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Intravitreal triamcinolone acetonide： a ＂real world＂ analysis of visual acuity, pressure and outcomes

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International Journal of Ophthalmology(English edition) 2016年第5期9卷 789-791页

作者： Victor Manuel Villegas Aaron Samuel Gold Andrea Wildner Azeema Latiff Timothy Garrett murray murray Ocular Oncology and Retina Miami Florida 33143USA

Dear Sir,Triamcinolone acetonide（TA）is worldwide available therapeutic agent that is commonly used throughout *** remains a safe and important ophthalmic therapeutic agent even after the advent of angiogenesis inhib... 详细信息

关键词： IOP TA analysis of visual acuity,pressure and outcomes real world Intravitreal triamcinolone acetonide

Axial length development in children

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 815-819页

作者： Austin Bach Victor M.Villegas Aaron S.Gold Wei Shi Timothy G.murray Larkin Eye Institute Bascom Palmer Eye Institute murray Ocular Oncology & Retina

AIM: To study ocular axial lengths in pediatric subjects without intraocular pathology. METHODS: An Institutional Review Board-approved consecutive retrospective chart review of axial lengths measured in pediatric subjects who underwent examination under anesthesia due to positive family history of retinoblastoma or other inherited ocular disease. Only subjects without any intraocular pathology in either eye were included. Subjects were stratified into age groups. An axial length model using a logarithmic regression algorithm was ***: Data from 330 eyes of 165 subjects were included in the study. The mean age at the time of examination was 30.62(SD 18.04)mo. The steepest increase in axial length was present during the first 10 mo of life. After 36 mo, there was no statistically significant axial length growth. CONCLUSION: This study presents the biggest series of pediatric axial lengths in healthy eyes. The axial length model developed with these data may assist in the diagnosis and management of a wide variety of pediatric ophthalmic diseases.

关键词： pediatric axial length model biometry eye development

Can patients determine the level of their dysphagia?

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World Journal of Gastroenterology 2017年第6期23卷 1038-1043页

作者： Hafiz Hamad Ashraf Joanne Palmer Harry Richard Dalton Carolyn Waters Thomas Luff Madeline Strugnell Iain Alexander murray Departments of Gastroenterology Royal Cornwall Hospital NHS Trust Research and Development Royal Cornwall Hospital NHS Trust Clinical Imaging Royal Cornwall Hospital NHS Trust

To determine if patients can localise dysphagia level determined endoscopically or radiologically and association of gender, age, level and *** review of consecutive patients presenting to dysphagia hotline between March 2004 and March 2015 was carried out. Demographics, clinical history and investigation findings were recorded including patient perception of obstruction level (pharyngeal, mid sternal or low sternal) was documented and the actual level of obstruction found on endoscopic or radiological examination (if any) was noted. All patients with evidence of obstruction including oesophageal carcinoma, peptic stricture, Schatzki ring, oesophageal pouch and cricopharyngeal hypertrophy were included in the study who had given a perceived level of dysphagia. The upper GI endoscopy reports (barium study where upper GI endoscopy was not performed) were reviewed to confirm the distance of obstructing lesion from central incisors. A previously described anatomical classification of oesophagus was used to define the level of obstruction to be upper, middle or lower oesophagus and this was compared with patient perceived *** thousand six hundred and sixty-eight patients were included, 42.0% of who were female, mean age 70.7 ± 12.8 years old. Of those with obstructing lesions, 726 gave a perceived level of dysphagia: 37.2% had oesophageal cancer, 36.0% peptic stricture, 13.1% pharyngeal pouches, 10.3% Schatzki rings and 3.3% achalasia. Twenty-seven point five percent of patients reported pharyngeal level (upper) dysphagia, 36.9% mid sternal dysphagia and 25.9% lower sternal dysphagia (9.5% reported multiple levels). The level of obstructing lesion seen on diagnostic testing was upper (17.2%), mid (19.4%) or lower (62.9%) or combined (0.3%). When patients localised their level of dysphagia to a single level, the kappa statistic was 0.245 (P < 0.001), indicating fair agreement. 48% of patients reporting a single level of dysphagia

关键词： Deglutition disorders Oesophageal stenosis Oesophageal neoplasm Gastroscopy Fluoroscopy Patient perception Pharyngeal pouch

Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter

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分子细胞生物学报:英文版 2016年第1期8卷 2-16页

作者： Yanping Zhu Ta-Wei Liu Zarina Madden Scott A.Yuzwa Kelsey murray Samy Cecioni Natasha Zachara David J.Vocadlo Department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6Canada Department of Molecular Biology and Biochemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6Canada Department of Biological Chemistry Johns Hopkins University Medical SchoolBaltimoreMD 21205USA

O-glycosylation of the nuclear pore complex(NPC)by O-linked N-acetylglucosamine(O-GlcNAc)is conserved within *** nucleoporins(Nups)comprising the NPC are constitutively O-GlcNAcylated,but the functional role of this modification remains *** loss ofO-GlcNAc,induced by either inhibition ofO-GlcNAc transferase(OGT)or deletion of the gene encoding OGT,leads to decreased cellular levels of a number of natively O-GlcNAcylated *** of O-GlcNAc enables increased ubiquitination of these Nups and their increased proteasomal *** decreased half-life of these deglycosylated Nups manifests in their gradual loss from the NPC and a downstream malfunction of the nuclear pore selective permeability barrier in both dividing and post-mitotic *** findings define a critical role of O-GlcNAc modification of the NPC in maintaining its composition and the function of the selectivity *** results implicate NPC glycosylation as a regulator of NPC function and reveal the role of conserved glycosylation of the NPC among metazoans.

关键词： post-translational modiﬁcation O-GlcNAcylation nuclear pore complex protein stability ubiquitination nucleoporin glycosylation

Assessment of oxidative and UV-C treatments for inactivating bacterial biofilms from groundwater wells

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Frontiers of Environmental Science & Engineering 2015年第1期9卷 39-49页

作者： Kyle E. murray Erin I. Manitou-ALVAREZ Enos C. INNISS Frank G. HEALY Adria A. BODOUR Oklahoma Geological Survey University of Oklahoma Norman OK 73019-0628 USA ERA Environmental Consulting Dollard des Ormeaux Montreal Quebec H9B 2C81 Canada Department of Civil and Environmental Engineering University of Missouri-Columbia MO 65211-2200 USA Department of Biology Trinity University One Trinity Place San Antonio TX 78212 USA Air Force Center for Engineering and the Environment (AFCEE) San Antonio TX 78236 USA

Microorganisms are ubiquitous in natural environments and in water supply infrastructure including groundwater wells. Sessile-state microorganisms may build up on well surfaces as biofilms and, if excessive, cause biofouling that reduces well productivity and water quality. Conditions can be improved using biocides and other traditional well rehabilitation measures; however, biofilm regrowth is inevitable given the continuous introduction of microorganisms from the surrounding environment. Alternative and less invasive well maintenance approaches are desirable for reducing biofilm densities while also minimizing harmful disinfection-by- products. The primary objective of this research was to evaluate effectiveness of alternative treatments for inacti- vating microorganisms comprising biofilms. A novel approach was designed for in situ growth of biofilms on steel coupons suspended from ＇chandeliers＇. After more than 100 days of in situ growth, biofilms were harvested, sampled, and baseline biofilm densities quantifed through cultivation. Ultraviolet-C （UV-C） and oxidative treatments including hydrogen peroxide （H2O2）, ozone （O3） and mixed oxidants were then applied to the biofilms in laboratory-scale treatments. Microbial inactivation was assessed by comparing treated versus baseline biofilm densities. H2O2 was the most effective treatment, and decreased density below baseline by as much as 3.1 orders of magnitude. Mixed oxidants were effective for the well having a lower density biofilm, decreasing density below baseline by as much as 1.4 orders of magnitude. Disparity in the response to treatment was apparent in the wells despite their spatial proximity and common aquifer source, which suggests that microbiological communities are more heterogeneous than the natural media from which they originate.

关键词： aquifer biofouling hydrogen peroxide sustainability well rehabilitation

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Mi-cycle

小学生时代（大嘴英语） 2022年第4期 22-25页

作者： Diana murray Logan Kline(图) 不详

The wheels are wrapped in rubber bands,The handlebars are red,The seat is a bottle cap,The spokes are yellow *** frame is made from paper clips,Which makes it kind of *** when the mice go down the street The bike is e... 详细信息

关键词： handle rubber cycle

Overlap graphs and de Bruijn graphs: data structures for de novo genome assembly in the big data era

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Quantitative Biology 2019年第4期7卷 278-292页

作者： Raffaella Rizzi Stefano Beretta murray Patterson Yuri Pirola Marco Previtali Gianluca Della Vedova Paola Bonizzoni Department of Informatics Systems and CommunicationsUniversity of Milan-BicoccaMilanViale Sarca 33620126Italy

Background:De novo genome assembly relies on two kinds of graphs:de Bruijn graphs and overlap *** graphs are the basis for the Celera assembler,while de Bruijn graphs have become the dominant technical device in the last *** two kinds of graphs are collectively called assembly ***:In this review,we discuss the most recent advances in the problem of constructing,representing and navigating assembly graphs,focusing on very large *** will also explore some computational techniques,such as the Bloom filter,to compactly store graphs while keeping all functionalities ***:We complete our analysis with a discussion on the algorithmic issues of assembling from long reads(eg.,PacBio and Oxford Nanopore).Finally,we present some of the most relevant open problems in this field.

关键词： overlap graphs de Bruijn graphs genome assembly long reads string graphs

An international program on Silk Road Disaster Risk Reduction--a Belt and Road initiative (2016-2020)

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Journal of Mountain Science 2018年第7期15卷 1383-1396页

作者： LEI Yu CUI Peng Amar Deep REGMI Virginia murray Alessandro PASUTO Giacomo TITTI Muhammad SHAFIQUE Tilak PRIYADARSHANA D.G. Key Laboratory of Mountain Hazards and Earth Surface Processes/Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu 610041 China University of Chinese Academy of Sciences Bering 100049 China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101 China Public Health England London 133-155 England UNISDR Scientific and Technical Advisory Group Geneva Switzerland Integrated Research on Disaster Risk Scientific Committee Beijing 100094 China Research Institute for C-eo-Hydrological Protection National Research Council 4- 35127 Padova Italy National Center of excellence in Geology University of Peshawar Peshawar 25130 Pakistan Internal Quality Assurance Unit &Center for International Affairs University ofRuhuna Matara Sri Lanka

Belt and Road Initiative(BRI) is a Chinese national strategy which calls for cooperative economic, political and cultural exchange at the global level along the ancient Silk Road. The overwhelming natural hazards located along the belt and road bring great challenges to the success of BRI. In this framework, a 5-year international program was launched to address issues related to hazards assessment and disaster risk reduction(DRR). The first workshop of this program was held in Beijing with international experts from over 15 countries. Risk conditions on Belt and Road Countries(BRCs) have been shared and science and technology advancements on DRR have been disseminated during the workshop. Under this program, six task forces have been setup to carry out collaborative research works and three prioritized study areas have been established. This workshop announced the launching of this program which involved partners from different countries including Pakistan, Nepal, Russia, Italy, United Kingdom, Sri Lanka and Tajikistan. The program adopted the objectives of Sendai Framework for Disaster Risk Reduction 2015-2030 and United Nation Sustainable Development Goals 2030 and was implemented to assess disaster risk in BRCs and to propose suitable measures for disaster control which can be appropriate both for an individual country and for specific sites. This paper deals with the outcomes of the workshop and points out opportunities for the near future international cooperation on this matter.

关键词： Natural hazards Silk Road Disaster risk reduction Belt and Road Initiative Sendai Framework International collaboration program

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Friends

小学生时代（大嘴英语） 2021年第6期 28-29页

作者： Diana murray Liza Woodruff(图) 不详