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Transradial versus transfemoral access for anterior circulation mechanical thrombectomy: analysis of 375 consecutive cases

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Stroke & Vascular Neurology 2021年第2期6卷 207-213页

作者： Timothy John Phillips Matthew Thomas Crockett Gregory D Selkirk Ruchi Kabra Albert Ho Yuen Chiu Tejinder Singh Constantine Phatouros william mcauliffe Neurological Intervention and Imaging Service of Western Australia Sir Charles Gairdner HospitalPerthWestern AustraliaAustralia Neurological Intervention and Imaging Service of Western Australia Fiona Stanley HospitalPerthWestern AustraliaAustralia Neurological Intervention and Imaging Service of Western Australia Royal Perth HospitalPerthWestern AustraliaAustralia

Objective To compare transradial artery access(TRA)to the gold standard of transfemoral artery access(TFA)in mechanical thrombectomy(MT)for stroke caused by anterior circulation large vessel *** The clinical outcomes,procedural speed,angiographic efficacy and safety of both techniques were analysed in 375 consecutive cases over an 18-month period in a high volume statewide neurointerventional *** There was no significant difference in patient characteristics,stroke parameters,imaging techniques or intracranial *** median time elapsed between CT scanning and reperfusion was 96.5 min(IQR 68-123)in the TFA group and 95 min(IQR 68-123)in the TRA group(p=0.456).Of 336 patients who were independent at presentation 58%(124/214)of the TFA group and 67%(82/122)of the TRA group had a modified Rankin score of 0-2 at 90-day follow-up(p=0.093).Cross-over from radial to femoral was 4.6%(4/130)compared with 1.6%cross-over from femoral to radial(4/245),but did not meet the predetermined level of statistical significance(OR2.92,95% CI 0.81 to 10.52,p=0.088) and did not impact median procedural *** angiographic reperfusion,first pass reperfusion,embolisation to new territory and symptomatic intracranial haemorrhage were similar in both *** was a significant difference in major access site complications requiring an additional *** of the TRA cases had a major access site complication but 6.5%(16/245)of the TFA cases did(p=0.003).Conclusion This study suggests that using TRA for anterior circulation MT is fast,efficacious,safe and not inferior to the gold standard of TFA.

关键词： service radial cases

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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

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The Integration of a Canonical Workflow Framework with an Informatics System for Disease Area Research

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Data Intelligence 2022年第2期4卷 186-195页

作者： Vivek Navale Matthew mcauliffe Center for Information Technology National Institutes of HealthBethesdaMaryland 20892USA

A recurring pattern of access to existing databases,data analyses,formulation of new hypotheses,use of an experimental design,institutional review board approvals,data collection,curation,and storage within trusted digital repositories is observable during clinical research *** workflows that support the repeated nature of these activities can be ascribed as a Canonical Workflow Framework for Research(CWFR).Disease area clinical research is protocol specific,and during data collection,the electronic case report forms can use Common Data Elements(CDEs)that have precisely defined questions and are associated with the specified value(s)as *** CDE-based CWFR is integrated with a biomedical research informatics computing system,which consists of a complete stack of technical layers including the Protocol and Form Research Management *** unique data dictionaries associated with the CWFR for Traumatic Brain Injury and Parkinson's Disease resulted in the development of the Federal Interagency Traumatic Brain Injury and Parkinson's Disease Biomarker *** to a canonical workflow,these two systems can use similar tools,applications,and service modules to create findable,accessible,interoperable,and reusable Digital *** Digital Objects for Traumatic Brain Injury and Parkinson's disease contain all relevant information needed from the time data is collected,validated,and maintained within a Storage Repository for future *** Traumatic Brain Injury and Parkinson's Disease studies can be shared as Research Objects that can be produced by aggregating related resources as information packages and is findable on the Internet by using unique ***,the integration of CWFR with an informatics system has resulted in the reuse of software applications for several National Institutes of Health-supported biomedical research programs.

关键词： Canonical Workflow Framework for Research Informatics system Traumatic brain injury Parkinson's disease

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Land use legacy for a tropical myco-heterotroph: how spatial patterns of abundance, reproductive effort and success vary

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Journal of Plant Ecology 2019年第2期12卷 367-375页

作者： Stephen mcauliffe James D.Ackerman Raymond L.Tremblay Department of Environmental Science Humboldt State UniversityArcataCAUSA Center for Applied Tropical Ecology and Conservation University of Puerto RicoSan JuanPRUSA Department of Biology University of Puerto Rico17 Ave Universidad Suite 1701San JuanPR 00925-2537USA Department of Biology University of Puerto RicoHumacaoPRUSA

Aims Human land use such as agriculture and logging can have cascad-ing effects on the environment and severely influence forest eco-systems by altering structure,species composition and community *** activities may have long-term consequences,which impact forest *** investigated the legacy of his-torical anthropogenic land use on the current reproductive effort(RE)and success of the understory,myco-heterotrophic orchid,Wullschlaegelia calcarata in Puerto Rico’s tropical rain forest after 80 years of forest *** Our study site was the 16-ha Luquillo Forest Dynamics Plot in the Luquillo Experimental *** used six 10 m×500 m transect lines that spanned areas with differing levels of historic canopy coverage which are correlated with land use *** recorded the abundance of *** plants and measured shoot height,number of flowers,fruit set for all plants and seed set from the most mature,undehisced fruit on a random subset of plants *** sought to determine whether or not there is a legacy of land use history on the RE and success of *** the varying degrees of historic disturbance,we predicted that RE and success would be highest in minimally disturbed old-growth forest,and that soil type differences would be insufficient to affect RE or *** Findings We found 1607 plants of ***,and only one was detected in the most historically disturbed area of the *** orchids were most abundant in the two least historically disturbed ***,the prevailing trend in all measures of RE is in the opposite direction with greater RE in the forest plots with intermediate levels of histori-cal ***,the best model(as a function of AICc and weights)to predict RE is a combination of soil type and cover ***,our measures of reproductive success(fruit and seed set)were best in the least historically disturbed sites and were not associated with soil ***,the b

关键词： forest recovery Orchidaceae tropical forest disturbance ecology Wullschlaegelia

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A Low-Cost, Portable Optical Sensing System With Wireless Communication Compatible of Real-Time and Remote Detection of Dissolved Ammonia

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Photonic Sensors 2016年第2期6卷 107-114页

作者： Shijie DENG william DOHERTY Michael AP mcauliffe Urszula SALAJ-KOSLA Liam LEWIS Guillaume HUYET Centre for Advanced Photonics & Process Analysis Cork Institute of Technology and Tyndall National Institute CorkIreland Department of Physical Science Cork Institute of Technology Cork Ireland Department of Chemical and Environmental Science University of Limerick Limerick Ireland

A low-cost and portable optical chemical sensor based ammonia sensing system that is capable of detecting dissolved ammonia up to 5 ppm is presented. In the system, an optical chemical sensor is designed and fabricated for sensing dissolved ammonia concentrations. The sensor uses eosin as the fluorescence dye which is immobilized on the glass substrate by a gas-permeable protection layer. A compact module is developed to hold the optical components, and a battery powered micro-controller system is designed to read out and process the data measured. The system operates without the requirement of laboratory instruments that makes it cost effective and highly portable. Moreover, the calculated results in the system can be transmitted to a PC wirelessly, which allows the remote and real-time monitoring of dissolved ammonia.

关键词： Ammonia sensing optical chemical sensor portable optical sensing system remote sensing

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应用CRISP清单,提升我国全科医学和基本医疗研究报告的质量

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中国全科医学 2025年第4期28卷 393-401页

作者：杨辉汪洋陈庆奇刘晨曦顾杰赵洋秦江梅曹新阳 Elizabeth Sturgiss william R.Phillips 许岩丽 Monash大学公共卫生与预防医学学院澳大利亚墨尔本市VIC 3168 上海市全科医学与社区卫生发展研究中心 200090 同济大学附属杨浦医院全科医学科上海市200090 香港大学家庭医学及基层医疗学系中国香港特别行政区999077 华中科技大学同济医学院医药卫生管理学院湖北省武汉市430000 复旦大学附属中山医院全科医学科上海市200032 复旦大学附属中山医院国际医疗部上海市200032 新南威尔士大学乔治全球健康研究院澳大利亚悉尼2050 墨尔本大学人口与全球健康学院澳大利亚墨尔本3010 国家卫生健康委卫生发展研究中心北京市100044 《中国全科医学》杂志社有限公司北京市100053 School of Primary and Allied Health Care Monash UniversityMelbourneVictoriaAustraliaVIC 3168 University of Washington SeattleWashington98195

基本医疗(初级保健)研究报告内容的条目共识(CRISP)工作组于2023年提出了CRISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CRISP清单进行了中文翻译,并通过这篇述评,在回顾我国全... 详细信息

基本医疗(初级保健)研究报告内容的条目共识(CRISP)工作组于2023年提出了CRISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CRISP清单进行了中文翻译,并通过这篇述评,在回顾我国全科医学和基本医疗研究的内涵和发展现状的基础上,归纳了该领域的科研报告中目前存在的主要问题,如“以作者为中心”“过度重视塑造权威性”“盲目生搬国际经验”“缺乏对方法学的透明报告”“在论文中压入大量冗繁信息”以及“遮蔽关键信息”等。最后,编辑团队推荐和鼓励中国的全科医学和基本医疗服务研究的作者、编辑和学术评议专家尝试使用CRISP清单,在改善中国全科医学和基本医疗研究报告质量的同时,进一步完善该工具在学科发展研究、临床研究、卫生服务研究、卫生政策研究、教育和培训研究以及社区流行病学研究等亚领域中的应用。

关键词：全科医学基本医疗研究报告内容共识

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Rethinking the definition of the word‘map’:an evaluation of Beck’s representation of the London Underground through a qualitative expert survey

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International Journal of Digital Earth 2015年第7期8卷 522-537页

作者： william Cartwright School of Mathematical and Geospatial Sciences RMIT UniversityMelbourneVICAustralia

This paper reports on the results from a qualitative expert survey of members of the international geospatial community to elicit their view of Henry(Harry)Beck’s iconic 1931 representation of the London *** begins by providing a background to the publishing era when Beck’s representation was developed under the‘umbrella’of the design style adopted by the London Passenger Transport Board to promote the image of‘the new’and contemporary *** then outlines Beck’s representation and his quest to develop a clearer and more understandable graphic information *** is followed by an overview of representative views from the design community about Beck’s ***,it provides the results of research undertaken with an informed international cartographic community to determine whether they viewed the product as a map or a *** is important to understand how Beck’s representation is viewed from the perspective of the geospatial *** it works as a map,albeit one where geography is generally abandoned,relative positions are favoured over the absolute and azimuth is distorted,then the view that successful(geo)communication artefacts must be linked to map designs that focus on precise and true representations of geographic information can be questioned.

关键词： maps diagrams design

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Metal-assisted chemical etching of silicon and the behavior of nanoscale silicon materials as Li-ion battery anodes

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Nano Research 2015年第5期8卷 1395-1442页

作者： william McSweeney Department of Chemistry University College Cork Cork Ireland Department of Physics and Energy University of Limerick Limerick Ireland Materials and Surface Science Institute University of Limerick Limerick Ireland Micro & Nanoelectronics Centre Tyndall National Institute Lee Maltings Cork Ireland

This review outlines the developments and recent progress in metal-assisted chemical etching of silicon, summarizing a variety of fundamental and innovative processes and etching methods that form a wide range of nanoscale silicon structures. The use of silicon as an anode for Li-ion batteries is also reviewed, where factors such as film thickness, doping, alloying, and their response to reversible lithiation processes are summarized and discussed with respect to battery cell performance. Recent advances in improving the performance of silicon-based anodes in Li-ion batteries are also discussed. The use of a variety of nanostructured silicon structures formed by many different methods as Li-ion battery anodes is outlined, focusing in particular on the influence of mass loading, core-shell structure, conductive additives, and other parameters. The influence of porosity, dopant type, and doping level on the electrochemical response and cell performance of the silicon anodes are detailed based on recent findings. Perspectives on the future of silicon and related materials, and their compositional and structural modifications for energy storage via several electrochemical mechanisms, are also provided.

关键词： silicon Li-ion battery nanostructures nanowires electrochemistry energy storage etching

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Functionals for Multilinear Fractional Embedding

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Acta Mathematica Sinica,English Series 2015年第1期31卷 1-28页

作者： william BECKNER Department of Mathematics The University of Texas at Austin 1 University Station C1200Austin TX 78712-0257 USA

A novel representation is developed as a measure for multilinear fractional embedding. Corresponding extensions are given for the Bourgain-Brezis-Mironescu theorem and Pitt＇s inequal- ity. New results are obtained for diagonal trace restriction on submanifolds as an application of the Hardy-Littlewood-Sobolev inequality. Smoothing estimates are used to provide new structural un- derstanding for density functional theory, the Coulomb interaction energy and quantum mechanics of phase space. Intriguing connections are drawn that illustrate interplay among classical inequalities in Fourier analysis.

关键词： Fractional embedding Hardy-Littlewood-Sobolev inequality diagonal trace restriction,Coulomb interaction Pitt's inequality

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