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Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency:A case report

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World Journal of gastroenterology 2020年第15期26卷 1841-1846页

作者： Andrew Fagbemi william g newman Stuart g Tangye Stephen M Hughes Edmund Cheesman Peter D Arkwright Department of Paediatric gastroenterology Royal Manchester Children’s HospitalManchester M199WLUnited Kingdom Department of Medical genetics Manchester University NHS Foundation TrustManchester M139WLUnited Kingdom Evolution and genomic Sciences University of ManchesterManchester M139WLUnited Kingdom garvan Institute of Medical Research DarlinghurstNSW 2010Australia St Vincent’s Clinical School Faculty of MedicineUNSW AustraliaSydneyNSW 2010Australia Department of Paediatric Allergy and Immunology Royal Manchester Children’s HospitalManchester M139WLUnited Kingdom Department of Paediatric Histopathology St Mary’s HospitalManchester M139WLUnited Kingdom Lydia Becker Institute of Immunology and Inflammation University of ManchesterManchester M139WLUnited Kingdom

BACKgROUND Aminoacyl tRNA synthetases/ligases(ARSs)are highly conserved enzymes involved in attaching amino acids to tRNA promoting protein *** deficiencies of ARSs localized to the mitochondria classically present with neuropathology,the clinical features of cytosolic ARS deficiencies are more *** have previously been associated with neonatal hepatitis,but never with early-onset inflammatory bowel *** SUMMARY A nine-year-old Bangladeshi boy presented with neonatal liver failure and deranged clotting,transaminitis and *** parents were first *** older brothers and a sister were *** patient suffered from loose stools from early infancy which became more troublesome and persistent from five years old with ten bloody motions a *** endoscopies showed persistent pancolitis,which was refractory to mesalazine,corticosteroids,azathioprine,sirolimus and anti-TNF(adalimumab)therapy,but has improved recently with subcutaneous *** genome Sequencing revealed a novel pathogenic missense variant(c.290A>g)in the cytosolic isoleucyl-tRNA synthetase gene,leading to an amino acid substitution(***97gly).Pathogenic variants in other genes associated with inflammatory bowel disease(IBD)(ADAM17,EgFR,FOXP3,IL10RA,IL10RB,IL21R,NCF4,STAT3)were *** assays demonstrated markedly elevated IL-2,IL-5,IL-13,IL-9 and IL-10 by the patient’s CD4+T-cells,while IL-17A,IL-17F,IFNβwere lower,and TNFαnot significantly different when compared to healthy *** This case report provides evidence that recessive mutations in cytosolic isoleucyltRNA synthetase are a novel monogenic cause of IBD,which should be considered,particularly in infants and children with a history of neonatal hepatitis and very early-onset IBD poorly responsive to treatment.

关键词： Inflammatory bowel disease Hepatitis gene Cytosolic isoleucine tRNA synthase

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Anneal-free ultra-low loss silicon nitride integrated photonics

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Light(Science & Applications) 2024年第8期13卷 1565-1577页

作者： Debapam Bose Mark W.Harrington Andrei Isichenko Kaikai Liu Jiawei Wang Nitesh Chauhan Zachary L.newman Daniel J.Blumenthal Department of Electrical and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA Octave Photonics LouisvilleCO 80027USA

Heterogeneous and monolithic integration of the versatile low-loss silicon nitride platform with low-temperature materials such as silicon electronics and photonics,III–V compound semiconductors,lithium niobate,organics,and glasses has been inhibited by the need for high-temperature annealing as well as the need for different process flows for thin and thick *** techniques are needed to maintain the state-of-the-art losses,nonlinear properties,and CMOS-compatible processes while enabling this next generation of 3D silicon nitride *** report a significant advance in silicon nitride integrated photonics,demonstrating the lowest losses to date for an anneal-free process at a maximum temperature 250℃,with the same deuterated silane based fabrication flow,for nitride and oxide,for an order of magnitude range in nitride thickness without requiring stress mitigation or *** report record low anneal-free losses for both nitride core and oxide cladding,enabling 1.77 dBm^(-1) loss and 14.9 million Q for 80 nm nitride core waveguides,more than half an order magnitude lower loss than previously reported sub 300℃ *** 800 nm-thick nitride,we achieve as good as 8.66 dBm^(-1) loss and 4.03 million Q,the highest reported Q for a low temperature processed resonator with equivalent device area,with a median of loss and Q of 13.9 dBm^(-1) and 2.59 million each *** demonstrate laser stabilization with over 4 orders of magnitude frequency noise reduction using a thin nitride reference cavity,and using a thick nitride micro-resonator we demonstrate OPO,over two octave supercontinuum generation,and four-wave mixing and parametric gain with the lowest reported optical parametric oscillation threshold per unit resonator *** results represent a significant step towards a uniform ultra-low loss silicon nitride homogeneous and heterogeneous platform for both thin and thick waveguides capable of linear and nonlinear photonic circuits and

关键词： resonator thick free

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富氮气调--磷化氢的可供替换技术

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粮油食品科技 2024年第3期32卷 55-68页

作者： Manjree AgARWAL James newman Yan-yu LI Li gU Bei-bei LI Yong-lin REN 李燕羽(译) 西澳大利亚政府化学中心澳大利亚珀斯WA 6102 CBH澳大利亚谷物有限公司澳大利亚珀斯WA 6000 默多克大学环境和生命科学学院澳大利亚珀斯WA 6150 国家粮食和物资储备局科学研究院粮食储运研究所北京100037 国家粮食和物资储备局科学研究院粮食储运研究所

在粮食储藏上利用氮气的方法已经有30多年的历史,但直到最近经济有效的变压吸附(PSA)和膜分离(MS)制氮设备的出现,才使得该技术在储粮上使用成为可能。本研究首先在25、30和35℃、99%、98%和97%氮气的环境下,对小麦、大麦、燕麦、羽扇... 详细信息

在粮食储藏上利用氮气的方法已经有30多年的历史,但直到最近经济有效的变压吸附(PSA)和膜分离(MS)制氮设备的出现,才使得该技术在储粮上使用成为可能。本研究首先在25、30和35℃、99%、98%和97%氮气的环境下,对小麦、大麦、燕麦、羽扇豆和油菜籽中的花斑皮蠹、赤拟谷盗、谷蠹和米象成虫和非成虫虫态进行了为期4、3和2周的实验室生物测定。然后在终端用户Lakegrace和CBH(Cooperative BulkHandling)谷物进出口公司Albany出口港码头开展实仓验证,测定小麦、大麦和油菜籽中不同储粮害虫虫种和油菜籽瓢虫和肖叶甲类两种田间害虫的防治效果。同时对处理后的粮食品质进行了测定。实验结果表明,害虫死亡率随着氧气浓度降低、暴露时间和温度的增加而增加,富氮低氧在低温条件下不能100%致死花斑皮蠹幼虫。氮气处理对磷化氢抗性和敏感品系储粮害虫防治效果没有差异。与其他粮种相比,在油菜籽中的防治效果更好。各种粮种的水分含量、蛋白质、含油量、淀粉和籽粒颜色品质指标均未受到影响。成功开发了富氮低氧商业规模应用模式,为磷化氢高抗性害虫治理提供了解决方案,满足市场日益增长对无害虫和无化学残留粮食的需求。

关键词：气调储藏害虫治理磷化氢抗药性粮食品质应用模式

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The“Tears of the Virgin”at Lakes Entrance,southeast Australia were made by the intertidal barnacle Chthamalus antennatus(Cirripedia:Thoracica)and cyanobacteria

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Integrative Zoology 2017年第3期12卷 228-236页

作者： John S.BUCKERIDgE william A.newman Earth&Oceanic Systems group RMIT UniversityMelbourneVictoriaAustralia Scripps Institution of Oceanography La JollaCaliforniaUSA

Curious eroded depressions,most resembling an eye shedding an elongate tear,are found in gently sloping,intertidal,carbonate-rich arenite outcropping on the sea coast near Lakes Entrance,Victoria,southeast *** depressions,known locally as“Tears of the Virgin,”are evidently formed by multiple generations of a barnacle,Chthamalus antennatus Darwin,1854 in association with *** the round part of a depression offers the barnacle a modicum of protection from impacts during high tides,it is also partially inhabited by cyanobacteria,which extend into and tend to fill the elongate *** such,this appears to be the first case of mutualism between a higher invertebrate and cyanobacteria,with the cyanobacteria reducing the barnacle’s risk of desiccation while receiving metabolic wastes from it during low *** is also the first record of a balanomorph barnacle eroding calcareous arenite beneath its shell,the net effect of which would be expected to reduce its adhesion to the ***,the siliceous residue,resulting from the barnacle’s dissolution of the more than 80%of the calcite-rich sedimentary rock,is sequestered in delicate folds on the inside of the shell wall as it grows.A brief review of cirripedes capable of excavation includes the first photographic documentation of excavation of a mollusc shell by a verrucomorph.

关键词： burrowing barnacles Chthamalus antennatus Cirripedia cyanobacteria mutualism

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富氮低氧+磷化氢防治储粮害虫技术的实仓应用研究

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粮油食品科技 2024年第3期32卷 39-54页

作者： Manjree AgARWAL James newman Yan-yu LI Li gU Bei-bei LI Sucharita BASAVARAJAPP Yong-lin REN 李燕羽(译) 西澳大利亚州政府化学中心澳大利亚珀斯WA 6102 CBH澳大利亚谷物有限公司澳大利亚珀斯WA 6000 默多克大学环境和生命科学学院澳大利亚珀斯WA 6150 国家粮食和物资储备局科学研究院粮食储运研究所北京100037 国家粮食和物资储备局科学研究院粮食储运研究所

为防治澳大利亚主要仓储害虫,开发富氮气调技术作为熏蒸剂的辅助手段。然而,由于成本问题,一直影响其在行业推广应用。本研究利用中国长顺安达公司的先进膜分离技术,与传统的制氮技术(变压吸附/PSA)进行性能比较,在西澳Kwinana的CBH粮食... 详细信息

为防治澳大利亚主要仓储害虫,开发富氮气调技术作为熏蒸剂的辅助手段。然而,由于成本问题,一直影响其在行业推广应用。本研究利用中国长顺安达公司的先进膜分离技术,与传统的制氮技术(变压吸附/PSA)进行性能比较,在西澳Kwinana的CBH粮食港,开展实仓应用实验,以解决阻碍其推广的运营和成本问题。为满足澳大利亚严格的标准操作条件,长顺安达专业团队对港口设备进行了升级改造,目标消杀成本设定为0.50澳元/吨粮(磷化氢的高端熏蒸成本)。研究表明,旧的PSA技术的运营成本为2.43澳元/吨粮,该技术在产生和维持控制害虫所需的99%氮气浓度水平方面也显示出操作局限性。相比之下,使用膜技术制氮的成本为0.99澳元/吨粮,其他性能增益还包括运行4.5天内即可产生所需的氮气浓度,且可维持14天以完全控制害虫。

关键词：粮食储藏储粮害虫管理氮气储藏变压吸附制氮机膜分离制氮机

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A new chelonibiid from the Miocene of Zanzibar (Eastern Africa) sheds light on the evolution of shell architecture in turtle and whale barnacles (Cirripedia: Coronuloidea)

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Integrative Zoology 2022年第1期17卷 24-43页

作者： Alberto COLLARETA william A.newman giulia BOSIO giovanni COLETTI Dipartimento di Scienze della Terra Universitàdi PisaPisaItaly Museo di Storia Naturale Universitàdi PisaCalciItaly MBRD Scripps Institution of OceanographyLa JollaCaliforniaUSA Dipartimento di Scienze dell’Ambiente e della Terra Universitàdegli Studi di Milano-BicoccaMilanoItaly

The fossil history of turtle and whale barnacles(Coronuloidea:Chelonibiidae,Platylepadidae,Coronulidae and†Emersoniidae)is fragmentary and has only been investigated in *** inferences and molecular phylogenetic analyses on extant specimens suggest that the roots of whale barnacles(Coronulidae)are to be found among the chelonibiid turtle barnacles,but the hard-part modifications that enabled early coronuloids to attach to the cetacean skin are still largely to be ***,we reappraise a fossil chelonibiid specimen from the Miocene of insular Tanzania that was previously referred to the living species Chelonibia *** largely forgotten specimen is here described as the holotype of the new species†Chelonibia *** similar to ***,†*** exhibits obvious external longitudinal parietal canals occurring in-between external longitudinal parietal septa that abut outwards to form T-shaped flanges,a character so far regarded as proper of the seemingly more derived Coronulidae and *** with these features,the presence of a substrate imprint on the shell exterior indicates that†*** grasped its host’s integument in much the same way as coronulids and platylepadids,albeit without the development of macroscopic parietal buttresses and *** section analyses of the inner parietal architecture of some extant and extinct coronuloids conclusively demonstrate that vestiges of comparable external parietal microstructures are present in some living members of *** observation strengthens the unity of Coronuloidea while significantly contributing to our understanding of the evolution of the coronuloid shell structure in adapting to a diverse spectrum of hosts.

关键词： †Chelonibia zanzibarensis sp.nov. epibiosis evolution functional morphology systematics

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以色列放松监管投资者可用聊天机器人炒股

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商业周刊（中文版） 2024年第15期 26-27页

作者： Saritha Rai Marissa newman 逸思(译) 不详

经以色列监管机构批准,一家人工智能初创公司将与一家大型银行联合推出一款可提供选股建议的聊天机器人,尽管其他国家政府已发出警告,认为人工智能若被广泛应用于投资领域,可能会危及金融市场的稳定。

关键词：初创公司大型银行聊天机器人人工智能金融市场选股监管机构放松监管

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Numerical analysis for the prediction of bump prone conditions:A southern Appalachian pillar coal bump case study

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International Journal of Mining Science and Technology 2021年第1期31卷 75-81页

作者： Christopher newman David newman Appalachian Mining&Engineering Inc.LexingtonKY 40503USA

Two miners were fatally injured when a pillar bump occurred during retreat mining in a southern West Virginia coal *** mine was operating in the Eagle seam with overmining in the No.2 gas and Powellton seams.A coal bump is defined as a sudden and violent failure of coal caused by the release of stored strain energy in the *** significant strides have been made by academia,industry,and regulatory agencies to better understand bump conditions and mitigation techniques,coal bumps represent a long standing,highly site-specific engineering problem in which the exact failure mechanism is not clearly *** this case history,a cut-by-cut analysis of retreat mining operations was conducted on the 4 East Main leading up to the pillar bump *** input parameters were derived from site-specific geologic information and mine geometry for the analysis of pillar stress conditions and energy release using *** overview of stress conditions in the panel was presented including a precursor event that occurred two crosscuts inby the bump *** methodology presented in the paper for the evaluation of the fatal bump event can be used for the identification of bump prone conditions prior to development and retreat of a mining area.

关键词： Bump Burst Coal Energy release rate LaModel Numerical modeling

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Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)

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Journal of Sport and Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Terri L.Blackwell Peggy M.Cawthon Paul M.Coen Steven R.Cummings giovanna Distefano Samaneh Farsijani Daniel E.Forman Bret H.goodpaster Stephen B.Kritchevsky Theresa Mau Frederico g.S.Toledo Anne B.newman Nancy W.glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(SB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn Actigraph gT9X over 7 ***-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:Every 30 min/day more of Actigraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(pght activity was not associated with maxOXPHOS or ATP_(max).Meanwhile,every 30 min/day spent in Actigraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOS and0.

关键词： Aging Exercise Mitochondria

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Development of a multiple level underground limestone mine from geology through mine planning

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International Journal of Mining Science and Technology 2020年第1期30卷 63-67页

作者： Christopher newman David newman Robert Dupuy Appalachian Mining&Engineering Inc.LexingtonKYUSA Rogers group Inc.NashvilleTNUSA

The development of a multiple level underground mine is a complex task in which geology,engineering,ground control,and unit operations are integrated into a single mine *** components are interdependent and must function cohesively to ensure a profitable underground mining *** optimize reserve recovery,mine planning should begin from the lowest level and progress *** limits any misjudgments or oversights of a given level affecting the underlying levels and ensures the ability to maximize recovery from each *** planning should start with the exploration and characterization of the geologic *** the reserve geology and quality is well understood,then mine planning can begin with respect to the following:(1)orientation of mine works with respect to horizontal stress;(2)access to the reserve;(3)determination of opening widths;(4)selection of back,floor horizons and pillar centers;(5)selection of development and secondary mining heights;(6)appropriate inter-burden thicknesses;and(7)examining the stability of the multiple level mine through numerical *** multiple level mine design process and decisions are presented through a case history *** theme is that there is one opportunity to"get it right"and many chances to overlook a small aspect within the design that will plague the mine throughout all levels and through the entirety of its operating life.

关键词： Limestone Mine planning geology Multiple level Rock mechanics

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