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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu Dian Jia william Yi Wang Jun-Lei Yin Xing-Yu Gao Shu-Feng Yang Hai-Feng Song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and ecological engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

Cascade of care for children and adolescents with chronic hepatitis C

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World Journal of Gastroenterology 2021年第12期27卷 1117-1131页

作者： Michael evan rogers william F Balistreri Department of Pediatrics Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

Chronic hepatitis C virus(HCV)infection presents a significant global public health *** 2015,over 400000 deaths worldwide were attributed to HCV *** led the World Health Organization(WHO)in 2016 to set the ambitious goal of eliminating HCV by ***-centered guidelines have been established in order to provide direction for healthcare professionals,allowing integration of the newest screening policies and therapeutic strategies into their ***,for children and adolescents,HCV is a significant,unrecognized public health *** infection rates in the United States in women of childbearing age and those who are pregnant have increased in parallel with the rising opioid *** estimated 29000 women with HCV infection gave birth each year from 2011 to 2014 in the United States,with approximately 1700 of their infants being infected with *** HCV-specific therapeutics,namely direct acting antivirals(DAA),has brought a new and highly successful approach to treatment of hepatitis *** studies have confirmed similar levels of effectiveness and safety of DAA therapies in the pediatric ***,an enhanced cascade of care,which should include the population under 18 years of age,can help achieve the WHO goal by focusing on elimination in the youngest *** review will present an overview of the natural history,clinical features,and management of HCV in children and adolescents.

关键词： Hepatitis C virus Hepatitis C education Hepatitis C elimination

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添加剂对CO2水合物生成的影响

天然气工业 2008年第12期28卷 104-106页

作者：刘妮 ZHANG Guo-chang Rudy e. rogers 上海理工大学动力工程学院 200093 Department of Chemical engineering MiSsissippi State University

以水合物的方式分离/储存CO2气体是一项具有挑战性的新技术。为了提高水合物的生成速率和储气密度,在小型可视化的水合物反应装置上实验研究了不同种类的添加剂对CO2水合物生成特性的影响。结果表明,实验用有机硅系列添加剂可以有效降... 详细信息

以水合物的方式分离/储存CO2气体是一项具有挑战性的新技术。为了提高水合物的生成速率和储气密度,在小型可视化的水合物反应装置上实验研究了不同种类的添加剂对CO2水合物生成特性的影响。结果表明,实验用有机硅系列添加剂可以有效降低气—水界面的表面张力,提高水合物的生成速率。CO2水合物的生成量随着添加剂浓度的增大而增大,但当浓度高于0.1%以后,其生成量增长非常缓慢。单组分添加剂SilwetL-77效果最好,而单组分添加剂THF对CO2水合物的生成没有任何改善,但将浓度为4%的THF和1%的SilwetL-77混合后却对水合物的生成起到了显著的改善效果,12h内的气体压降可达到0.27MPa,是纯水体系的10倍之多,照片显示有大量的水合物生成。研究结果对寻找适合于CO2水合物快速生成的添加剂,为其应用于高效分离储存CO2气体技术等方面提供了指导。

关键词：添加剂 CO2 水合物表面张力

Analysis of cellulolytic and hemicellulolytic enzyme activity within the Tipula abdominalis （Diptera： Tipulidae） larval gut and characterization of Crocebacterium ilecola gen. nov., sp. nov., isolated from the Tipula abdominalis larval hindgut

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Insect Science 2010年第3期17卷 291-302页

作者： Theresa e. rogers Joy Doran-Peterson Microbiology Department University of Georgia Athens Georgia USA

In forested stream ecosystems of the north and eastern United States, larvae of the aquatic crane fly Tipula abdominalis are important shredders of leaf litter detritus. T. abdominalis larvae harbor a dense and diverse microbial community in their hindgut that may aide in the degradation oflignocellulose. In this study, the activities ofcellulolytic and hemicellulolytic enzymes were demonstrated from hindgut extracts and from bacterial isolates using model sugar substrates. One of the bacterial isolates was further characterized as a member of the family Microbacteriaceae. Taxonomic position of the isolate within this family was determined by a polyphasic approach, as is commonly employed for the separation of genera within the family Microbacteriaceae. The bacterial isolate is Gramtype positive, motile, non-sporulating, and rod-shaped. The G ＋ C content of the DNA is 64.9 mol%. The cell wall contains B2y type peptidoglycan, D- and L-diaminobutyric acid as the diamino acid, and rhamnose as the predominant sugar. The predominant fatty acids are 12-methyltetradecanoic acid （ai-C15：0） and 14-methylhexadecanoic acid （ai-C17：0）. The isolate forms a distinct lineage within the family Microbacteriaceae, as determined by 16S rRNA sequence analysis. We propose the name Crocebacterium ilecola gen. nov., sp. nov., to accommodate this bacterial isolate. The type species is T202T （ATCC BAA-1359; GenBank Accession DQ826511）.

关键词： cellulolytic hemicellulolytic hindgut

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Development and validation of SuperDeM for non-spherical particulate systems using a superquadric particle method

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Particuology 2022年第2期20卷 74-90页

作者： Xi Gao Jia Yu Ricardo J.F.Portal Jean-François Dietiker Mehrdad Shahnam william A.rogers National energy Technology Laboratory MorgantownWV 26506USA Leidos Research Support Team MorgantownWV 26506USA Centro de Investigação em Modelação e Otimização de Sistemas Multifuncionais Instituto Superior de Engenharia de LisboaPolytechnic Institute of Lisbon1959-007 LisboaPortugal Instituto de engenharia Mecânica–Instituto Superior Técnico Universidade de Lisboa1049-001 LisboaPortugal

This article presents the development and validation of the Superquadric Discrete element Method(SuperDeM)for non-spherical particle simulation using a superquadric particle method in open-source CFD suite MFiX.A superquadric particle-particle contact algorithm with accelerating and stabilizing strategy was developed.A superquadric particle-arbitrary wall contact algorithm was developed,which enables the simulation in complex *** solver was validated by comparing with experimental data generated in this study or available in the *** include cylinder contacting with a wall,static packing of M&M chocolate candies in a cylindrical container,static packing of cylinders in a cylindrical container,dynamic angle of repose of cylinders in a rotating drum,and discharging of chocolate candies from a ***,MPI parallelization of the solver was implemented and the parallel performance of the solver using MPI was assessed through large-scale simulations of 1 million,10 million,and 100 million particles on up to 6800 cores,which demonstrates that the SuperDeM solver has great potential for industrial-scale systems simulation.

关键词： DeM Particle Non-spherical Superquadric Parallelization MFiX

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汽车用异丁烯弹性体的研究

橡胶参考资料 2000年第3期30卷 13-22页

作者： John e.rogers 黄祖长

1 异丁烯聚合物异丁烯基弹性体包括:丁基橡胶,异丁烯与异戊二烯共聚物,卤化丁基橡胶,这些聚合物的星形支链传化物和异丁烯-对-甲基苯乙烯-溴-对-甲基苯乙烯(BIMS)的三元聚合物。目前有大量关于异丁烯基弹性体的加工、物理与化学性能及... 详细信息

1 异丁烯聚合物异丁烯基弹性体包括:丁基橡胶,异丁烯与异戊二烯共聚物,卤化丁基橡胶,这些聚合物的星形支链传化物和异丁烯-对-甲基苯乙烯-溴-对-甲基苯乙烯(BIMS)的三元聚合物。目前有大量关于异丁烯基弹性体的加工、物理与化学性能及应用的研究报告。

关键词：汽车异丁烯弹性体橡胶