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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： Hui-Yi hsiao Chung-Yi Nien Ruei-Feng Shiu Wei-Chun Chin Tzung-Hai Yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

农村通向全民健康覆盖的障碍及其原因分析--基于供需双方经济激励机制角度

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中国卫生政策研究 2014年第8期7卷 4-8页

作者：胡敏 Winnie C-M Yip 陈文萧庆伦复旦大学公共卫生学院上海200032 牛津大学布拉瓦尼克政府学院哈佛大学公共卫生学院美国波士顿02115

以宁夏回族自治区为案例,本研究对五个样本县进行大规模家庭入户调查、乡镇卫生院和村卫生室机构调查,分析了西部农村通向全民健康覆盖之路的障碍,并从供需双方经济激励机制角度剖析其原因。分析认为西部农村面临基层门诊服务可及性不足... 详细信息

以宁夏回族自治区为案例,本研究对五个样本县进行大规模家庭入户调查、乡镇卫生院和村卫生室机构调查,分析了西部农村通向全民健康覆盖之路的障碍,并从供需双方经济激励机制角度剖析其原因。分析认为西部农村面临基层门诊服务可及性不足,居民经济负担沉重;服务流向不合理,资源配置效率低下;基层供方服务技术效率和质量不佳等问题。造成这些障碍的原因包括:从需方角度来看,新农合保障"轻门诊重住院、轻基层重高层"的特点;从供方角度剖析,对村医经济激励效力低下,按项目付费提供不恰当的经济刺激,难以引导供方提高自身服务效率和质量,以及欠缺促进体系整合的激励。

关键词：农村全民健康覆盖障碍原因经济激励机制

FuzEmotion as a Backward Kansei Engineering Tool

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International Journal of Automation and computing 2012年第1期9卷 16-23页

作者： Hsiang-Hung hsiao william Wei-Lin Wang Department of Mechanical Engineering School of Engineering University of Auckland

Kansei engineering, also known as k, unsei ergonomics or emotional engineering, aims at analysing and incorporating customer＇s feeling and demands into product function and product design. Founded in the late 1970＇s, kansei is now considered as a key consumer-oriented technology for new product development. This paper described a system called FuzEmotion for the purpose of assessing the kansei aspects of a product by considering design attributes of a product. Fuzzy logic is used to represent kansei words and process fuzzy input. The system has been successfully implemented to ascertain gender inclination of a mobile phone. Principal parameters of a mobile phone are considered, i.e., length, width, thickness, and mass. The system can inform gender inclination of a mobile phone with accuracy up to 76 %. This is based on a set of 92 mobile phone samples from the five major mobile phone manufacturers.

关键词： Kansei emotional engineering product design fuzzy logic mobile phones.

Conjugate Heat Transfer for Free Convection along a Vertical Plate Fin

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Journal of Thermal Science 2010年第4期19卷 337-345页

作者： Kai-Long hsiao Department of Digital Entertainment and Game Design Diwan University

In this study,a new and effective improved Semi-Analytic and Semi-Empirical formula f(Pr)= (0.749999437Pr^(1/2))/((0.609+1.221Pr^(1/2)+1.238Pr)^(1/4))has been proposed to solve a conjugate problem with free convection in the incompressible laminar boundary layer flow and heat conduction in a solid wall for the flow passing a flat plate fin. A combination of flat-plate flow and flat-plate fin heat conduction has been considered in the present *** -difference solutions for the interface temperature profiles and the heat transfer rates have been presented over the entire thermo-fluid-dynamic field for Prandtl numbers from 0.001 to ***,the similar flow field has been solved by the Runge-Kutta method and the shooting methods,then the correlation equation of the local heat transfer coefficient have been ***,the empirical formula has been substituted into the fin temperature heat conduction calculation processes to obtain the iterative solutions of the conjugate problems.

关键词： Conjugate heat transfer Free convection Vertical plate fin Finite difference Runge-Kutta method Shooting method.

The culture and establishment of embryonic germ(EG)cell lines from Chinese mini swine

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Cell Research 2003年第3期13卷 195-202页

作者： hsiao CHIEN TSUNG Shanghai Institutes for Biologcal Sciences of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai 200031 Institute Laboratory of Embryonic Stem Cell China

As a part of a basic research project on Xeno-transplantion,we have been engaged in the derivation ofembryonic stem cell lines from Chinese mini ***,we reported for the first time the establishmentof two porcine EG cell lines(BPEG1 and BPEG2)from primordial germ cells of genital ridges of a 28 anda 27 d embryos *** pluripotent nature has been identified by colony morphology,markercharacterization as well as well as by in vitro and in vivo *** porcine EG cells are potentiallyuseful for further basic studies.

关键词： primordial germ cells EG cells porcine Chinese mini swine.

A Comparative Study of TiO_2 Nanoparticles Synthesized in Premixed and Diffusion Flames

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Journal of Thermal Science 2010年第6期19卷 567-575页

作者： hsiao-Kang Ma Hsiung-An Yang Department of Mechanical Engineering National Taiwan University

Previous studies have been shown that synthesis of titania （TiO2） crystalline phase purity could be effectively controlled by the oxygen concentration through titanium tetra-isopropoxide （TTIP） via premixed flame from a Bunsen burner. In this study, a modified Hencken burner was used to synthesize smaller TiO2 nanoparticles via short diffusion flames. The frequency of collisions among particles would decrease and reduce TiO2 nanoparticle size in a short diffusion flame height. The crystalline structure of the synthesized nanoparticles was characterized by X-ray diffraction （XRD）, transmission electron microscope （TEM）, Barrett-Joyner- Halenda （BJH） and Brnnauer-Emmett-Teller （BET） measurements. The characteristic properties of TiO2 nanoparticles synthesized from a modified Hencken burner were compared with the results from a Bunsen burner and commercial TiO2 （Degussa P25）. The results showed that the average particle size of 6.63 nm from BET method was produced by a modified Hencken burner which was smaller than the TiO2 in a Bunsen burner and commercial TiO2. Moreover, the ruffle content of TiO2 nanoparticles increased as the particle collecting height increased. Also, the size of TiO2 nanoparticles was highly dependent on the TTIP loading and the collecting height in the flame.

关键词： Synthesis TiO2 nanoparticles titanium tetra-isopropoxide modified Hencken burner

Quasi-neutral limit of the drift-diffusion model for semiconductors with general sign-changing doping profile

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Science China Mathematics 2008年第9期51卷 1619-1630页

作者： hsiao Ling Academy of Mathematics and Systems Science Chinese Acadamy of Sciences

The quasi-neutral limit of time-dependent drift diffusion model with general sign-changing doping profile is justified rigorously in super-norm (i.e., uniformly in space). This improves the spatial square norm limit b... 详细信息

关键词： quasi-neutral limit drift-diffusion equations multiple scaling asymptotic expansions 35B25 35B40 35K57