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Hepatitis C virus burden:Treating and educating people without prejudice

World Journal of Hepatology 2022年第7期14卷 1495-1503页

作者： Elettra Merola Elisa Menotti Giovanna Branz Andrea Michielan Sonia Seligmann Annora Ratti Flora Agugiaro Luisa Moser Giovanni Vettori Anna Franceschini william mantovani Riccardo Pertile Giovanni de Pretis Cecilia Pravadelli Department of Gastroenterology Santa Chiara HospitalAzienda Provinciale Per I Servizi Sanitari(APSS)Trento 38122Italy Department of SerD Service for Drug AddictionAzienda Provinciale Per I Servizi Sanitari(APSS)Trento 38122Italy Department of Prevention Azienda Provinciale Per I Servizi Sanitari(APSS)Trento 38122Italy Department of Clinical and Evaluative Epidemiology Azienda Provinciale Per I Servizi Sanitari(APSS)Trento 38122Italy

Hepatitis C virus(HCV)infection has a worldwide incidence of 1.1%.In Italy,60%of people who inject drugs(PWIDs)and are receiving assistance for substance use disorder are infected with ***,this subset of patients has extremely limited access to care due to multiple factors,including alcohol abuse,psychological comorbidities,and homeless *** To describe the impact of our HCV-dedicated service for substance use disorder(SSUD)service on PWIDs receiving anti-HCV *** A dedicated,multidisciplinary team was set up at the SSUD of Trento in October 2020 to provide antiviral treatment to HCV RiboNucleic Acid-positive patients with an active or previous history of substance *** treatment was followed by a health education *** were treated with Direct-Acting Antivirals(DAAs).Data were retrospectively analyzed to assess the efficacy of our dedicated program in terms of therapy completion,HCV eradication,and compliance(primary endpoint).The rate of HCV reinfection and DAA-related toxicity were also assessed(secondary endpoints).RESULTS A total of 40 patients were enrolled in the study:28(70.0%)were treated with Sofosbuvir/Velpatasvir,while 12(30.0%)received Glecaprevir/*** the time of inclusion in the study,36 patients were receiving opioid agonist maintenance therapy,whilst another 4 had just finished the treatment.37.5%had a history of alcoholism and 42.5%received concomitant psychiatric *** 40 patients(100.0%)completed the therapy cycle and 92.5%of patients adhered to the *** patients tested negative for viral load at the end of the *** were no significant drug interactions with common psychiatric treatments and no side effects were *** sustained virological response was achieved in 92.5%of cases with good tolerability,although two patients discontinued treatment *** HCV eradication,one patient died from an overdose,another from complications of cirrhosis,and one rein

关键词： Hepatitis C virus Service for substance use disorder Direct-acting antivirals Sustained virologic response Compliance Tolerability

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Tumor-associated myeloid cells:diversity and therapeutic targeting

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Cellular & Molecular Immunology 2021年第3期18卷 566-578页

作者： Alberto mantovani Federica Marchesi Sebastien Jaillon Cecilia Garlanda Paola Allavena Department of Immunology and Inflammation Humanitas Clinical and Research Center-IRCCSRozzanoItaly Department of Biomedical Science Humanitas UniversityRozzanoItaly The william Harvey Research Institute Queen Mary University of LondonLondonUK Department of Biotechnology and Translational Medicine University of MilanMilanItaly

Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional *** tumor-associated macrophages(TAMs),which are more abundantly represented,and tumor-associated neutrophils(TANs)are known to sustain tumor cell growth and invasion,support neoangiogenesis and suppress anticancer adaptive immune *** recent decades,several therapeutic approaches have been implemented in preclinical cancer models to neutralize the tumor-promoting roles of both TAMs and *** of the most successful strategies have now reached the clinic and are being investigated in clinical *** this review,we provide an overview of the recent literature on the evergrowing complexity of the biology of TAMs and TANs and the development of the most promising approaches to target these populations therapeutically in cancer patients.

关键词： tumor-associated macrophages tumor microenvironment macrophage targeting

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Hepatobiliary surgeons meet immunologists: the case of colorectal liver metastases patients

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 370-377页

作者： Matteo Donadon Nina Cortese Federica Marchesi Matteo Cimino Alberto mantovani Guido Torzilli Department of Hepatobiliary and General Surgery Humanitas UniversityPieve EmanueleItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Department of Immunology and Inflammation Humanitas Clinical and Research CenterRozzanoMilanItaly Department of Medical Biotechnology and Translational Medicine University of MilanMilanItaly The william Harvey Research Institute Queen Mary University of LondonLondonUK

The burgeoning field of cancer immunology demands a change in the paradigm of cancer patient management. The understanding of the course of a given malignant disease should also include the host immune system as one of the key factors in determining the patient's prognosis. Surgical and medical oncologists need to understand the basic and advanced applications of immunotherapies, which are rapidly evolving, and are nowadays an integral part of the armamentarium for the treatment of cancer patients. In the present work, we review the current knowledge concerning the immune landscape of colorectal cancer (CRC) patients with liver metastases, as recently discovered.

关键词： Host immune system colorectal liver metastases (CLM) colorectal cancer liver metastases colorectal cancer (CRC) immune response immunotherapy

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