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Importance of sperm morphology during sperm transport and fertilization in mammals

Asian Journal of Andrology 2016年第6期18卷 844-850页

作者： Francisco A Garcia-vazquez Joaquin Gadea Carmen Matas william v holt Department of Physiology Faculty of Veterinary Science International Excellence Campus for Higher Education and Research 'Campus Mare Nostrum' University of Murcia Murcia 30100 Spain Institute for Biomedical Research of Murcia (IMIB-Arrixaca) Murcia Spain Department of Human Metabolism Academic Unit of Reproductive and Developmental Medicine Sheffield S10 2SF UK

After natural or artificial insemination, the spermatozoon starts a journey from the site of deposition to the place of fertilization. However, only a small subset of the spermatozoa deposited achieves their goal： to reach and fertilize the egg. Factors involved in controlling sperm transport and fertilization include the female reproductive tract environment, cell-cell interactions, gene expression, and phenotypic sperm traits. Some of the significant determinants of fertilization are known （i.e., motility or DNA status）, but many sperm traits are still indecipherable. One example is the influence of sperm dimensions and shape upon transport within the female genital tract towards the oocyte. Biophysical associations between sperm size and motility may influence the progression of spermatozoa through the female reproductive tract, but uncertainties remain concerning how sperm morphology influences the fertilization process, and whether only the sperm dimensions per se are involved. Moreover, such explanations do not allow the possibility that the female tract is capable of distinguishing fertile spermatozoa on the basis of their morphology, as seems to be the case with biochemical, molecular, and genetic properties. This review focuses on the influence of sperm size and shape in evolution and their putative role in sperm transport and selection within the uterus and the ability to fertilize the oocyte.

关键词： CASA-Morph female reproductive tract flagellum morphometry sperm competition sperm head sperm selectionsperm size

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In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation

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Journal of Magnesium and Alloys 2022年第6期10卷 1631-1639页

作者： Di Tie Renguo Guan Huinan Liu Minfang Chen Sviatlana A.Ulasevich Ekaterina v.Skorb Patricia holt-Torres Xiaopeng Lu Norbert Hort Engineering Research Center of Continuous Extrusion Ministry of EducationDalian Jiaotong UniversityDalian 116028China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Department of Bioengineering University of CaliforniaRiversideCA 92521USA School of Materials Science and Engineering Tianjin University of TechnologyTianjin 300384China Infochemistry Scientific Center ITMO UniversitySt.Petersburg 192007Russia Magnesium Innovation Center-MAGIC Helmholtz Zentrum GeesthachtGeesthacht D-21502Germany

The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades,among which magnesium alloy is widely considered a favorable choice as its appropriate biodegradability and evident antibacterial ***,we reveal a semisolid rheo-formed Mg–Zn–Sr alloy ureteral implant that displayed suitable degradability and biocompatibility in a pig *** non-dendritic microstructure was observed in the rheo-formed alloy,which led to ca.47%increase in ultimate tensile strength(from 195.0 MPa to 288.1 MPa)and more homogeneous degradation process compared with the untreated *** post-interventional inflammation or pathological changes of the test animals were observed during the implantation period,and the corrosion rate(0.22±0.04 mm·y^(-1))perfectly fitted the clinical ureteral stent indwelling *** urine bacteria numbers decreased from 88±13 CFU·mL^(-1)at 7 weeks post operation to 59±8 CFU·mL^(-1)at 14 weeks post operation,which confirmed the evident antibacterial activity of the *** study demonstrates that the Mg–Zn–Sr alloy is clinically safe for urinary system,enabling its efficacious use as ureteral implant materials.

关键词： In vivo Biodegradability Biocompatibility Mg–Zn–Sr alloy Ureteral implant

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作者： v.·霍尔特(v. holt)

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In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model

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Bioactive Materials 2022年第1期7卷 254-262页

作者： Di Tie Norbert Hort Minfang Chen Renguo Guan Sviatlana Ulasevich Ekaterina v.Skorb Dapeng Zhao Yili Liu Patricia holt-Torres Huinan Liu Engineering Research Center of Continuous Extrusion Ministry of EducationDalian Jiaotong UniversityDalian116028China Magnesium Innovation Center Helmholtz-Zentrum GeesthachtD-21502GeesthachtGermany School of Materials Science and Engineering Tianjin University of TechnologyTianjin300384China Infochemistry Scientific Center ITMO UniversitySt.Petersburg192007Russia College of Biology Hunan University410082ChangshaChina Department of Urology China Medical UniversityShenyang110084China Department of Bioengineering Bourns College of EngineeringUniversity of California at RiversideCA92521USA

A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a *** we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties,adjustable indwelling time in urinary tract and evident antibacterial activity via in vivo experiments in a swine *** to the rheo-solidification process,equiaxial microstructure and significantly refined grains(average grain size:27.1μm)were ***17Sr2 and Mg4Ag were found as the primary precipitates in the matrix,due to which the alloy obtained ca.111%increase in ultimate tensile strength in comparison to pure *** the in vitro and in vivo results demonstrated the satisfactory biocompatibility of the *** evaluation and bioindicators analysis suggested that there was no tissue damage,inflammation and lesions in the urinary system caused by the degradation *** stent also improved the post-operative bladder functions viewed from the urodynamic *** findings highlight the potential of this alloy as antibacterial biodegradable urinary implant material.

关键词： In vivo Magnesium alloy Biodegradable metals Mechanical properties Urinary compatibility

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