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Long-term cost and efficacy analysis of latanoprost versus timolol in glaucoma patients in Germany

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 155-159页

作者： Ulrich Thelen Dietmar Schnober Sonja Schlzel Michael S.Kristoffersen Lindsay A.Nelson Jeanette A.stewart william c.stewart Westfalische Wilhelms-Universitat AugenarztpraxisMünster Germany Augenarzt Werdohl Germany Department of Surgery Institutes of Molecular Medicine University of Freiburg PRN Pharmaceutical Research Network LLC Cheyenne WY USA

AIM: To evaluate 5-year effectiveness and cos between latanoprost or timolol monotherapy in a pilot ***: A retrospective, multi-center trial performed at 6 sites in Germany of patients who had a diagnosis of primary open-angle or pigmentary glaucoma, in at least one eye, initiated on monotherapy with latanoprost or timolol maleate. Qualified consecutive charts were reviewed in which 5-year efficacy, safety and cost data was ***: Seventy-seven latanoprost and 49 timolo patients were included, at the final visit no difference existed between the two groups in disc parameters including: rim area, rim area/disc area ratio, cup volume or vertical cup/disc ratio (P >0.05). There was no difference in intraocular pressure (IOP) between the initial latanoprost (17.4 ±2.6) and timolol (16.3 ±2.8mmHg) groups. There was less change in medicines over the follow-up period (0.1 vs 0.8) and fewer medications at the final visit (1.2 vs 1.8) with latanoprost compared to timolol. No patient treated with latanoprost discontinued therapy during follow-up, while 12% discontinued timolol mostly due to inadequate IOP control. cost/year was less with initial timolol ($458±236) as compared to latanoprost ($552±202). cONcLUSION: Patients begun on latanoprost o timolol and followed over 5 years may have similar clinical outcomes. However, timolol patients may require more medicines and medicine changes to control IOP for long-term, but at a lower cost.

关键词： glaucoma economic efficacy safety latanoprost timolol Germany

拉坦、曲伏及比马前列素治疗青光眼的成本效用分析(英文)

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国际眼科杂志 2009年第5期9卷 812-816页

作者： william c stewart Jeanette A stewart Marko A Mychaskiw PRN制药研究公司美国德克萨斯州达拉斯辉瑞公司美国纽约州纽约市

目的:评估拉坦前列素,曲伏前列素和比马前列素在挪威,瑞典及丹麦(斯堪的纳维亚)治疗开角型青光眼的成本效用。方法:建立马尔可夫卫生经济学决策分析模型,评估比较前列腺素类似物的成本效用。健康状态为稳定及进展期青光眼。原发性开角... 详细信息

目的:评估拉坦前列素,曲伏前列素和比马前列素在挪威,瑞典及丹麦(斯堪的纳维亚)治疗开角型青光眼的成本效用。方法:建立马尔可夫卫生经济学决策分析模型,评估比较前列腺素类似物的成本效用。健康状态为稳定及进展期青光眼。原发性开角型青光眼和表皮剥脱性青光眼的转换概率均由发表的医学文献数据计算所得。通过对分散遍及于各国家的45位眼科医生进行调查获得临床医疗模式。各国家的具体单位成本包括药费,就诊费,诊断及治疗费。生命质量权重值指定为视力0.50 ～0.84,时间范围为5a。所有分析均为付款人观点成本效益分析,成本结果每年降低3%。结果:在挪威和瑞典,拉坦前列素较曲伏前列素和比马前列素费用低而效益高,拉坦前列素比其他药物费用低达4%。在丹麦,所有三种药物的费用在彼此的1.5%之内,比马前列素与曲伏前列素费用相当,而较拉坦前列素费用略低,但是拉坦前列素较曲伏前列素和比马前列素效益高。各国家所有药物的效用在一个窄范围内。结论:在斯堪的纳维亚,拉坦前列素为其他可买到的前列腺素类似物提供了经济有效的替代物。

关键词：成本拉坦前列素曲伏前列素比马前列素马尔可夫模型

Isolating higher yielding and more stable rice genotypes in stress environments: fine-tuning a selection method using production and resilience score indices

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Frontiers of Agricultural Science and Engineering 2024年第1期11卷 169-185页

作者： Arnauld THIRY william J.DAVIES Ian c.DODD Lancaster Environment centre Lancaster UniversityLancasterLancashire LA14YWUK

In Asia, the rice crop sustains millions of people. However, growing demand for this crop needs to be met while simultaneously reducing its water consumption to cope with the effects of climate change. Lowland cropping systems are the most common and productive but have particularly high water requirements. High-yielding rice genotypes adapted to drier environments(such as rainfed or aerobic rice ecosystems) are needed to increase the water use efficiency of cropping. Identifying these genotypes requires fast and more accurate selection methods. It is hypothesized that applying a new quantitative selection method(the score index selection method), can usefully compare rice yield responses over different years and stress intensities to select genotypes more rapidly and efficiently. Applying the score index to previously published rice yield data for 39 genotypes grown in no-stress and two stress environments, identified three genotypes(ARB 8, IR55419-04 and ARB 7) with higher and stable yield under moderate to severe stress conditions. These genotypes are postulated to be better adapted to stress environment such as upland and aerobic environments. Importantly, the score index selection method offers improved precision than the conventional breeding selection method in identifying genotypes that are well-suited to a range of stress levels within the target environment.

关键词： Aerobic rice breeding selection drought resilience production capacity index resilience capacity index stress score index upland

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埃塞俄比亚中部的青光眼流行病学(英文)

国际眼科杂志 2008年第9期8卷 1729-1733页

作者： Abiye Mulugeta Alemu Lindsay A. Nelson Bonnie Kruft Jeanette A. stewart william c. stewart 埃塞俄比亚亚的斯亚贝巴 RasDesta医院美国南卡罗来纳州查尔斯顿查尔斯顿研究所美国德克萨斯州达拉斯 PRN制药研究公司美国南卡罗来纳州哥伦比亚南卡罗来纳大学北卡罗来纳州眼科研究所

目的:探讨埃塞俄比亚的青光眼的流行状况、治疗方式以及患者的心态。方法:观察埃塞俄比亚亚的斯亚贝巴的住院青光眼患者。结果:在研究的415例青光眼患者中,Gurage(33%)人群最常见的为剥脱综合征(17%),而在Amhara/Tigre(6%)人群中,慢性... 详细信息

目的:探讨埃塞俄比亚的青光眼的流行状况、治疗方式以及患者的心态。方法:观察埃塞俄比亚亚的斯亚贝巴的住院青光眼患者。结果:在研究的415例青光眼患者中,Gurage(33%)人群最常见的为剥脱综合征(17%),而在Amhara/Tigre(6%)人群中,慢性闭角型青光眼为5%,二者间有显著差异性(P=0.006)。患者接受平均1.4±8种药物治疗:52%的患者没有短期的不适症状,36%的患者接受了滤过手术。93%的患者相信他们的主管医师试图给予帮助,89%认为是上帝让其接受治疗,82%感到他们的配偶体谅其病情。有87%的患者注意到社区不体察其病情,这在Gurage人群中更为多见(31%,P<0.0001),而穆斯林人群中有此感受的患者为25%(P=0.01),Amhara/Tigre患者则坚信其医师更关注他们的病痛(94%,P=0.04)。结论:不同类型的青光眼在埃塞俄比亚的不同种族人群中的发病有差异,在Gurage人群以剥脱综合征多见,而慢性闭角型青光眼则在Amhara/Tigre人群中的发病较高。

关键词：埃塞俄比亚青光眼心态信仰

Developing a new agenda for increased food and climate security

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Frontiers of Agricultural Science and Engineering 2024年第1期11卷 35-54页

作者： william J.DAVIES Lancaster Environment centre Lancaster UniversityLancasterLA14YQUK

In many countries, political and environmental pressures are currently combining to generate a perfect storm of circumstances that is reducing food availability, increasing food costs and thereby reducing the availability of food to many. The UK is currently considering new national food and land management policies, and attention is also being given to legislation to address diet-related health issues. Many now argue for a revolution in UK farming practices to reduce their impact on the natural environment. The UK is not alone in facing these and other challenges. Both the contribution of agriculture to greenhouse gas(GHG) emissions and the effects of climate change on food production are issues receiving worldwide *** agricultural practices can result in greater c capture, reduced GHG emissions, enhanced soil quality and enhanced biodiversity. However, it is questioned if such farming systems will be productive enough to feed a growing population with the food required for social and health benefits. To fully exploit the impact of new plant science in farmer fields, it is imperative to effectively link science to farming practices and conduct a broader conversation around the food revolution with social scientists and with the general public.

关键词： climate resilience food security human health planetary health regenerative agriculture

cYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer

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Genes & Diseases 2024年第4期11卷 381-399页

作者： Ming Shao Qingfei Pan Haiyan Tan Jing Wu Ha Won Lee Andrew D.Huber william c.Wright Ji-Hoon cho Jiyang Yu Junmin Peng Taosheng chen Department of chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA Department of computational Biology St.Jude Children's Research HospitalMemphisTN 38105USA center for Proteomics and Metabolomics St.Jude Children's Research HospitalMemphisTN 38105USA Department of Structural Biology St.Jude Children's Research HospitalMemphisTN 38105USA Department of Developmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

cYP3A5 is a cytochrome P450(cYP)enzyme that metabolizes drugs and contributes to drug resistance in ***,it remains unclear whether cYP3A5 directly influences cancer *** this report,we demonstrate that cYP3A5 regulates glucose metabolism in pancreatic ductal ***-omics analysis showed that cYP3A5 knockdown re-sults in a decrease in various glucose-related metabolites through its effect on glucose trans-port.A mechanistic study revealed that cYP3A5 enriches the glucose transporter GLUT1 at the plasma membrane by restricting the translation of TXNIP,a negative regulator of ***,cYP3A5-generated reactive oxygen species were proved to be responsible for atten-uating the AKT-4EBP1-TXNIP signaling ***3A5 contributes to cell migration by maintaining high glucose uptake in pancreatic *** together,our results,for the first time,reveal a role of cYP3A5 in glucose metabolism in pancreatic ductal adenocarcinoma and identify a novel mechanism that is a potential therapeutic target.

关键词： cell migration cYP3A5 Glucose metabolism GLUT1 Pancreatic cancer TXNIP

Unraveling links between aging,circadian rhythm and cancer:Insights from evidence-based analysis

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chinese Journal of cancer Research 2024年第3期36卷 341-350页

作者： Dechao Feng Yuhan Xiao Jie Wang Ruicheng Wu Zhouting Tuo Koo Han Yoo Wuran Wei Dilinaer Wusiman Zhipeng Wang Dengxiong Li Yubo Yang william c.cho Mang Ke Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Division of Surgery&Interventional Science University College LondonLondon W1W 7TSUK Department of Urology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityTaizhou 317000China Department of Urology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Urology Kyung Hee UniversitySeoul 130-701South Korea Department of comparative Pathobiology College of Veterinary MedicinePurdue UniversityWest LafayetteIN47907USA Purdue Institute for cancer Research Purdue UniversityWest LafayetteIN 47907USA Department of Urology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Urology Three Gorges HospitalChongqing UniversityChongqing 404000China Department of clinical Oncology Queen Elizabeth HospitalHong Kong SARChina

Aging and circadian rhythms have been connected for decades,but their molecular interaction has remained unknown,especially for *** this situation,we summarized the current research actuality and problems in this field using the bibliometric *** in the PubMed and Web of Science databases were ***,there is a rising trend in the publication volume regarding aging and circadian rhythms in the field of *** from USA,Germany,Italy,china and England have greater studies than *** three publication institutions are University of california System,UDIcE-French Research Universities and University of Texas *** research hotspots include oxidative stress,breast cancer,melatonin,cell cycle,calorie restriction,prostate cancer and NF-κ*** conclusion,results generated by bibliometric analysis indicate that many approaches involve in the complex interactions between aging and circadian rhythm in *** established and emerging research directions guide our exploration of the regulatory mechanisms of aging and circadian rhythms in cancer and provide a reference for developing new research avenues.

关键词： Aging circadian rhythm human cancer bibliometric analysis oxidative stress

Macroalgal deep genomics illuminate multiple paths to aquatic,photosynthetic multicellularity

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Molecular Plant 2024年第5期17卷 747-771页

作者： David R.Nelson Alexandra Mystikou Ashish Jaiswal cecilia Rad-Menendez Michael J.Preston Frederik De Boever Diana c.El Assal Sarah Daakour Michael W.Lomas Jean-claude Twizere David H.Green william c.Ratcliff Kourosh Salehi-Ashtiani Division of Science and Math New York University Abu DhabiAbu DhabiUAE center for Genomics and Systems Biology(cGSB) New York University Abu DhabiAbu DhabiUAE Biotechnology Research center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE culture collection of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK National center for Marine Algae and Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interactomes GIGA InstituteUniversity of LiegeLiegeBelgium School of Biological Sciences Georgia Institute of TechnologyAtlantaGAUSA

Macroalgae are multicellular,aquatic autotrophs that play vital roles in global climate maintenance and have diverse applications in biotechnology and eco-engineering,which are directly linked to their multicellularity ***,their genomic diversity and the evolutionary mechanisms underlying multicellularity in these organisms remain *** this study,we sequenced 110 macroalgal genomes from diverse climates and phyla,and identified key genomic features that distinguish them from their microalgal *** for cell adhesion,extracellular matrix formation,cell polarity,transport,and cell differentiation distinguish macroalgae from microalgae across all three major phyla,constituting conserved and unique gene sets supporting multicellular *** genes show phylum-and climate-specific expansions that may facilitate niche ***,our study reveals genetic determinants of convergent and divergent evolutionary trajectories that have shaped morphological diversity in macroalgae and provides genome-wide frameworks to understand photosynthetic multicellular evolution in aquatic environments.

关键词： macroalgae multicellularity comparative genomics evolution adhesome endogenous viral elements

The Effects of Zinc Sulfate on the in Vitro Digestibility of Feeds in cervids

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Open Journal of Animal Sciences 2024年第3期14卷 157-167页

作者： Reese J. Thibodeaux Philip M. Urso Stanley F. Kelley Marcy M. Beverly chris R. stewart Ian c. Dunn Gentech Diagnostics Dallas Texas USA Department of Animal Science South Dakota State University Brookings South Dakota USA School of Agricultural Sciences Sam Houston State University Huntsville Texas USA 3-S Texas Outdoors/3-S Whitetails Bedias Texas USA

The captive white-tailed deer industry has an estimated impact of 1.6 billion USD in the state of Texas alone. However, nutritional requirements for cervids are determined through research based on sheep and goats. The objective of this study was to determine the effects of zinc on differences in dry matter digestibility in vitro for white-tailed does (Odocoileus virginianus). Deer (n = 2) were ethically harvested, rumens were collected, and placed into a cooler containing warm water. Rumen contents were agitated, and fluid was filtered using cheese cloth while applying cO2. Fluid was placed into four separate incubator jars with filter bags containing a 1:1 alfalfa to coastal hay blend. Zinc doses of 0.073 mg/kg/d equivalents were added to two of the jars ( Zn), and the additional two jars received 0.00 mg/kg/d (cON). Following 48 h of incubation, in vitro true digestibility (IVTD) showed no significant differences between the control and the treatment groups. Average dry matter digested in vitro was 91.87% and 95.13%, respectively. There were no differences detected in ADF, NDF, IVTD, or OM between the treatment groups. While no detectable differences were observed in this study, this methodology did prove to be viable and functional for microbial digestion in vitro. This study can be replicated with multiple experimental units to confirm the observations of increased digestibility. Formal nutritional guidelines can be created to allow for more efficient feeding of cervids thereby reducing feed costs and continuing the growth of the captive deer industry.

关键词： Zinc IVDMD In Vitro cervids