检索结果-南通市图书馆

Recent developments in neuropsychological endophenotypes for schizophrenia: Development of the MATRICS battery, liability syndromes and the near future

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2011年第32期56卷 3385-3393页

作者： STONE william S HSI Xiaolu Department of Psychiatry Massachusetts Mental Health Center Division of Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02115-6092 USA MIT Medical Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA

Cognitive deficits are now recognized widely as core features of schizophrenia, and as major contributors to the clinical outcome of the disorder. They are also studied widely as 'endophenotypes', reflecting a growing consensus that schizophrenia is a broader, more multidimensional illness than the diagnostic criteria required for its formal diagnosis. This evolving view of cognition underlies its utilization in recent initiatives for intervention and assessment in schizophrenia. Two of these initiatives are reviewed in this paper. The first focuses on the development and validation of the MATRICS Cognitive Consensus Battery, a standardized battery of neuropsychological tests developed to assess the effectiveness of cognitive enhancing treatments in schizophrenia. A part of this effort includes the identification of performance-based, 'co-primary' measures of functional capacity that are related to cognition, and that are likely to show improvement at least partly as a function of improved cognition. The second initiative involves efforts to utilize neuropsychological deficits in the identification, validation and remediation of a liability syndrome for schizophrenia ('schizotaxia'). The discussion of this effort focuses on the development of a syndrome that is both measurable and meaningful clinically, and that may provide useful intervention targets. The utilization of cognition in both of these initiatives underscores its functional importance in the clinical outcome of schizophrenia. Moreover, it helps to illuminate indicators of liability for schizophrenia that might be amenable to remediation.

关键词：精神分裂症心理测验综合征电池神经稳定责任认知功能

The Psychosis of Power:A Lacanian Reading of Augusto Roa Bastos’s I the Supreme

在线全文

学校读者我要写书评

暂无评论

Journal of Foreign Languages and Cultures 2021年第2期5卷 4-11,155页

作者： william Egginton John Hopkins University

In the mid-seventies,Paraguay was two decades into what would ultimately be the second longest dictatorship in its history,second only to the reign of its“founding father,”Doctor Jose Rodriguez Gaspar de *** regime of Alfredo Stroessner justified its existence and articulated its continued role in Paraguayan politics on a genealogy of national identity that had its supposed roots in the Francia government,Francia’s political ideology and,in fact,in the historical person of Francia *** this essay I show how the great Paraguayan writer Augusto Roa Bastos’s 1974 novel,I,the Supreme,takes aim at the“kernel of the real”in the Stroessner regime’s political genealogy,using fiction to make evident its anamorphic manipulation of national and nationalist *** taking at its word the regime’s historical discourse,I,the Supreme reveals the psychotic logic animating its version of political power.

关键词： Augusto Roa Bastos Paraguayan politics power and psychosis Lacan Zizek psychoanalysis authoritarianism

Process engineering for primary care:Quality improvement and population health

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2016年第2期4卷 29-35页

作者： william Riley Science Health Care Delivery Arizona State University6930 East Bighorn CourtSuperstition MtAZ 85118USA

A fundamental paradox of the health care delivery systems in many industrialized nations is that desired population health metrics are often not achieved despite large expenditures in the health care delivery *** example,the United States commits nearly 18%of its GDP to the health care delivery system,the largest amount of any nation,yet is 37th in achieving health or health care delivery *** article addresses how general practice can be an important driver of population health in the Chinese health care delivery system through the application of quality improvement *** article shows examples of how the cause-and-effect diagram,the process map,and the plan,do,study,act(PDSA)cycle are important techniques to assist primary care practitioners for improving population health.

关键词： Population health general practice primary care quality improvement techniques

Composite Integers n for Which φ(n)|n-1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2007年第10期23卷 1915-1918页

作者： william D.BANKS Florian LUCA Department of Mathematics University of MissouriColumbiaMO 65211USA Instituto de Matemáticas Universidad Nacional Autdnoma de MéxicoC.P.58089 MoreliaMichoacánMéxico

In this note, we show that the number of composite integers n ≤ x such that φ（n）｜n - 1 is at most O（x^1/2（loglog x）^1/2）, thus improving earlier results by Pomerance and by Shan.

关键词： Euler function Lehmer conjecture

A facile approach to tricyclo[6.4.0.0^(4,9)]-dodecane framework

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2015年第2期26卷 238-242页

作者： Dong Wang william E.Crowe Longwood Biopharmaceuticals Inc. Tianjin International Joint.Academy of Biomedicine Department of Chemistry Louisiana State University

The unusual tricyclo[6.***.0.0^4,9]dodecane framework was constructed in eight linear steps in 13%overall *** innovative strategy accessing the framework from bicyclo[3.3.1]nonanes was *** key steps involve a Robinson a... 详细信息

关键词： Tricyclo[6.4.0.0^4 9]dodecane Vinigrol Robinson annulation Bicyclo[3.3.1]nonane

To linguists in the People’s Republic of China

在线全文

学校读者我要写书评

暂无评论

世界汉语教学 2001年第1期15卷 3-6页

作者： william Labov Director AtlasofNorthAmericanEnglish

In May of this year, I will be visiting China, along with my colleague from the University of Pennsylvania, Anthony Kroch. I am looking forward with keen anticipation to the opportunity to make contact with Chinese linguists. I hope to learn as much as possible about your researgh and the progress you have made in the study of the Chinese language as it is developing today.

关键词：语言学家中国学术研究思想活动

The politics of anti-corruption reforms and reversals in Uganda’s changing political terrain

在线全文

学校读者我要写书评

暂无评论

Economic and Political Studies 2016年第1期4卷 62-84页

作者： william Muhumuza Department of Political Science Makerere UniversityKampalaUganda

The article discusses the increasing levels of public sector corruption despite the NRM government’s pursuing of accountability reforms and anti-corruption policy *** asserts that having an impressive legal and institutional framework in place to enhance accountability and control corrupt tendencies may not be enough if political factors are *** the absence of exemplary political leadership and support to institutions that enforce compliance,fighting corruption will remain a far *** article further argues that in circumstances where the political terrain ascribes to patron-client and neo-patrimonial instruments to consolidate and retain power,curbing public sector corruption will be *** article insists that fighting public sector corruption largely depends on political commitment and less on the semblance of laws,institutions and technocrats.

关键词： Anti-corruption institutions neo-patrimonial politics patronage public sector corruption Uganda

Dissecting the multifactorial nature of demyelinating disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第4期13卷 628-632页

作者： Karolina Kucharova william B.Stallcup Sanford Burnham Prebys Medical Discovery Institute Cancer Center Tumor Microenvironment and Cancer Immunology ProgramLa Jolla CA USA

Chondroitin sulfate proteoglycan-4（CSPG4） is a surface component of two key cell types（oligodendrocyte progenitor cells（OPCs） and myeloid cells） present in lysolecithin-induced lesions in mouse spinal *** types of CSPG4 manipulations have been used to study the roles of these cells in myelin damage and repair：（1） OPC and myeloid-specific ablation of CSPG4,and（2） transplantation of enhanced green fluorescent protein（EGFP）-labeled progenitors to distinguish between bone marrow-derived macrophages and resident *** of CSPG4 in OPCs does not affect myelin damage,but decreases myelin repair,due to reduced proliferation of CSPG4-null OPCs that diminishes generation of mature oligodendrocytes for *** of CSPG4 in myeloid cells greatly decreases recruitment of macrophages to spinal cord lesions,resulting in smaller initial lesions,but also in significantly diminished myelin *** the absence of macrophage recruitment,OPC proliferation is greatly impaired,again leading to decreased generation of myelinating *** may promote OPC proliferation via phagocytosis of myelin debris and/or secretion of factors that stimulate OPC *** are not able to substitute for macrophages in promoting OPC *** additional feature of lesions in myeloid-specific CSPG4 null mice is the persistence of poorly-differentiated platelet-derived growth factor receptor α（PDGFRα）＋ macrophages that may prolong damage.

关键词： myelin damage myelin repair chondroitin sulfate proteoglycan 4 oligodendrocyte progenitors macrophages microglia Cre-Lox technology bone marrow transplantation

The importance of combined radiation and endocrine therapy in locally advanced prostate cancer

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第2期14卷 245-246页

作者： PhiUip J Gray william U Shipley Harvard Radiation Oncology Program BostonMA 02114USA Department of Radiation Oncology Massachusetts General HospitalBostonMA 02114USA

The management of all stages of prostate cancer has become an increasingly com-plex task as new treatment paradigms are tested and the results of large randomized studies become available. Despite these advances, prostate cancer remains the second leading cause of cancer death and the seventh overall cause of death in men in the United States.

关键词： radiation endocrine therapy cancer