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Proton-pump inhibitor use does not affect semen luality in subfertile men

Asian Journal of Andrology 2018年第3期20卷 290-293页

作者： Sorena Keihani James R Craig Chong Zhang Angela P Presson Jeremy B Myers william o brant Kenneth I Aston Benjamin R Emery Timothy G Jenkins Douglas T Carrell James M Hotaling Division of Urology Department of Surgery University of Utah Salt Lake City Utah 84132 USA Division of Epidemiology Department of Internal Medicine University of Utah Salt Lake City Utah 84132 USA Andrology and IVF Laboratory Department of Surgery (Urology) University of Utah Salt Lake City Utah 84108 USA

Proton-pump inhibitors （PPIs） are among the most widely used drugs worldwide. PPI use has recently been linked to adverse changes in semen quality in healthy men; however, the effects of PPI use on semen parameters remain largely unknown specifically in cases with male factor infertility. We examined whether PPI use was associated with detrimental effects on semen parameters in a large population of subfertile men. We retrospectively reviewed data from 12 257 subfertile men who had visited our fertility clinic from 2003 to 2013. Patients who reported using any PPIs for 〉3 months before semen sample collection were included; 7698 subfertile men taking no medication served as controls. Data were gathered on patient age, medication use, and conventional semen parameters; patients taking any known spermatotoxic medication were excluded. Linear mixed-effect regression models were used to test the effect of PPI use on semen parameters adjusting for age. A total of 248 patients （258 samples） used PPIs for at least 3 months before semen collection. In regression models, PPI use （either as the only medication or when used in combination with other nonspermatotoxic medications） was not associated with statistically significant changes in semen parameters. To our knowledge, this is the largest study to compare PPI use with semen parameters in subfertile men. Using PPIs was not associated with detrimental effects on semen quality in this retrospective study.

关键词： infertility proton-pump inhibitors semen analysis sperm quality spermatozoa

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Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis

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World Journal of Gastroenterology 2017年第11期23卷 2023-2028页

作者： Animesh Jain Evan J Lipson william H Sharfman Steven R brant Mark G Lazarev Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of North Carolina Chapel Hill Department of oncology Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center Division of Gastroenterology and Hepatology Department of Internal MedicineJohns Hopkins University School of Medicine

AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line *** We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were *** A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were *** In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course.

关键词： Ipilimumab Melanoma Enterocolitis Colitis Infliximab Corticosteroid Colonic ulcer

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Effect of medical and surgical treatment of Barrett's metaplasia

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World Journal of Gastroenterology 2010年第30期16卷 3773-3779页

作者： Eelco B Wassenaar brant K oelschlager Center for Videoendoscopic Surgery Department of SurgeryUniversity of WashingtonSeattleWA 98195United States

Barrett’s esophagus (BE) is a change in the esophageal mucosa as a result of long-standing gastroesophageal reflux disease. The importance of BE is that it is the main risk factor for the development of esophageal adenocarcinoma, whose incidence is currently growing faster than any other cancer in the Western world. The aim of this review was to compare the common treatment modalities of BE, with the focus on proton pump inhibitors and operative fundoplication. We performed a literature search on medical and surgical treatment of BE to determine eligible studies for this review. Studies on medical and surgical treatment of BE are discussed with regard to treatment effect on progression and regression of disease. Although there is some evidence for control of reflux with either medical or surgical therapy, there is no def initive evidence that either treatment modality decreases the risk of progression to dysplasia or cancer. Even though there is a trend toward antireflux surgery being superior, there are no def initive studies to prove this.

关键词： Barrett’s esophagus Intestinal metaplasia Proton pump inhibitors Nissen fundoplication Esophageal adenocarcinoma Gastroesophageal reflux

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HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein

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Virologica Sinica 2019年第2期34卷 211-221页

作者： Ayslan Castro brant Vladimir Majerciak Miguel Angelo Martins Moreira Zhi-Ming Zheng Tumor Virus RNA Biology Section RNA Biology Laboratory Center for Cancer Research National Cancer Institute NIH Frederick MD 21702 USA Genetics Post-Graduation Program Rio de Janeiro Federal University Rio de Janeiro Brazil Genetics Program Nacional Cancer Institute INCA Rio de Janeiro 20231-050 Brazil

Human papillomavirus 18(HPV18) E6 and E7 oncogenes are transcribed as a single bicistronic E6 E7 pre-mRNA. The E6 oRF region in the bicistronic E6 E7 pre-mRNA contains an intron. Splicing of this intron disrupts the E6 oRF integrity and produces a spliced E6*I RNA for efficient E7 translation. Here we report that the E6 intron has two overlapped branch point sequences(BPS) upstream of its 30 splice site, with an identical heptamer AACUAAC, for E6*I splicing. one heptamer has a branch site adenosine(underlined) at nt 384 and the other at nt 388. E6*I splicing efficiency correlates to the expression level of E6 and E7 proteins and depends on the selection of which branch site. In general, E6*I splicing prefers the 30 ss-proximal branch site at nt 388 over the distal branch site at nt 384. Inactivation of the nt 388 branch site was found to activate a cryptic acceptor site at nt 636 for aberrant RNA splicing. Together, these data suggest that HPV18 modulates its production ratio of E6 and E7 proteins by alternative selection of the two mapped branch sites for the E6*I splicing, which could be beneficial in its productive or oncogenic infection according to the host cell environment.

关键词： Human papillomavirus 18 (HPV18) HPV splicing Branch point E6,E7,E6 intron HPV oncogenes

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Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients

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World Journal of Gastroenterology 2019年第10期25卷 1266-1277页

作者： Alice Jane Foster Matthew Smyth Alam Lakhani Benjamin Jung Rollin F brant Kevan Jacobson Division of Gastroenterology Hepatology and NutritionBritish Columbia Children’s Hospital Pediatrics B.C.Children’s Hospital Research Institute Pediatrics British Columbia children’s HospitalUniversity of British Columbia Department of Statistics University of British Columbia Department of Cellular and Physiological Sciences Faculty of Medicine

BACKGRoUND Asymptomatic children with Crohn's disease(CD) require ongoing monitoring to ensure early recognition of a disease *** In a cohort of pediatric CD patients, we aimed to assess the utility of serial fecal calprotectin measurements to detect intestinal inflammatory activity and predict disease *** In this prospective longitudinal cohort study, children with CD on infliximab therapy in clinical remission were included. Fecal calprotectin levels were assessed at baseline and at subsequent 2-5 visits. Clinical and biochemical disease activity were assessed using the Pediatric Crohn's Disease Activity Index, Creactive protein and erythrocyte sedimentation rate at baseline and at visits over the following 18 *** 53 children were included and eighteen patients(34%) had a clinical disease relapse during the study. Baseline fecal calprotectin levels were higher in patients that developed symptomatic relapse [median(interquartile range), relapse 723μg/g(283-1758) vs 244 μg/g(61-627), P = 0.02]. Fecal calprotectin levels > 250μg/g demonstrated good predictive accuracy of a clinical flare within 3 mo(area under the receiver operator curve was 0.86, 95% confidence limits 0.781 to 0.937).CoNCLUSIoN Routine fecal calprotectin testing in children with CD in clinical remission is useful to predict relapse. Levels > 250 μg/g are a good predictor of relapse in the following 3 mo. This information is important to guide monitoring standards used in this population.

关键词： Fecal calprotectin Disease relapse Biomarker Crohn’s disease Children

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THE ART oF TEACHING

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基础教育外语教学研究 2004年第11期 38-42页

作者： Michael brant Monica brant

There are keys to understanding children, and when you have them and know how to use them, your job as a teacher or parent can become much easier. Instead of working against a tired, maybe bored student, you can be working with an enthusiastic, anxious student. How? Everyone has something that sparks their interest, something they like to talk about,

关键词：中小学英语教学教学艺术课堂提问教学目标

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Polysilicon Manufacturing Techniques Improve Steadily in China--But large-scale integrated device clusters have not yet appeared

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China Chemical Reporter 2009年第2期20卷 14-15页

作者： brant Bai

The emerging polysilicon industry in Chinais expanding rapidly at present,and its publiclydeclared designed capacity has reached160 000-190 000 t/*** the global economiccrisis,the polysilicon expansion inChina has not... 详细信息

关键词： expanding Baotou emerging cooled appeared nonferro

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organosilicon Sector: New Breakthrough--Chinese Alkoxy Silane Sector Speeds up in Promotion

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China Chemical Reporter 2009年第31期20卷 20-20页

作者： brant Bai CNCIC-Si

Recently, the 10 000 tonnage-class alkoxysilane production unit developed and builtindependently by WD Silicone New MaterialCo., Ltd. (WD SILICoNE) producedqualified products. This means that Chinesealkoxy silane and its downstream sectorswill enter a faster development era, boththeir production capacity and outputwould leap to the first place in the world.

关键词： downstream silane silicone hasbeen sector faster s

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Uncertain Future for the Rapid Expansion of Silicone Monomer Projects

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China Chemical Reporter 2009年第21期20卷 21-21页

作者： brant Bai

Ever since 2008,the growth of domestic demandfor silicone monomers has slowed downvery much owing to the economic *** end of 2008,the price of silicone monomersfell to its lowest point in three *** January to May in 2... 详细信息

关键词： silicone slowed fertilizer monomer Shandong Jiangs

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Quantitative Study on Nonmetallic Inclusion Particles in Steels by Automatic Image Analysis With Extreme Values Method

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Journal of Iron and Steel Research International 2009年第4期16卷 18-21,32页

作者： Cássio Barbosa José brant de Campos Jneo Lopes do Nascimento Iêda Maria Vieira Caminha National Institute of Technology

The presence of nonmetallic inclusion particles which appear during steelmaking process is harmful to the properties of steels, which is mainly as a function of some aspects such as size, volume fraction, shape, and distribution of these particles. The automatic image analysis technique is one of the most important tools for the quantitative determination of these parameters. The classical Student approach and the Extreme Values Method （EVM） were used for the inclusion size and shape determination and the evaluation of distance between the inclusion particles. The results thus obtained indicated that there were significant differences in the characteristics of the inclusion particles in the analyzed products. Both methods achieved results with some differences, indicating that EVM could be used as a faster and more reliable statistical methodology.

关键词： image analysis steel microstructure nonmetallic inclusion

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