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Biomedical and Environmental Sciences 2021年第4期34卷 290-298页

作者： wANG Tong Shuai SONG Bo SUN Qing Hua LIN Yong Xin SUN Yuan SUN Pin JIA Xiao Dong william w.au MEI Can Hua XIA Zhao Lin Department of Occupation Health and Toxicology School of Public HealthFudan UniversityShanghai 200000China Department of Occupation Health Shanghai Municipal Health CommissionShanghai 200000China Shanghai Institute of Occupational Disease for Chemical Industry(Shanghai Institute of Occupational Safety&Health) Shanghai 200000China Division of Health Risk Factors Monitoring and Control Shanghai Municipal Center for Disease Control and PreventionShanghai 200000China University of Medicine PharmacyScience and TechnologyTargu MuresRomania and Shantou University Medical CollegeShantou 515000GuangdongChina

Objective This study was designed to conduct a retrospective and systematic occupational health risk assessment(OHRA)of enterprises that used benzene,toluene,and xylene(BTX)in Shanghai,*** All data for the study were obtained from 1,705 occupational health examination and evaluation reports from 2013 to 2017,and a semiquantitative model following Chinese OHRA guidelines(GBZ/T 298-2017)was applied for the *** The selected enterprises using BTX were mainly involved in manufacturing of *** the exposure level method,health risk levels associated with exposure to BTX were classified as medium,negligible,or ***,the risk levels associated with benzene and toluene were significantly different according to job types,with gluers and inkers exhibiting greater health *** the same job type,the health risk levels assessed using the comprehensive index method were higher than those using the exposure level *** Our OHRA reveals that workers who are exposed to BTX still face excessive health ***,the risk level varied depending on job categories and exposure to specific ***,additional control measures recommended by OHRA guidelines are essential to reduce worker exposure levels.

关键词： Benzene Toluene Xylene Occupational health risk assessment Exposure level method Comprehensive index method

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导致吸烟者淋巴细胞染色体损伤的因素

癌变．畸变．突变 1992年第1期4卷 59-59,45页

作者： william w.au 董艳

人们普遍认为吸烟可以引起许多健康问题。但是吸烟与生物诱导效应以及吸烟者健康损害的广度之间的因果关系尚未得到充分证实。已知香烟雾由数千种化学物质组成,其中一些物质是诱变剂和/或致癌剂。在生物学活性方面,已表明香烟雾及其凝... 详细信息

人们普遍认为吸烟可以引起许多健康问题。但是吸烟与生物诱导效应以及吸烟者健康损害的广度之间的因果关系尚未得到充分证实。已知香烟雾由数千种化学物质组成,其中一些物质是诱变剂和/或致癌剂。在生物学活性方面,已表明香烟雾及其凝聚物可以和DNA及蛋白质形成加合物,诱导吸烟者淋巴细胞发生染色体畸变、姐妹染色单体互换和基因突变。作者采用淋巴细胞微核分析法,对67位吸烟者和59位非吸烟对照者进行了染色体畸变率分析。发现吸烟者平均微核率略高于非吸烟者。

关键词：吸烟淋巴细胞染色体损伤微核率

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癌症延迟就医研究

中国肿瘤 2016年第9期25卷 667-671页

作者：林璜 william w.au 欧利民汕头大学医学院公共卫生系广东汕头515041 汕头大学医学院第一附属医院广东汕头515041

癌症延迟就医存在自然性、社会性和普遍性,是早诊早治的消极因素,给予干预的健康促进意义重大。全文通过文献研究,讨论了延迟就医的定义、研究指标、样本、信息适用等问题。目前癌症患者延迟就医≥3个月发生率为30%~60%,亟需普及人群的... 详细信息

癌症延迟就医存在自然性、社会性和普遍性,是早诊早治的消极因素,给予干预的健康促进意义重大。全文通过文献研究,讨论了延迟就医的定义、研究指标、样本、信息适用等问题。目前癌症患者延迟就医≥3个月发生率为30%~60%,亟需普及人群的癌症认知常识并强化各地诊疗检测手段。在未来研究中以各类延迟就医时间与癌种5年生存率关系为基础,具有重要意义。

关键词：癌症延迟就医

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食管癌流行现状及潮汕食管癌病因学研究

中国实用医药 2015年第32期10卷 277-279页

作者：林璜 william w.au 欧利民汕头大学医学院公共卫生系 515041 汕头大学医学院第一附属医院

本文就食管癌科研文献相关结论作描述性研究,简述潮汕内外食管癌流行特征,综述潮汕地区食管癌危险因子并提出策略,提供了潮汕研究基础资料与借鉴。潮汕食管癌持续高发,存在遗传易感性、生活习惯和环境污染危险因素;改善环境,养成健康饮... 详细信息

本文就食管癌科研文献相关结论作描述性研究,简述潮汕内外食管癌流行特征,综述潮汕地区食管癌危险因子并提出策略,提供了潮汕研究基础资料与借鉴。潮汕食管癌持续高发,存在遗传易感性、生活习惯和环境污染危险因素;改善环境,养成健康饮食与及时就医等生活习惯,具有现实的防癌意义。

关键词：潮汕食管癌流行病学病因学

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Toward understanding Cretaceous climate An updated review

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Science China Earth Sciences 2017年第1期60卷 5-19页

作者： william w. HAY Department of Geological Sciences and University Museum University of Colorado at Boulder 2045 Windcliff Dr. Estes Park CO 80517 USA

New data and ideas are changing our view of conditions during the *** of the continents was lower than originally thought,eliminating the'cold continental interior paradox'of fossils of plants that could not tolerate freezing occurring in regions indicated by climate models to be well below freezing in *** controversy over the height of Cretaceous sea levels has been resolved by knowledge of the effects of passage of the subducted slab of the Farallon Plate beneath the North American *** cause of shorter term sea level changes of the order of 30 to 50 meters is not because of growth and decay of ice sheets,but more likely the filling and release of water from groundwater reservoirs and lakes although there may have been some ice in the Early and latest *** dioxide was not the only significant greenhouse gas;methane contributed significantly to the warmer *** of very warm tropical ocean temperatures(>40℃)have implications for the nature of plant life on land limited by Rubisco *** land surfaces were much wetter than has been thought,with meandering rivers and many oxbow lakes providing habitat for large dinosaurs.A major rethinking of the nature of conditions on a warmer Earth is underway,and a new suite of paleoclimate simulations for the Cretaceous is needed.

关键词： Cretaceous Paleogeography Paleotopography Sea level Greenhouse Paleohydrology Paleoclimate

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof