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Progression of intervention-focused research for Gulf War illness

Military Medical Research 2020年第1期7卷 104-121页

作者： Jeremy E.Chester Mazhgan Rowneki william van doren Drew A.Helmer War Related Illness and Injury Study Center Veterans Affairs New Jersey Healthcare System385 Tremont AvenueEast OrangeNJ 07018USA War Related Illness and Injury Study Center Veterans AffairsMedicalCenter50lrvingSt.WashingtonDCNW20422USA Rutgers University New Jersey Medical School185 South Orange AvenueNewarkNJ 07103USA

The Persian Gulf War of 1990 to 1991 involved the deployment of nearly 700,000 American troops to the Middle ***-related exposures to toxic substances such as pesticides,nerve agents,pyridostigmine bromide(PB),smoke from burning oil wells,and petrochemicals may have contributed to medical illness in as many as 250,000 of those American *** cluster of chronic symptoms,now referred to as Gulf War Illness(GWI),has been studied by many researchers over the past two *** over$500 million has been spent on GWI research,to date,no cures or condition-specific treatments have been discovered,and the exact pathophysiology remains *** the 2007 National Institute of Health(NIH)Roadmap for Medical Research model as a reference framework,we reviewed studies of interventions involving GWI patients to assess the progress of treatment-related GWI *** GWI clinical trial studies reviewed involved investigations of existing interventions that have shown efficacy in other diseases with analogous *** reviewing the published and ongoing registered clinical trials for cognitivebehavioral therapy,exercise therapy,acupuncture,coenzyme Q10(CoQ10),mifepristone,and carnosine in GWI patients,we identified only four treatments(cognitive-behavioral therapy,exercise therapy,CoQ10,and mifepristone)that have progressed beyond a phase II *** conclude that progress in the scientific study of therapies for GWI has not followed the NIH Roadmap for Medical Research *** of a standard case definition,prioritized GWI research funding for the characterization of the pathophysiology of the condition,and rapid replication and adaptation of early phase,single site clinical trials could substantially advance research progress and treatment discovery for this condition.

关键词： Gulf War illness Chronic multisymptom illness Gulf War veterans Gulf War syndrome Persian Gulf War Cognitive-behavioral therapy Exercise therapy Acupuncture Coenzyme Q10 Mifepristone Carnosine Mindfulness-based stress reduction

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Deep learning's fitness for purpose:A transformation problem frame's perspective

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CAAI Transactions on Intelligence Technology 2023年第2期8卷 343-354页

作者： Hemanth Gudaparthi Nan Niu Yilong Yang Matthew van doren Reese Johnson Department of EECS University of CincinnatiCincinnatiOhioUSA School of Software Beihang UniversityBeijingChina Metropolitan Sewer District of Greater Cincinnati CincinnatiOhioUSA

Combined sewer overflows represent significant risks to human health as untreated water is discharged to the ***,such as the Metropolitan Sewer District of Greater Cincinnati(MSDGC),recently began collecting large amounts of water-related data and considering the adoption of deep learning(DL)solutions like recurrent neural network(RNN)for predicting overflow ***,assessing the DL's fitness for the purpose requires a systematic understanding of the problem *** this study,we propose a requirements engineering framework that uses the problem frames to identify and structure the stakeholder concerns,analyses the physical situations in which the highquality data assumptions may not hold,and derives the software testing criteria in the form of metamorphic relations that incorporate both input transformations and output *** our framework to MSDGC's overflow prediction problem enables a principled way to evaluate different RNN solutions in meeting the requirements.

关键词： deep learning deep neural networks software engineering

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Part III: Explaining the “Extra” Heat of Intergalactic Hydrogen Clouds with Probabilistic Spacetime

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Journal of High Energy Physics, Gravitation and Cosmology 2023年第2期9卷 542-551页

作者： Dennis doren James Harasymiw Independent Researcher Wisconsin USA

Recent observations have consistently shown a greater degree of heat in intergalactic hydrogen clouds when redshift z < 2 than what well-designed simulations have indicated. The reason for this “extra” energy has not been established, with the latest hypothesis being the effect of a certain type of dark matter. This paper presents a contrasting straightforward non-dark explanation for the extra energy based on the Probabilistic Spacetime Theory (PST). Both the dark matter and PST models are shown to involve the creation of new photons to explain the thermal enigma, but with very different underlying mechanisms. As this is the third paper in a three-part series of articles on the utility of that theory, a discussion is offered at the end of this paper concerning what the collective set of three articles has shown. Despite dark entities being hypothesized as a cause of all three reviewed research findings, dark entities are not needed to explicate the excess energy documented in each paper. Instead, the PST offers explanations for the reviewed research findings based solely on its five tenets and no dark entities. When viewed from an even larger context of other studies’ unexpected results, the PST was found to be a comprehensive yet parsimonious cosmological theory worthy of further testing.

关键词： Intergalactic Medium Absorption Lines Lyman-α Forest Probabilistic Spacetime Dark Photons Dark Matter

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Improvement in electrokinetic remediation of Pb-contaminated soil near lead acid battery factory

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Transactions of Nonferrous Metals Society of China 2015年第9期25卷 3088-3095页

作者：蔡宗平 Jeremiahvan doren 方战强李伟善华南师范大学化学与环境学院广州510006 Department of Chemical Biology State University of New Jersey 华南师范大学广东高校电化学储能与发电技术重点实验室广州510006 华南师范大学教育部电化学储能工程研究中心广州510006

To improve the conventional electrokinetic remediation of Pb-contaminated soil,the Pb-contaminated soil near a lead acid battery factory in the Pearl River Delta region of China was electrokinetically remedied with polarity exchange *** variations in Pb removal efficiency and the soil p H value with the treatment time and the exchange polarity interval were *** is found that the removal efficiency of Pb reaches a maximum of 87.7% when the voltage gradient is 1 V/cm and the exchange polarity interval is 48 *** value is far higher than that obtained with conventional electrokinetic remediation（61.8%）.Additionally,the ＂focusing effect＂ which appears in the conventional electrokinetic remediation can be avoided,and thus additional chemicals are not needed for the polarity exchange *** mechanism of Pb electromigration behavior in soil during the treatment with the polarity exchange technique was described.

关键词： electrokinetic remediation polarity exchanges Pb-contaminated soil

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Part II: Explaining Black Hole Growth due to Universal Expansion: Probabilistic Spacetime versus GEODEs

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Journal of High Energy Physics, Gravitation and Cosmology 2023年第2期9卷 530-541页

作者： Dennis M. doren James Harasymiw Independent Researcher Wisconsin USA

Recent research indicates that black holes can grow based on the expansion of the universe and not just through accretion and mergers. Two different models independently predicted that finding. One model, describing the relevant massive star remnants as “generic objects of dark energy”, rejects the traditional view of black holes while hypothesizing that dark energy causes the cosmologically coupled growth of these objects. The other model, based on the probabilistic spacetime theory, indicates the growth of black holes is based on the same spacetime mechanism underlying all universal expansion, and does so while leaving the traditional black hole conceptualization essentially intact. The fact these two models predicted this observational finding but did so from different perspectives suggests more can be learned by further study of their differences. This paper explores similarities and differences in the two models’ explanations for massive star remnants’ growth, concluding with suggestions for research testing their relative veracity. An exploration of the relative utility and parsimony of the two models is also described.

关键词： Probabilistic Spacetime GEODE Cosmological Coupling Universal Expansion Black Holes

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Part I: Explaining the “Muon g - 2” Results with Probabilistic Spacetime

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Journal of High Energy Physics, Gravitation and Cosmology 2023年第2期9卷 524-529页

作者： Dennis M. doren James Harasymiw Independent Researcher Wisconsin USA

A recent experimental finding replicated an earlier research result, both of which demonstrated conflict with a specific Standard Model prediction. The “Muon g - 2” studies have indicated that the degree of muon precession predicted by the Model is not the same as observed. The researchers offer many posteriori atheoretical hypotheses as possible explanations of their findings, but no fundamental theoretical understanding of the near discovery is among them. This article describes both an explication for the unexpected result and describes its underlying mechanism based on an existing cosmological theory, the Probabilistic Spacetime Theory. The paper also discusses the potential value of this theory.

关键词： Muon g - 2 Probabilistic Spacetime Muon Anomaly Muon Precession Standard Model

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Resolving the Information Paradox with Probabilistic Spacetime

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Journal of High Energy Physics, Gravitation and Cosmology 2023年第1期9卷 83-99页

作者： Dennis M. doren James Harasymiw Wisconsin USA

It has been 50 years since Hawking described the black hole (BH) information paradox. The combination of BH radiation and subsequent BH evaporation was found to take trapped information into oblivion contrary to the law of conservation of quantum information. Numerous attempts have been made since to resolve this paradox. A brief review herein documents how all these attempts have significant shortcomings, meaning the paradox is still unresolved. A relatively new cosmological theory offers a resolution despite not being developed for that purpose. The theory, entitled the probabilistic spacetime theory (PST), starts with an alteration in one basic assumption compared to all current cosmological theories. Spacetime, instead of being seen as a void or container of other entities, is viewed as the most fundamental entity in the universe, composed of energy fragments, and (in keeping with the conservation principle) impermeable to destruction. The potential contribution of the PST in resolving the information paradox is delineated, with the finding that the single change in the conceptualization of spacetime results in the disappearance of the paradox and not information.

关键词： Information Paradox Hawking Radiation Probabilistic Spacetime Black Holes Energy Fragment

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自整定控制的应用

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软件 2008年第1期29卷 23-25页

作者： vance van doren 江旭强

回路整定是既是科学也是艺术。一个经过完善整定的反馈控制回路可以快速并且安全地消除过程变量和极点之间的误差，但是要让控制器在激进与耐心之间具有一个平衡的话就需要有一定程度的技术及经验。

关键词：自整定控制反馈控制回路应用过程变量控制器

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西方思想宝库

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1991年

作者：（英）阿德勒（Adler M.J.）（英）范多伦（van doren G.）周汉林等

书名原文:Great treasury of western thought:据《西方思想伟大宝库》纽约/伦敦1977年英文版译出:本书精选了从柏拉图、阿奎那到培根、弗洛伊德等西方思想家对人类生活、自然、思维等领域二十个方面上百个问题的分析和论断。

ISBN: (数字)7504308838

ISBN: (纸本)7504308838

关键词：社会科学学科:文摘地点:世界

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浮选捕收剂——非离子型表面活性剂

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国外金属矿选矿 1977年第3期 33-38页

作者： Aurora doren 赵援

研究了烷基聚氧乙烯型表面活性剂的捕收性能。这类表面活性剂是浮选石英、锡石的一种良好捕收剂,无机盐浓度、pH值等对浮选回收率都有影响。但这类化合物却不能浮选硅孔雀石。按照假设,此类表面活性剂在矿物表面的吸附,是氧乙烯基团与... 详细信息

研究了烷基聚氧乙烯型表面活性剂的捕收性能。这类表面活性剂是浮选石英、锡石的一种良好捕收剂,无机盐浓度、pH值等对浮选回收率都有影响。但这类化合物却不能浮选硅孔雀石。按照假设,此类表面活性剂在矿物表面的吸附,是氧乙烯基团与硅烷醇位(Silanol sites)之间氢键键合的结果。pH增加时,由于能够产生氢键的硅烷醇基团减少,致使浮选回收率下降。文中对于硫酸盐的活化效应以及硫氰酸盐的抑制作用,联系到盐类的“盐析”(Salting-out)或“盐溶”(Salting-in)特性,进行了专门讨论。作出了详细的吸附等温线,用于浮选结果的讨论。根据浮选及吸附之间,缺乏严密的联系说明,矿物表面的疏水性当与其他一些作用有关。

关键词：捕收剂回收率石英锡石浮选药剂实收率硅氧矿物锡矿物非离子型表面活性剂环状硅酸盐矿物硅孔雀石

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