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Military Medical Research 2024年第3期11卷 467-468页

作者： Sankalp Tandle Jared M.Wohlgemut Max E.R.Marsden Erhan Pisirir Evangelia Kyrimi Rebecca S.Stoner william Marsh Zane B.Perkins Nigel R.M.tai Centre for Trauma Sciences Blizard InstituteQueen Mary University of LondonLondon E12ATUK The Royal London Hospital Barts Health NHS TrustLondon E11FRUK Academic Department of Military Surgery and Trauma Research and Clinical InnovationThe Royal Centre for Defence MedicineBirmingham B152WBUK Department of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK

We read with interest the recent systematic reviewaArtificial intelligence and machine learning for hemorrhagic trauma careoby Peng et al.[1],which evaluated literature on machine learning(ML)in the management of trau... 详细信息

关键词： Trauma Injury Blood transfusion Massive transfusion Prediction Artificial intelligence Machine learning

Sb^(3+)and Sm^(3+)co-doped lead-free cs_(2)NaInCl_(6)double perovskite nanocrystals for single-component cold white emitter

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Journal of Rare Earths 2024年第9期42卷 1646-1651,I0001页

作者： Biao Zhou Xiangtong Zhang Ranran Hu Ruixue Hou william W.Yu Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Centre for High-Efficiency Display and Lighting TechnologySchool of Materials and EngineeringCollaborative Innovation Centre of Nano Functional Materials and ApplicationsHenan UniversityKaifeng475000China School of Chemistry and Chemical Engineering Shandong UniversityJinan250100China

Metal halide perovskites exhibit promising prospect in light-emitting diodes,solar cells,photodetectors and ***,the workhorse of metal halide perovskites relies on toxicity lead element,which severely damages human body and *** lead-free perovskites,cs_(2)NaInCl_(6)double perovskite is one of the most promising candidates because of its great stability and easy synthesis,but suffers inadequate optical ***,we doped Sb^(3+)and Sm^(3+)into cs_(2)NaInCl_(6)nanocrystals by a hot injection ***_(2)NaInCl_(6):Sb^(3+)exhibits blue emission at 447 ***_(2)NaInCl_(6):Sm^(3+),Sb^(3+)nanocrystals simultaneously generate the blue emission of Sb^(3+)and the multiple emissions of Sm^(3+)at 565,602,650 and 710 *** the increase of Sm^(3+)feed ratio,the emission color of cs_(2)NaInCl_(6):Sm^(3+),Sb^(3+)gradually moves to cold white region at(0.27,0.28)in CIE chromaticity diagram and correlated color temperature of 11840 *** work shows the potential application of cs_(2)NaInCl_(6):Sm^(3+),Sb^(3+)nanocrystals as a single-component cold white emitter.

关键词： Lead-free Double perovskites Single component White emitter Doping Rare earths

MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

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World Journal of Gastroenterology 2018年第27期24卷 2949-2973页

作者： Kenneth KW To Christy WS Tong Mingxia Wu william cs Cho School of Pharmacy Faculty of Medicine the Chinese University of Hong Kong Department of Clinical Oncology Queen Elizabeth Hospital

MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs.

关键词： microRNA colorectal cancer multidrug resistance prognosis therapeutic target apoptosis metastasis recurrence risk stratification

Screw dislocation structure and mobility in body centered cubic Fe predicted by a Gaussian Approximation Potential

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npj Computational Materials 2018年第1期4卷 90-96页

作者： Francesco Maresca Daniele Dragoni Gábor csányi Nicola Marzari william A.Curtin Laboratory for Multiscale Mechanics Modeling(LAMMM) Institute of Mechanical EngineeringÉcole Polytechnique Fédérale de LausanneLausanne CH-1015Switzerland Theory and Simulation of Materials(THEOS) and National Centre for Computational Design and Discovery of Novel Materials(NCCR MARVEL)École Polytechnique Fédérale de LausanneLausanne CH-1015Switzerland Dipartimento di Scienza dei Materiali Universitàdi Milano-BicoccaVia R.Cozzi 55Milan I-20125Italy Department of Engineering University of CambridgeTrumpington StreetCambridge CB21PZUK

The plastic flow behavior of bcc transition metals up to moderate temperatures is dominated by the thermally activated glide of screw dislocations,which in turn is determined by the atomic-scale screw dislocation core structure and the associated kink-pair nucleation mechanism for *** complex plasticity phenomena requires the simulation of many atoms and interacting dislocations and *** sizes are beyond the scope of first-principles methods and thus require empirical interatomic *** for the technological important case of bcc Fe,existing empirical interatomic potentials yield spurious ***,the structure and motion of the screw dislocations in Fe are studied using a new Gaussian Approximation Potential(GAP)for bcc Fe,which has been shown to reproduce the potential energy surface predicted by density-functional theory(DFT)and many associated *** Fe GAP predicts a compact,non-degenerate core structure,a single-hump Peierls potential,and glide on{110},consistent with DFT *** thermally activated motion at finite temperatures occurs by the expected kink-pair nucleation and propagation *** stress-dependent enthalpy barrier for screw motion,computed using the nudgedelastic-band method,follows closely a form predicted by standard theories with a zero-stress barrier of~1 eV,close to the experimental value of 0.84 eV,and a Peierls stress of~2 GPa consistent with DFT predictions of the Peierls potential.

关键词： structure dislocation cubic

Molecular verification of the integration of Tripsacum dactyloides DNA into wheat genome through wide hvbridization

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Chinese Science Bulletin 2000年第6期45卷 528-532页

作者： QIU Jiwen JIN Demin LI Chuanyou JIA Jianhang OUYANG Ping william tai WANG Bin LI Dawei State Key Laboratory of Plant Cell and Chromosome Engineering Institute of GeneticsChinese Academy of SciencesBeijing100101.China Plant Biotechnology Laboratory Institute of GeneticsChinese Academy of SciencesBeijing 100101China Institute for Global Chinese Affairs University of MarylandUSA

RAPD and RFLP analyses of double haploid lines which derived from hybridization between hexaploid wheat (Triticum aestivum L. 2n=42) and eastern gamagrass (Tripsacum dactyloides L. 2n=4x=72) are reported. Two of the 340 Operon primers have been screened, which stably amplified Tripsacum dactyloides (male parent) specific bands in the double haploid lines. These results confirm the fact that Tripsacum dactyloides DNA has been integrated into wheat genome by sexual hybridization at molecular level. This idea has been further testified by RFLP analysis. Application and potentials of transferring Tripsacum dactyloides DNA into wheat genome by sexual hybridization in wheat breeding are discussed.

关键词： bread wheat Tripsacum dactyloides wide hybridization RAPD RFLP.

Anticancer Activities and the Drug Targets of Botanical Saponins from a Medicinal Herb,Gynostemma Pentaphyllum

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Journal of Acupuncture and Tuina Science 2008年第5期6卷 271-272页

作者： W.L.Wendy HSIAO william Chi Shing tai Ziyao MO Pui Kei WU School of Chinese Medicine Hong Kong Baptist UniversityHong KongP.R.China

Triterpenoid saponins are metabolites produced in most plant species through complex biosynthetic pathways. They play important roles to humans owing to their diverse medicinal effects, including antiinflammatory, antimicrobial, and anticancer activities. In our laboratory, the author have been investigating the anticancer activities of a mixture of triterpenoid saponins （designated GpMix） extracted from a medicinal plant, known as Jiao Gu Lan （Gynostemma pentaphyllum, 胶股蓝） or southern ginseng in China. The key findings are summed up as following.

关键词： Neoplasms, Second Primary Gynostemma Triterpenes

Crystallization behavior of F-free mold fluxes

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International Journal of Minerals,Metallurgy and Materials 2011年第2期18卷 150-158页

作者： Zuo-tai Zhang Guang-hua Wen Ying-yi Zhang College of Engineering Peking University Beijing 100871 China College of Materials Science and Engineering Chongqing University Chongqing 400044 China

The time-temperature-transformation （TTT） diagrams of F-free mold fluxes was constructed using single hot thermocouple technique （SHTT） and confocal scanning laser microscopy （csLM） to study the crystallization behavior of F-free mold fluxes. The tendency of crystallization is found to increase whereas the incubation time decreases with increasing basicity. Zirconia addition enhances the crystallization tendency due to its limited solubility in the slag melt and the solid particles acting as nucleation sites. Pseudo-wollastonite is found to precipitate in the slag with low basicity （cs-1 and cs-2）, kilchoanite and larnite are formed with further increasing basicity （cs-3）, and larnite is finally formed as the basicity beyond unit （cs-4）. The crystal morphology changes with varying compositions and isothermal temperatures. The measured growth rate is found to be linear with time under isothermal conditions and decreases with increasing isothermal temperature.

关键词： continuous casting mold fluxes crystallization zirconia crystal growth

腐植酸改良铜污染土壤对小麦生长与吸收利用养分的影响

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中国土壤与肥料 2024年第3期 168-173页

作者：于伟伟邓祎寇太记夏东方刘鹏陈常友河南省科学院地理研究所河南郑州450052 河南科技大学农学院河南洛阳471023 河南省资源环境调查二院河南郑州450007

为了评价腐植酸对铜污染土壤的改良效果,以冬小麦为研究对象,设置施加铜和腐植酸双因素田间盆栽试验,研究成熟期小麦的干物质积累与分配以及对氮、磷、铜素的吸收与利用。结果表明:(1)铜污染土壤中小麦器官的生长受到抑制,总生物量显著... 详细信息

为了评价腐植酸对铜污染土壤的改良效果,以冬小麦为研究对象,设置施加铜和腐植酸双因素田间盆栽试验,研究成熟期小麦的干物质积累与分配以及对氮、磷、铜素的吸收与利用。结果表明:(1)铜污染土壤中小麦器官的生长受到抑制,总生物量显著降低28.7%~66.9%;小麦吸收氮、磷量分别显著降低18.4%~61.5%、9.6%~65.5%,氮、磷素收获指数显著下降;尽管铜污染使小麦对铜素的吸收量显著增加40.5%~115.2%,但茎向叶和穗的迁移系数下降,使得收获指数无变化。(2)施用腐植酸明显改善铜污染造成的小麦根、茎、穗生长受到的抑制,缓解小麦吸收氮、磷素减少的不利影响;相比铜污染处理,腐植酸低(20 g/kg干土)和高(40 g/kg干土)用量可使小麦生物量分别提高25.0%和115.6%,促进小麦对氮(22.6%~111.9%)、磷(28.3%~161.9%)的吸收并提高氮、磷素的收获指数。高腐植酸用量更有助于小麦抵抗铜污染危害胁迫。(3)增施腐植酸能使小麦铜素收获指数显著降低7.2%~9.0%,但会显著增加铜素由茎向叶(12.2%~30.7%)和由茎向穗(46.8%~71.9%)的迁移,导致铜在穗中的积累量增加。由此可见,施用腐植酸改良铜污染土壤的农用效果仍需要进一步研究。

关键词：土壤污染腐植酸土壤改良冬小麦

探索microRNAs在人类癌症中的治疗潜能

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中国肺癌杂志 2012年第8期15卷 501-505页

作者： william cs CHO 丁燕 Department of Clinical Oncology Queen Elizabeth Hospital 天津医科大学总医院天津市肺癌研究所天津市肺癌转移与肿瘤微环境重点实验室

大量研究表明microRNAs(miRNAs)的异常调节与癌症的发生和进展相关。新近研究发现了若干在各种人类癌症中具有可作为治疗靶标巨大潜能的miRNAs。这些肿瘤miRNAs的抑制或过表达可调节相关基因的表达,从而抑制各种癌症的增殖或转移。一些m... 详细信息

大量研究表明microRNAs(miRNAs)的异常调节与癌症的发生和进展相关。新近研究发现了若干在各种人类癌症中具有可作为治疗靶标巨大潜能的miRNAs。这些肿瘤miRNAs的抑制或过表达可调节相关基因的表达,从而抑制各种癌症的增殖或转移。一些miRNAs可逆转上皮-间质转化的表型,有些则可用于增强细胞对抗癌药物的敏感性。它们大部分的抗癌作用均已在临床前动物模型中得到验证。miRNA治疗的一个优点是它可靶向作用于不同信号通路中的许多基因,但同时亦伴有许多未知的脱靶效应的缺点。此外,对于有效的miRNA治疗来说,成功转运也是一个主要的挑战。然而,新近研究的发现及药物转运系统的高速发展为该领域的飞跃展现了一个乐观的前景。

关键词：癌症 microRNA miRNA 肿瘤miRNA 治疗靶标