative abundance of beneficial bacteria. Based on untargeted metabolomics analysis， CP was found to be involved in the regulation of pathways including ‘alanine， aspartate and glutamate metabolism’ and ‘arginine and proline metabolism’. Notably， CP exposure primarily induced alterations in microbial metabolites within these pathways， such as L-(+)-aspartic acid and L-glutamic acid. Additionally， individual metabolites， such as the lipid mediator (oleoyl ethanolamide)， also demonstrated alterations upon CP exposure. Furthermore， Spearman correlation analysis revealed several noteworthy associations between microbial alterations， metabolite changes， and phenotypes. The results of the study demonstrate a connection between microbiota， metabolites， and the effects of CP exposure on HFD-induced obesity， elucidating the critical role of the gut microbiota and its metabolites in the toxic effects of CP.

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习近平文化思想的实践要求

攀登（藏文版） 2024年第1期 1-7页

作者：才多中共青海省委党校藏学研究中心

习近平文化思想是习近平新时代中国特色社会主义思想的重要组成部分,是新时代党领导文化建设实践经验的理论总结,为我们担负起新的文化使命、建设中华民族现代文明提供了根本遵循和行动指南。习近平文化思想的形成和提出,在党的宣传思... 详细信息

习近平文化思想是习近平新时代中国特色社会主义思想的重要组成部分,是新时代党领导文化建设实践经验的理论总结,为我们担负起新的文化使命、建设中华民族现代文明提供了根本遵循和行动指南。习近平文化思想的形成和提出,在党的宣传思想文化事业发展史上具有里程碑意义,在马克思主义文化理论发展史上也具有深远意义。新时代新征程,我们要坚定文化自信,在强根固魂中推进中华民族现代文明建设;秉持开放包容,在交流互鉴中推进中华民族现代文明建设;坚持守正创新,在继承发展中推进中华民族现代文明建设。

关键词：习近平文化思想文化自信守正创新

Design,synthesis,and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents

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Chinese Chemical Letters 2024年第3期35卷 326-331页

作者： Yu Wen Shichun Lun Yuxue Jiao Wei Zhang Tianyu Hu Ting Liu Fan Yang Jie Tang Bing Zhang william R.Bishai Li-Fang Yu Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Center for Tuberculosis Research Department of MedicineDivision of Infectious DiseaseJohns Hopkins School of MedicineBaltimoreMD21231-1044United States Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China

Inhibition of mycobacterial membrane protein large 3(MmpL3)thereby affecting the mycolic acid biosynthetic pathway has been proven to be an effective strategy for developing antitubercular *** on the X-ray crystal structure of MmpL3 inhibitor complexes,a series of novel 1,2,4-triazole derivatives were designed,synthesized and evaluated antitubercular activity against Mtb strain *** structure–activity relationship exploration resulted in the identification of compounds 21 and 28,which possess potent antitubercular activity against Mtb strain H37Rv[minimum inhibitory concentration(MIC)=0.03–0.13μg/mL]and the clinical isolates of multidrug resistance(MDR)and extensive drug resistance(XDR)tuberculosis(MIC=0.06–1.0μg/mL).Moreover,compounds 21 and 28 showed neglectable cytotoxicity(IC_(50)≥32μg/mL)to the mammalian Vero cells and favorable physicochemical and pharmacokinetic properties according to the in silico absorption,distribution,metabolism and excretion(ADME)***,the potential target of representative 1,2,4-triazole 28 was identified to be MmpL3 using a microscale thermophoresis(MST)assay.

关键词： Tuberculosis MDR and XDR-TB MmpL3 inhibitor 1 2 4-Triazole Structure-based drug design

Hydromechanical characterization of gas transport amidst uncertainty for underground nuclear explosion detection

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2019-2032页

作者： Wenfeng Li Chelsea W.Neil J william Carey Meng Meng Luke P.Frash Philip H.Stauffer Earth and Environmental Sciences Los Alamos National LaboratoryLos AlamosNM87544USA Department of Mineral Engineering New Mexico TechSocorroNM87801USA

Given the challenge of definitively discriminating between chemical and nuclear explosions using seismic methods alone,surface detection of signature noble gas radioisotopes is considered a positive identification of underground nuclear explosions(UNEs).However,the migration of signature radionuclide gases between the nuclear cavity and surface is not well understood because complex processes are involved,including the generation of complex fracture networks,reactivation of natural fractures and faults,and thermo-hydro-mechanical-chemical(THMC)coupling of radionuclide gas transport in the *** this study,we provide an experimental investigation of hydro-mechanical(HM)coupling among gas flow,stress states,rock deformation,and rock damage using a unique multi-physics triaxial direct shear rock testing *** testing system also features redundant gas pressure and flow rate measurements,well suited for parameter uncertainty *** porous tuff and tight granite samples that are relevant to historic UNE tests,we measured the Biot effective stress coefficient,rock matrix gas permeability,and fracture gas permeability at a range of pore pressure and stress *** Biot effective stress coefficient varies from 0.69 to 1 for the tuff,whose porosity averages 35.3%±0.7%,while this coefficient varies from 0.51 to 0.78 for the tight granite(porosity<1%,perhaps an underestimate).Matrix gas permeability is strongly correlated to effective stress for the granite,but not for the porous *** experiments reveal the following key engineering implications on transport of radionuclide gases post a UNE event:(1)The porous tuff shows apparent fracture dilation or compression upon stress changes,which does not necessarily change the gas permeability;(2)The granite fracture permeability shows strong stress sensitivity and is positively related to shear displacement;and(3)Hydromechanical coupling among stress states,rock damage,and gas flow appears to be

关键词： Underground nuclear explosion uncertainty quantification Radionuclide transport Biot effective stress coefficient Fracture permeability Matrix permeability

Sustainable plasticulture in Chinese agriculture: a review of challenges and routes to achieving long-term food and ecosecurity

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Frontiers of Agricultural Science and Engineering 2024年第1期11卷 155-168页

作者： Samuel J.CUSWORTH william J.DAVIES Martin R.MCAINSH Carly J.STEVENS Weilu WANG Lancaster Environment Centre Lancaster UniversityLancasterLA14YQUK The Institutes of Agricultural Science and Technology Development Yangzhou UniversityYangzhou 225009China

Plastic pollution is global concern, affecting most aspects of global food production systems. Plasticulture, a practice used in agriculture to improve crop quality and quantity, among other factors, is a significant source of plastic pollution. This review examines the extent of plasticulture in China, the implications of the practice across decades of use and the legislative instruments used to resolve those issues. It briefly assesses the effectiveness of these policies and proposes possible future innovations to promote increases in long-term food and eco-security, where sustainable plasticulture is a key agent for change. While plasticulture has increased agricultural productivity in growth-limiting conditions, plastic pollution in agricultural soils has become acute in China. Consequently, plastic pollution is having deleterious effects on soil health and in turn, crop productivity in China. Plastic pollution in agriculture is a multifaceted issue and so proposed solutions should be informed by this complexity. Current measures do not reflect a holistic approach to solving this socioecological challenge and adopt a top-down approach, with little or no supportive mechanisms. Future recommendations need to consider the particular set of conditions that influence the production, use and end-of-life management of agriplastics,specific to the environmental, economic and social conditions in each location.

关键词： Circular plastics economy crop production food security plastic pollution sustainable plasticulture

Coordinating environmental protection and agricultural development: a village-based case study for promoting green transformation

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Frontiers of Agricultural Science and Engineering 2024年第1期11卷 100-112页

作者： Kemo JIN Nico HEERINK william JDAVIES Jianbo SHEN Yifeitong ZHANG Yong HOU Yaqiao ZHAO Zhengxiong ZHAO Fusuo ZHANG State Key Laboratory of Nutrient Use and Management College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China Department of Social Sciences Wageningen University and Research6700 AA Wageningenthe Netherlands Lancaster Environment Centre University of LancasterLancasterLA14YQUK College of Agricultural and environmental science University of CaliforniaDavisCA 95616USA College of Economics and Management Yunnan Agricultural UniversityKunming 650201China College of Resources and Environment Yunnan Agricultural UniversityKunming 650201China

Balancing ecological preservation with sustainable agricultural practices is a global issue. Erhai Lake has felt this challenge keenly. To address it, in 2022, a Science and Technology Backyards(STBs) project was launched in Gusheng Village. The goal of this is to care for the environment while ensuring that farms and farmers can thrive sustainably. The uniqueness of the Erhai STB arises from its interdisciplinary integration, encompassing fields such as ecology, agronomy and social science, resulting in specifically-designed solutions for the Erhai context. While this model aligns with broader STB paradigms, its distinctive edge lies in technological innovation and robust support mechanisms for local agricultural stakeholders. This paper describes the methodology and outcomes of the STB initiative, highlighting its pivotal role in spearheading sustainable transition in Erhai. Preliminary findings underscore the potential of the STB model as an efficacious tool for harmonizing environmental conservation and agricultural practices, that are both financially and environmentally sustainable, rendering it a potential model for comparable regions in China and other counties.

关键词： Agriculture green development Science and Technology Backyards Erhai environmental protection smallholders