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Radiation-Induced Liposarcoma of the Groin in a Patient with Prior Vulvar Cancer: A Case Report and Literature Review

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Journal of Cancer Therapy 2025年第1期16卷 28-37页

作者： Lorena Munoz Guzman william manning Valentina Zanfagnin Kyle M. Devins Fantine Giap Andrea Russo Annekathryn Goodman Department of Obstetrics and Gynecology Massachusetts General Hospital Boston USA Department of Pathology Massachusetts General Hospital Boston USA Department of Radiation Oncology Massachusetts General Hospital Boston USA

Radiation-induced sarcomas (RIS) are rare but severe long-term complications of radiotherapy (RT). They typically arise years after exposure to ionizing radiation used to treat primary malignancies and complicate patient outcomes. Determining the risk associated with these radiation-induced cancers is challenging due to confounding factors such as lifestyle and genetic predisposition. Liposarcomas, which are the most common type of soft tissue sarcomas, originate from adipose tissue and can develop as a late complication of RT. Although they account for a significant portion of soft tissue sarcomas, radiation-induced liposarcomas are still considered rare, making them a noteworthy diagnostic and therapeutic concern. In this report, we present a rare case of radiation-induced dedifferentiated liposarcoma arising 12 years after RT for vulvar cancer. The patient presented with a mass in the groin, which was initially suspected to be a local recurrence. Imaging studies revealed a suspicious lesion on PET/CT, while MRI showed no significant findings. Histopathological evaluation confirmed the diagnosis of dedifferentiated liposarcoma. Surgical resection was performed with a focus on achieving negative margins. A literature review identified nine similar cases, with five being pleomorphic liposarcomas. The average time to presentation was 15 years (interval 3 - 47 years), with a mean radiation dose of 62 Gy. This case highlights the importance of long-term follow-up for cancer survivors and the need for vigilance in diagnosing secondary malignancies following RT.

关键词： Radiation-Induced Neoplasms Liposarcoma Radiotherapy Vulvar Neoplasms

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大气臭氧浓度升高对樱桃萝卜生长和生物量的影响

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南京林业大学学报（自然科学版） 2019年第5期43卷 187-192页

作者：李丽 manning william 王效科南京林业大学竹类研究所江苏南京210037 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085 美国麻省大学阿姆赫斯特分校农业科学学院马萨诸塞州阿姆赫斯特01003

【目的】近地层臭氧(O3)是具有强氧化性的二次污染物,可损伤植物内部结构和生理功能,造成作物生长量和品质下降。了解不同大气O3浓度下樱桃萝卜各生长时期的叶片受害和生物量状况,分析其受害症状、生物量与O3暴露剂量之间的相关关系,为... 详细信息

【目的】近地层臭氧(O3)是具有强氧化性的二次污染物,可损伤植物内部结构和生理功能,造成作物生长量和品质下降。了解不同大气O3浓度下樱桃萝卜各生长时期的叶片受害和生物量状况,分析其受害症状、生物量与O3暴露剂量之间的相关关系,为探讨O3浓度升高对农作物产量的影响及作物大气O3标准的制定提供参考。【方法】利用12个生长室设置了4个大气臭氧(O3)浓度(30、50、70和90 nmol/mol),对樱桃萝卜叶片的受害症状和第7、14、21和28天的生长和生物量变化进行了研究,并拟合计算了O3暴露剂量AOT40和叶片受害症状、生物量变化间的相关关系。【结果】①70和90 nmol/mol O3处理下,第7天观测发现樱桃萝卜子叶上部出现褪绿斑点,整叶局部薄厚不均,叶片受害症状随着O3熏蒸时间的增加而加重,出现O3受害症状的叶片比例和O3暴露剂量AOT40极显著相关(P<0.01)。②处理第21天时观测发现,O3熏蒸均对樱桃萝卜整体干质量产生影响;与30 nmol/mol处理的相比,第28天时观察发现,50、70和90 nmol/mol O3处理后的樱桃萝卜肉质根干质量分别下降了45.1%、57.3%和79.9%。干质量下降的幅度大于体积的,肉质根体积和干物质量都与O3暴露剂量AOT40线性相关。【结论】樱桃萝卜的生长和生物量受到O3浓度和累积时间两个因素共同影响,O3浓度升高显著抑制了樱桃萝卜生长,造成叶片受损,可食用肉质根体积和总干物质量显著下降。

关键词：大气臭氧 AOT40 樱桃萝卜肉质根生物量受害症状

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The Ozone Component of Global Change:Potential Effects on Agricultural and Horticultural Plant Yield,Product Quality and Interactions with Invasive Species

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Journal of Integrative Plant Biology 2009年第4期51卷 337-351页

作者： Fitzgerald Booker Russell Muntifering Margaret McGrath Kent Burkey Dennis Decoteau Edwin Fiscus william manning Sagar Krupa Arthur Chappelka David Grantz United States Department of Agriculture-Agricultural Research Service Plant Science Research Unitand Department of Crop Science NorthCarolina State UniversityRaleigh North Carolina 27695 USA Department of Animal Sciences Auburn UniversityAuburn Alabama 36849 USA Department of Plant Pathology and Plant-Microbe Biology Long Island Horticultural Research Extension Center Cornell UniversityRiverheadNew York 11901 USA Department of Horticulture Pennsylvania State UniversityState College Pennsylvania 16802 USA Department of Plant Soil and Insect Sciences University of Massachusetts AmherstMassachusetts 01003 USA Department of Plant Pathology University of MinnesotaSt. Paul Minnesota 55108 USA School of Forestry and Wildlife Sciences Auburn UniversityAuburn Alabama 36849 USA Department of Botany and Plant Sciences University of CaliforniaRiverside California 92521 USA

The productivity, product quality and competitive ability of important agricultural and horticultural plants in many regions of the world may be adversely affected by current and anticipated concentrations of ground-level ozone （O_3）. Exposure to elevated O_3 typically results in suppressed photosynthesis, accelerated senescence, decreased growth and lower yields. Various approaches used to evaluate O_3 effects generally concur that current yield losses range from 5% to 15% among sensitive plants. There is, however, considerable genetic variability in plant responses to O_3.

关键词： climate change crop forage horticultural plant ozone product quality weedyield.

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thylenediurea(EDU)effects on Japanese larch:an one growing season experiment with simulated regenerating communities and a four growing season application to individual saplings

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Journal of Forestry Research 2021年第5期32卷 2047-2057页

作者： Evgenios Agathokleous Mitsutoshi Kitao Xiaona Wang Qiaozhi Mao Hisanori Harayama william Jmanning Takayoshi Koike Key Laboratory of Agrometeorology of Jiangsu Province Institute of Applied EcologyNanjing University of Information Science and Technology(NUIST)Nanjing 210044People’s Republic of China Division of Environment and Resources Research Research Faculty of AgricultureHokkaido UniversitySapporo 060-8589Japan Hokkaido Research Center Forestry and Forest Products Research Institute(FFPRI)Sapporo 062-8516Japan College of Landscape Architecture and Tourism Hebei Agricultural UniversityNo.2596 Lekai South StreetLianchi DistrictBaoding 071000People’s Republic of China College of Resources and Environment Southwest UniversityChongqing 400700People’s Republic of China Ecophysiology Laboratory Department of Plant EcologyForestry and Forest Products Research Institute(FFPRI)Matsunosato-1Tsukuba 305-8687Japan Department of Plant Soil and Insect SciencesUniversity of Massachusetts80 Campus Center WayAmherstMA 01003USA Shenzhen Graduate School of Environment and Energy Peking UniversityShenzhen 518055People’s Republic of China Research Center for Eco-Environmental Science Chinese Academy of ScienceBeijing 100085People’s Republic of China

Japanese larch(Larix kaempferi(Lamb.)Carr.)and its hybrid are economically important coniferous trees widely grown in the Northern ***-level ozone(O_(3))concentrations have increased since the preindustrial era,and research projects showed that Japanese larch is susceptible to elevated O_(3)***,methodologies are needed to(1)protect Japanese larch against O_(3)damage and(2)conduct biomonitoring of O_(3)in Japanese larch forests and,thus,monitor O_(3)risks to Japanese *** the first time,this study evaluates whether the synthetic chemical ethylenediurea(EDU)can protect Japanese larch against O_(3)damage,in two independent *** the first experiment,seedling communities,simulating natural regeneration,were treated with EDU(0,100,200,and 400 mg L^(-1))and exposed to either ambient or elevated O_(3)in a growing *** the second experiment,individually-grown saplings were treated with EDU(0,200 and 400 mg L-1)and exposed to ambient O_(3)in two growing seasons and to elevated O_(3)in the succeeding two growing *** two experiments revealed that EDU concentrations of 200-400 mg L^(-1)could protect Japanese larch seedling communities and individual saplings against O_(3)-induced inhibition of growth and ***,EDU concentrations≤200 mg L^(-1)did offer only partial protection when seedling communities were coping with higher level of O_(3)-induced stress,and only 400 mg EDU L^(-1)fully protected communities under higher ***,we conclude that among the concentrations tested the concentration offering maximum protection to Japanese larch plants under high competition and O_(3)-induced stress is that of 400 mg EDU L^(-1).The results of this study can provide a valuable resource of information for applied forestry in an O_(3)-polluted world.

关键词： Air pollution Antiozonant Ethylenediurea(EDU) Plant protection Tropospheric ozone(O_(3))

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Frontier as Peril and Promise:The Paradox of Xiao Gang's Western Regions

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中国比较文学 2025年第01期 56-78+44页

作者： william A.Julian the Department of East Asian Languages and Civilizations at Harvard University

本文旨在解开萧纲边塞诗中的一个悖论，通过对他两首同名“从军行”的细读，揭示他在描绘汉武帝征服西域过程中所呈现的两种截然不同的方式。本文认为这一悖论的内涵可以从汉代史书模式、萧纲在南梁边境的亲身经历，以及他对世界万象的... 详细信息

本文旨在解开萧纲边塞诗中的一个悖论，通过对他两首同名“从军行”的细读，揭示他在描绘汉武帝征服西域过程中所呈现的两种截然不同的方式。本文认为这一悖论的内涵可以从汉代史书模式、萧纲在南梁边境的亲身经历，以及他对世界万象的无常性和本质空无的佛教观点出发加以理解。

关键词：边塞诗西域帝国萧纲

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北京夏季地表臭氧污染分布特征及其对植物的伤害效应

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生态学报 2014年第16期34卷 4756-4765页

作者：张红星孙旭姚余辉万五星肖扬孙滨峰 william J.manning 韩春萌郜世奇高付元徐卫华冯兆忠欧阳志云王效科中国科学院生态环境研究中心城市与区域生态国家重点实验室北京城市生态系统研究站北京100085 中国科学院大学北京100049 阿北师范大学石家庄050016 马萨诸塞大学中国矿业大学北京100083 北京教学植物园北京100061

臭氧是重要的空气氧化剂,适当浓度的臭氧可以消菌杀毒,但过高浓度的臭氧可能对生物健康构成威胁。随着城市汽车保有量的迅速上升,臭氧的前体物氮氧化物和VOCs排放增多,臭氧浓度随之不断升高,地表臭氧污染日趋严重。地表臭氧的分布特征... 详细信息

臭氧是重要的空气氧化剂,适当浓度的臭氧可以消菌杀毒,但过高浓度的臭氧可能对生物健康构成威胁。随着城市汽车保有量的迅速上升,臭氧的前体物氮氧化物和VOCs排放增多,臭氧浓度随之不断升高,地表臭氧污染日趋严重。地表臭氧的分布特征以及其对植物的胁迫伤害效应引起了人们的重视。是通过监测北京夏季地表臭氧污染分布规律,鉴定是否有植物受到臭氧伤害,以及受伤害植物的种类及地理分布特征,为城市与区域臭氧风险评估提供依据。从2012年7月4日到8月30日,采用被动采样分析的方法,在北京东北、西北、西南、东南郊区以及城区设置了10个研究样点,监测平均臭氧浓度的变化。同时,运用"森林健康专家咨询系统"鉴定植物受臭氧伤害的特征。结果表明:(1)监测期间,北京西部和北部山区的臭氧浓度高于平原地区;在平原地区,公园中的臭氧浓度高于道旁绿化带;山区的臭氧浓度平均为105.39μg/m3,公园中为68.49μg/m3,道旁绿化带为56.54μg/m3;(2)在北京的公园和山区发现了18种植物符合"森林健康专家咨询系统"所述臭氧伤害特征,有五叶地锦(Parthenocissus quinquefolia)、核桃(Juglans regia)、臭椿(Ailanthus altissima)、喇叭花(Pharbitis purpurea)、桑树(Morus alba)、榆树(Ulmus pumila)、国槐(Sophora japonica)金叶槐(Sophora japonica ***-rameus)、木槿(Hibiscus syriacus)、重瓣棣棠花(Kerria japonica)、山香(Hyptis suaveolens)、决明(Cassia tora)、毛白杨(Populus tomentosa)、黄花柳(Salix caprea)、大花地榆(Sanguisorba sitchensis)、火炬树(Rhus typhina)、大豆(Glycine max)、向日葵(Helianthus annuus);没有在道旁绿化带的植物叶片发现臭氧伤害症状;(3)臭椿(Ailanthus altissima)幼树臭氧伤害症状明显,易于辨认,且臭椿出现频率最高,是分布广泛的乡土树种,适合作为臭氧污染指示植物。

关键词：北京臭氧分布植物伤害效应

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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

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标准定则市场兴——技术标准对专利交易的促进作用研究

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管理世界 2025年第1期41卷 51-66页

作者：曹春方龚曼宁中山大学管理学院中山大学现代会计与财务研究中心

技术不确定性是制约技术要素市场发展的重要因素,但现有研究未充分探讨。本文以国家标准化指导性技术文件的出台作为技术不确定性降低的外生冲击,基于全国专利交易数据,构建双重差分模型,实证研究发现:(1)技术标准出台促进该行业专利交... 详细信息

技术不确定性是制约技术要素市场发展的重要因素,但现有研究未充分探讨。本文以国家标准化指导性技术文件的出台作为技术不确定性降低的外生冲击,基于全国专利交易数据,构建双重差分模型,实证研究发现:(1)技术标准出台促进该行业专利交易提升7.1%;(2)行业特征方面,这种促进作用在搜索成本、信息不对称以及套牢风险较高的行业中更强;(3)标准类型方面,技术内容型、市场导向型和持续有效的技术标准对专利交易的促进作用更强。交易主体方面,这种促进作用主要体现在公司买方中;(4)这种促进作用也优化了专利交易市场的结构和效率,增加了交易主体数量,降低了交易主体集中度,促进了跨行业交易,还促进了交易完成后专利的价值提升。本文的研究表明,更好地发挥技术标准降低技术不确定性的作用,是促进技术要素市场高质量发展、优化技术资源配置的有效途径。

关键词：技术不确定性技术标准专利交易技术资源配置优化

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Chlorantraniliprole exposure aggravates high-fat diet-induced metabolic disorders in mice by regulating gut microbiota and its metabolites

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Food Science and Human Wellness 2025年第1期14卷 91-100页

作者： Ting Gu Jie Lin Jiani Yang william Mumby Quancai Sun Ye Peng School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013China Faculty of Medicine Macao University of Science and TechnologyMacao 999078China Department of Health Nutritionand Food SciencesFlorida State UniversityTallahassee 32306USA

Food contaminants,particularly insecticides,are important factors contributing to obesity and other adverse *** the most widely used diamide insecticide worldwide,chlorantraniliprole(CP)is ubiquitous in food and the ***,the influence of CP on obesity and the gut microbiota remains *** this study,we administered CP/carboxymethyl cellulose sodium to C57BL/6J mice with a high-fat diet(HFD)via gavage for 13 *** CP exposure induced significant increases in body weight gain,fat mass,serum total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C).Moreover,CP aggravated the imbalance in the gut microbiota by increasing the relative abundance of obesity-associated bacteria and reducing the relative abundance of beneficial *** on untargeted metabolomics analysis,CP was found to be involved in the regulation of pathways including Alanine,aspartate and glutamate metabolism and Arginine and proline ***,CP exposure primarily induced alterations in microbial metabolites within these pathways,such as L-(+)-aspartic acid and L-glutamic ***,individual metabolites,such as the lipid mediator(oleoyl ethanolamide),also demonstrated alterations upon CP ***,Spearman correlation analysis revealed several noteworthy associations between microbial alterations,metabolite changes,and *** results of the study demonstrate a connection between microbiota,metabolites,and the effects of CP exposure on HFD-induced obesity,elucidating the critical role of the gut microbiota and its metabolites in the toxic effects of CP.

关键词： Chlorantraniliprole Obesity Metabolic disorder Gut microbiota Untargeted metabolomics

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