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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Growth of the tropical Pinus kesiya as influenced by climate and nutrient availability along an elevational gradient

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Journal of Plant Ecology 2020年第1期13卷 97-106页

作者： Le Tuan Ho Raimund Schneider Frank m.thomas Department of Geobotany University of TrierFaculty of Regional and Environmental SciencesBehringstraße 2154296 TrierGermany Department of Forest Resources management Faculty of ForestryNong Lam University HCMCThu Duc DistrictHo Chi Minh CityVietnam Department of Soil Science University of TrierFaculty of Regional and Environmental SciencesBehringstraße 2154296 TrierGermany

Aims In contrast to temperate regions,the reasons for growth reductions of individual tree species along elevational gradients in tropical mountain ranges are poorly known,especially for tropical *** aimed at testing whether climatic or edaphic conditions are responsible for the reduced growth of Pinus kesiya,a widely distributed pine species of southern and south-eastern Asia,at higher *** We analysed the stem diameter increment and the isotope discrimination against ^(13)C(△^(13)C)in tree rings of *** along an elevational gradient of~900 to~2000 m *** the mountain ranges of South-Central Vietnam,and related growth to△^(13)C and to climatic and edaphic *** findings We found no consistent correlation patterns between the basal area increment(BAI)of the trees and temperature or *** contrast,across the elevational gradient,we obtained significantly negative correlations of BAI with△^(13)C and with the C/N ratios and theδ^(15)N signature of the upper mineral *** was positively correlated with the concentrations of plant-available phosphorus(P_(a))and of“base”cations(calcium,magnesium,potassium)in the *** conclude that lower temperatures at higher elevations exert an indirect effect on tree growth by inducing higher C/N ratios and by reducing the rate of nitrogen(N)and P mineralization,which may be further hampered by lower concentrations of“base”cations(upon enhanced leaching by precipitation)and a negative feedback from low availability of mineralized N and P at higher *** results may be transferable to the uppermost growth limit of *** and to other montane regions of the species’occurrence.

关键词： dendroecology pine pointer year soil nutrient stable isotope

Power flow forecasts at transmission grid nodes using Graph Neural Networks

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Energy and AI 2023年第4期14卷 189-200页

作者： Dominik Beinert Clara Holzhuter Josephine m.thomas Stephan Vogt Fraunhofer Institute for Energy Economics and Energy System Technology IEE Joseph-Beuys-Straße 8Kassel34117Germany Intelligent Embedded Systems Lab University of KasselWilhelmshöher Allee 73Kassel34121Germany

The increasing share of renewable energy in the electricity grid and progressing changes in power consumption have led to fluctuating,and weather-dependent power *** ensure grid stability,grid operators rely on power forecasts which are crucial for grid calculations and *** this paper,a multi-Task Learning approach is combined with a Graph Neural Network(GNN)to predict vertical power flows at transformers connecting high and extra-high voltage *** proposed method accounts for local differences in power flow characteristics by using an Embedding multi-Task Learning *** use of a Bayesian embedding to capture the latent node characteristics allows to share the weights across all transformers in the subsequent node-invariant GNN while still allowing the individual behavioral patterns of the transformers to be *** the same time,dependencies between transformers are considered by the GNN architecture which can learn relationships between different transformers and thus take into account that power flows in an electricity network are not independent from each *** effectiveness of the proposed method is demonstrated through evaluation on two real-world data sets provided by two of four German Transmission System Operators,comprising large portions of the operated German transmission *** results show that the proposed multi-Task Graph Neural Network is a suitable representation learner for electricity networks with a clear advantage provided by the preceding embedding *** is able to capture interconnections between correlated transformers and indeed improves the performance in power flow prediction compared to standard Neural Networks.A sign test shows that the proposed model reduces the test RmSE on both data sets compared to the benchmark models significantly.

关键词： Power flow forecasting Graph Neural Network Graph Convolutional Network Embedding multi-Task Learning

Stand structure and productivity of Populus euphratica along a gradient of groundwater distances at the tarim River(NW china)

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Journal of Plant Ecology 2017年第5期10卷 753-764页

作者： Frank m.thomas michael Jeschke Ximing Zhang Petra Lang Geobotany Faculty of Regional and Environmental SciencesUniversity of TrierBehringstraße 2154296 TrierGermany Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences40 South Beijing Road830011 UrumqiChina

Aims Along central-Asian rivers in arid regions,lowering of the ground-water level constitutes a major threat to the riparian forests,whose tree layers are dominated by Euphrates poplar(Populus euphratica).Some of these fragile ecosystems are supplied with additional(‘eco-logical’)water for protection and *** investigated interrelationships among groundwater distance,stand structure and above-ground wood production(at the tree and the stand level)in *** stands along a groundwater gradient(distances of 2.0-12.0 m)that also included a plot supplied with‘ecological water’.methods We measured the height,diameter at breast height and basal area of poplar trees and determined the annual above-ground wood production for the three most recent years on the basis of tree-ring analyses and allometric regressions at three sites at the upper,mid-dle and lower reaches of the tarim River,Xinjiang,NW *** Findingsthe distribution of age classes differed significantly among the plots:in accordance with their life histories,stands growing at a larger distance to the groundwater harboured a larger fraction of old trees(>80 years)and,in most cases,a smaller fraction of young trees(≤20 years).the annual above-ground wood production per ha was highest on a plot with a short groundwater distance(2.0 m;maxi-mum of the 3-year investigation period:3.0 t ha−1 a−1)and lowest,at a plot with a large distance to the water table(6.6 m;minimum:0.23 t ha^(−1)a^(−1)).However,the plot located close to the groundwater(and to the river)at the middle reaches exhibited a relatively large interannual variation in above-ground wood production,which can be attributed to interannual variations in the river *** the middle and the lower reaches,these interannual variations on plots with the most favourable water supply were even more obvious at the tree *** the fraction of mature trees(60-99 years old),no significant differences in above-ground wood production were

关键词： allometry ground water life history tree-age distribution tugai forest

Weather or weathering?Growth of Nothofagus dombeyi on volcanic soils differing in nitrogen and phosphorus concentrations

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Journal of Plant Ecology 2016年第5期9卷 596-607页

作者： Christoph Walter Cecilia A.Pérez Frank m.thomas Faculty of Regional and Environmental Sciences GeobotanyUniversity of TrierBehringstraße 2154296 TrierGermany Departamento de Ecología de Ecosistemas Instituto de Ecología y Biodiversidad(IEB)Alameda 340SantiagoChile

Aims We tested whether—in addition to weather conditions—the concentrations of nitrogen and phosphorus in the substrate have an effect on the radial stem increment of Nothofagus dombeyi trees in old-growth forest stands on volcanic soil at the western slopes of the Andes in South-Central *** We took soil samples and tree increment cores from five proximate sites(1000-1300 m a.s.l.)that are located in the volcanic region of the Conguillío National Park and differ in the age of the substrate(miocene—3500 years B.P.)and in its concentrations of nitrogen(N)and phosphorus(P).The soil samples were also analysed on their concentrations of other plant mineral nutrients,carbon(C)and nitrogen isotope ratios(δ^(15)N).Tree-ring widths and the stem basal area increment(BAI)were related to climate *** selected tree rings,the stable isotope ratios of carbon(δ^(13)C)and oxygen(δ^(18)O)were determined and related to growth and climate *** FindingsConsistent with theory,the soils on the oldest substrate showed the highest(least negative)δ^(15)N values,but mineral N was the only nutrient whose concentration exhibited a straightforward(increasing)relationship with increasing substrate *** BAI was largest on the soil with the highest concentration of plant-available *** contrast to BAI,tree-ring chronologies did not differ among the study ***,tree-ring chronologies and BAI exhibited significantly positive correlations with summer precipitation,and negative correlations,with summer(December)temperature.A negative correlation was found betweenδ^(13)C and precipitation anomalies in the growing season(November-march).We interpret the negative correlations between growth and temperature,and betweenδ^(13)C andδ^(18)O in the tree rings,as an impairment of net carbon assimilation by anomalously warm weather conditions during the growing *** conclude that the growth of *** is mainly affected by high temperature and low precipitation

关键词： Andisol annual ring dendroecology temperate broadleaf forest weather anomalies

Innovations with the scapula and subscapular system for head and neck microvascular reconstruction

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Plastic and Aesthetic Research 2023年第1期10卷 5-17页

作者： Farshad Chowdhury Eitan Prisman Carissa m.thomas Department of Otolaryngology-Head and Neck Surgery University of RochesterRochesterNY 14618USA Department of Otolaryngology-Head and Neck Surgery Vancouver General HospitalUniversity of British ColumbiaVancouverBC V5Z 1M9Canada Department of Otolaryngology-Head and Neck Surgery University of Alabama at BirminghamBirminghamAL 35294USA

microvascular free flap reconstruction based on the subscapular system is an established and versatile method of reconstructing complex head and neck *** the first published description in the mid-1980s,advances have been made to the harvest technique,positioning,use of virtual surgical planning,and endosseous ***,the most recent literature is reviewed for innovations related to the subscapular *** head and neck surgeon preferences related to the subscapular system are surveyed and *** concordance between virtual surgical plans using scapula cutting guides and pre-contoured plates with the postoperative result is assessed,and novel applications of the scapula free flap are *** system free flaps are an established and essential component of the reconstructive armamentarium for head and neck defects with minimal limitations and low donor site morbidity.

关键词： Scapula subscapular system microvascular reconstruction virtual surgical planning

How competitive is the‘pioneer-climax’tree species Nothofagus alpina in pristine temperate forests of Chile?

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Journal of Plant Ecology 2019年第1期12卷 144-156页

作者： Rebekka Bögelein Cecilia APérez Philipp Schäferand Frank m.thomas Faculty of Regional and Environmental Sciences GeobotanyUniversity of TrierBehringstraße 2154296 TrierGermany Present address:Thünen-Institut Institut für WaldökosystemeAlfred-Möller-Straße 116225 EberswaldeGermany Departamento de Ecología de Ecosistemas Instituto de Ecología y Biodiversidad(IEB)Alameda 340SantiagoChile

Aims Nothofagus species are constitutive elements of the temperate forests along the Southern Andes *** deciduous Nothofagus alpina is a fast-growing,but long-lived opportunistic pioneer spe-cies(‘pioneer-climax species’)and co-occurs with the evergreen *** tested whether *** is competitively superior to *** in mature stands and whether intra-specific competition in *** is stronger than inter-specific competition with *** In a pristine old-growth forest in South-Central Chile,we compared the growth of *** trees in pure stands and in mixture with *** to the growth of *** and calculated compe-tition *** related growth variables to climate data and weather *** Findings In ***,juvenile basal area increment was signifi-cantly higher in pure than in mixed *** to our hypothesis,*** exhibited larger radial stem increments than *** in the most recent 40 *** the most recent two decades,this was caused by high growth rates of large *** *** both Nothofagus species,stem growth was negatively related to temperature,but *** responded more sensitively to weather conditions than *** ***,stem increment was negatively related to the intensity of competition,but the size of the competition effects on this species was similar in pure and mixed ***,compared to ***,the‘pioneer-climax species’concept is even more appropriate for *** with its relatively high growth rates even in the early stages of its life.

关键词： competition index dendroecology growth-competition relationship pointer year productivity tree-ring analysis

microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation m1/m2 activation macrophages microglia neuroinflammation spinal cord injury therapy