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Journal of Genetics and Genomics 2019年第8期46卷 405-407页

作者： hongwei Li willem h.p.boshoff Zacharias A.pretorius Qi Zheng Bin Li Zhensheng Li State Key Laboratory of plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing100101China Department of plant Sciences University of the Free StateBloemfontein9300South Africa

Stem rust, caused by puccinia graminis pers.:pers. f. sp. tritici Eriks. & E. henn. (pgt), is a destructive wheat disease and has the potential to cause significant yield losses (Olivera et al., 2015;Soko et al., 2018). The emergence of pgt race TTKSK, virulent to the widely deployed stem rust resistance gene Sr31 and originally named as isolate pgt-Ug99 (pretorius et al., 2000).

关键词： Establishment wheat-Thinopyrum ponticum

The Use of Intramuscular praziquantel in South-African Ruminants against Cestode parasites. A First pilot Study

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pharmacology & pharmacy 2022年第10期13卷 417-428页

作者： C. Vermaak C. boshoff Endip Wildlife Laboratory Phalaborwa South Africa

The objective of this small pilot study was to test the efficacy and potential development for the use of praziquantel IM Cestodicide in South African goats. Two farms were identified as infected with the Cestode Moniezia spp, and a test herd as well as a control herd was set aside on each of these farms. Fecal float coprological analyses were performed before and after treatment of the test herds, while no treatment was administered to the animals in the control herds of each farm. praziquantel treatment proofed to be effective in reducing Cestode numbers based on egg counts using the Mac-Master method.

关键词： praziquantel Tapeworms Moniezia Goats Mac-Master

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非小细胞肺癌的个体化治疗进展

中国肺癌杂志 2022年第3期25卷 I0007-I0024页

作者： Meina WANG Roy S hERBST Chris boshoff 杨雪(译校) 赵军(译校) Yale Comprehensive Cancer Center Yale School of MedicineNew HavenCTUSA pfizer Inc. New York CityNYUSA 北京大学肿瘤医院胸部肿瘤内一科

肺癌是全球癌症相关死亡的最常见原因.在过去20年中,分子靶向治疗和免疫治疗显著改善了非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者的预后.然而,绝大多数的晚期NSCLC会对目前治疗产生耐药,最终出现疾病进展.基于此,本综述就近... 详细信息

肺癌是全球癌症相关死亡的最常见原因.在过去20年中,分子靶向治疗和免疫治疗显著改善了非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者的预后.然而,绝大多数的晚期NSCLC会对目前治疗产生耐药,最终出现疾病进展.基于此,本综述就近年来出现的一些突破性NSCLC治疗方法,尤其是免疫治疗和靶向治疗展开讨论.同时强调了目前我们对耐药机制的理解以及将基因组分析纳入临床研究以进一步理解机制的重要性.我们认为新辅助和联合的维持治疗在未来有可能使早期阶段疾病得到治愈.合理的联合治疗未来发展所面临的主要挑战是如何通过可靠的预测性生物标志物将患者清晰分层.本文阐述了我们对未来十年可能影响NSCLC治疗策略的临床研究领域的观点.

关键词：分子靶向治疗非小细胞肺癌个体化治疗维持治疗免疫治疗晚期NSCLC 疾病进展基因组分析

ChARACTERIZATION OF A NOVEL ANTIApOpTOTIC pROTEIN,SURVIVIN-DELEX3,A NATURALLY OCCURRING SpLICED VARIANT OF hUMAN SURVIVIN

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CHARACTERIZATION OF A NOVEL ANTIAPOPTOTIC PROTEIN,SURVIVIN-D...

抗Ug99小偃麦易位系的细胞遗传学分析及标记开发

The 4th Asian-pacific Organization for Cell Biology Congress Cell Biology in the post-Genomic Era

作者： hsei-Wei Wang Andrew Koumi Chris boshoff The Cancer Research UK Viral Oncology Group Wolfson Institute for Biomedical ResearchCruciform BuildingUniversity College LondonLondon WC1E 6BT

Survivin is the smallest known 1Ap family protein that contains a single BIR domain with which it binds caspases and prevents caspase-induced apoptosis. A splice variant of Survivin, Survivin-delEx3, which can protect cells from apoptosis by an undefined mechanism, has been identified in cancer cells and fetal tissues. Computational analyses revealed survivin-delEx3 is structurally

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抗Ug99小偃麦易位系的细胞遗传学分析及标记开发

第十届全国小麦基因组学及分子育种大会

作者：杨国堂 willem boshoff Zacharias A.pretorius 李宏伟罗巧玲胡盼李滨李振声郑琪植物细胞与染色体工程国家重点实验室/中国科学院遗传与发育生物学研究所/中国科学院种子创新研究院/中国科学院中国科学院大学南非自由州立大学植物科学系

秆锈病是世界范围内小麦的重要病害之一。新型秆锈菌致病小种Ug99于1998年首次在乌干达被发现。因其变异能力强、传播速度快、蔓延范围广,Ug99及其变异小种对全球小麦生产造成严重威胁,已引起各国小麦科技工作者的高度重视。本课题组利... 详细信息

秆锈病是世界范围内小麦的重要病害之一。新型秆锈菌致病小种Ug99于1998年首次在乌干达被发现。因其变异能力强、传播速度快、蔓延范围广,Ug99及其变异小种对全球小麦生产造成严重威胁,已引起各国小麦科技工作者的高度重视。本课题组利用Ug99变异小种pTKST,通过苗期抗病性鉴定筛选到一份高抗(IT=1;)的小偃麦易位系WTT34。顺序荧光原位杂交及双色荧光原位杂交(Sequential genomic and multicolor-fluorescent in situ hybridization,Sequential GISh-FISh)检测表明,该易位系含有42条染色体,包括20对小麦染色体及1对小麦-长穗偃麦草易位染色体T5DS-5DL-Th。利用与长穗偃麦草已知抗秆锈病基因Sr24,Sr25,Sr26和Sr43紧密连锁的标记扩增WTT34的基因组DNA,结果未能扩增出目标条带,推测该易位片段可能携带新的抗病基因。利用SLAF测序(Specific length amplified fragment sequencing,SLAF-Seq)技术和生物信息学分析WTT34,长穗偃麦草和中国春基因组,共开发51个长穗偃麦草易位片段的特异分子标记。利用这些标记可以高效追踪外源染色体片段,为开展小麦抗病育种研究奠定坚实的基础。

关键词： Ug99 小偃麦易位系抗病顺序GISh-FISh SLAF测序

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用混合相气体色谱测定甲拌磷及其代谢物

世界农药 1981年第4期 49-53页

作者： philip R. boshoff Victor pretorius 林荫诚 (南非)pretoria大学 (南非)pretoria大学

近来,混合相气体色谱出现了新的进展并且用于测定甲拌磷及其代谢物。采用的固定相有OV-101,OV-17,OV-225和Apolar-5Cp。甲拌磷——O,O-二乙基S-乙硫基甲基二硫代磷酸酯（I）作为杀虫剂已广泛用于各种作物的保护。由于它对温血动物高毒(... 详细信息

近来,混合相气体色谱出现了新的进展并且用于测定甲拌磷及其代谢物。采用的固定相有OV-101,OV-17,OV-225和Apolar-5Cp。甲拌磷——O,O-二乙基S-乙硫基甲基二硫代磷酸酯（I）作为杀虫剂已广泛用于各种作物的保护。由于它对温血动物高毒(大鼠LD501.5毫克/公斤),就特别需要监测其残留量。

关键词：甲拌磷代谢物代谢产物有机磷杀虫剂混合相气体色谱

右室流出道的Contegra导管可导致主动脉瓣上狭窄

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 59-60页

作者： Meyns B. Van Garsse L. boshoff D. 孟欣

We sought to evaluate the incidence and nature of pulmonary stenosis after imp lantation of the bovine jugular vein graft(Contegra; Medtronic, Inc, Minneapolis , Minn) in the right ventricular outflow tract. Between May 2000 and September 2 002, 58 Contegra conduits(8-22 mm) were implanted during primary(n=27) or redo operations (n=31) in 57 patients, with ages ranging from 2 days to 48 years(mean , 9 years). Indications were truncus arteriosus(n=16), tetralogy of Fallot(n=28) , pulmonary replacement in the Ross operation(n=10), and Rastelli-type repair f or double-outlet right ventricle(n=4). Echocardiography was prospectively perfo rmed by a fixed team of investigators during follow-up(mean, 22.7±10 months). A peak gradient of greater than 50 mm hg was considered severe stenosis. Two pat ients died from Staphylococcus aureus-induced septicemia and enterococcal endoc arditis after 12 days and 12 weeks, respectively. One patient died of heart fail ure caused by endocardial fibroelastosis after 1 year. Freedom from severe steno sis at the distal anastomosis was 91%±. 3%at 3 months, 68%±6%at 12 months, and 49%±8%at 24 months. The risk of development of stenosis does not change over time. Younger age and its derivatives(graft sizeand indication) are signifi cantly related to the occurrence of severe stenosis(pplanted(endocarditis, 2; stenosis, 5). histologic analy sis of the explanted conduits showed excessive proliferation of neointima at the level of the distal anastomosis. Valve regurgitation was observed in 9(16%) co nduits and was always secondary to dilatation in the presence of severe distal s tenosis. The Contegra conduit induces a neointimal proliferation at the level of the pulmonary anastomosis. This leads to a high incidence of severe stenosis at intermediate-term follow-up. Copyright.

关键词：主动脉瓣上狭窄 Contegra 右室流出道动脉瓣置换法洛四联症右心室双出口心内膜炎肺动脉狭窄超声心动图动脉干

The Use of Intramuscular praziquantel in South-African Ruminants against Cestode parasites. A First pilot Study

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氮对深色晾烟中非还原氮和烟草特有亚硝胺的影响

pharmacology ＆ pharmacy 2022年第10期

作者： c. vermaak c. boshoff

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中国烟草学报 2004年第6期10卷 32-32页

作者： boshoff h J 孙希芳南非