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Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

Cellular & Molecular Immunology 2019年第10期16卷 810-819页

作者： Mohamad Omar Ashi Nivine Srour Jean-Marie lambert Anne Marchalot Ophelie Martin Sandrine Le Noir Eric Pinaud Maria Victoria Ayala Christophe Sirac Jerome Sauliere Jerome Moreaux Michel Cogne Laurent Delpy Unite Mixte de Recherche Centre National de la Recherche Scientifique 7276 INSERM U1262-Controle de la Reponse Immune B et LymphoproliferationsUniversitede LimogesLimogesFrance Institute of Human Genetics CNRS-UM UMR9002Department of Biological HaematologyCHU MontpellierUniversity of MontpellierUFR MedecineMontpellierFrance Institut Universitaire de France Universitede LimogesLimogesFrance Present address:Lady Davis Institute for Medical Research McGill University3755 Cote Ste-Catherine RoadMontrealQC H3T 1E2Canada

The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin(Ig)*** recently demonstrated that aberrant Ig chains lacking variable(V)domains can be produced after nonsense-associated altered splicing(NAS)***,the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell(PC)*** questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion(TIE-)checkpoint and its restriction to the ultimate stage of B-cell *** address these issues,we evaluated the extent of NAS of Ig pre-mRNAs using an Ig heavy chain(IgH)knock-in model that allows for uncoupling of V exon skipping from TIE-induced *** found high levels of V exon skipping in PCs compared with B cells,and this skipping was correlated with a biallelic boost in IgH transcription during PC *** analysis further revealed that the skipped V exon turned into a ***,we showed that hypertranscription of Ig genes facilitated V exon skipping upon passive administration of splice-switching antisense oligonucleotides(ASOs).Thus,V exon skipping is coupled to transcription and increases as PC differentiation proceeds,likely explaining the late occurrence of the TIE-checkpoint and opening new avenues for ASO-mediated strategies in PC disorders.

关键词： Immunoglobulin Exon skipping Plasma cells Antisense Oligonucleotides Nonsense-associated altered splicing

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微生物封堵技术(Bio-Sealing)用于隧道防水

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现代隧道技术 2007年第Z1期44卷 42-44页

作者： John lambert Vasco Veenbergen Nathalie Ross 荷兰国家岩土工程研究所(GeoDelft) 荷兰国家岩土工程研究所(GeoDelft) 加拿大渥太华大学

　　荷兰国家岩土工程研究所(GeoDelft)近来提出了一个称为SmartSoils的新概念.Smart Soils,意即人们所需要的土,其着眼点在于土的某些性质(如渗水性、刚度和强度),以及如何将它们改良,使之能满足工程建设的某些要求.这些新的技术在岩...

　　荷兰国家岩土工程研究所(GeoDelft)近来提出了一个称为SmartSoils的新概念.Smart Soils,意即人们所需要的土,其着眼点在于土的某些性质(如渗水性、刚度和强度),以及如何将它们改良,使之能满足工程建设的某些要求.这些新的技术在岩土工程中可以被广泛应用.……

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氨基酸在SiO2表面的吸附选择性研究

氨基酸在SiO2表面的吸附选择性研究

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中国化学会第二十五届学术年会

作者：朴玲钰 Jean-Francois lambert Lorenzo Stievano 国家纳米科学中心 Laboratoire de Réactivité de Surface Université Pierre et Marie Curie 75252 Paris France Laboratoire de Réactivité de Surface Université Pierre et Marie Curie 75252 Paris France

We have investigated the adsorption selectivity of glycine and lysine on silica by using many kinds of characterization methods, such as TGA, FT-IR, XRD, TPD-MS, 13C NMR. We have carried out molecular

关键词：氨基酸 SiO2 选择性吸附

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The Role of p53 in HPV-associated Cancers

The Role of p53 in HPV-associated Cancers

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24th International Papillomavirus Conference and Clinical Workshop

作者： Shai Anny Henry Pitot Paul lambert University of Wisconsin-Madison University of Wisconsin-Madison University of Wisconsin-Madison

＜正＞HPV16 is the high risk HPV most commonly associated with anogenital and head and neck *** have utilized K14E6 WT and K14E7 WT transgenic mice expressing HPV16 E6 and E7,respectively,to dissect the individual roles of these two oncogenes in cervical *** treatment of K14E6 WT mice with exogenous estrogen for six months did not result in cervical cancer,all K14E7 WT and K14E6 WT/E7 WT mice developed high-grade cervical intraepithelilia neoplasia(CIN

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2007 Microsoft Office System Step by Step

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2007年

作者： Online Training Solutions Inc. Curtis D. Frye Joan Preppernau Joyce K. Cox Steve lambert

来源：畅想之星图书光盘版（南... 评论

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A continental back-arc setting for the Namaqua belt:Evidence from the Kakamas Domain

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Geoscience Frontiers 2022年第4期13卷 193-221页

作者： P.H.Macey R.J.Thomas A.F.M.Kisters J.F.A.Diener M.Angombe S.Doggart C.A.Groenewald C.W.lambert J.A.Miller H.Minnaar H.Smith H.F.G.Moen E.Muvangua A.Nguno G.Shifotoka J.Indongo D.Frei C.Spencer P.le Roux R.A.Armstrong C.Tinguely Council for Geoscience P.O.Box 572BellvilleSouth Africa Department of Geology University of StellenboschSouth Africa Department of Geological Sciences University of Cape TownSouth Africa Geological Survey of Namibia WindhoekNamibia Department of Geology University of Free StateSouth Africa Department of Earth Sciences University of the Western CapeSouth Africa The Institute of Geoscience Research Dept.Applied GeologyCurtin UniversityPerthAustralia Department of Geological Sciences and Geological Engineering Queen’s UniversityKingstonCanada Geochronology and Tracers Facility British Geological SurveyNottingham NG125GGUK RSES Australian NationalUniversityCanberraACTAustralia

A study of the NW Kakamas Domain in South Africa/Namibia provides a new,unified lithostratigraphy and evolutionary history applicable to the whole Namaqua *** Mesoproterozoic history ranges from~1350 Ma to 960 Ma,but isotopic evidence suggests it was built upon pre-existing Paleoproterozoic continental crust that extended west from the Archaean *** eastern Namaqualand,early rift-related magmatism and sedimentation at~1350 Ma occurred in a confined ocean *** tectonic reversal and subduction at~1290–1240 Ma led to establishment of the Areachap,Konkiep and Kaaien *** the Kakamas Domain,widespread deposition of pelitic sediments occurred at~1220 Ma(Narries Group).These contain detrital zircons derived from proximal crust with ages between~2020 Ma and 1800 Ma(western Palaeoproterozoic domains)and 1350–1240 Ma(eastern early Namaqua domains),suggesting pre-sedimentation *** pelites underwent granulite grade metamorphism at~1210 Ma(peak conditions:4.5–6 kbar and 770–850°C),associated with voluminous,predominantly S-type granitoid orthogneisses between~1210 Ma and 1190 Ma(Eendoorn and Ham River Suites)and low-angle ductile(D_(2))deformation which continued until~1110 Ma,interspersed with periods of *** enduring P-T regime is inconsistent with the expected crustal over-thickening associated with the generally-accepted collision-accretion Namaqualand ***,we propose the Namaqua Sector is a‘hot orogen’developed in a wide continental back-arc with subduction west of the present-day *** observed high geotherm resulted from thinned back-arc lithosphere accompanied by an influx of mantle-derived *** D_(2)deformation resulted from"bottom-driven"tectonics and viscous drag within the crust by convective flow in the underlying asthenospheric *** extended tectonothermal regime ceased at~1110 Ma when SW-directed thrusting stacked the Namaqua Domains into their current positions,constrained in

关键词： Kakamas Namaqua Geodynamics Geochronology Hot orogeny Mesoproterozoic

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Comparison of Interval Constraint Propagation Algorithms for Vehicle Localization

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Journal of Software Engineering and Applications 2012年第12期5卷 157-162页

作者： I. K. Kueviakoe A. lambert P. Tarroux LIMSI CNRS 91400 Orsay France ENS 45 rue d'ULM 75230 Paris France LIMSI CNRS 91400 Orsay France Univ. Paris Sud IEF 91400 Orsay France LIVIC IFSTTAR 14 route de la minière 78000 VersaillesFrance

Interval constraint propagation (ICP) algorithms allow to solve problems described as constraint satisfaction problems (CSP). ICP has been successfully applied to vehicle localization in the last few years. Once the localization problem has been stated, a large class of ICP solvers can be used. This paper compares a few ICP algorithms, using the same experimental data, in order to rank their performances in terms of accuracy and computing time.

关键词： Interval Analysis Constraint Propagation Data Fusion Vehicle Positioning GPS

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Elucidation of the life cycle of the endophytic genus Muscodor and its transfer to Induratia in Induratiaceae fam. nov., based on a polyphasic taxonomic approach

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Fungal Diversity 2020年第2期101卷 177-210页

作者： Milan C.Samarakoon Benjarong Thongbai Kevin D.Hyde Mark Brönstrup Ulrike Beutling Christopher lambert Andrew N.Miller Jian‑Kui(Jack)Liu Itthayakorn Promputtha Marc Stadler Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of Sciences132Lanhei RoadKunming 650201People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006People’s Republic of China Department of Microbial Drugs Helmholtz-Zentrum für Infektionsforschung GmbHInhoffenstrasse 738124 BrunswickGermany Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemical Biology Helmholtz-Zentrum für Infektionsforschung GmbHInhoffenstrasse 738124 BrunswickGermany Illinois Natural History Survey University of Illinois1816 South Oak StreetChampaignIL 61820‑6970USA Research Center in Bioresources for Agriculture Industry and MedicineChiang Mai UniversityChiang Mai 50200Thailand

Molecular phylogenetic studies of cultures derived from some specimens of plant-inhabiting Sordariomycetes using ITS,LSU,rpb2 and tub2 DNA sequence data revealed close affinities to strains of *** taxonomy of this biotechnologi-cally important genus,which exclusively consists of endophytes with sterile mycelia that produce antibiotic volatile secondary metabolites,was based on a rather tentative taxonomic *** though it was accommodated in Xylariaceae,its phylo-genetic position had so far remained *** phylogeny shows that Muscodor species have affinities to the xylarialean genera Emarcea and Induratia,which is corroborated by the fact that their sexual states produce characteristic *** data allow for the integration of Muscodor in Induratia,*** genus that was historically described *** multi-locus phylogenetic tree clearly revealed that a clade comprising Emarcea and Induratia forms a monophylum separate from representatives of Xylariaceae,for which we propose the new family *** time estimations revealed that Induratiaceae has been diverged from the Xylariaceae+Clypeosphaeriaceae clade at 93(69-119)million years ago(Mya)with the crown age of 61(39-85)Mya during the Cretaceous *** ascospore-derived cultures were studied for the production of volatile metabolites,using both,dual cultures for assessment of antimicrobial effects and extensive analyses using gas chromatography coupled with mass spectrometry(GC-MS).The antimicrobial effects observed were significant,but not as strong as in the case of the previous reports on Muscodor *** GC-MS results give rise to some doubt on the validity of the previous identification of certain *** peaks in the GC-MS chromatograms could not be safely identified by database searches and may represent new natural *** isolation of these compounds by preparative chromatography and their subsequent characterisation by nuclear magnetic re

关键词： 9 new taxa 16 new combinations Biocontrol Endophytes Secondary metabolites Sordariomycetes

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Impact of intragastric balloon on blood pressure reduction:A retrospective study in Eastern North Carolina

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World Journal of Gastrointestinal Endoscopy 2021年第5期13卷 115-124页

作者： Gbeminiyi Olanrewaju Samuel Karissa lambert Elijah Asagbra Glenn Harvin Eric Ibegbu Division of Gastroenterology East Carolina UniversityGreenvilleNC 27834United States Department of Internal Medicine Brody School of MedicineEast Carolina UniversityGreenvilleNC 27834United States Department of Health Services and Information Management East Carolina UniversityCollege of Allied Health SciencesGreenvilleNC 27834United States

BACKGROUND Obesity has evolved into a global *** prevalence of obesity and hypertension in eastern North Carolina are comparable,if not higher,than the national *** the United States,an estimated 34%of adults have hypertension,the most modifiable risk factor for heart disease and *** and pharmacological interventions often do not provide sustained weight loss in obese *** surgery offers an effective weight reduction with short-and long-term health improvements;however,a higher body mass index is associated with higher surgical morbidity and mortality,longer hospitalization,and increasing rates of 30-day readmission due to *** balloon may bridge a critical gap in the treatment of *** objective of this paper is to showcase the impact of endoscopic bariatric therapy on blood pressure *** To investigate the impact of intragastric balloon on blood pressure *** A retrospective chart review was conducted from January 1,2016 to January 31,2019 of consecutive adults who received intragastric balloon therapy(IGBT)in a gastroenterology private practice in Eastern North *** balloon was introduced into the stomach under endoscopic guidance,and while in the region of the gastric body,inflation with saline was performed at increments of 50 mL until target volume between 500 to 650 mL of saline was attained depending on the patient's gastric *** procedural complications were noted during endoscopic placement and removal of the balloon.A cohort study design was used for data analysis.A total of 172 patients had the Orbera^(■)intragastric balloon *** the 172 patients who had IGBT at baseline,11 patients(6.4%)requested early balloon removal due to foreign body sensation(n=1),and/or intolerable gastrointestinal adverse events(n=10).The reported gastrointestinal adverse events were nausea,vomiting,abdominal pain,and ***,6-mo follow-up data were ava

关键词： Intragastric balloon Orbera^(■) Obesity Hypertension Systolic blood pressure Diastolic blood pressure

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庞泉沟自然保护区寒温性针叶林演替优势种格局动态分析

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生态学报 2012年第18期32卷 5713-5720页

作者：张钦弟毕润成张金屯 lambert Nyobe 苗艳明刘晓宁山西师范大学生命科学学院临汾041004 北京师范大学生命科学学院北京100875

以华北落叶松和青杆为主的寒温性针叶林是庞泉沟自然保护区的重要林型,也是主要保护对象之一。通过空间代时间构建庞泉沟自然保护区寒温性针叶林演替的时间序列,序列1是华北落叶松单优群落稳定发展的过程,序列2是从华北落叶松单优群落... 详细信息

以华北落叶松和青杆为主的寒温性针叶林是庞泉沟自然保护区的重要林型,也是主要保护对象之一。通过空间代时间构建庞泉沟自然保护区寒温性针叶林演替的时间序列,序列1是华北落叶松单优群落稳定发展的过程,序列2是从华北落叶松单优群落演替至华北落叶松-青杆共优群落再到青杆单优群落的过程,采用点格局分析法和与Monte-Carlo拟合检验对演替过程中华北落叶松和青杆的分布格局及其相互关系进行了研究。结果表明:(1)序列1在华北落叶松单优群落稳定发展过程中,华北落叶松的分布格局由集群分布趋向于随机分布,甚至在0—2.5 m上表现为均匀分布,驱动力是种内竞争引起的自疏现象。序列2从华北落叶松单优群落演替至青杆单优群落过程中,华北落叶松的分布格局同样是由集群分布趋向于随机分布,驱动力主要来自于由于青杄侵入扩散而形成的种间竞争;青杄集群的尺度逐步增大,驱动力主要是种群拓殖和种内竞争。(2)二者种间关系,在华北落叶松单优群落阶段无明显相关,共优阶段由于竞争在0—6.5 m尺度上呈显著正相关,在青杄单优群落,青杄竞争获胜,在0—2.5 m尺度上无明显相关,二者种间关系的变化主要来自于群落剩余资源驱动下的种内种间竞争。

关键词：庞泉沟自然保护区寒温性针叶林演替格局动态点格局分析

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