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Journal of Integrative Plant biology 2007年第8期49卷 1208-1218页

作者： Michael b Sheahan Ray J rose David W McCurdy School of Environmental and Life Sciences The University of NewcastleCallaghan NSW 2308Australia Australian Research Council Centre of Excellence for Integrative Legume ResearchSchool of Environmental and Life SciencesThe University of NewcastleCallaghan NSW 2308Australia School of Environmental and Life Sciences The University of NewcastleCallaghan NSW 2308Australia

Organelles form essential compartments of all eukaryotic cells. Mechanisms that ensure the unbiased inheritance of organelles during cell division are therefore necessary to maintain the viability of future cell generations. Although inheritance of organelles represents a fundamental component of the cell cycle, surprisingly little is known about the underlying mechanisms that facilitate unbiased organelle inheritance. Evidence from a select number of studies, however, indicates that ordered organelle inheritance strategies exist in dividing cells of higher plants. The basic requirement for unbiased organelle inheritance is the duplication of organelle volume and distribution of the resulting organelle populations in a manner that facilitates unbiased partitioning of the organelle population to each daughter cell. Often, partitioning strategies are specific to the organelle, being influenced by the functional requirements of the organelle and whether the cells are mitotically active or re-entering into the cell cycle. Organelle partitioning mechanisms frequently depend on interactions with either the actin or microtubule cytoskeleton. In this focused review, we attempt to summarize key findings regarding organelle partitioning strategies in dividing cells of higher plants. We particularly concentrate on the role of the cytoskeleton in mediating unbiased organelle partitioning.

关键词： Actin cytoskeleton cell division green fluorescent protein-fimbrin AbD2 organelle partitioning protoplast

Not yet defect-free: the current landscape for women in computational materials research

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npj Computational Materials 2023年第1期9卷 1342-1351页

作者： Livia b.Pártay Erin G.Teich rose K.Cersonsky Department of Chemistry University of WarwickCoventry CV47ALUnited Kingdom Department of Physics Wellesley College106 Central StreetWellesley 02481 MAUSA Department of Chemical and biological Engineering University of Wisconsin-Madison1415 Engineering DriveMadison 53706 WIUSA

INTRODUCTION“I really am not seeing how women are still considered disadvantaged in our field.”This phrase is heard all-too-often by woman scientists across many *** while attitudes on gender equity and parity have considerably improved in recent history,there are still measurable inequities stemming from systemic bias in the career progression,recognition,and perception of women in the sciences,including our sub-field of computational materials *** the obstacles to equity is in the interests of all of *** research inclusive is critical,not only from an ethical standpoint,but also for attracting and retaining dedicated and talented minds,enhancing the vibrancy of all fields,and nurturing a diverse range of ideas.

关键词： landscape attracting retaining

Tomato molecular biology–special collection of papers for molecular horticulture

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Molecular Horticulture 2022年第1期2卷 280-283页

作者： Graham b.Seymour Jocelyn K.C.rose School of biosciences Division of Plant and Crop ScienceUniversity of NottinghamLoughboroughLeics LE125RDUK School of Integrative Plant Science Cornell University331 Emerson HallIthacaNY 14853USA

Tomato(Solanum lycopersicum)is the second most important vegetable crop globally,after potato,with about 100 million tons fresh fruit being grown on 3.7 million hectares(FAO 2021),and is of great importance in the human diet due to the large amount of fruit *** fruit are eaten both fresh and,equally importantly,as a processed product in puree,soups and canned *** provide an important dietary source of vitamins and minerals,such as K,Fe and Ca,and are known for the large number of health promoting secondary metabolites,including the carotenoid and flavonoid pigments that give the fruit a spectrum of yellow,red and orange colours.

关键词： culture orange globally

Effects of lime addition on geotechnical properties of sedimentary soil in Curitiba,brazil

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第1期10卷 188-194页

作者： Jair A.baldovino Eclesielter b.Moreira Wagner Teixeira Ronaldo L.S.Izzo Juliana L.rose Department of Civil Construction Federal University of Technology-Paraná Campus Curitiba

The soil of the Guabirotuba geological formation（Paraná basin, brazil） has physico-mechanical properties which are not suitable for its utilization in pavement construction, in protection of hillsides and slopes, or as shallow foundation support. Treatment of this soil by lime addition would improve its usability. The present context intends to determine the ratio between the splitting tensile strength（q;）and the unconfined compressive strength（q;） of clayey soil in the metropolitan region of Curitiba City,which has been treated with different lime contents and curing times. The control parameters evaluated include lime content（L）, curing time（t）, moisture content（w）, and ratio of porosity to volumetric lime content（η/L;）. It was observed that the q;/q;ratio is between 0.17 and 0.2 in relation to the curing time,and an exponential relation exists between them. Meanwhile, the unconfined compressive strength of lime-treated soil was found to be approximately four times the initial value.

关键词： Clayey soil stabilization Soil strength Lime-soil mixture Curing time

Status of brominated flame retardants,polychlorinated biphenyls,and polycyclic aromatic hydrocarbons in air and indoor dust in AFRICA:A review

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Emerging Contaminants 2020年第1期6卷 405-420页

作者： Olumide Emmanuel Akinrinade william Stubbings Mohamed Abou-Elwafa Abdallah Olusegun Ayejuyo rose Alani Stuart Harrad School of Geography Earthand Environmental SciencesUniversity of BirminghamBirminghamB152TTUK Department of Chemistry University of LagosLagosNigeria

While many African countries are signatories of the United Nations’Environment Programme(UNEP)Stockholm Convention aimed at eradication or reduction of persistent organic pollutants(POPs)in the environment,many such countries have limited financial and technical capacities to either combat the effects of POPs or effect their removal from the *** those chemicals listed as POPs under the Stockholm Convention are polychlorinated biphenyls(PCbs),polybrominated diphenyl ethers(PbDEs),and hexabromocyclododecane(HbCDD).Also of concern are polycyclic aromatic hydrocarbons(PAH),which are listed under the UN Economic Commission for Europe(UN-ECE)’s protocol on long range transboundary air pollution(LRTAP).This review examines the state of knowledge pertaining to concentration levels and trends of these contaminants in air(both indoor and outdoor)and indoor dust in *** there being no known manufacture of PbDEs or HbCDD in Africa,concentrations in air of these contaminants in Africa are comparable to those in continents where the chemicals were initially produced and known to be widely *** data were available to discern any temporal trend in concentrations of the target ***,the evidence highlights sources of PCbs,PbDEs,and HbCDD in Africa to include obsolete electrical and electronic equipment and informal handling and treatment of electronic *** concentrations of PAHs in air and in indoor dust are *** of PAHs in indoor dust can be significantly influenced by outdoor sources,particularly vehicular emissions leading to higher concentrations in urban *** the current and projected increase in African urbanisation and demand for consumer goods,there is substantial potential for concentrations of PbDEs,HbCDD,PCbs,and PAHs to rise in the near *** is therefore a need for long-term monitoring of concentrations of these chemicals in air and indoor dust at a range of locations acros

关键词： POPs PbDEs HbCDD PCbs PAHs

动态增强CT评估恶性胸膜间皮瘤的肿瘤反应:一项试验性研究

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国际医学放射学杂志 2019年第2期42卷 251-252页

作者： E.Gudmundsson Z.Labby C.M.Straus W.F.Sensakovic F.Li b.rose 徐晶(译) 赵世华(校) Department of Radiology The University of Chicago5841 South Maryland AvenueChicagoIL 60637USA 不详

目的研究动态增强(DCE)-CT获得的血流动力学参数对评估恶性胸膜间皮瘤(MPM)病人治疗反应的价值。方法纳入9例接受化疗和5例接受观察的病人。对每例病人进行2次DCE-CT扫描,2次间隔约2个月。

关键词：恶性胸膜间皮瘤 DCE 动态增强肿瘤体积 CT 试验性

Preliminary evaluation of the VIsion PERformance(VIPER) simulator

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Military Medical Research 2020年第3期7卷 312-323页

作者： Denise S.Ryan rose K.Sia Jennifer b.Eaddy Lorie A.Logan Jide O.Familoni Hind beydoun Samantha b.Rodgers bruce A.Rivers Warfighter Refractive Eye Surgery Program and Research Center Fort Belvoir Community HospitalFort BelvoirVA 22060USA Night Vision and Electronic Sensors Directorate Fort BelvoirVA 22060USA Department of Research Programs Fort Belvoir Community HospitalFort BelvoirVA 22060USA

background:This study evaluated the VIsion PERformance(VIPER)simulator’s ability to assess the functional visual performance in warfighters conducting civilian and military ***:Thirty service members,aged 25–35 years old with a best corrected distance visual acuity(VA)better than or equal to 20/20 or logarithm of the minimum angle of resolution(logMAR)0.00,were randomized to locate and identify road signs and mock improvised explosive devices(IEDs)under either daytime conditions or with infrared imagery,with(cc)and without(sc)wearing their habitual *** also underwent binocular uncorrected(UDVA)and corrected(CDVA)visual assessment,refraction,contrast sensitivity testing and wavefront ***:The mean age was 28.47 *** manifest spherical equivalent was–3.16±1.75 diopters(D),the UDVA in both eyes(OU)was logMAR 0.83±0.47,and the CDVA OU was–0.11±*** VIPER,the mean difference in the detection distance(DD)for road signs ccDD *** was(76.7±52.8)m(Pbility to assess functional visual performance when detecting and identifying signs and ***,VIPER is able to detect performance changes with and without correction.

关键词： Functional visual performance Military task performance

Do statins reduce hepatitis C RNA titers during routine clinical use?

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World Journal of Gastroenterology 2009年第40期15卷 5020-5027页

作者： Kimberly A Forde Connie Law rose O’Flynn David E Kaplan Philadelphia Veterans Administration Medical Center Department of Medicine Division of GastroenterologyUniversity of Pennsylvania Department of Pharmacy Philadelphia Veterans Administration Medical Center

AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group b (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral ***: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group b: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P ble antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy.

关键词： Hepatitis C 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Statins Geranylgeranyl Prenylation

In drug-induced, immune-mediated hepatitis, interleukin-33 reduces hepatitis and improves survival independently and as a consequence of FoxP3+ T-cell activity

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Cellular & Molecular Immunology 2019年第8期16卷 706-717页

作者： Merylin Cottagiri Maeva Nyandjo Matthew Stephens Joel J.Mantilla Hirohisa Saito Ian R.Mackay Noel R.rose Dolores b.Njoku Department of Anesthesiology and Critical Care Medicine Johns Hopkins University1800 Orleans StreetSuite 6349BaltimoreMD 21287USA RIKEN Center for Developmental biology 2-2-3 Minatojima MinamimachiChuo-kuKobeJapan650-0047 Department of biochemistry and Molecular biology School of Biomedical SciencesMonash UniversityMelbourneAustralia Department of Pathology Brigham and Women’s HospitalHarvard Medical School75 Francis St.BostonMA 02115USA Department of Pathology Johns Hopkins University720 Rutland AvenueBaltimoreMD 21205USA

Immune-mediated,drug-induced hepatitis is a rare complication of halogenated volatile anesthetic ***-4-regulated Th2-polarized reactions initiate this type and other types of hepatitis,while the mechanisms that regulate the severity remain ***-33 is an innate,IL-4-inducing,Th2-polarizing cytokine that has been detected in patients with liver failure and has been associated with upregulated ST2+Foxp3+CD4+CD25+T cells;however,roles for IL-33 in drug-induced hepatitis are *** investigated IL-33 in an anesthetic,immune-mediated hepatitis modeled in bALb/c,IL-33−/−and ST2−/−mice,as well as in patients with anesthetic *** hepatic IL-33 and ST2 levels were elevated in bALb/c mice(pbsence of IL-33 reduced IL-10(pbut we detected splenic IL-33 and ST2-negative Foxp3+CD4+CD25+T cells in ST2−/−mice that developed less hepatitis than bALb/c mice(pbut not in anesthetic hepatitis patients(r2=0.01),who had elevated IL-33(pbut IL-33,likely independent of ST2,reduces hepatitis via upregulation of Foxp3+CD4+CD25+T *** studies are needed to translate the role of IL-33 to human liver disease.

关键词： IL-33 hepatitis drug-induced immune-mediated Foxp3+Tregs autoimmunity