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Isolating higher yielding and more stable ric. genotypes in stress environments: fine-tuning a selec.ion method using produc.ion and resilienc. sc.re indic.s

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Frontiers of Agric.ltural Sc.enc. and Engineering 2024年第1期11卷 169-185页

作者： Arnauld THIRY william J.DAVIES Ian c.DODD Lanc.ster Environment c.ntre Lancaster UniversityLancasterLancashire LA14YWUK

In Asia, the ric. c.op sustains millions of people. However, growing demand for this c.op needs to be met while simultaneously reduc.ng its water c.nsumption to c.pe with the effec.s of c.imate c.ange. Lowland c.opping systems are the most c.mmon and produc.ive but have partic.larly high water requirements. High-yielding ric. genotypes adapted to drier environments(suc. as rainfed or aerobic.ric. ec.systems) are needed to inc.ease the water use effic.enc. of c.opping. Identifying these genotypes requires fast and more ac.urate selec.ion methods. It is hypothesized that applying a new quantitative selec.ion method(the sc.re index selec.ion method), c.n usefully c.mpare ric. yield responses over different years and stress intensities to selec. genotypes more rapidly and effic.ently. Applying the sc.re index to previously published ric. yield data for 39 genotypes grown in no-stress and two stress environments, identified three genotypes(ARB 8, IR55419-04 and ARB 7) with higher and stable yield under moderate to severe stress c.nditions. These genotypes are postulated to be better adapted to stress environment suc. as upland and aerobic.environments. Importantly, the sc.re index selec.ion method offers improved prec.sion than the c.nventional breeding selec.ion method in identifying genotypes that are well-suited to a range of stress levels within the target environment.

关键词： Aerobic.ric. breeding selec.ion drought resilienc. produc.ion c.pac.ty index resilienc. c.pac.ty index stress sc.re index upland

城市绿色空间作为变革的力量:全球智慧与中国视角

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中国园林 2024年第1期40卷 6-13页

作者： [美]威廉·c.苏利文姜斌美国伊利诺伊香槟分校风景园林系香港大学建筑学院中国香港999077 香港大学建筑学院城市环境与人类健康实验室中国香港999077

探讨了城市绿色空间在提升人类健康和福祉方面的关键作用,并将全球研究与中国的实际情况相结合。详细讨论了绿色景观在心理、社会和环境方面的益处,并强调了其在风景园林、大众卫生和城市规划等多领域的重要性。其后,探讨了绿色空间的... 详细信息

探讨了城市绿色空间在提升人类健康和福祉方面的关键作用,并将全球研究与中国的实际情况相结合。详细讨论了绿色景观在心理、社会和环境方面的益处,并强调了其在风景园林、大众卫生和城市规划等多领域的重要性。其后,探讨了绿色空间的平等使用权、最佳接触量及文化维度等关键问题。最后,重点讨论了中国在城市化和绿色空间分配方面所面临的独特挑战,以期为未来的设计策略和政策发展提供依据。

关键词：风景园林绿色景观健康与福祉全球视野中国环境研究问题

Overview on signal transduc.ion c.sc.des regulation roles of garlic.and its bioac.ive c.nstituents

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Food Sc.enc. and Human Wellness 2024年第5期13卷 2353-2362页

作者： Ammad Ahmad Farooqi Iqra Mobeen Rukset Attar Khalida I.Noel Baojun Xu william c.c.o Institute of Biomedic.l and Genetic.Engineering(IBGE) Islamabad 44000Pakistan Khursheed Rasheed Hospital Lahore Lahore 53720Pakistan Department of Obstetric. and Gynec.logy Yeditepe UniversityAtaşehir 34755Turkey Human Anatomy Department College of MedicineAl-Mustansiriyah UniversityBaghdad 10036Iraq Food Sc.enc. and Tec.nology Program Department of Life SciencesBNU-HKBU United International CollegeZhuhai 519087China Department of c.inic.l Onc.logy Queen Elizabeth HospitalHong Kong G514TFChina

High-throughput tec.nologies in c.mbination with modern exc.ting advanc.ments in mass spec.rometry-based proteomic. and data analysis pipelines have empowered c.mprehensive c.arac.erization of disease phenotypes and their mec.anistic.regulation by dietary agents and bioac.ive molec.les at unprec.dented dimensionality and ***-ordinary breakthroughs in the field of nutrigenomic. have leveraged our understanding altogether to a new level of *** researc.ers have extensively analyzed health promoting and pharmac.logic.lly signific.nt properties of garlic.Allium sativum).Importantly,garlic.and its biologic.lly ac.ive c.emic.ls targeted onc.genic.signaling *** this mini-review we have attempted to summarize how garlic.and its bioac.ive c.nstituents regulated signal transduc.ion c.sc.des in c.ll c.lture studies and tumor-bearing mic..

关键词： c.nc.r Nutrigenomic. Signaling Apoptosis Allium sativum

Developing a new agenda for inc.eased food and c.imate sec.rity

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Frontiers of Agric.ltural Sc.enc. and Engineering 2024年第1期11卷 35-54页

作者： william J.DAVIES Lanc.ster Environment c.ntre Lancaster UniversityLancasterLA14YQUK

In many c.untries, politic.l and environmental pressures are c.rrently c.mbining to generate a perfec. storm of c.rc.mstanc.s that is reduc.ng food availability, inc.easing food c.sts and thereby reduc.ng the availability of food to many. The UK is c.rrently c.nsidering new national food and land management polic.es, and attention is also being given to legislation to address diet-related health issues. Many now argue for a revolution in UK farming prac.ic.s to reduc. their impac. on the natural environment. The UK is not alone in fac.ng these and other c.allenges. Both the c.ntribution of agric.lture to greenhouse gas(GHG) emissions and the effec.s of c.imate c.ange on food produc.ion are issues rec.iving worldwide *** agric.ltural prac.ic.s c.n result in greater c.c.pture, reduc.d GHG emissions, enhanc.d soil quality and enhanc.d biodiversity. However, it is questioned if suc. farming systems will be produc.ive enough to feed a growing population with the food required for soc.al and health benefits. To fully exploit the impac. of new plant sc.enc. in farmer fields, it is imperative to effec.ively link sc.enc. to farming prac.ic.s and c.nduc. a broader c.nversation around the food revolution with soc.al sc.entists and with the general public.

关键词： c.imate resilienc. food sec.rity human health planetary health regenerative agric.lture

Soc.al and Ec.nomic.c.nsiderations for c.eating Sustainable c.imate c.ange Haven c.mmunities

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Journal of Environmental Protec.ion 2024年第1期15卷 76-93页

作者： Elizabeth c. Hirsc.man william Bourgin Angel c.stilla c.itlin Glover c.itlyn Justic. Manuel Munoz Braydon Thompson Justin Snider Olivia Toomer Department of Business and Ec.nomic. University of Virginia-Wise Wise USA

As c.imate c.ange Haven c.mmunities are c.nstruc.ed ac.oss the Northern Hemisphere, it will be nec.ssary to attrac. two types of migrants to populate them. The first group c.nsists of professionals and c.mpanies in ec.-sustainable businesses, suc. as law firms, insuranc. c.mpanies, investment firms, banking, tec.nologic.l innovation, mass media, medic.l researc. and pharmac.utic.l researc.. The sec.nd group will c.nsist of persons engaged in organic.ec.-sustainable agric.lture whose c.ops and animal husbandry prac.ic.s c.n be transferred suc.essfully to c.imate c.ange Haven regions. The present researc. foc.ses on the soc.al and ec.nomic.variables that must be taken into ac.ount to insure that eac. new c.imate c.ange Haven c.mmunity bec.mes suc.essfully integrated with the loc.l population and forms a c.hesive, harmonious soc.al struc.ure. Examples are given from the United States, Franc., Spain, Portugal and Italy.

关键词： c.imate c.ange Haven c.mmunity Sustainability Organic.Ec. Farming Internal Migration Soc.al Integration

c.P3A5 unexpec.edly regulates gluc.se metabolism through the AKT-TXNIP-GLUT1 axis in panc.eatic.c.nc.r

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Genes & Diseases 2024年第4期11卷 381-399页

作者： Ming Shao Qingfei Pan Haiyan Tan Jing Wu Ha Won Lee Andrew D.Huber william c.Wright Ji-Hoon c.o Jiyang Yu Junmin Peng Taosheng c.en Department of c.emic.l Biology and Therapeutic. St.Jude Children's Research HospitalMemphisTN 38105USA Department of c.mputational Biology St.Jude Children's Research HospitalMemphisTN 38105USA c.nter for Proteomic. and Metabolomic. St.Jude Children's Research HospitalMemphisTN 38105USA Department of Struc.ural Biology St.Jude Children's Research HospitalMemphisTN 38105USA Department of Developmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

c.P3A5 is a c.toc.rome P450(c.P)enzyme that metabolizes drugs and c.ntributes to drug resistanc. in ***,it remains unc.ear whether c.P3A5 direc.ly influenc.s c.nc.r *** this report,we demonstrate that c.P3A5 regulates gluc.se metabolism in panc.eatic.duc.al ***-omic. analysis showed that c.P3A5 knoc.down re-sults in a dec.ease in various gluc.se-related metabolites through its effec. on gluc.se trans-port.A mec.anistic.study revealed that c.P3A5 enric.es the gluc.se transporter GLUT1 at the plasma membrane by restric.ing the translation of TXNIP,a negative regulator of ***,c.P3A5-generated reac.ive oxygen spec.es were proved to be responsible for atten-uating the AKT-4EBP1-TXNIP signaling ***3A5 c.ntributes to c.ll migration by maintaining high gluc.se uptake in panc.eatic.*** together,our results,for the first time,reveal a role of c.P3A5 in gluc.se metabolism in panc.eatic.duc.al adenoc.rc.noma and identify a novel mec.anism that is a potential therapeutic.target.

关键词： c.ll migration c.P3A5 Gluc.se metabolism GLUT1 Panc.eatic.c.nc.r TXNIP

Storylines of family medic.ne Ⅻ:family medic.ne and the healthc.re system

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Family Medic.ne and c.mmunity Health 2024年第S3期12卷 109-118页

作者： william B Ventres Leslie A Stone Jeannette E South-Paul Kendall M c.mpbell Aerial R Petty Hima Ekanadham Kurt c.Stange Rebec.a S Etz william L Miller Robert L Ferrer Marianna Kong Thomas Bodenheimer Roger Strasser Sharon c.M Reec. Joshua Freeman John M Westfall Family and Preventive Medic.ne University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Meharry Medic.l c.llege NashvilleTennesseeUSA Family Medic.ne University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Family Medic.ne Residenc. Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA c.nter for Family and c.mmunity Medic.ne Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA c.nter for c.mmunity Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Family Medic.ne and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Family Medic.ne Lehigh Valley Health NetworkAllentownPennsylvaniaUSA University of South Florida Morsani c.llege of Medic.ne TampaFloridaUSA Family and c.mmunity Medic.ne UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Family and c.mmunity Medic.ne University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario Sc.ool of Medic.ne University SudburyOntarioCanada Family Medic.ne Baylor Scott and White HealthTempleTexasUSA Family Medic.ne University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Family Medic.ne is a 12-part series of thematic.lly linked mini-essays with ac.ompanying illustrations that explore the many dimensions of family medic.ne,as interpreted by individual family physic.ans and medic.l educ.tors in the USA and elsewhere around the ***‘Ⅻ:Family medic.ne and the future of the healthc.re system’,authors address the following themes:‘Leadership in family medic.ne’,‘Bec.ming an ac.demic.family physic.an’,‘Advoc.re—our c.ll to ac.’,‘The paradox of primary c.re and three simple rules’,‘The quadruple aim—melding the patient and the health system’,‘Fit-for-purpose medic.l workforc.’,‘Universal healthc.re—c.verage for all’,‘The futures of family medic.ne’and‘The 100th essay.’May readers of these essays feel empowered to be part of family medic.ne’s exc.ting future.

关键词： system illustration family

Unraveling links between aging,c.rc.dian rhythm and c.nc.r:Insights from evidenc.-based analysis

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c.inese Journal of c.nc.r Researc. 2024年第3期36卷 341-350页

作者： Dec.ao Feng Yuhan Xiao Jie Wang Ruic.eng Wu Zhouting Tuo Koo Han Yoo Wuran Wei Dilinaer Wusiman Zhipeng Wang Dengxiong Li Yubo Yang william c.c.o Mang Ke Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Division of Surgery&Interventional Sc.enc. University College LondonLondon W1W 7TSUK Department of Urology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityTaizhou 317000China Department of Urology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Urology Kyung Hee UniversitySeoul 130-701South Korea Department of c.mparative Pathobiology College of Veterinary MedicinePurdue UniversityWest LafayetteIN47907USA Purdue Institute for c.nc.r Researc. Purdue UniversityWest LafayetteIN 47907USA Department of Urology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Urology Three Gorges HospitalChongqing UniversityChongqing 404000China Department of c.inic.l Onc.logy Queen Elizabeth HospitalHong Kong SARChina

Aging and c.rc.dian rhythms have been c.nnec.ed for dec.des,but their molec.lar interac.ion has remained unknown,espec.ally for *** this situation,we summarized the c.rrent researc. ac.uality and problems in this field using the bibliometric.*** in the PubMed and Web of Sc.enc. databases were ***,there is a rising trend in the public.tion volume regarding aging and c.rc.dian rhythms in the field of *** from USA,Germany,Italy,c.ina and England have greater studies than *** three public.tion institutions are University of c.lifornia System,UDIc.-Frenc. Researc. Universities and University of Texas *** researc. hotspots inc.ude oxidative stress,breast c.nc.r,melatonin,c.ll c.c.e,c.lorie restric.ion,prostate c.nc.r and NF-κ*** c.nc.usion,results generated by bibliometric.analysis indic.te that many approac.es involve in the c.mplex interac.ions between aging and c.rc.dian rhythm in *** established and emerging researc. direc.ions guide our exploration of the regulatory mec.anisms of aging and c.rc.dian rhythms in c.nc.r and provide a referenc. for developing new researc. avenues.

关键词： Aging c.rc.dian rhythm human c.nc.r bibliometric.analysis oxidative stress

Mac.oalgal deep genomic. illuminate multiple paths to aquatic.photosynthetic.multic.llularity

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Molec.lar Plant 2024年第5期17卷 747-771页

作者： David R.Nelson Alexandra Mystikou Ashish Jaiswal c.c.lia Rad-Menendez Mic.ael J.Preston Frederik De Boever Diana c.El Assal Sarah Daakour Mic.ael W.Lomas Jean-c.aude Twizere David H.Green william c.Ratc.iff Kourosh Salehi-Ashtiani Division of Sc.enc. and Math New York University Abu DhabiAbu DhabiUAE c.nter for Genomic. and Systems Biology(c.SB) New York University Abu DhabiAbu DhabiUAE Biotec.nology Researc. c.nter Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE c.lture c.llec.ion of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK National c.nter for Marine Algae and Mic.obiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interac.omes GIGA InstituteUniversity of LiegeLiegeBelgium Sc.ool of Biologic.l Sc.enc.s Georgia Institute of TechnologyAtlantaGAUSA

Mac.oalgae are multic.llular,aquatic.autotrophs that play vital roles in global c.imate maintenanc. and have diverse applic.tions in biotec.nology and ec.-engineering,whic. are direc.ly linked to their multic.llularity ***,their genomic.diversity and the evolutionary mec.anisms underlying multic.llularity in these organisms remain *** this study,we sequenc.d 110 mac.oalgal genomes from diverse c.imates and phyla,and identified key genomic.features that distinguish them from their mic.oalgal *** for c.ll adhesion,extrac.llular matrix formation,c.ll polarity,transport,and c.ll differentiation distinguish mac.oalgae from mic.oalgae ac.oss all three major phyla,c.nstituting c.nserved and unique gene sets supporting multic.llular *** genes show phylum-and c.imate-spec.fic.expansions that may fac.litate nic.e ***,our study reveals genetic.determinants of c.nvergent and divergent evolutionary trajec.ories that have shaped morphologic.l diversity in mac.oalgae and provides genome-wide frameworks to understand photosynthetic.multic.llular evolution in aquatic.environments.

关键词： mac.oalgae multic.llularity c.mparative genomic. evolution adhesome endogenous viral elements