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A Note on Reviving the Goddard Satellite-Based Surface Turbulent Fluxes (GSSTF) Dataset

Advances in Atmospheric Sciences 2009年第6期26卷 1071-1080页

作者： Chung-Lin SHIE Long S. CHIU Robert ADLER Eric NELKIN I-I LIN Pingping XIE Feng-Chin WANG R. CHOKNGAMWONG william olson D. Allen CHU UMBC/GEST Baltimore Maryland USA Code 613.1 NASA/GSFC Greenbelt Maryland USA GMU/CEOSR Fairfax Virginia USA CUHK/ISEIS Shatin NT Hong Kong UMCP/ESSIC College Park Maryland USA SSAI Lanham Maryland USA NTU Taipei Taiwan NOAA/CPC Camp Springs Maryland USA CWB Taipei Chinese Taiwan UMBC/JCET Baltimore Maryland USA Code 613.2 NASA/GSFC Greenbelt Maryland USA

Accurate sea surface flux measurements are crucial for understanding the global water and energy cycles. The oceanic evaporation, which is a major component of the global oceanic fresh water flux, is useful for predicting oceanic circulation and transport. The global Goddard Satellite-based Surface Turbulent Fluxes Version-2 （GSSTF2; July 1987–December 2000） dateset that was o？cially released in 2001 has been widely used by scientific community for global energy and water cycle research, and regional and short period data analyses. We have recently been funded by NASA to resume processing the GSSTF dataset with an objective of continually producing a uniform dataset of sea surface turbulent fluxes, derived from remote sensing data. The dataset is to be reprocessed and brought up-to-date （GSSTF2b） using improved input datasets such as a recently upgraded NCEP/DOE sea surface temperature reanalysis, and an upgraded surface wind and microwave brightness temperature V6 dataset （Version 6） from the Special Sensor Microwave Imager （SSM/I） produced by Remote Sensing Systems （RSS）. A second new product （GSSTF3） is further proposed with a finer temporal （12-h） and spatial （0.25° × 0.25°） resolution. GSSTF2b （July 1987–December 2008） and GSSTF3 （July 1999–December 2009） will be released for the research community to use by late 2009 and early 2011, respectively.

关键词： surface turbulent fluxes global oceanic satellite-based

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Factors associated with success of telaprevir-and boceprevir-based triple therapy for hepatitis C virus infection

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World Journal of Hepatology 2017年第11期9卷 551-561页

作者： Kian Bichoupan Neeta Tandon Valerie Martel-Laferriere Neal M Patel David Sachs Michel Ng Emily A Schonfeld Alexis Pappas James Crismale Alicia Stivala Viktoriya Khaitova Donald Gardenier Michael Linderman william olson Ponni V Perumalswami Thomas D Schiano Joseph A Odin Lawrence U Liu Douglas T Dieterich Andrea D Branch Division of Liver Diseases Icahn School of Medicine at Mount Sinai Icahn Medical Instititute Janssen Pharmaceuticals Com-panies Division of Janssen Scientific Affairs Inc. Genetics and Genomics Icahn School of Medicine at Mount Sinai

To evaluate new therapies for hepatitis C virus (HCV), data about real-world outcomes are needed. METHODSOutcomes of 223 patients with genotype 1 HCV who started telaprevir- or boceprevir-based triple therapy (May 2011-March 2012) at the Mount Sinai Medical Center were analyzed. Human immunodeficiency virus-positive patients and patients who received a liver transplant were excluded. Factors associated with sustained virological response (SVR24) and relapse were analyzed by univariable and multivariable logistic regression as well as classification and regression trees. Fast virological response (FVR) was defined as undetectable HCV RNA at week-4 (telaprevir) or week-8 (boceprevir). RESULTSThe median age was 57 years, 18% were black, 44% had advanced fibrosis/cirrhosis (FIB-4 ≥ 3.25). Only 42% (94/223) of patients achieved SVR24 on an intention-to-treat basis. In a model that included platelets, SVR24 was associated with white race [odds ratio (OR) = 5.92, 95% confidence interval (CI): 2.34-14.96], HCV sub-genotype 1b (OR = 2.81, 95%CI: 1.45-5.44), platelet count (OR = 1.10, per x 104 cells/μL, 95%CI: 1.05-1.16), and IL28B CC genotype (OR = 3.54, 95%CI: 1.19-10.53). Platelet counts > 135 x 103/μL were the strongest predictor of SVR by classification and regression tree. Relapse occurred in 25% (27/104) of patients with an end-of-treatment response and was associated with non-FVR (OR = 4.77, 95%CI: 1.68-13.56), HCV sub-genotype 1a (OR = 5.20; 95%CI: 1.40-18.97), and FIB-4 ≥ 3.25 (OR = 2.77; 95%CI: 1.07-7.22). CONCLUSIONThe SVR rate was 42% with telaprevir- or boceprevir-based triple therapy in real-world practice. Low platelets and advanced fibrosis were associated with treatment failure and relapse.

关键词： Sustained virologic response Hepatitis C virus Relapse Telaprevir Boceprevir Triple-therapy Classification and regression Adverse event Real-world

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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu Dian Jia william Yi Wang Jun-Lei Yin Xing-Yu Gao Shu-Feng Yang Hai-Feng Song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

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Structural and Optical Properties and Emerging Applications of Metal Nanomaterials

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Journal of Materials Science & Technology 2008年第4期24卷 433-446页

作者： Tammg Y.olson Department of Chemistry and Biochemistry University of CaliforniaSanta CruzCA 95064USA

Nanomaterials possess intriguing optical properties that depend sensitively on size, shape, and material content of the structures. Controlling such structural characteristics of the nanostructures allows the tailoring of their physical and chemical properties, e.g. optical, electronic, and catalytic, to achieve what is desired lot specific applications of interest. This review will cover the development of various shapes for silver and gold nanomaterials with emphasis on their relation to optical properties. Examples of various modern synthetic methods and characterization techniques are highlighted. The influence of the metal nanomaterial＇s shape and optical absorption on surface enhanced Raman scattering （SERS） and a final note on new emerging applications of metal nanostructures are also discussed.

关键词： Nanomaterial Metal nanostructure Optical properties Size and shape effect

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Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation

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World Journal of Clinical Cases 2015年第2期3卷 191-195页

作者： Sonal S Noticewala Loren K Mell Scott E olson william Read Department of Radiation Medicine and Applied Sciences Center for Advanced Radiotherapy TechnologiesUniversity of California San Diego Division of Neurosurgery University of California San Diego Department of Hematology and Medical Oncology Emory University

We report the successful use of RADPLAT to treat a patient with an unresectable T4N0 sinonasal undifferentiated carcinoma. This patient received 4 cycles of weekly intra-arterial cisplatin together with thiosulfate infusion with concurrent radiation therapy. Radiation therapy was given in 28 daily fractions to 54 Gy using intensity-modulated radiation therapy followed by a hypofractionated stereotactic boost of 3 fractions to 13 Gy to a total dose of 67 Gy in 31 fractions to the nasal sinus and bilateral neck. Intra-arterial cisplatin was administered using a bilateral approach due to the midline site of this tumor. Within days of the first intra-arterial cisplatin, there was an obvious decrease in tumor size. She has been followed with magnetic resonance imaging and positron emission tomography, and remains disease-free 47 mo post-treatment. Centers with expertise in intra-arterial chemotherapy could consider the RADPLAT approach for patients with unresectable sinonasal undifferentiated carcinoma.

关键词： Sinonasal undifferentiated carcinoma Radiation Intra-arterial cisplatin Survival RADPLAT

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A Behind-the-Scenes Story of Precision Medicine

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Genomics, Proteomics & Bioinformatics 2017年第1期15卷 3-10页

作者： Maynard V.olson Department of Genome Sciences and Department of Medicine University of WashingtonSeattleWA 98195USA

Let me start with a few words about the goals and intended audience for this introduction to republication of two reports of the U.S. National Research Council （NRC） - Mapping and Sequencing the Human Genome （1988） and Toward Precision Medicine （2011）. I do not intend to summarize what the reports say. They are both short, well written, and can speak for themselves. I encourage readers who want a quick sum- mary to read these reports the way most policy-makers do： start with the Executive Summaries, particularly the Conclu- sions and Recommendations. NRC committees write these summaries with great care since they are read far more widely, and by a more influential audience, than the bodies of the reports. With respect to audience, I assume this book will be of greatest interest to scientists and policy-makers interested in how the policy-making apparatus in the United States works and how it shaped two key initiatives in biology and medicine during their formative stages.

关键词： A Behind-the-Scenes Story of Precision Medicine NRC

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Cybermaterials: materials by design and accelerated insertion of materials

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npj Computational Materials 2016年第1期2卷 233-246页

作者： Wei Xiong Gregory B olson Department of Materials Science and Engineering Northwestern UniversityEvanstonILUSA QuesTek Innovations LLC EvanstonILUSA

Cybermaterials innovation entails an integration of Materials by Design and accelerated insertion of materials(AIM),which transfers studio ideation into industrial *** assembling a hierarchical architecture of integrated computational materials design(ICMD)based on materials genomic fundamental databases,the ICMD mechanistic design models accelerate *** here review progress in the development of linkage models of the process-structure–property-performance paradigm,as well as related design accelerating *** the materials development capability based on phase-level structural control requires more fundamental investment at the level of the Materials Genome,with focus on improving applicable parametric design models and constructing high-quality *** opportunities in materials genomic research serving both Materials by Design and AIM are addressed.

关键词： insertion linkage constructing

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Numerical prediction of fiber motion in a branching channel flow of fiber suspensions

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Acta Mechanica Sinica 2005年第4期21卷 322-329页

作者： Jianzhong Lin Shanliang Zhang James A. olson Department of Mechanics The State Key Laboratory of Fluid Power Transmission and ControlZhejiang University: Ha ngzhou 310027 China Department of Mechanical Engineering Pulp and Paper CenterThe University of British ColumbiaVancouver BC Canada V6T IZ4

Fiber orientation and dispersion in the dilute fiber suspension that flows through a T-shaped branching channel are simulated numerically based on the slender-body theory. The simulated results are consistent qualitatively with the experimental data available in the literature. The results show that the spatial distribution of fibers is dependent on the fiber aspect ratio, but has no relation with the volume fraction of fiber. The content ratio of fibers near the upper wall increases monotonically with an increasing Re number, and the situation is reverse for the region near the bottom wall. The orientation of fibers depends on Re number, however, the function of fiber volume fraction and aspect ratio is negligible. The fibers near the wall and in the central region of the channel align along the flow direction at all times, but the fibers in the other parts of the channel tend to align along the flow direction only in the downstream region.

关键词： Fiber suspension Distribution Orientation ,Numerical simulation Branching flow

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