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Candidate genes underlying QTL for flowering time and their interactions in a wide spring barley(Hordeum vulgare L.) cross

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The Crop Journal 2021年第4期9卷 862-872页

作者： Ana M.Casas Carlota R.Gazulla Arantxa Monteagudo Carlos P.Cantalapiedra Marian Moralejo MPilar Gracia Francisco J.Ciudad william T.B.Thomas Jose L.Molina-Cano scott Boden Bruno Contreras-Moreira Ernesto Igartua Department of Genetics and Plant Production Aula Dei Experimental Station(EEAD-CSIC)Avda Montanana 1005E-50059 ZaragozaSpain University of Lleida-AGROTECNIO Center Avda.Rovira Roure 19125198 LleidaSpain Instituto de Tecnologia Agraria Junta de Castilla y LeonITACyLP.O.Box 17247071 ValladolidSpain The James Hutton Institute InvergowrieDundee DD25DAUK Institut de Recerca i Tecnologia Agroalimentaries(UdL-IRTA) Avda Rovira Roure 19125198 LleidaSpain John Innes Centre Norwich Research ParkNorwich NR47UHUK Fundacion ARAID calle Maria de Luna 1150018 ZaragozaSpain Present address:Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid(UPM)and Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria(INIA)Madrid 28223Spain Present address:School of Agriculture Food and WineWaite Research InstituteUniversity of AdelaideGlen OsmondSA 5064Australia Present address:The European Bioinformatics Institute(EMBL-EBI) Wellcome Trust Genome CampusHinxtonUK

Response to vernalization and photoperiod are the main determinants controlling the time to flowering in temperate cereals. While the individual genes that determine a plant's response to these environmental signals are well characterized, the combinatorial effect on flowering time of allelic variants for multiple genes remains unresolved. This study investigated the genetic control of flowering-time in a biparental population of spring barley, derived from a wide cross between a late-flowering European and an early-flowering North-American cultivar. While the major flowering time genes are not segregating in the Beka ×Logan cross, large variation in flowering was observed. We identified five QTL, with both parents found to contribute early alleles. The catalog of QTL discovered aligns with several candidate genes affecting flowering time in barley. The combination of particular alleles at HvCEN, HvELF3 and HvFT1 in Logan are responsible for the earliness of this cultivar. Interestingly, earliness for flowering could be further enhanced, with Beka found to contribute three early alleles, including a QTL colocating with a HvFD-like gene, suggesting that there are diverse aspects of the flowering-time pathway that have been manipulated in these two cultivars. Epistatic interactions between flowering-time QTL or candidate genes were observed in field data and confirmed under controlled conditions. The results of this study link photoperiod-dependent flowering-time genes with earliness per se genes into a single model, thus providing a unique framework that can be used by geneticists and breeders to optimize flowering time in barley.

关键词： Barley Flowering HvELF3 HvCEN HvFT1

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FORMATION OF THE SINO-U.S. CENTERS FOR SOIL AND WATER CONSERVATION AND ENVIRONMENTAL PROTECTION

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International Journal of Sediment Research 2003年第2期 248-252页

作者： John R. GRAY,W.R. OSTERKAMP,scott CHRISTIANSEN,william A. SPRIGG Hydrologist U.S. Geological Survey Research Hydrologist U.S. Geological Survey International Program Leader U.S. Department of Agriculture Agricultural Research Service Director Sino-US Centers for Soil and Water Conservation and Environmental Protection Institute for the Study of Planet Earth The University of Arizona Reston Virginia Tucson Arizona Beltsville Maryland Tucson

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Catastrophic and persistent environmental consequences of an acid crater-lake discharge, Chiginagak Volcano, Alaska

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Chinese Journal Of Geochemistry 2006年第B8期25卷 230-231页

作者： Janet R. Schaefer william C. Evans Bronwen Wang william E. scott Robert G. McGimsey Janet Jorgenson Alaska Volcano Observatory Alaska Division of Geological ＆ Geophysical Surveys USA U.S. Geological Survey USA Alaska Volcano Observatory U.S. Geological Survey USA Cascades Volcano Observatory U.S. Geological Survey USA U.S. Fish and Wildlife Service USA

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Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation

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World Journal of Clinical Cases 2015年第2期3卷 191-195页

作者： Sonal S Noticewala Loren K Mell scott E Olson william Read Department of Radiation Medicine and Applied Sciences Center for Advanced Radiotherapy TechnologiesUniversity of California San Diego Division of Neurosurgery University of California San Diego Department of Hematology and Medical Oncology Emory University

We report the successful use of RADPLAT to treat a patient with an unresectable T4N0 sinonasal undifferentiated carcinoma. This patient received 4 cycles of weekly intra-arterial cisplatin together with thiosulfate infusion with concurrent radiation therapy. Radiation therapy was given in 28 daily fractions to 54 Gy using intensity-modulated radiation therapy followed by a hypofractionated stereotactic boost of 3 fractions to 13 Gy to a total dose of 67 Gy in 31 fractions to the nasal sinus and bilateral neck. Intra-arterial cisplatin was administered using a bilateral approach due to the midline site of this tumor. Within days of the first intra-arterial cisplatin, there was an obvious decrease in tumor size. She has been followed with magnetic resonance imaging and positron emission tomography, and remains disease-free 47 mo post-treatment. Centers with expertise in intra-arterial chemotherapy could consider the RADPLAT approach for patients with unresectable sinonasal undifferentiated carcinoma.

关键词： Sinonasal undifferentiated carcinoma Radiation Intra-arterial cisplatin Survival RADPLAT

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Evading the host response:Staphylococcus“hiding”in cortical bone canalicular system causes increased bacterial burden

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Bone Research 2020年第4期8卷 447-457页

作者： Stephen D.Zoller Vishal Hegde Zachary D.C.Burke Howard Y.Park Chad R.Ishmael Gideon W.Blumstein william Sheppard Christopher Hamad Amanda H.Loftin Daniel O.Johansen Ryan A.Smith Marina M.Sprague Kellyn R.Hori Samuel J.Clarkson Rachel Borthwell scott I.Simon Jeff F.Miller scott D.Nelson Nicholas M.Bernthal Department of Orthopedic Surgery University of CaliforniaLos Angeles125016th St Suite 2100Santa MonicaCA 90404USA David Geffen School of Medicine University of CaliforniaLos Angeles10833 Le Conte AveLos AngelesCA 90095USA Department of Internal Medicine University of CaliforniaLos Angeles757 Westwood PlazaSuite 7501Los AngelesCA 90095USA Department of Biomedical Engineering University of CaliforniaDavisDavisCA 95616USA California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA 90095USA Department of Microbiology Immunologyand Molecular GeneticsDavid Geffen School of MedicineUniversity of CaliforniaLos Angeles 90095USA Department of Pathology University of CaliforniaLos Angeles125016th St Suite 3450Santa MonicaCA 90404USA

Extremity reconstruction surgery is increasingly performed rather than amputation for patients with large-segment pathologic bone *** persists as to the optimal void filler for this“limb salvage”surgery,whether metal or allograft *** focus on optimizing important functional gains for patients,and the risk of devastating implant infection has been thought to be similar regardless of implant *** insights into infection pathophysiology are challenging this equipoise,however,with both basic science data suggesting a novel mechanism of infection of Staphylococcus aureus(the most common infecting agent)into the host lacunar–canaliculi network,and also clinical data revealing a higher rate of infection of allograft over *** current translational study was therefore developed to bridge the gap between these insights in a longitudinal murine model of infection of allograft bone and ***-time Staphylococci infection characteristics were quantified in cortical bone vs metal,and both microarchitecture of host implant and presence of host immune response were *** orders-of-magnitude higher bacterial burden was established in cortical allograft bone over both metal and cancellous *** establishment of immune-evading microabscesses was confirmed in both cortical allograft haversian canal and the submicron canaliculi network in an additional model of mouse femur bone *** study results reveal a mechanism by which Staphylococci evasion of host immunity is possible,contributing to elevated risks of infection in cortical *** presence of this local infection reservoir imparts massive clinical implications that may alter the current paradigm of osteomyelitis and bulk allograft infection treatment.

关键词： immunity insight reservoir

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节点边际价格和电力市场(中)

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中国电力企业管理 2023年第4期 40-45页

作者： scott Harvey william Hogan 柴玮王澍美国FTI咨询公司哈佛大学肯尼迪学院电力政策部门国家能源集团经济技术研究院有限责任公司天津华大亿电科技有限公司

在1995~2014年市场环境和能源构成条件下采用LMP的优势,LMP定价机制是在20世纪90年代开发并初步实施的,在当时的市场条件和能源结构下使用时,已经展现出很大的优势。主要体现在LMP定价与经济调度一致,并支持经济调度,而且不需要单独考... 详细信息

在1995~2014年市场环境和能源构成条件下采用LMP的优势,LMP定价机制是在20世纪90年代开发并初步实施的,在当时的市场条件和能源结构下使用时,已经展现出很大的优势。主要体现在LMP定价与经济调度一致,并支持经济调度,而且不需要单独考虑输电阻塞成本,而这个就是存在于非LMP市场中造成最大壁垒的主要因素。

关键词：经济调度能源结构输电阻塞定价机制节点边际价格环境和能源 LMP 20世纪90年代

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先进固体火箭助推器的合同竞争的焦点集中在制造技术上

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国外导弹与航天运载器 1990年第2期 62-67页

作者： william B.scott 贺日新

一个十亿美元研制 NASA 的航天飞机系统先进固体火箭助推器的合同竞争正逐渐发展为不同的自动化生产原理之间的激烈竞争。本文综述了各投标公司在生产设备、专利情报、连续检查、合格的工人四方面所具备的条件及其各自的竞争优势。

关键词：固体火箭助推器制造技术

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重度卒中的预后与临床决策

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美国医学会杂志（中文版） 2006年第3期25卷 162-169页

作者： Robert G Holloway Curtis G Benesch W scott burgin Justine B Zentner 邢海英（译）黄一宁（校） Departrment of Neurology Department of Community and Preventive Medicine Department of Imaging Sciences the Center for Palliative Care and Clinkal Ethics 不详

背景：重度卒中患者最后拔管死亡人数越来越多。终止治疗时机的差别提示存在延长患者不必要痛苦或造成不必要死亡的可能性。目的：回顾机械通气卒中患者预后的现有证据，为临床医生、患者及家属优化临床决策提供一总体框架。资料来源：... 详细信息

背景：重度卒中患者最后拔管死亡人数越来越多。终止治疗时机的差别提示存在延长患者不必要痛苦或造成不必要死亡的可能性。目的：回顾机械通气卒中患者预后的现有证据，为临床医生、患者及家属优化临床决策提供一总体框架。资料来源：于MEDLINE搜索1980年到2005年3月有关机械通气卒中患者预后的英文文章。我们从搜集的689篇文章中选出17篇进行综述。我们还确定了维持生命治疗应用过度或应用不足的影响因素以及可能造成的决策偏差，重点放在机械通气因素。证据综合：实施机械通气的卒中患者总死亡率很高，30天死亡率接近58％（文献报道范围，46％～75％）。尽管资料有限，但是高达1／3的存活者没有或仅有轻度残疾，然而其余患者则有重度残疾。我们可以根据对卒中综合征的认识、患者早期特征、临床预测规则以及持续干预的必要性进一步判断患者的转归。影响选择生命支持治疗的因素包括：将来临床缺陷的严重程度和类型，临床缺陷发生的可能性，以及治疗的负担。可能影响终止治疗决策制定的偏差包括：预后评估错误，沟通方式不当，错误理解患者的价值观和期望，以及未能正确评价患者的生理和心理适应程度。结论：虽然实施机械通气的卒中患者预后一般很差，但是确实有少数患者存活而且没有严重残疾。可以根据临床表现和患者特征评估预后。急需更好地了解这些患者治疗上的标志性差异，急需可靠地权衡并改善这种以患者为中心的决策。

关键词：卒中患者预后评估临床决策重度生命支持治疗 MEDLINE 机械通气治疗时机严重残疾以患者为中心

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Integrating planar photonics for multi-beam generation and atomic clock packaging on chip

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Light(Science & Applications) 2023年第4期12卷 691-701页

作者： Chad Ropp Wenqi Zhu Alexander Yulaev Daron Westly Gregory Simelgor Akash Rakholia william Lunden Dan Sheredy Martin MBoyd scott Papp Amit Agrawal Vladimir Aksyuk Physical Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Vector Atomic Inc.PleasantonCA 94588USA Physical Measurement Laboratory National Institute of Standards and TechnologyBoulderCO 80305USA

The commercialization of atomic technologies requires replacing laboratory-scale laser setups with compact and manufacturable optical *** arrangements of free-space beams can be generated on chip through a combination of integrated photonics and metasurface *** this work,we combine these two technologies using flip-chip bonding and demonstrate an integrated optical architecture for realizing a compact strontium atomic *** planar design includes twelve beams in two co-aligned magneto-optical *** beams are directed above the chip to intersect at a central location with diameters as large as 1 *** design also includes two co-propagating beams at lattice and clock *** beams emit collinearly and vertically to probe the center of the magneto-optical trap,where they will have diameters of≈100μ*** these devices we demonstrate that our integrated photonic platform is scalable to an arbitrary number of beams,each with different wavelengths,geometries,and polarizations.

关键词： planar diameters atomic

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禅与饮茶的艺术

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2020年

作者： (美)威廉·斯科特·威尔逊(william scott Wilson)

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