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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Environmental similarity is more important than distance in the community structuring processes of ammonia-oxidizing archaea in agricultural soils

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Pedosphere 2023年第6期33卷 819-827页

作者： Dorsaf KERFAHI Yu SHI Baozhan WANG Hokyung SONG Haiyan CHU Jonathan m.adams School of Natural Sciences Department of Biological SciencesKeimyung UniversityDaegu 42601Korea State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475001China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Key Lab of miboyrgriculural Eonment MintryfgrculureCllege of Life SciencesNanjing Agricultural Univery Nanjing 21008China Department of Earth and Environmental Sciences The University of ManchesterManchester M139PLUK University of Chinese Academy of Sciences Beijing 101408China School of Geography and Oceanography Nanjing UniversityNanjing 210008China

Ammonia-oxidizing archaea(AOA) are important in converting ammonia into nitrate in soils. While many aspects of their community structure have been studied, the relative importance of stochastic versus deterministic processes has poorly been understood. We compared AOA communities across the North China Plain, targeting the amoA gene. A phylogenetic null modelling approach was used to calculate the beta nearest taxon index to quantify the influence of stochastic and deterministic processes. We found that spatial distance between samples predicted the perceived processes involved in community structuring, with stochastic processes dominating at local scales. At greater distances, stochasticity became weaker. However, soil pH, which was also the strongest determinant of AOA community, was a much stronger predictor of community structuring, leaving the distance effect redundant as an explanation of community structuring processes. The communities of AOA differing by less than 1 pH unit differed mainly stochastically in terms of operational taxonomic unit composition. At larger pH differences, deterministic processes based on heterogeneous selection between clades became increasingly dominant. It appears that AOA community composition is largely determined by the environment. However, very similar pH environments are the exception. In environments with very close pH values, stochastic effects dominantly cause differences in community composition, whether spatially near or far.

关键词： amoA gene ammonia-oxidizing bacteria assembly processes beta nearest taxon index community structure operational taxonomic unit

Enduring legacy of coal mining on the fungal community in a High Arctic soil after five decades

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Pedosphere 2022年第5期32卷 698-706页

作者： Dorsaf KERFAHI Kevin K.NEWSHAm Ke DONG Hokyung SONG mark TIBBETT Jonathan m.adams School of Natural Sciences Department of Biological SciencesKeimyung UniversityDaegu 42601(Republic of Korea) NERC British Antarctic Survey Madingley RoadCambridge CB3 OET(UK) Department of Life Science Kyonggi UniversitySuwon-si 16227(Republic of Korea) School of Earth and Environmental Sciences The University of ManchesterManchester M139PL(UK) Department of Sustainable Land management&Soil Research Center School of AgriculturePolicy and DevelopmentUniversity of ReadingReading RG66AR(UK) School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210008(China)

mineral extraction is known to affect soil fungi in polar environments,but it is unknown how long these effects ***,by amplifying the internal transcribed spacer regions of rRNA genes in soil fungi,we compared soil fungal community in intact natural tundra with that in a nearby former coal mining area,abandoned 52 years previously,on Svalbard in the High *** with those in intact tundra,soils in the former mining area were more acidic and had lower plant *** of similar diversity in the two areas,the fungal community was dominated by Basidiomycota in the intact tundra,but by Ascomycota in the former mining *** genera formed a major part of the tundra community,but were notably less abundant in the mining *** principal variation among samples was soil ***,network connectivity analysis indicated that the fungal community in the former mining area had greater network connectivity than that in the tundra ***,the ecosystem in the former mining area has made only limited recovery towards the natural tundra state even after more than five *** is unclear whether the recovery of the fungal community is limited more by the low primary productivity,slow migration of fungi and plants,or slow changes in soil *** findings emphasize the susceptibility of polar ecosystems to disturbance,given their particularly slow recovery back towards the natural state.

关键词： abandoned mining site ectomycorrhizal fungi intact tundra mine tailings mineral extraction polar ecosystem recovery

Structural confirmation of sulconazole sulfoxide as the primary degradation product of sulconazole nitrate

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Journal of Pharmaceutical Analysis 2018年第2期8卷 96-102页

作者： Qun Xu Ashraf Khan Di Gao Kristie m.adams Fatkhulla Tadjimukhamedov Shane Tan John T.Simpson Compendial Development Laboratory United States Pharmacopeia

Sulconazole has been reported to degrade into sulconazole sulfoxide via sulfur oxidation; however,structural characterization data was lacking and the potential formation of an N-oxide or sulfone could not be excluded. To clarify the degradation pathways and incorporate the impurity profile of sulconazole into the United States Pharmacopeia–National Formulary(USP–NF) monographs, a multifaceted approach was utilized to confirm the identity of the degradant. The approach combines stress testing of sulconazole nitrate, chemical synthesis of the degradant via a hydrogen peroxide-mediated oxidation reaction,semi-preparative HPLC purification, and structural elucidation by LC–mS/mS and NmR *** determination was primarily based on the comparison of spectroscopic data of sulconazole and the oxidative degradant. The mass spectrometric data have revealed a mc Lafferty-type rearrangement as the characteristic fragmentation pathway for alkyl sulfoxides with a β-hydrogen atom, and was used to distinguish the sulfoxide from N-oxide or sulfone derivatives. moreover, the generated sulconazole sulfoxide was utilized as reference material for compendial procedure development and validation, which provides support for USP monograph modernization.

关键词： Sulconazole nitrate Sulconazole sulfoxide Forced degradation Structural characterization LC–mS/mS

Scaffoldless tissue-engineered nerve conduit promotes peripheral nerve regeneration and functional recovery after tibial nerve injury in rats

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Neural Regeneration Research 2017年第9期12卷 1529-1537页

作者： Aaron m.adams Keith W.VanDusen Tatiana Y.Kostrominova Jacob P.mertens Lisa m.Larkin Department of molecular and Integrated Physiology University of Michigan Department of Anatomy and Cell Biology Indiana University School of Medicine Department of Biomedical Engineering University of Michigan

Damage to peripheral nerve tissue may cause loss of function in both the nerve and the targeted muscles it innervates. This study compared the repair capability of engineered nerve conduit （ENC）, engineered fibroblast conduit （EFC）, and autograft in a 10-mm tibial nerve gap. ENCs were fabricated utilizing primary fibroblasts and the nerve cells of rats on embryonic day 15 （E 15）. EFCs were fabricated utilizing primary fi- broblasts only. Following a 12-week recovery, nerve repair was assessed by measuring contractile properties in the medial gastrocnemius muscle, distal motor nerve conduction velocity in the lateral gastrocnemius, and histology of muscle and nerve. The autografts, ENCs and EFCs reestablished 96%, 87% and 84% of native distal motor nerve conduction velocity in the lateral gastrocnemius, 100%, 44% and 44% of native specific force of medical gastrocnemius, and 63%, 61% and 67% of native medial gastrocnemius mass, re- spectively. Histology of the repaired nerve revealed large axons in the autograft, larger but fewer axons in the ENC repair, and many smaller axons in the EFC repair. muscle histology revealed similar muscle fiber cross-sectional areas among autograft, ENC and EFC repairs. In conclusion, both ENCs and EFCs promot- ed nerve regeneration in a 10-mm tibial nerve gap repair, suggesting that the El5 rat nerve cells may not be necessary for nerve regeneration, and EFC alone can suffice for peripheral nerve injury repair.

关键词： nerve regeneration peripheral nerve repair neural conduit tissue engineering fibroblasts neuralcells

The RQ-Tech methodology:a new paradigm for conceptualizing strategic enterprise architectures

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Journal of management Analytics 2014年第1期1卷 55-77页

作者： Christine A.Hoyland Kevin m.adams Andreas Tolka Li D.Xu National Centers for System of Systems Engineering(NCSoSE) Old Dominion UniversityNorfolkUSA University of maryland University College AdelphiUSA Engineering management and Systems Engineering Old Dominion UniversityNorfolkUSA Department of Information Technology and Decision Science Old Dominion UniversityNorfolkUSA

The purpose of this paper is to report on a new system-theoretic based methodology and corresponding model for Enterprise Architecture *** model captures the essence of the strategic,conceptual,doctrinal layer of the *** Quality Technical Architectures(RQ-Tech)graphically reveals a comprehensive array of enterprise decision alternatives in easily understandable views;all while maintaining the hyperlinks to its provenance in strategic authoritative *** RQ-Tech method has combined the practice of Enterprise Architectures with a modern perspective grounded in Systems Theory and the theory regarding the computer science-oriented Semantic *** recombination results in a distinctive methodology for developing *** new methodology supports the conclusion that system-specific solutions produce islands of technology and can be prevented by employing better enterprise change planning.A review of the literature in three major areas illustrates the overlap common to all three *** review provides support for critical thinking concerning how to enrich the Enterprise Architecture *** research centered on finding the most significant factors to consider when translating the authoritative text and rich pictures that enterprise managers use to describe the strategic mission and vision of their complex,service-oriented enterprise into user-oriented semantic *** provides the basis for RQ-Tech as a methodology that enables increased understanding of complex systems through use of Semantic Web standards.

关键词： enterprise architecture systems engineering system of systems engineering strategic management semantic web systems principles

Bacterial community network complexity and role of stochasticity decrease during primary succession

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Soil Ecology Letters 2024年第3期6卷 45-59页

作者： Yucheng He Binu m.Tripathi Jie Fang Zihao Liu Yaping Guo Yue Xue Jonathan m.adams School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Korea Polar Research Institute Incheon 21990Republic of Korea

In microbial ecology,there is limited understanding of the mechanisms governing patterns in community structure across space and ***,we studied the changes of bacterial co-occurrence network structure over four primary successional soils after glacier retreat,including a sand dune system and three glacier foreland series,varying in timescale from centuries to *** found that in all series,network structure was most complex in the earliest stages of succession,and became simpler over *** and abundance of keystone species and network stability also declined over *** appears that with less productive,nutrient poor and physiologically extreme conditions of early succession,closer interactions among bacterial species are ecologically selected *** may take the form of consortia(with positive interactions)or stronger niche exclusion(with negative interactions).Additionally,we quantified the relative roles of different structuring processes on bacterial community using a bin-based null model analysis(iCAmP).With each successional series,community composition was initially governed by stochasticity,but as succession proceeded there was a progressive increase in deterministic selection over time,correlated with decreasing ***,our results show a consistency among the four series in long-term processes of community succession,with more integrated networks and greater stochasticity in early stages.

关键词： glacial retreat bacteria chronosequence co-occurrence network 16S rRNA sequencing community assembly

Straw biochar strengthens the life strategies and network of rhizosphere fungi in manure fertilized soils

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Soil Ecology Letters 2019年第1期1卷 72-84页

作者： Dandan Wang Na Zhang Haoqi Tang Jonathan m.adams Bo Sun Yuting Liang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China School of Environmental and Safety Engineering Changzhou UniversityChangzhou 213164China University of the Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China

Soil fungi have many important ecological functions,however,their life strategies and interactions in manure fertilized soils are not well *** aim of this study was to investigate the effects of biochar amendment on the fungal life strategies and species interactions in ryegrass(Lolium perenne L.)rhizosphere soil by high-throughput *** soil treatments were evaluated:soil and pig manure mixture without planting ryegrass and biochar application(bulk soil),mixture with ryegrass planting(rhizosphere soil(RS)),and addition of 2%(w/w)biochar with ryegrass(RS+biochar).Our results indicated that temporal turnover,defined as the slope of linear regression between community similarity and time,was significantly higher in the biochar amendment(slope=-0.2689,pmploying slow acclimation ecological strategies decreased(from 27% to 17%)and the percentage of sensitive species increased(from 40% to 50%)in comparison to the rhizosphere *** analysis indicated that fungal communities in the biochar amendment enhanced positive correlations compared to the rhizosphere soil and bulk *** equation model indicated that soil pH was the most important factor in altering fungal life strategies and interactions in manure fertilized soils.

关键词： Rhizosphere Biochar Fungal community Life strategies Network analysis

A biogeographic map of soil bacterial communities in wheats field of the North China Plain

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Soil Ecology Letters 2019年第1期1卷 50-58页

作者： Yu Shi Yuntao Li meiqing Yuan Jonathan m.adams Xianzhang Pan Yunfeng Yang Haiyan Chu State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Forensic Genetics of ministry of Public Security Institute of Forensic Science of Ministry of Public SecurityBeijing 100038China School of Water Energy and EnvironmentCranfield UniversityCranfield MK460ALUK State Key Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China

The vast diversity of soil bacteria provides essential ecosystem services that support agricultural *** in the diversity and composition of soil biota may have predictive values for soil nutrient cycling and resilience of ecosystem services,thus providing valuable insights to improve food *** North China Plain(NCP)is one of the world’s key agricultural regions,supplying more than 50% of the cereal consumed in ***,it is unknown whether soil microbial diversity is predictable across the *** the miSeq Illumina platform,we examined bacterial community variation in relation to spatial and environmental factors from 243 soils in wheat-maize double cropping rotation fields across the NCP,which cover nearly 0.3 million km^(2).Based on observed bacterial communities and their relationships with environmental factors,we generated a map of bacterial communities across the *** highest bacterial diversity was found in the middle part of the NCP,with most of the variation in diversity attributable to differences in the community similarity of Actinobacteria and *** findings provide important baseline information for analyzing the relationships between microbial community,soil functionality and crop yields.

关键词： Predicting map Bacteria diversity Actinobacteria Alphaproteobacteria