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World Journal of Gastrointestinal Oncology 2016年第4期8卷 358-365页

作者： Crystal S Seldon Lauren E Colbert william a hall Sarah B Fisher David S Yu Jerome C Landry Department of Radiation Oncology Winship Cancer Institute Emory University School of Medicine Department of Radiation Oncology Memorial Sloan Kettering Cancer Center Department of Radiation Oncology the Medial College of Wisconsin Division of Surgical Oncology Department of Surgery Emory University School of Medicine

Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies.

关键词： Chromodomain-helicase-DNA binding protein 5 Chromodomain-helicase-DNA binding protein 7 Mixed lineage kinase domain-like protein Pancreatic adenocarcinoma Biomarker

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比较符合实际的注塑制品测试方法

国外塑料 1986年第4期 63-66页

作者： william J.hall 梁基照华南工学院

设计高性能构件的工程师们正面临着市场需要不断增加的问题。除了需选择具有合适的刚度、耐磨性和耐热性的综合性能的材料之外,工程师还必须考虑制品外形的美观及功能的合理性,且制品要符合FDA标准和耐火要求。将材料与数据表上的值进... 详细信息

设计高性能构件的工程师们正面临着市场需要不断增加的问题。除了需选择具有合适的刚度、耐磨性和耐热性的综合性能的材料之外,工程师还必须考虑制品外形的美观及功能的合理性,且制品要符合FDA标准和耐火要求。将材料与数据表上的值进行比较对设计者来说是有帮助的,但是,要把ASTM标准的物性数据变换为成品的工作性能

关键词：挠曲 ABS 聚合物大分子化合物聚苯乙烯聚合塑料改性聚苯醚耐冲击完全退火制品柔性

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee william J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

PROJECT MANAGEMENT:RECENT DEVELOPMENTS AND RESEARCH OPPORTUNITIES

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Journal of Systems Science and Systems Engineering 2012年第2期21卷 129-143页

作者： Nicholas G.hall Department of Management Sciences Fisher College of Business The Ohio State UniversityUSA

This paper studies the business process known as project management. This process has exhibited a remarkable growth in business interest over the last 15 years, as demonstrated by a 1000% increase in membership in the Project Management Institute since 1996. This growth is largely attributable to the emergence of many new diverse business applications that can be successfully managed as projects. The new applications for project management include IT implementations, research and development, new product and service development, corporate change management, and software development. The characteristics of modem projects are typically very different from those of traditional projects such as construction and engineering, which necessitates the development of new project management techniques. We discuss these recent practical developments. The history of project management methodology is reviewed, from CPM and PERT to the influential modem directions of critical chain project management and agile methods. We identify one important application area for future methodological change as new product and service development. A list of specific research topics within project management is discussed. The conclusions suggest the existence of significant research opportunities within project management.

关键词： Project management overview recent practical developments opportunities for research

Processing of measurement while drilling data for rock mass characterization

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International Journal of Mining Science and Technology 2016年第6期26卷 989-994页

作者： Babaei Khorzoughi Mohammad hall Robert Norman B.Keevil Institute of Mining Engineering University of British Columbia School of Mining and Petroleum Engineering University of Alberta

The information extracted from monitoring of rotary blasthole drills helps to optimize the overall mining operation. Rock hardness, drillability, blastability and specific energy of drilling are examples of parameters that have been estimated in the past using measurement while drilling techniques. In order to be able to properly utilize measurement while drilling techniques, it is important to properly collect, analyze and interpret extracted data. This paper deals with processing of measurement while drilling data such as rate of penetration, rotary speed, rotary torque and pulldown force collected from rotary blasthole *** methods are discussed to calculate a true rate of penetration which is the most important monitored drill variable for use in rock mass characterization. Then specific energy of drilling is defined and calculated based on electrical and mechanical inputs and the results are compared. The results show that specific energy of drilling can be estimated using the drill's primary drive systems' electrical responses with good accuracy when compared to values based on mechanical inputs.

关键词： Measurement while drilling Rotary blasthole drill Specific energy Rate of penetration

Identifying MicroRNA and Gene Expression Networks Using Graph Communities

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Tsinghua Science and Technology 2016年第2期21卷 176-195页

作者： Benika hall Andrew Quitadamo Xinghua Shi Department of Bioinformatics University of North Carolina at CharlotteCharlotteNC 28213USA.

Integrative network analysis is powerful in helping understand the underlying mechanisms of genetic and epigenetic perturbations for disease studies. Although it becomes clear that microRNAs, one type of epigenetic factors, have direct effect on target genes, it is unclear how microRNAs perturb downstream genetic neighborhood. Hence, we propose a network community approach to integrate microRNA and gene expression profiles, to construct an integrative genetic network perturbed by microRNAs. We apply this approach to an ovarian cancer dataset from The Cancer Genome Atlas project to identify the fluctuation of microRNA expression and its effects on gene expression. First, we perform expression quantitative loci analysis between microRNA and gene expression profiles via both a classical regression framework and a sparse learning model. Then, we apply the spin glass community detection algorithm to find genetic neighborhoods of the microRNAs and their associated genes. Finally, we construct an integrated network between microRNA and gene expression based on their community structure. Various disease related microRNAs and genes, particularly related to ovarian cancer, are identified in this network. Such an integrative network allows us to investigate the genetic neighborhood affected by microRNA expression that may lead to disease manifestation and progression.

关键词： network integration graph community detection spin glass algorithm microRNA networks

A Survey of Image Synthesis and Editing with Generative Adversarial Networks

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Tsinghua Science and Technology 2017年第6期22卷 660-674页

作者： Xian Wu Kun Xu Peter hall TNList and the Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China the Department of Computer Science University of BathBathUK

This paper presents a survey of image synthesis and editing with Generative Adversarial Networks（GANs）. GANs consist of two deep networks, a generator and a discriminator, which are trained in a competitive way. Due to the power of deep networks and the competitive training manner, GANs are capable of producing reasonable and realistic images, and have shown great capability in many image synthesis and editing *** paper surveys recent GAN papers regarding topics including, but not limited to, texture synthesis, image inpainting, image-to-image translation, and image editing.

关键词： image synthesis image editing constrained image synthesis generative adversarial networks imageto-image translation

Building a Distributed Infrastructure for Scalable Triple Stores

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Journal of Computer Science & Technology 2009年第3期24卷 447-462页

作者：周菁 Wendy hall David De Roure School of Computer Science Communication University of China School of Electronics and Computer Science University of SouthamptonSouthamptonU.K.

Built specifically for the Semantic Web, triple stores are required to accommodate a large number of RDF triples and remain primarily centralized. As triple stores grow and evolve with time, there is a demanding need for scalable techniques to remove resource and performance bottlenecks in such systems. To this end, we propose a fully decentralized peer-to-peer architecture for large scale triple stores in which triples are maintained by individual stakeholders, and a semantics-directed search protocol, mediated by topology reorganization, for locating triples of interest. We test our design through simulations and the results show anticipated improvements over existing techniques for distributed triple stores. In addition to engineering future large scale triple stores, our work will in particular benefit the federation of stand-alone triple stores of today to achieve desired scalability.

关键词： peer-to-peer RDF data management semantics awareness scalability topology reorganization

Holocene vegetation change in relation to fire and volcanic events in Jilin, Northeastern China

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Science China Earth Sciences 2015年第8期58卷 1404-1419页

作者： ZHAO HongLi LI XiaoQiang Valerie A.hall State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of Sciences School of Geography Archaeology and Palaeoecology Queen's University Belfast

Volatiles erupted from large-scale explosive volcanic activities have a significant impact on climate and environmental *** an important ecological factor,the occurrence of fire is affected by vegetation cover,and fire can feed back into both vegetation and climatic *** causes of fire events are diverse;and can include volcanic *** amount of charcoal in sediment sequences is related to the frequency and intensity of fire,and hence under good preservation conditions fire history can be reconstructed from fossil charcoal *** now,little research on the role of fire has been carried out in northeastern *** this study,through research on charcoal and tephra shards from Gushantun and Hanlongwan,Holocene vegetation change in relation to fire and volcanic events in Jilin,Northeastern China,was *** tephra shards are present in Gushantun it is associated with low level of both conifers and broadleaved trees,and is also associated with a pronounced charcoal *** suggests forest cover was greatly reduced from a fire caused by an eruption of the Tianchi *** also detected one tephra layer in Hanlongwan,which also has the almost same depth with low level forest pollen values and one charcoal *** was caused probably by an eruption of the Jinlongdingzi volcano.

关键词： Holocene vegetation change fire history tephra shards volcanic events Northeastern China