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World Journal of Radiology 2011年第4期3卷 105-113页

作者： Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed william vennart Susan T Francis Peter G Morris The Sir Peter Mansfield Magnetic Resonance Centre School of Physics and AstronomyUniversity of Nottingham School of Biomedical Sciences University of Nottingham Medical School Academic Radiology University of Nottingham Molecular Medicine PfizerSandwich

AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of *** at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies.

关键词： Magnetic resonance spectroscopy 13C 1H 7 Tesla Glutamate Glutamine γ-aminobutyric acid

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颈动脉的血流动力学:应用MRI计算流体动力学方法观察应用氨氯地平和赖诺普利病人的特异性变化

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国际医学放射学杂志 2011年第1期34卷 80-页

作者： B.B.Ariff F.P.Glor L.Crowe W.vennart D.N.Firmin 任崧 Department of Imaging Imperial College National Health Service TrustHammersmith Hospital

目的评估联合应用MRI和流体动力学计算(CFD)是否能够显示降压效果相似的两种降压药——氨氯地平(钙离子通道拮抗剂)和赖诺普利(血管紧张素转换酶抑制剂)

关键词：赖诺普利降压效果颈总动脉抗高血压药氨氯地平血流动力 MRI 病人

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