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Ovarian autoimmune disease： clinical concepts and anima models

Cellular & Molecular Immunology 2014年第6期11卷 510-521页

作者： Bryce D Warren william k kinsey Lynda k McGinnis Lane k Christenson Susmita Jasti Anne M Stevens Brian k Petroff Margaret G Petroff Department of Anatomy and Cell Biology University of Kansas Medical Center Kansas City KS USA Department of Molecular and Integrative Physiology University of Kansas Medical Center Kansas City KS USA Research Center for Immunity and I mmunotherapies Children's Hospital and Regional Medical Center and Division of Rheumatology Department of Pediatrics University of Washington Seattle WA USA Department of Internal Medicine University of Kansas Medical Center Kansas City KS USA Present address: Department of Pathobiology and Diagnostic Investigation Michigan State University College of Veterinary Medicine East Lansing MI USA

The ovary is not an immunologically privileged organ, but a breakdown in tolerogenic mechanisms for ovary-specific antigens has disastrous consequences on fertility in women, and this is replicated in murine models of autoimmune disease. Isolated ovarian autoimmune disease is rare in women, likely due to the severity of the disease and the inability to transmit genetic information conferring the ovarian disease across generations. Nonetheless, autoimmune oophoritis is often observed in association with other autoimmune diseases, particularly autoimmune adrenal disease, and takes a toll on both society and individual health. Studies in mice have revealed at least two mechanisms that protect the ovary from autoimmune attack. These mechanisms include control of autoreactive T cells by thymus-derived regulatory T cells, as well as a role for the autoimmune regulator （AIRE）, a transcriptional regulator that induces expression of tissue-restricted antigens in medullary thymic epithelial cells during development of T cells. Although the latter mechanism is incompletely defined, it is well established that failure of either results in autoimmune-mediated targeting and depletion of ovarian follicles. In this review, we will address the clinical features and consequences of autoimmune-mediated ovarian infertility in women, as well as the possible mechanisms of disease as revealed by animal models.

关键词： Ovarian autoimmune clinical concepts animal models

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Developing momentum in vanishing index photonics

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Light(Science & Applications) 2022年第8期11卷 1633-1634页

作者： Nathaniel kinsey Department of Electrical&Computer Engineering Virginia Commonwealth UniversityRichmondVA23284USA

Refractive index invariably describes the speed at which light passes through materials,and subsequently its perceived *** what happens to these quantities as the index becomes zero?A new work explores this question,h... 详细信息

关键词： processes. momentum index

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Assessing gully erosion and rehabilitation using multi temporal LiDAR DEMs:Case study from the Great Barrier Reef catchments,Australia

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International Soil and Water Conservation Research 2024年第1期12卷 184-199页

作者： Sana khan Rebecca Bartley Anne kinsey-Henderson Aaron Hawdon The Commonwealth Scientific and Industrial Research Organisation(CSIRO) Environment1 James Cook DrDouglas4814Australia The Commonwealth Scientific and Industrial Research Organisation(CSIRO) EnvironmentGPO Box 2583BrisbaneQLD4001Australia

Millions of dollars are being spent on gully rehabilitation to help reduce excess fine sediment delivery to the Great Barrier Reef(GBR).There is an urgent need for(i)prioritisation of active gullies for rehabilitation and(ii)the development of methodologies to inform the effectiveness of *** this study we analyse DEMs of Difference derived from 0.5 m resolution 2-3 year interval multi-temporal LiDAR data collected pre and post rehabilitation at three variable gully morphologies in the Burdekin *** analysis indicates that the highest annual average fine sediment erosion rates for the untreated control gullies occur at the linear gully(53.38 t ha^(-1)y^(-1))followed by linear-alluvial gully(34.24 t ha^(-1)y^(-1))and least at the alluvial gully(14.41 t ha^(-1)y^(-1)).The proportional loss or export of fine sediment from the gullies in their un-treated condition ranges from∼68 to 90%of what is eroded,and when the gullies are treated the proportion of fine sediment that is retained in the gully proportional to what is eroded increases to∼60%at all *** pre-treatment baseline erosion rates,and additional post treatment LiDAR captures,it is difficult to quantify the treatment *** results offer insights in the erosion mechanisms within different geomorphic gully morphologies and rehabilitation effects in these erosional *** study provides crucial knowledge of gully dynamics that can be coupled with other lines of evidence for better prioritisation of rehabilitation in the GBR catchments.

关键词： Digital elevation models (dis)connectivity Restoration Geomorphic change detection Geomorphic effectiveness GIS

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Response to comment by Daley et al.,on"Assessing gully erosion and rehabilitation using multi temporal LiDAR DEMs:Case study from the Great Barrier Reef catchments,Australia"

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International Soil and Water Conservation Research 2024年第3期12卷 741-745页

作者： Sana khan Rebecca Bartley Anne kinsey-Henderson Aaron Hawdon The Commonwealth Scientific and Industrial Research Organisation(CSIRO) EnvironmentDouglas4814Australia The Commonwealth Scientific and Industrial Research Organisation(CSIRO) EnvironmentBrisbaneQLD4001Australia

Daley et al.(2023a)argue that at least 10-15 years apart Digital Elevation Model(DEM)derived DEMs of Difference(DoD)surveys are needed to detect reliable geomorphic change within the gullied landscapes of the Great Barrier Reef,*** acknowledge that the reliability of observed geomorphic change increases as more subtle geomorphic processes are detected with longer monitoring *** further good quality long-term legacy datasets become available,we encourage utilising these to improve confidence in targeting erosion ***,our approach to consistently apply 2-3 year DoDs to contrasting gully morphologies enabled capture of more intense geomorphic processes acting over shorter timeframes and provided valuable and timely information on(i)contrasting erosional mechanisms and erosion rates between variable gully morphologies,and(ii)rehabilitation efforts *** this paper,we take the opportunity to concisely address all the concerns raised by Daley et al.(2023a).

关键词： Digital elevation models(dis)connectivity Restoration Geomorphic change detection Geomorphic effectiveness GIS

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基于实际演练和仿真模拟的高速列车人员疏散行为模式

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中国铁道科学 2022年第2期43卷 172-182页

作者：陶桂东李莉张国安 Michael kinsey 宋楠中车青岛四方机车车辆股份有限公司技术中心山东青岛266000 奥雅纳工程咨询(上海)有限公司消防组上海200030

采用全尺寸高速列车作为演练地,研究发生火灾时列车上整体人员的疏散行为。设计不同实验变量,设置涵盖整列站台疏散、整列轨面疏散、单车行李疏散和单车团体疏散4大类别的疏散场景13个,运用实际演练和MassMotion软件仿真模拟2种方法,对... 详细信息

采用全尺寸高速列车作为演练地,研究发生火灾时列车上整体人员的疏散行为。设计不同实验变量,设置涵盖整列站台疏散、整列轨面疏散、单车行李疏散和单车团体疏散4大类别的疏散场景13个,运用实际演练和MassMotion软件仿真模拟2种方法,对比不同场景下不同实验变量对高速列车上人员疏散的行为影响,研究MassMotion软件用于高速列车人员疏散仿真的适用性。结果表明:在列车所有出口均保持开启状态的整列站台疏散场景中,全定员576人完成疏散共用时96 s,各出口的疏散流量基本在1.2~1.4人·(s·m)^(-1);对疏散效率造成影响的因素主要包括车厢出口数量、乘客疏散时是否携带行李以及携带行李的乘客比例,为尽量减小火灾带来的影响,列车设计时应尽量避免单出口车厢,并在火灾时通过疏散广播等形式明确告知乘客不要携带行李;MassMotion软件能够较好地预测人员疏散趋势,但由于内置参数较实际情况存在差异,模拟得到的疏散率整体趋于保守,在回避其局限性的基础上仍可将此软件用于新型列车的前期设计。

关键词：高速列车列车火灾人员疏散实际演练仿真模拟

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TkA术中股骨假体悬突的危险因素与临床后果

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中华骨科杂志 2010年第12期30卷 I0015-I0020页

作者： OrmondeM. Mahoney Tracy kinsey 张宇(译) 刘军(译) Investigation performed at the Athens Orthopedic Clinic Athens Georgia 天津市人民医院关节外科 300121

背景：近年来，全膝关节置换（total knee arthroplasty，TkA）术中的股骨假体悬突现象日益引起骨科医生的重视。本文目的为研究男性与女性患者TkA术后股骨假体悬突的发生率、确定预测悬突发生的危险因素以及假体悬突是否与术后疼痛或... 详细信息

背景：近年来，全膝关节置换（total knee arthroplasty，TkA）术中的股骨假体悬突现象日益引起骨科医生的重视。本文目的为研究男性与女性患者TkA术后股骨假体悬突的发生率、确定预测悬突发生的危险因素以及假体悬突是否与术后疼痛或膝关节活动度的降低有关。方法：对437例使用同一假体系统的TkA术中的股骨假体悬突进行测量。假体牢固固定后，分别在10个分区的中点以mm刻度测量其超出截骨面边缘的悬突程度。寻找假体悬突的预测因素，并研究假体悬突对术后疼痛及膝关节屈曲度的影响。结果：男性患者176膝中的40％（71膝）、女性患者261膝中的68％（177膝）至少在1个分区内发生≥3mm悬突，且常见于外侧2区（前远侧区）和3区（远侧区）。多因素分析模型中，女性、身材矮小以及使用大号股骨假体是发生明显悬突的强预测因素。1个或1个以上分区存在≥3mm股骨假体悬突几乎可使术后2年发生明显膝关节疼痛的风险加倍[比数比1．9，95％可信区间为（1．1，3．3）]。结论：本组病例中股骨假体悬突的发生率高，女性患者更常见且更严重；不论男性患者还是女性患者，使用的股骨假体越大，假体悬突的发生率和严重程度越高。≥3mm股骨假体悬突可使TkA术后2年有临床意义的疼痛发生率加倍。

关键词：股骨假体危险因素 TkA 悬突临床后果全膝关节置换术后疼痛女性患者

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Physiological phenotypes differ among color morphs in introduced common wall lizards(Podarcis muralis)

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Integrative Zoology 2024年第3期19卷 505-523页

作者： Ali AMER Sierra SPEARS Princeton L.VAUGHN Cece COLWELL Ethan H.LIVINGSTON Wyatt MCQUEEN Anna SCHILL Dustin G.REICHARD Eric J.GANGLOFF kinsey M.BROCk Department of Biological Sciences Ohio Wesleyan UniversityDelawareOhioUSA Department of Ecology and Evolutionary Biology Princeton UniversityPrincetonNew JerseyUSA Department of Biology Idaho State UniversityPocatelloIdahoUSA Department of Environmental Science Policyand ManagementCollege of Natural ResourcesUniversity of CaliforniaBerkeleyUSA Museum of Vertebrate Zoology University of CaliforniaBerkeleyUSA

Many species exhibit color polymorphisms which have distinct physiological and behavioral ***,the consistency of morph trait covariation patterns across species,time,and ecological contexts remains *** trait covariation is especially relevant in the context of invasion biology and urban ***,physiological traits pertaining to energy maintenance are crucial to fitness,given their immediate ties to individual reproduction,growth,and population *** investigated the physiological traits of Podarcis muralis,a versatile color polymorphic species that thrives in urban environments(including invasive populations in Ohio,USA).We measured five physiological traits(plasma corticosterone and triglycerides,hematocrit,body condition,and field body temperature),which compose an integrated multivariate *** then tested variation among co-occurring color morphs in the context of establishment in an urban *** found that the traits describing physiological status and strategy shifted across the active season in a morph-dependent manner—the white and yellow morphs exhibited clearly different multivariate physiological phenotypes,characterized primarily by differences in plasma *** suggests that morphs have different strategies in physiological regulation,the flexibility of which is crucial to urban *** white-yellow morph exhibited an intermediate phenotype,suggesting an intermediary energy maintenance *** morphs also exhibited distinct phenotypes,but the low prevalence of this morph in our study populations precludes clear *** work provides insight into how differences among stable polymorphisms exist across axes of the phenotype and how this variation may aid in establishment within novel environments.

关键词： color polymorphism physiological status seasonal variation thermoregulation urban habitat

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金属薄板微型弯曲过程中几何位错密度的预测模型研究

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热加工工艺 2013年第7期42卷 112-113,117页

作者：王丽捷 kinsey B L 韩翠红刘鹏鑫天津职业技术师范大学机械工程学院天津300222 Unversity of New Hmapshire NH US 03824

在加工过程中,应变梯度硬化会消耗更多的外力,引起不必要的耗损。从应变梯度硬化角度出发,对平面弯曲过程的几何关系进行了分析,得到了几何必需位错密度与应变梯度的理论关系式,并据此建立了模型预测金属薄板平面微型弯曲过程中应变梯... 详细信息

在加工过程中,应变梯度硬化会消耗更多的外力,引起不必要的耗损。从应变梯度硬化角度出发,对平面弯曲过程的几何关系进行了分析,得到了几何必需位错密度与应变梯度的理论关系式,并据此建立了模型预测金属薄板平面微型弯曲过程中应变梯度与薄板厚度的关系。预测模型计算结果与其他预测方法的结果一致。

关键词：几何位错密度微型弯曲平面应变应变梯度硬化

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Providing refuges for adult Pacific lamprey Entosphenus tridentatus inside fishways

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Aquaculture and Fisheries 2021年第2期6卷 144-150页

作者： Mary L.Moser Matthew L.keefer Stephen C.Corbett kinsey E.Frick Christopher C.Caudill Sean C.Tackley Northwest Fisheries Science Center National Marine Fisheries ServiceNational Oceanic and Atmospheric AdministrationSeattleWA98112USA Department of Fish and Wildlife Sciences College of Natural ResourcesUniversity of IdahoMoscowID83844-1136USA Ocean Associates ArlingtonVA22207USA U.S.Army Corps of Engineers Environmental Resources BranchPortlandOR97204-3440USA

Fishways at hydroelectric dams are unnatural environments that typically present fish with channels of uniform depth,variable water velocity,and lack of *** retention and overall passage success may be improved by providing rest and sheltering areas inside *** examined adult Pacific lamprey Entosphenus tridentatus use of two specially designed fishway refuges at Bonneville Dam on the Columbia River(northwestern USA).These relatively small boxes(1.1 m×0.4 m×0.2 m)provided low-velocity,dark refuge from predation for Pacific lamprey,a largely nocturnal *** boxes were equipped with antennas to detect entry of lamprey tagged with passive integrated transponder(PIT)*** PIT tagged and released 3,247 lamprey,including 599 that were double-tagged with a PIT and a radio transmitter,over three study years(2012-2014).In each year,PIT-tagged lamprey detected at nearby fishway exits had used a refuge:12%in 2012,28%in 2013,and 36%in *** residence time of PIT-tagged lamprey in the refuges for each year was 20.3 h,16.6 h,and 13.1 *** entrance into refuges peaked at 0300-0500 PDT,and they typically exited at around 2000 PDT,suggesting that refuges primarily functioned as shelter from *** of refuge use increased with a morphological indicator of sexual maturity(distance between dorsal fins).In the radio-tagged group,refuge users were equally likely to pass Bonneville Dam as ***,refuge users were less likely than non-users to be detected at sites upstream from the dam,perhaps owing to their maturation status or longer mean passage time through our study area(2.0 vs.0.6 d for non-users).Refuges show promise for improving fish retention in fishways,particularly for nocturnal and/or small-bodied species that seek shelter from light or predation.

关键词： fish passage retention

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员工为何知而不言

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管理@人 2008年第3期 54-55页

作者： CAROL kinsey GOMAN

以知识分享实现员工充分交流下的协作，被看作是企业成功的根本。领导者要鼓励知识分享，保证每个员工都能了解企业的方方面面，包括财务、有竞争力的产品或服务，以及企业的战略。要让员工分享知识，领导者首先要了解员工为何不愿意分享。

关键词：员工知识分享企业成功领导者竞争力财务工分

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