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Anterior knee pain following primary total knee arthroplasty

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World Journal of Orthopedics 2015年第10期6卷 795-803页

作者： David Shervin Katelyn Pratt Travis Healey Samantha Nguyen william m mihalko mouhanad m El-Othmani Khaled J Saleh Division of Orthopaedics and Rehabilitation Department of SurgerySouthern Illinois University School of Medicine Campbell Clinic Department of Orthopaedic Surgery and Biomedical Engineering University of Tennessee

Despite improvements in technique and technology for total knee arthroplasty(TKA),anterior knee pain impacts patient outcomes and *** the prosthetic and surgical technique related causes of pain after TKA,specifically as it relates to anterior knee pain,can aid surgeons in addressing these issues with their *** features of the femoral and patellar components which have been reported as pain generators include: Improper femoral as well as patellar component sizing or designs that result in patellofemoral stuffing; a shortened trochlear groove distance from the flange to the intercondylar box; and then surgical technique related issues resulting in: Lateral patellar facet syndrome; overstuffed patella/flange combination; asymmetric patellar resurfacing,improper transverse plane component rotation resulting in patellar subluxation/*** design consideration that allows impingement of extensor mechanism anatomical elements has the possibility of impacting outcome by becoming a pain *** the number of TKA procedures continues to increase,it is increasingly critical to develop improved,evidence based prostheses that maximize function and patient satisfaction while minimizing pain and other complications.

关键词： Anterior knee pain Total knee arthroplasty Primary Knee replacement Arthroplasty

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

The Aerosol-monsoon Climate System of Asia:A New Paradigm

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Journal of meteorological Research 2016年第1期30卷 1-11页

作者： william K.m.Lau Earth Science Interdisciplinary Center University of MarylandCollege Park

This commentary is based on a series of recent lectures on aerosol-monsoon interactions I gave at the Beijing Normal University in August 2015. A main theme of the lectures is on a new paradigm of ＂An Aerosol-monsoon-Climate-System＂, which posits that aerosol, like rainfall, cloud, and wind, is an integral component of the monsoon climate system, influencing monsoon weather and climate on m1 timescales. Here, salient issues discussed in my lectures and my personal perspective regarding interactions between atmospheric dynamics and aerosols from both natural and anthropogenic sources are summarized. my hope is that under this new paradigm, we can break down traditional disciplinary barriers, advance a deeper understanding of weather and climate in monsoon regions, as well as entrain a new generation of geoscientists to strive for a sustainable future for one of the most complex and challenging human-natural climate sub-system of the earth.

关键词： aerosol monsoon climate system interaction new paradigm

Assessment of mercury(II) bioavailability using a bioluminescent bacterial biosensor: Practical and theoretical challenges

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Journal of Environmental Sciences 2010年第8期22卷 1137-1143页

作者： Paulo R G Barrocas william m Landing Robert J m Hudson Department of Sanitation and Environmental Health National School of Public Health Oswaldo Cruz Foundation Department of Oceanography Florida State University. Tallahassee Department of Natural Resources and Environmental Sciences University of Illinois

Critical methodological challenges in the microbial biosensor approach to assessing Hg（II） bioavailability were evaluated from the perspective of analytical chemists. The main challenge stems from the fact that the chemical speciation of Hg（II） in natural waters exerts a major control on its bioavailability, yet its natural complexation equilibria are extensively altered during conventional bioassays. New data, obtained using a bioluminescent Hg（II）-biosensor, that illustrate these challenges are presented and potential solutions proposed.

关键词： mercury bioavailability biosensor chemical speciation bioluminescent

Predictive value of hypo-osmotic swelling test to identifyviable non-motile sperm

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Asian Journal of Andrology 2003年第3期5卷 209-212页

作者： william m.Buckett University of Liverpool and the Reproductive medicine Unit Liverpool Women's Hospital Liverpool UK

Aim: To determine the predictive value of the hypo-osmotic swelling (HOS) test to identify viable, non-motile sperm. methods: Semen samples from 20 men with severe asthenozoospermia underwent traditional seminal analysis, eosin-nigrosin (EN) staining and the HOS test. A further EN stain was then performed on a HOS pre-treated aliquot and a total of 2000 further sperm examined. Results: The median sperm density was 5.1 million/mL (IQR 4.3-13.1) and the median motility was 3.0 % (IQR 0-7). Seven samples showed complete asthenozoospermia. Initial EN staining showed 59 % viability (range 48-69) despite the poor standard parameters and 47 % (range 33-61) in the complete asthenozoospermia subgroup. The HOS test showed 49.9 % reacted overall (range 40-59) and 41.7 % (range 22-61) in the complete asthenozoospermia subgroup. The combined HOS/EN stain showed the positive predictive value of the HOS test to identify viable sperm was 84.2 % overall and 79.7 % in the complete asthenozoospermia subgroup. Conclusion: The HOS test can effectively predict sperm viability in patients with severe and complete asthenozoospermia.

关键词： azoospermia sperm spermmotility hypo-osmotic swelling (HOS) test sperm viability predictive value

Reproductive biology of an old endemic murid rodent of Australia, the Spinifex hopping mouse, Notomys alexis:adaptations for life in the arid zone

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Integrative Zoology 2011年第4期6卷 321-333页

作者： william G.BREED Chris m.LEIGH Discipline of Anatomy and Pathology University of AdelaideAdelaideAustralia

The Spinifex hopping mouse(Notomys alexis Thomas,1922)is an arid adapted Australo–Papuan old endemic rodent that undergoes boom and bust population *** this communication,we review our findings on the timing of reproduction and the potential reproductive rate of this *** investigate the first question,the reproductive condition of adult females,and occurrence of immatures,in a population on a cattle station in central Australia was determined and,for the second,data from a laboratory colony compared to those previously published on closely related species in other *** findings show that,at least in the population at the times that monitoring was performed,reproductive activity was only taking place in spring and early summer,whereas the laboratory study indicates that females have a similar gestation length and litter size to those of most close relatives occurring in other *** have extremely small testes and store relatively few *** findings suggest that Notomys alexis might show some seasonality of reproduction at least in this region of central Australia and that this species does not have a higher reproductive rate than that of related species in other,more predictable,environments.

关键词： arid environment hopping mouse reproduction

Industry mix and Curvilinear Spillovers from FDI in China

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2013年第4期8卷 535-551页

作者： william m. Tracy Lally School of management and Technology Rensselaer Polytechnic Institute Troy NY 12309 USA

This paper uses industry and province specific Chinese industrial data to demonstrate a potential causal link between two strands of the FDI literature. The first strand suggests that the impact of spillovers from inward FDI is less robust in middle-income economies than in either high-income or low-income economies. The second strand suggests diminishing returns of inward FDI on horizontal labor productivity in low-technology industries but not in high-technology industries. This paper suggests a link between these two phenomena. Specifically, if both FDI intensity and industry mix vary with the level of economic development, then an industry-dependent relationship between inward FDI and horizontal spillovers could cause middle-income economies to derive fewer benefits from inward FDI than either high- or low-income economies. This paper also verifies the curvilinear relationship between FDI in low-technology industries and horizontal labor productivity without relying on problematic FDI from Hong Kong, Taiwan and macao.

关键词： foreign direct investment curvilinear China spillovers

Comparison of closure measurements with finite element model results in an underground coal mine in central Utah

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International Journal of mining Science and Technology 2019年第1期29卷 9-15页

作者： william G.Pariseau michael K.mcCarter Jessica m.Wempen Department of mining Engineering University of Utah

Quantitative analysis of mine-wide subsidence at the kilometer scale and details of stress distribution about an advancing longwall face are estimated using an adaptation of the finite element method. The method is well suited to the tasks at hand. For greater realism, variability of strata properties is taken into account as are the effects of joints and cleats on elastic moduli and strengths. Evolution of pillar stress and entry closure remote from the face is readily quantified in a series of analyses that simulate face advance. Computed results compare favorably with the evolution of closure measurements about an instrumented pillar in a two-entry headgate. The appropriateness of the finite element method is confirmed. This method is based on first principles that avoid empirical schemes of uncertain applicability and numerical models ‘‘calibrated" by fitting computer output to mine measurements.

关键词： Finite element modeling Longwall mining mine subsidence Stress modeling

Understanding business william G. Nickels, James m. mcHugh, Susan m. mcHugh 5th ed

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