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Gender-specific associations between coronary heart disease and other chronic diseases: cross-sectional evaluation of national survey data from adult residents of Germany

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Journal of Geriatric Cardiology 2019年第9期16卷 663-670,I0002-I0005页

作者： Marie-Isabel K murray Kerstin Bode Peter Whittaker Department of Cardiology University Hospital Frankfurt am Main Frankfurt Germany Department of Electrophysiology Heart Center Leipzig Leipzig Germany Cardiovascular Research Institute and Department of Emergency Medicine Wayne State University Detroit MI USA

Background Combinations of coronary heart disease(CHD) and other chronic conditions complicate clinical management and increase healthcare costs. The aim of this study was to evaluate gender-specific relationships between CHD and other comorbidities. Methods We analyzed data from the German Health Interview and Examination Survey(DEGS1), a national survey of 8152 adults aged 18-79 years. Female and male participants with self-reported CHD were compared for 23 chronic medical conditions. Regression models were applied to determine potential associations between CHD and these 23 conditions. Results The prevalence of CHD was 9%(547 participants): 34%(185) were female CHD participants and 66%(362) male. In women, CHD was associated with hypertension(OR = 3.28(1.81-5.9)), lipid disorders(OR = 2.40(1.50-3.83)), diabetes mellitus(OR = 2.08(1.24-3.50)), kidney disease(OR = 2.66(1.101-6.99)), thyroid disease(OR = 1.81(1.18-2.79)), gout/high uric acid levels(OR = 2.08(1.22-3.56)) and osteoporosis(OR = 1.69(1.01-2.84)). In men, CHD patients were more likely to have hypertension(OR = 2.80(1.94-4.04)), diabetes mellitus(OR = 1.87(1.29-2.71)), lipid disorder(OR = 1.82(1.34-2.47)), and chronic kidney disease(OR = 3.28(1.81-5.9)). Conclusion Our analysis revealed two sets of chronic conditions associated with CHD. The first set occurred in both women and men, and comprised known risk factors: hypertension, lipid disorders, kidney disease, and diabetes mellitus. The second set appeared unique to women: thyroid disease, osteoporosis, and gout/high uric acid. Identification of shared and unique gender-related associations between CHD and other conditions provides potential to tailor screening, preventive, and therapeutic options.

关键词： Chronic diseases Comorbidities Gender Heart disease Risk factors Survey data

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Gap analysis on open data interconnectivity for disaster risk research

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Geo-Spatial Information Science 2019年第1期22卷 45-58页

作者： Guoqing Li Jing Zhao Virginia murray Carol Song Lianchong Zhang Key Laboratory of Digital Earth Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijingChina Hainan Key Laboratory of Earth Observation SanyaChina Institute of Remote Sensing and Digital Earth University of Chinese Academy of SciencesBeijingChina Public Health England Health and Social CareLondonUK Rosen Centre for Advance Computing Purdue UniversityWest LafayetteINUSA

Open data strategies are being adopted in disaster-related data particularly because of the need to provide information on global targets and indicators for implementation of the Sendai Framework for Disaster Risk Reduction 2015–*** all phases of disaster risk management including forecasting,emergency response and post-disaster reconstruction,the need for interconnected multidisciplinary open data for collaborative reporting as well as study and analysis are apparent,in order to determine disaster impact data in timely and reportable *** extraordinary progress in computing and information technology in the past decade,such as broad local and wide-area network connectivity(***),highperformance computing,service and cloud computing,big data methods and mobile devices,provides the technical foundation for connecting open data to support disaster risk research.A new generation of disaster data infrastructure based on interconnected open data is evolving *** are two levels in the conceptual model of Linked Open Data for Global Disaster Risk Research(LODGD)Working Group of the Committee on Data for Science and Technology(CODATA),which is the Committee on Data of the International Council for Science(ICSU):data characterization and data *** data characterization,the knowledge about disaster taxonomy and data dependency on disaster events requires specific scientific study as it aims to understand and present the correlation between specific disaster events and scientific data through the integration of literature analysis and semantic knowledge *** connection concepts deal with technical methods to connect distributed data resources identified by data characterization of disaster *** the science community,interconnected open data for disaster risk impact assessment are beginning to influence how disaster data are shared,and this will need to extend data coverage and provide better ways of utilizing data across domains

关键词： Open data interconnectivity gap analysis disaster risk

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攻击性广告的影响

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商学院 2024年第5期 14-14页

作者： Seb murray 宾夕法尼亚大学沃顿商学院

20世纪80年代,可口可乐和百事可乐之间的“可乐大战”带来了激烈的广告竞争。宾夕法尼亚大学沃顿商学院市场营销和经济学教授耶尔德勒姆指出,攻击性广告可能导致产品出现同质化现象和产品种类减少现象。现实世界的例子表明,当公司出现... 详细信息

20世纪80年代,可口可乐和百事可乐之间的“可乐大战”带来了激烈的广告竞争。宾夕法尼亚大学沃顿商学院市场营销和经济学教授耶尔德勒姆指出,攻击性广告可能导致产品出现同质化现象和产品种类减少现象。现实世界的例子表明,当公司出现带有攻击性的广告时,它们往往会暴露所有产品的缺陷,导致消费者根据这些缺陷来比较品牌,这反过来又会给整个市场带来不利的后果。

关键词：广告竞争宾夕法尼亚大学经济学教授百事可乐可口可乐沃顿商学院市场营销同质化现象

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Hidden symmetry operators for asymmetric generalized quantum Rabi models

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Chinese Physics B 2022年第1期31卷 320-323页

作者： Xilin Lu Zi-Min Li Vladimir V Mangazeev murray T Batchelor Department of Theoretical Physics Research School of PhysicsAustralian National UniversityCanberra ACT 2601Australia Mathematical Sciences Institute Australian National UniversityCanberra ACT 2601Australia Centre for Modern Physics Chongqing UniversityChongqing 40444China

The hidden Z2 symmetry of the asymmetric quantum Rabi model(AQRM)has recently been revealed via a systematic construction of the underlying symmetry *** on the AQRM result,we propose an ansatz for the general form of the symmetry operators for AQRM-related *** this ansatz we obtain the symmetry operator for three models:the anisotropic AQRM,the asymmetric Rabi–Stark model(ARSM),and the anisotropic ARSM.

关键词： light-matter interaction hidden symmetry asymmetric quantum Rabi model asymmetric Rabi-Stark model

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Complex role for the immune system in initiation and progression of pancreatic cancer

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World Journal of Gastroenterology 2014年第32期20卷 11160-11181页

作者： Kristin S Inman Amanda A Francis Nicole R murray Department of Cancer Biology Mayo Clinic Jacksonville FL 32224United States

The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed.

关键词： Immune system Pancreatitis Pancreatic ductal adenocarcinoma Immunosuppression Immunotherapy Inflammation

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阶梯停车场芬兰郝尔辛基

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世界建筑导报 2024年第2期39卷 117-119页

作者： uho Grönholm Antti Nousjoki Samuli Woolston Pekka Tainio Tuulikki Tanska Rachel murray Anssi Luodemäki Harri Humppi Tuomas Uusheimo(摄影) Marc Goodwin(摄影) ALA建筑师事务所不详

新的五角形、五层高的Saukonlaituri停车设施包括六条流线,可停放600辆私家车,中央庭院被布满巨石、苔藓和蕨类植物的景观环绕。其中五个停车场有顶棚,第六个停车场位于屋顶。庭院具有双重功能:它既是一个采光井,阳光可通过庭院照射到... 详细信息

新的五角形、五层高的Saukonlaituri停车设施包括六条流线,可停放600辆私家车,中央庭院被布满巨石、苔藓和蕨类植物的景观环绕。其中五个停车场有顶棚,第六个停车场位于屋顶。庭院具有双重功能:它既是一个采光井,阳光可通过庭院照射到较低的停车场,又是雨水蓄水池和积雪堆积地。建筑的南侧从入口广场后退,将地面公共空间延伸为阶梯式公园,一直延伸到屋顶。这种解决方案使周围公寓楼的居民可以沿着阶梯走到正确的楼层取车,而不是乘坐电梯。阶梯区域也可以用于野餐和日光浴。

关键词：入口广场空间延伸采光井停车设施公寓楼停车场阶梯式电梯

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Semi-Markov adaptive critic heuristics with application to airline revenue management

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控制理论与应用（英文版） 2011年第3期9卷 421-430页

作者： Ketaki KULKARNI Abhijit GOSAVI Susan murray Katie GRANTHAM Department of Engineering Management and Systems Engineering Missouri University of Science and Technology

The adaptive critic heuristic has been a popular algorithm in reinforcement learning(RL) and approximate dynamic programming(ADP) *** is one of the ?rst RL and ADP *** and ADP algorithms are particularly useful for solving Markov decision processes(MDPs) that suffer from the curses of dimensionality and *** real-world problems,however,tend to be semi-Markov decision processes(SMDPs) in which the time spent in each transition of the underlying Markov chains is itself a random *** for the average reward case,unlike the discounted reward case,the MDP does not have an easy extension to the *** of SMDPs can be found in the area of supply chain management,maintenance management,and airline revenue *** this paper,we propose an adaptive critic heuristic for the SMDP under the long-run average reward *** present the convergence analysis of the algorithm which shows that under certain mild conditions,which can be ensured within a simulator,the algorithm converges to an optimal solution with probability *** test the algorithm extensively on a problem of airline revenue management in which the manager has to set prices for airline tickets over the booking *** problem has a large scale,suffering from the curse of dimensionality,and hence it is difficult to solve it via classical methods of dynamic *** numerical results are encouraging and show that the algorithm outperforms an existing heuristic used widely in the airline industry.

关键词： Adaptive critics Actor critics Semi-Markov Approximate dynamic programming Reinforcement learning

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Correlation of MRI-determined small bowel Crohn’s disease categories with medical response and surgical pathology

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World Journal of Gastroenterology 2009年第27期15卷 3367-3375页

作者： Ian Craig Lawrance Christopher J Welman Peter Shipman Kevin murray School of Medicine and Pharmacology University of Western AustraliaFremantle Hospital WA 6160 Australia Department of Gastroenterology Fremantle Hospital WA 6160 Australia Department of Radiology Fremantle Hospital WA 6160 Australia Statistical Consulting Group School of Mathematics and Statistics University of Western AustraliaWA 6160 Australia

AIM: To determine whether magnetic resonance imaging (MRI) can be used to categorize small bowel Crohn's disease (SB CD) into groups that correlate with response to medical therapy and surgical ***: Data was collected from all patients with MRI evidence of SB CD without significant colonic disease over a 32-mo period. Two radiologists, blinded to clinical findings, evaluated each MRI and grouped them based on bowel wall thickness and wall enhancement. These categories were: (1) "fibrosis", (2) "mild segmental hyper-enhancement and mild wall thickening", (3) "mild segmental hyper-enhancement and marked wall thickening", (4) "marked segmental transmural hyper-enhancement". Patient response to additional medical therapy post-MRI was prospectively determined at 8-wk. Non-responders underwent endoscopy and were offered therapeutic endoscopy or surgery. Surgical pathology was assessed against the MRI category. RESULTS: Fifty-five patients were included. Females and category "2" patients were more likely, and patients with luminal narrowing and hold-up less likely, to respond to medical therapy (P < 0.05). Seventeen patients underwent surgery. The surgical pathologicalfindings of fibrosis and the severity of inflammation correlated with the MRI category in all ***: Our fi ndings suggest that SB CD can be grouped by the MRI f indings and that these groups are associated with patients more likely to respond to continued medical therapy. The MRI categories also correlated with the presence and level of intestinal inflammation and fibrosis on surgical pathology, and may be of prognostic use in the management of CD patients.

关键词： Magnetic resonance imaging Crohn's disease Fibrosis Prognosis Pathology

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Challenges of modeling solar disturbances' arrival times at the Earth

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Science China(Technological Sciences) 2008年第10期51卷 1580-1588页

作者： C. D. FRY Chin-Chun WU murray DRYER Center for Space Plasma and Aeronomic Research The University of Alabama in Huntsville Huntsville AL 35899 USA Exploration Physics International Inc. Huntsville AL 35806 USA Center for Space Plasma and Aeronomic Research The University of Alabama in Huntsville Huntsville AL 35899 USA Space Weather Laboratory NASA/Goddard Space Flight Center Greenbelt MD 20771 USA Center for Space Plasma and Aeronomic Research The University of Alabama in Huntsville Huntsville AL 35899 USA Exploration Physics International Inc. Huntsville AL 35806 USA Space Weather Prediction Center National Oceanic and Atmospheric Administration (NOAA) Boulder Colorado USA

In recent years remarkable advances have been made in the development of phys-ics based models of various parts of the solar-terrestrial system (see JASTP special issues, October, November 2004; February 2007). In this paper, we focus our dis-cussions in a specific region of the Sun to the Earth’s environment (i.e. 1 AU). It is well-known that geomagnetic storms are caused by solar eruptions. The conse-quences of these storms include particle acceleration, solar wind impact on the Earth’s magnetosphere and ionosphere, UV-EUV radiation effects on the lower at-mosphere, etc. One of the main challenges is to predict the arrival time at 1 AU of the solar disturbance. The prospects look good for an accurate, real-time forecast scheme built on the acquisition of solar, heliosphere and the near-Earth data and large-scale models. However, the accuracy of these models still needs improve-ment. We will discuss the present status of the models and challenges to improve the simulation models.

关键词： space weather――magnetohydrodynamic (MHD) Modeling MHD Sun-Earth connection MHD Sun-Corona

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Ocular therapies for neuronal ceroid lipofuscinoses: more than meets the eye

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Neural Regeneration Research 2022年第8期17卷 1755-1756页

作者： Samantha J.murray Nadia L.Mitchell Faculty of Agricultural and Life Sciences Lincoln UniversityLincolnNew Zealand

The neuronal ceroid lipofuscinoses(NCLs),also known as Batten disease,are a group of inherited,neurodegenerative,lysosomal storage diseases typically manifesting in *** are currently 13 known forms of NCL resulting from various mutations in the CLN(ceroid lipofuscinoses neuronal)genes(CLN1-8 and CLN10-14).Although varying in onset and severity,the NCLs share several phenotypic features including seizures,motor dysfunction,cognitive decline,and progressive loss of vision(Mole et al.,2011).Current treatment strategies being investigated in pre-clinical studies and early stage clinical trials primarily target the brain and spinal *** these potential therapeutics show promise in attenuating neurological disease,protection against retinal dysfunction and degeneration is generally ineffective or not reported.

关键词： degeneration primarily typically

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