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The effect of Antiretroviral Therapy (ART) on Body Composition and Clinical Markers of Lipodystrophy in HIV-Infected Children Assessed in Follow-Up Study

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World Journal of AIDS 2012年第3期2卷 252-258页

作者： Agnieszka B. Dzwonek Vas Novelli C. Smith Margaret lawson Childhood Nutrition Research Centre Institute of Child Health University College London London UK Clinical Infectious Diseases Unit Great Ormond Street Children’s Hospital NHS Trust London UK Research Department of Infection and Population Health University College London Medical School London UK

Objectives: Antiretroviral therapy (ART) has been associated with lipodystrophy in children. We evaluated changes in various anthropometric measurements for the assessment of lipodystrophy and assessed whether there was an association with use of protease inhibitors (PI), non-PI containing ART and/or stavudine (d4T). Methods: eighty-five HIV-infected children attending the HIV clinic at Great Ormond Street Hospital (GOSH) were included. The average follow-up was 8.4 months (range 3 - 12 months). Body fat redistribution was assessed by anthropometric measurements including skinfold thickness and circumferences of upper and lower limbs. Measurements were converted to age- and sex-adjusted z-scores through development stages including puberty. Results: Sixty children had taken ART;37 received PI-containing;38 received d4T;25 had never been treated. In the studied population, clinically important changes with decreases in biceps (BSF), subscapular skinfolds and total body fat (4SFT) over period of 12 months were observed. Some increase was noticed in triceps skinfolds (TSF). Limbs circumferences remained at the same level. Further we looked at 4 months basis changes in anthropometric measurements stratified by baseline ART. Generally z-scores of anthropometric measurements were lower in therapy naive children when compared to ART groups. PI-based ART regimens resulted in significant increases in BSF with a trend towards increases in TSF, suprailiac and 4SFT. Mid-arm and thigh circumferences were higher in PI compared to naive group. Similarly, significant changes in BSF z-scores were associated with d4T use. Increases were seen in TSF and mid-arm circumference and decreases were observed in subscapular skinfolds and calf circumference z-scores. Conclusions: Body fat redistribution in HIV-infected children with sub-clinical lipodystrophy could be detected by anthropometric measurements, particularly when PI or d4T is included in ART. Over time, changes with increase in a

关键词： Body Fat Redistribution Anthropometric Measurements HIV Children Art

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Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane

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American Journal of Analytical Chemistry 2020年第6期11卷 261-268页

作者： Chioma Don-lawson Daniel Okechukwu Nweneka Reminus Okah Kingsley J. Orie Department of Science Laboratory Technology Captain Elechi Amadi Polytechnic Rumuola Port Harcourt Nigeria Department of Pure and Industrial Chemistry University of Port Harcourt Port Harcourt Nigeria

This study reports the synthesis of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane, characterisation and bioactivities on selected microorganism. The first step involves the coupling of furfural with urea to obtain 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea, which was subsequently refluxed with more urea in ethanol for 1 hour to afford the product. Both intermediate and product were characterized by GC-MS, IR, 1H-NMR, 13C-NMR. The synthesized compound1,1-bis(2-carbamoylguanidino)furan-2-ylmethane was bioactive on escherichia coli, Salmomellatyphi and Bacillus subtilis to different extent and is inactive on Staphylococcus aureus. The presences of bioactive moieties and pharmacological activities have proved the potency of furfural derivatives in the development of novel drug in future.

关键词： Furfural 1 1-bis(2-Carbamoylguanidino)furan-2-ylmethane Bioactivity

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地磁测量——定向井工程师的实时指南针

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国外测井技术 2014年第5期34卷 57-67页

作者： Andrew Buchanan Carol A.Finn Jeffrey J.Love e.william Worthington Fraser lawson Stefan Maus Shola Okewunmi Benny Poedjono 意大利埃尼集团美国运营公司美国地质调查局图洛石油加纳公司磁变服务公司雪佛龙公司

为精准确定地下井眼的位置和方向，定向井工程师要依靠重力计、磁力计和陀螺仪的测量数据。在过去，要通过中断钻井作业来获得高精度的定向测量数据。如今，地磁测量方面技术的发展使得在钻井过程中获得的实时数据来精准定位水平井，缩... 详细信息

为精准确定地下井眼的位置和方向，定向井工程师要依靠重力计、磁力计和陀螺仪的测量数据。在过去，要通过中断钻井作业来获得高精度的定向测量数据。如今，地磁测量方面技术的发展使得在钻井过程中获得的实时数据来精准定位水平井，缩小井口距离，在有限的地表位置进行多井钻探成为可能。

关键词：地磁测量实时数据工程师定向井指南针测量数据钻井作业钻井过程

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地磁测量——定向井工程师的实时指南针

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国外测井技术 2015年第4期35卷 58-69页

关键词：地磁测量实时数据工程师定向井指南针测量数据钻井作业钻井过程

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中国的成本计算方法和成本管理实践研究

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国际商务财会 2008年第8期 5-11页

作者： Raef lawson 美国管理会计师协会

为消除目前国际社会特别是欧美对我国企业成本计算数据的疑虑、从技术层面上推动我国市场经济地位工作和应对贸易摩擦,2005年以来,商务部财务司与美国管理会计师协会(IMA)联合开展了中国企业成本计算课题研究。经过2年多的调查、研究、... 详细信息

为消除目前国际社会特别是欧美对我国企业成本计算数据的疑虑、从技术层面上推动我国市场经济地位工作和应对贸易摩擦,2005年以来,商务部财务司与美国管理会计师协会(IMA)联合开展了中国企业成本计算课题研究。经过2年多的调查、研究、论证、分析,今年年初最终完成了课题研究报告,并于近日举行了课题研究报告发布会。本刊根据研究报告摘录整理了相关文字,简单介绍本课题的研究背景、接受实地调查企业的成本会计实务以及课题研究结论,供参考。

关键词：成本计算方法中国企业成本管理实践研究课题研究报告管理会计师协会市场经济地位国际社会

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Thyroid Metastasis Revealing Prostatic Adenocarcinoma

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第6期10卷 519-525页

作者： Warou Dolou Ablavi Adani-Ifè Stephen L. A. lawson essodina Padja Kwamé Doh Department of Oto-Rhino-Laryngology University Teaching Hospital of Kara Kara Togo Department of Oncology University Teaching Hospital of Lom&#233 Lom&#233 Togo Department of Urology University Teaching Hospital of Lom&#233 Lom&#233 Togo Department of Pathology University Teaching Hospital of Lom&#233 Lom&#233 Togo

Introduction: Metastasis to the thyroid gland is rarely encountered and usually detected after the diagnosis of the primary tumor. The most common sites of primary are breast, kidney, and lung. Prostate has been rarely reported as primary site. Here is reported a case of thyroid metastasis revealing prostate adenocarcinoma. Case summary: A 59-year-old man was admitted for pulmonary embolism. CT scan showed a hypertrophy of left thyroid lobe, and ultrasonography of the neck revealed cervical nodes. Thyroid function tests were within normal limits. Total thyroidectomy associated to cervical nodes dissection was done. There was no postoperative complication. Histopathological examination of the surgical specimen concluded to a papillary carcinoma. Then, immunohistochemistry examination revealed prostatic metastatic adenocarcinoma to lymph node and thyroid gland. The patient was treated by androgen deprivation therapy. After thirty three months of follow-up, he is still in good condition with stable disease. Conclusion: This case suggests thyroid cancer might be metastasis, and more frequent than known. Surgical specimen of thyroidectomy requires further histological examination such as immunohistochemistry to document primary tumor. Prostate is one of the primary, despite not the most common.

关键词： Thyroid Metastasis Prostatic Adenocarcinoma Immunohistochemistry

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A Rare Case of 83-Year-Old Transgender Female: Can Thyroid Hormone Deficiency Be Involved in Transgenderism and Gender Dysphoria?

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Advances in Sexual Medicine 2020年第2期10卷 23-40页

作者： Andrey Frolov Lauren Polcaro Craig lawson Yun Tan John R. Martin III Center for Anatomical Science and education Department of Surgery School of Medicine Saint Louis University Saint Louis Missouri USA

In the current report, we describe an 83-year-old biological male who self- identified as a female by legally changing his first and middle names to female ones and whose death certificate states his sex as a female. The medical history of this individual indicated complete penectomy without further specification. Postmortem physical examination revealed an absence of penis with a large scrotum, transposed urethral orifice, and small testes. The histological analysis of the testes identified abnormal epithelium in the seminiferous tubules that lacked germ and Sertoli cells as well as the interstitium without Leydig cells present. The exome sequencing of the individual’s DNA using the Next Generation Sequencing (NGS) Illumina platform revealed no genetic variants associated with either penile or urethral cancer that could have explained the complete penectomy, but pointed toward a potentially impaired production of T3 and T4 thyroid hormones which could account for the observed testicular malformation. Overall, the data obtained raise an important question as to whether the thyroid hormone axis could be an important part of the hormonal architecture supporting male sexual behavior.

关键词： Transgenderism Gender Dysphoria Next Generation Sequencing Thyroid Peroxidase Cilia

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A JNK signaling pathway is involved in LPS-induced indoleamine 2,3-dioxygenase expression in an interferon-γ-independent manner in primary murine microglia

A JNK signaling pathway is involved in LPS-induced indoleami...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Marcus A.lawson Robert Dantzer Keith W.Kelley Integrative Immunology and Behavior Program Department of Animal Sciences College of ACESUniversity of Illinois at Urbana-ChampaignUSA

＜正＞Chronic inflammation is often associated with clinical *** studies have focused on potential mechanisms that might link inflammation-induced depression to tryptophan metabolism,particularly in the brain,where a reduction in the bioavailability of tryptophan could affect serotoninergic neurotransmission and play a synergistic role in the induction of depressive symptoms.A pivotal protein that has recently been shown to be required for development of inflammation-induced depressive-like behavior in mice is indoleamine 2,3-dioxygenase（IDO）,the first rate-limiting tryptophan -degrading enzyme in the kynurenine *** of this enzyme by inflammatory signals leads to an increase in the kynurenine/tryptophan ratio in plasma and the generation of neuroactive mediators,including 3- hydroxykynurenine（3-HK） and quinolinic acid（QUIN）.High levels of 3-HK and QUIN induce neuronal damage via oxidative stress and over stimulation of N-memyl-D-aspartate（NMDA） *** we investigated the mechanism of IDO expression following acute activation of the innate immune system by lipopolysaccharide（LPS） in primary cultures of microglia derived from neonatal C57BL/6 ***（10 ng/ml） induced IDO transcripts that peaked at 8 h and enzymatic activity at 24 h,resulting in an increase in extracellular kynurenine,the catabolic product of IDO-induced tryptophan *** IDO induction by LPS was accompanied by synthesis and secretion of the proinflammatory cytokines TNFαand IL-6,but without detectable IFNγ*** explore the mechanism of LPS-induced IDO expression, microglia were pretreated with the c-Jun N-terminal kinase（JNK） inhibitor SP600125 for 30 min before LPS *** found that SP600125 blocked JNK phosphorylation and significantly decreased IDO expression induced by LPS,which was accompanied by a reduction of LPS-induced expression of TNFαand ***,these data extend to microglia the property that LPS induces IDO expression v

关键词： nitric oxide indoleamine 2,3-dioxygenase lipopoly saccharide kynurenine interferon-7 primary microglia

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Patients’ Lived experience and Injuries Observed during Upper Digestive endoscopy at KARA Teaching Hospital (Togo)

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Open Journal of Gastroenterology 2021年第12期11卷 285-294页

作者： Oumboma Bouglouga Rafiou el-Hadji Yakoubou Laté Mawuli lawson-Ananissoh Aklesso Bagny Datouda Redah Department of Hepatology and Gastroenterology CHU-KARA Kara Togo Department of Hepatology and Gastroenterology CHU-CAMPUS Lomé Togo

Background: endoscopy remains the most performant medical exam exploring the upper digestive tract;but depending on patients, its tolerance is variable. Objective: This study aimed at describing the experience and eva... 详细信息

Background: Endoscopy remains the most performant medical exam exploring the upper digestive tract;but depending on patients, its tolerance is variable. Objective: This study aimed at describing the experience and evaluating the tolerance, acceptability and injuries observed during upper gastrointestinal endoscopy. Methods: This is a prospective and descriptive study carried out from April to July 2017 in the digestive endoscopy unit of the Kara teaching hospital (Togo). The gastroscopy was performed by the same operator (Hepatogastroenteroloogist). The premedication was done with direct intravenous injection of 10 mg of Metoclopramide hydrochloride and viscous Lidocaine oral gel. Previously, essential information about the examination course was given to patients after obtaining their verbal consent. Patients’ impressions of the experience, tolerance and acceptability were collected on a survey sheet, before and after the examination. Results: One hundred and eleven patients were included, 62 women and 49 men. The average age was 45.9 years (15 - 88 years), and the sex ratio e="font-family:;" "="">(F/M) was 1.2. Most of the patients (89.2%) were experiencing the gastroscopy for the first time, and the main reason was epigastralgia in 55%. The examination duration was good at 88.3% and tolerance was good at 72.1%. Tingling, irritation, pain or sore throat feelings were noted in 13.5%. Pati

关键词： Upper Digestive endoscopy experience Tolerance Acceptability Injuries Togo

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Place of Partial Arytenoidectomy in the Management of Bilateral Vocal Cord Immobilitis

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第3期12卷 163-172页

作者： Alexis do Santos Zounon Ulrich B. Vodouhe Vanessa Aissi Wassi Adjibabi Georges lawson eNT-HNS Department FSS Cotonou Abomey Calavi University Cotonou Republic of Benin

Surgical management of laryngeal paralysis varies depending on whether the vocal cords are in abduction, adduction or paramedian position. Various surgical techniques have been described including partial arytenoidectomy which is reported to give good surgical results that are stable over time. The objective of the study was to analyze the surgical therapeutic elements of bilateral paralysis, especially to assess partial arytenoidectomy, one of the most performed techniques. This was a descriptive retrospective study of cases of bilateral immobility admitted between January 1st 2008 and March 31st 2018 and treated surgically. Socio-demographic and therapeutic data were collected. The survey involved 46 patients, with an equal number of male and female (23) with 50% of male patients and 23 patients were female, or a sex ratio of 1. The average age of the patients was 56 ± 17 years ranging between 14 and 89 years. Posterior partial arytenoidectomy was the most widely performed surgical technique (26 patients or 56.5%), followed by cordopexia or lateral-fixing of a vocal cord (19.6%) and posterior cordectomy (17.4%). Patients who received a partial arytenoidectomy and cordopexia had their vocal cords either in adduction or in the paramedian position. Those who received a posterior cordectomy had their vocal cords in adduction. 18 patients (39.13%) were taken to the operating theatre in less than 6 hours, 28 (60.9%) had no post-operative complications, and 9 patients received a surgical enlargement resumption. In post-operative follow-up, 11 patients suffered pulmonary aspiration corrected after speech therapy;26 patients (56.5%) did not. Partial arytenoidectomy remains the most performed surgical procedure in the management of closed bilateral laryngeal paralysis at the Mont-Godinne University Hospital. It allows a reliable and durable breathing function over time with less impact on the voice.

关键词： Vocal Cords Bilateral Laryngeal Paralysis Surgery Partial Arytenoidectomy

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