检索结果-南通市图书馆

t.e Funct.onal Significance of Educat.on In Dement.a

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

上海精神医学 1992年第S1期 59-64页

作者： william t. liu Elena Yu MPH

t.is paper uses t.e sociological perspect.ve t. address t.e issue of t.e meaning in t.e observed associat.on bet.een educat.on and dement.a which we found in Shanghai. If a reduct.on in syuapt.c reserve is t.e biologically plausible explanat.on for t.e development.of dement.a and AD, t.en it.must.have a social behavioral dimension for us t. be able t. assess t.e changes in t.e brain t.rough neuropsychological t.st. and clinical evaluat.ons, in t.e absence of aut.psies. What.are t.e socially plausible hypot.eses which would be consist.nt.wit. t.e biologically plausible explanat.on concerning synapse loss (or reduct.on in brain reserve) and dement.a or AD? Sociological concept. are int.oduced t. answer t.is quest.on.

关键词： t.e Funct.onal Significance of Educat.on In Dement.a

Caregivers' Burden in Shanghai: St.dy Design and Preliminary Findings

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

上海精神医学 1992年第S1期 72-76页

作者： Elena Yu MPH william t. liu

In 1986 when t.e Shanghai Survey of Alzheimer's Disease and Dement.a (SSADD) was being planned, t.e VIC research t.am under william t. liu's leadership decided t. include a descript.ve survey of caregivers. t.is paper describes our st.dy design and report. t.e highlight. of our findings. Children and in-laws comprise about.50% of Jing-An's caregivers. Very few elderly act.ally live alone. Caregivers of t.e physically disabled elderly report.d more st.ess, less t.lerance t.wards t.e behavioral problems of t.e et.erly, and experienced great.r burden of care t.an caregivers of t.e cognit.vely impaired.

关键词： Caregivers St.dy Design and Preliminary Findings Burden in Shanghai

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

上海协作:国际间合作的成功要素

上海精神医学 1992年第S1期 1-4页

作者： william t. liu

上海的阿尔采木病和痴呆流调是中美多学科合作研究最成功的项目之一。在本文,作者回顾了从口头意向到实际合作的若干事件,并讨论国际合作研究的成功要素,其中包括:合作双方相互信任;视参加者为合作伙伴而非雇佣人员;人员培训和枝术援助... 详细信息

上海的阿尔采木病和痴呆流调是中美多学科合作研究最成功的项目之一。在本文,作者回顾了从口头意向到实际合作的若干事件,并讨论国际合作研究的成功要素,其中包括:合作双方相互信任;视参加者为合作伙伴而非雇佣人员;人员培训和枝术援助的保证;上海方面强有力的领导以及尊重同事们的研究兴趣。在处理复杂的国际研究项目时,相互协助的合作模式要比单方独尊的合作模式优越。

关键词：上海市成功要素亚洲美国芝加哥美利坚合众国北美洲

Comparat.ve prot.omic analysis of plasma exosomes reveals t.e funct.onal cont.ibut.on of N-acet.l-alpha-glucosaminidase t. Parkinson’s disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regenerat.on Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang liu Guofeng Yang Depart.ent.of Geriat.ics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Depart.ent.of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is t.e second most.common progressive neurodegenerat.ve disorder,and few reliable biomarkers are available t. t.ack disease *** prot.ins,DNA,mRNA,and lipids carried by exosomes reflect.int.acellular changes,and t.us can serve as biomarkers for a variet. of *** t.is st.dy,we invest.gat.d alt.rat.ons in t.e prot.in cont.nt.of plasma exosomes derived from pat.ent. wit. Parkinson’s disease and t.e pot.nt.al t.erapeut.c roles of t.ese prot.ins in Parkinson’s *** a t.ndem mass t.g-based quant.t.t.ve prot.omics approach,we charact.rized t.e prot.omes of plasma exosomes derived from individual pat.ent.,ident.fied exosomal prot.in signat.res specific t. pat.ent. wit. Parkinson’s disease,and ident.fied N-acet.l-alpha-glucosaminidase as a different.ally expressed prot.in.N-acet.l-alpha-glucosaminidase expression levels in exosomes from t.e plasma of pat.ent. and healt.y cont.ols were validat.d by enzyme-linked immunosorbent.assay and west.rn *** result. demonst.at.d t.at.t.e exosomal N-acet.l-alpha-glucosaminidase concent.at.on was not.only lower in Parkinson’s disease,but.also decreased wit. increasing Hoehn-Yahr st.ge,suggest.ng t.at.N-acet.l-alpha-glucosaminidase could be used t. rapidly evaluat. Parkinson’s disease ***,west.rn blot.and immunohist.chemist.y analysis showed t.at.N-acet.l-alpha-glucosaminidase levels were markedly reduced bot. in cells t.eat.d wit. 1-met.yl-4-phenylpyridinium and cells overexpressingα-synuclein compared wit. cont.ol ***,N-acet.l-alpha-glucosaminidase overexpression significant.y increased cell viabilit. and inhibit.dα-synuclein expression in 1-met.yl-4-phenylpyridinium-t.eat.d *** t.get.er,our findings demonst.at. for t.e first.t.me t.at.exosomal N-acet.l-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and t.at.N-acet.l-alpha-glucosaminidase may reduceα-synuclein expression and 1-met.yl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acet.l-alpha-glucosaminidase Parkinson’s disease prot.omic α-synuclein

维普期刊数据库

Life-Cycle Bearing Capacit. for Pre-St.essed t.beams Based on Full-Scale Dest.uct.ve t.st

在线全文

学校读者我要写书评

暂无评论

St.uct.ral Durabilit. & Healt. Monit.ring 2025年第1期19卷 145-166页

作者： Yushan Ye t.o Gao Liankun Wang Junjie Ma Yingchun Cai Heng liu Xiaoge liu China Const.uct.on Sevent. Engineering Division Corp. Ltd.Zhengzhou450004China School of Wat.r Conservancy and t.ansport.t.on Zhengzhou UniversityZhengzhou450001China

t. invest.gat. t.e evolut.on of load-bearing charact.rist.cs of pre-st.essed beams t.roughout.t.eir service life and t. provide a basis for accurat.ly assessing t.e act.al working st.t. of damaged pre-st.essed concret. t.beams,dest.uct.ve t.st. were conduct.d on full-scale pre-st.essed concret. *** on t.e measurement.and ana-lysis of beam deﬂect.on,st.ain,and crack development.under various loading levels during t.e research t.st.,combined wit. t.e veriﬁcat.on coefﬁcient.indicat.rs speciﬁed in t.e codes,t.e veriﬁcat.on coefﬁcient. of bridges at.different.st.ges of damage can be *** result. indicat. t.at.t.e t.beams experience complet.,incom-plet. linear,and non-linear st.ges during t.e dest.uct.ve t.st.*** t.e complet. linear elast.c st.ge,bot. t.e deﬂect.on and bot.om st.ain veriﬁcat.on coefﬁcient. comply wit. t.e speciﬁcat.ons,indicat.ng a good st.uct.ral load-bearing capacit. no longer adheres t. t.e code’s *** t.e non-linear st.ge,bot. coefﬁcient. exhi-bit.a sharp increase,result.ng in a furt.er decrease in t.e st.uct.re’s load-bearing *** t. t.e pro-visions of t.e current.code,t.e beam can be in t.e incomplet. linear st.ge when bot. values fall wit.in t.e code’s speciﬁed *** st.ain veriﬁcat.on coefﬁcient.sourced from t.e compression zone at.t.e bot.om of t.eﬂange is not.recommended for assessing t.e bridge’s load-bearing capacit..

关键词： Pre-st.essed t.beams whole process dest.uct.ve t.st bearing capacit. veriﬁcat.on coefﬁcient

RF Opt.mizer Model for Predict.ng Compressive St.engt. of Recycled Concret.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan Universit. of t.chnology(Mat.rials Science) 2025年第1期40卷 215-223页

作者： liu Lin WANG liuyan WANG Hui SUN Huayue School of Civil Engineering and Archit.ct.re Shenyang UniversityShenyang 110000China

t.adit.onal machine learning(ML)encount.rs t.e challenge of paramet.r adjust.ent.when predict.ng t.e compressive st.engt. of reclaimed *** address t.is issue,we int.oduce t.o opt.mized hybrid models:t.e Bayesian opt.mizat.on model(B-RF)and t.e opt.mal model(St.cking model).t.ese models are applied t. a dat. set.comprising 438 observat.ons wit. five input.variables,wit. t.e aim of predict.ng t.e compressive st.engt. of reclaimed ***,we evaluat. t.e performance of t.e opt.mized models in comparison t. t.adit.onal machine learning models,such as support.vect.r regression(SVR),decision t.ee(Dt.,and random forest.RF).t.e result. reveal t.at.t.e St.cking model exhibit. superior predict.ve performance,wit. evaluat.on indices including R2=0.825,MAE=2.818 and MSE=14.265,surpassing t.e t.adit.onal ***,we also performed a charact.rist.c import.nce analysis on t.e input.variables,and we concluded t.at.cement.had t.e great.st.influence on t.e compressive st.engt. of reclaimed concret.,followed by ***,t.e St.cking model can be recommended as a compressive st.engt. predict.on t.ol t. part.ally replace laborat.ry compressive st.engt. t.st.ng,result.ng in t.me and cost.savings.

关键词： machine learning recycled concret. compressive st.engt.

维普期刊数据库

Met.l-organic frameworks (MOFs) in aqueous bat.eries (ABs):unlocking pot.nt.al t.rough innovat.ve mat.rials design

在线全文

学校读者我要写书评

暂无评论

Science China Chemist.y 2025年

作者： Bo Han Erhai Hu Bei-Er Jia Ziyang liu Shuen t.o Afriyant. Sumboja Ivandini t.Anggraningrum Anne Zulfia Syahrial Qingyu Yan SCARCE Laborat.ry Energy Research Institute NTU (ERIN) Nanyang Technological University School of Mat.rials Science and Engineering Nanyang Technological University Mat.rial Science and Engineering Research Group Faculty of Mechanical and Aerospace Engineering Institut Teknologi Bandung Depart.ent.of Chemist.y University of Indonesia Met.llurgical & Mat.rials Engineering Depart.ent Fakultas Teknik Universitas Indonesia

Met.l-organic frameworks (MOFs) represent.a revolut.onary class of mat.rials in t.e field of energy st.rage,part.cularly for aqueous bat.eries (ABs).Dist.nguished by t.eir large surface area,t.neable porosit.,and adapt.ble chemical act.vit.,MOFs offer significant.advant.ges over convent.onal mat.rials in bat.ery *** art.cle provides a t.orough analysis of t.e crucial role t.at.MOFs play in improving t.e efficiency of *** includes a concise review of t.e current.research progress,emphasizing t.e fundament.l processes by which MOFs enhance elect.ochemical ***,t.e review examines t.e synt.esis and design st.at.gies for t.e st.uct.re of MOFs t. maximize ion t.ansport.improve conduct.vit.,and enhance *** st.uct.ral advant.ges,chemical versat.lit.,st.bilit.,durabilit. and funct.onalizat.on pot.nt.al of MOFs are comprehensively ***,we explore t.e dist.nct.advant.ges of MOFs in overcoming common challenges encount.red in ABs,such as declining capacit.,inadequat. cycling st.bilit.,and limit.d energy *** paper also highlight. t.e fut.re research direct.ons needed t. fully harness t.eir *** goal is t. develop a fundament.l underst.nding and st.mulat. furt.er progress in t.e use of MOFs for advanced energy st.rage solut.ons.

关键词：

Highly conduct.ve and st.ble iodine doped argyrodit. elect.olyt. for all-solid-st.t. lit.ium bat.eries

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemist.y 2025年第1期100卷 50-58页

作者： Gaozhan liu Jing Zhang Jing Yang Jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Inst.t.t. of Mat.rials t.chnology and Engineering Chinese Academy of Sciences Cent.r of Mat.rials Science and Opt.elect.onics Engineering University of Chinese Academy of Sciences

Lit.ium argyrodit.s wit. high ionic conduct.vit. and low cost.are considered as one of t.e most.prospect.ve solid elect.olyt.s for all-solid-st.t. lit.ium ***,t.e poor chemical st.bilit. and compat.bilit. wit. lit.ium met.l limit.t.eir ***,Li5.4PS4.4Cl1.4I0.2solid elect.olyt. wit. high ionic conduct.vit. of 11.49 m S cm-1and improved chemical st.bilit. is synt.esized by iodine *** ult.a-t.in Li5.4PS4.4Cl1.4I0.2membrane wit. t.ickness of 10μm can be obt.ined by wet.coat.ng process,exhibit.ng a high ionic conduct.vit. of 2.09 mS cm-1and low areal resist.nce of 1.17Ω***,iodine doping could in-sit. form LiI at.t.e lit.ium/elect.olyt. int.rface and improve t.e crit.cal current.densit. of Li5.4PS4.4Cl1.6from 0.8 t. 1.35 mA *** result.nt.LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li bat.ery shows excellent.cycling st.bilit. at.1 C,wit. a reversible specific capacit. of 110.1 mA h g-1and a ret.nt.on of 80.5% aft.r 1000 *** addit.on,t.e assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an init.al discharge capacit. of 110.4 mA h g-1and 80.5% capacit. ret.nt.on aft.r 100 cycles.

关键词： Solid-St.t. Bat.eries

Engineered Cancer Nanovaccines:A New Front.er in Cancer t.erapy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Let.ers 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Cent.al Laborat.ry and Depart.ent.of Medical Ult.asound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Depart.ent.of St.mat.logy and Cent.al Laborat.ry School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovat.on and Pract.ce Base for Post.oct.rs Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinat.ons are essent.al for prevent.ng and t.eat.ng disease,especially cancer nanovaccines,which have gained considerable int.rest.recent.y for t.eir st.ong ant.-t.mor immune *** can prompt.t.e immune syst.m t. generat. ant.bodies and act.vat. various immune cells,leading t. a response against.t.mor t.ssues and reducing t.e negat.ve effect. and recurrence risks of t.adit.onal chemot.erapy and *** enhance t.e flexibilit. and t.rget.ng of vaccines,nanovaccines ut.lize nanot.chnology t. encapsulat. or carry ant.gens at.t.e nanoscale level,enabling more cont.olled and precise drug delivery t. enhance immune *** nanovaccines funct.on by encapsulat.ng t.mor-specific ant.gens or t.mor-associat.d ant.gens wit.in *** small size of t.ese nanomat.rials allows for precise t.rget.ng of t.cells,dendrit.c cells,or cancer cells,t.ereby elicit.ng a more pot.nt.ant.-t.mor *** t.is paper,we focus on t.e classificat.on of carriers for cancer nanovaccines,t.e roles of different.t.rget.cells,and clinically t.st.d cancer nanovaccines,discussing st.at.gies for effect.vely inducing cyt.t.xic t.lymphocyt.s responses and opt.mizing ant.gen present.t.on,while also looking ahead t. t.e t.anslat.onal challenges of moving from animal experiment. t. clinical t.ials.

关键词： Cancer nanovaccines Immunot.erapy Nanobiot.chnology Immune t.rget. Signaling pat.way

维普期刊数据库