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Koena, a Novel Compound That Dampens Inflammation in the Skin

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第1期13卷 45-52页

作者： Paul turner Koena Pharmaceuticals Melbourne Australia Department of Otolaryngology Faculty of Medicine Dentistry and Health Sciences University of Melbourne Melbourne Australia

Inflammatory skin diseases are characterized by the activation of the innate and adaptive immune system via the production of pro-inflammatory cytokines. The main proinflammatory cytokines responsible for this development include TNF-alpha, Interleukin 1, 6 and 17, also the transcription factor NF-kappa B. Small molecule anti-inflammatory compounds such as those detailed in the paper, show much promise in dealing with these skin disorders. Four nutraceutical molecules that are well characterized by their capacity to interact with many of the pro-inflammatory cytokines, importantly IL-17, are found in an Australian product, Koena. Koena has been shown to not only decrease these cytokines but also help increase the production of Interleukin 10 and important anti-inflammatory cytokines. This paper reports clinical benefits of Koena in a variety of circumstances;eczema and psoriasis;insect bites and sting;solar damaged skin and keratosis. An analysis of patient/purchaser reviews via the website *** to ascertain what condition they purchased the product for, if any, and the satisfaction rating after use. More than 35% of reviewers reported purchasing Koena to help with inflamed skin. Those reporting being satisfied with the result was 95% for this use. This paper reports on the benefit of small molecule anti-inflammatories in modulating and not blocking an immune response. It also illustrates the benefits of multitherapy when dealing with complex inflammatory responses as opposed to monotherapy.

关键词： Cytokines Inflammatory Skin Disorders Transcription Factors Koena

On the Pre-Forging Heating Methods for AA2014 Alloy

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World Journal of Engineering and Technology 2023年第4期11卷 893-901页

作者： richard turner William turner Hao Wu School of Metallurgy & Materials University of Birmingham Birmingham UK

The aluminium alloy AA2014 is one of the most widely used of the 2xxx series alloys, owing to its superior strength-to-weight ratio and stiffness. It is commonly forged to shape for use in aerospace parts. Three different small pilot-scale AA2014 billets were subjected to different heating operations, to physically simulate a pre-forge heating operation. The unheated sample and heated samples were then analysed for micro structural evolution and mechanical properties, to understand how the pre-forge heat treatments may vary the starting condition of the alloy before being forged. It was shown that an induction heating process has the greatest impact upon the precipitation distribution. Whilst this variation is commonly considered a negative impact, the opportunity to control the induction heating to promote preferential microstructure at specific locations within the billet may be possible.

关键词： Precipitate Hardness Microstructure Heat Treatment

A Systematic Approach to Pulmonary Valve replacement in the Current Era

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Congenital Heart Disease 2021年第3期16卷 285-297页

作者： r.Allen Ligon Larry A.Latson Mark M.ruzmetov Kak-Chen Chan Todd roth Immanuel I.turner Frank G.Scholl Steve Bibevski The Pediatric Heart Institute Joe DiMaggio Children’s HospitalMemorial Regional Hospital-Memorial Healthcare SystemHollywoodFloridaUSA Division of Congenital Cardiothoracic Surgery The Pediatric Heart InstituteJoe DiMaggio Children’s HospitalFloridaUSA

Background:Pulmonary valve replacement(PVr)can be accomplished via surgical,transcatheter,or hybrid *** are inherent advantages to transcatheter PVr and hybrid PVr without cardiopulmonary *** review the methods and results of a standardized institutional approach to ***:retrospective review of all PVr cases between February 2017 and February *** PVr entailed off-pump rVOT plication with percutaneous transcatheter ***:Primary transcatheter PVr was attempted in 37,hybrid PVr was performed in 11,and on-pump surgical PVr was performed in *** age at PVr was 27 years(6–65).Primary transcatheter PVr was successful in 35/37(2 converted to surgical).Standard surgical PVr was utilized for positive coronary compression testing(n=4),stent/valve system migration(n=2),or patient preference(n=3).In the hybrid group mean rVOT diameter was 34 mm(32–38).Median length of stay was 1 day for transcatheter PVr,5 for surgical,and 3 for hybrid(p=0.02).Median follow-up was 1.5 ***-interventions were one balloon valve dilation in a transcatheter PVr,and one valve dilation with subsequent transcatheter valve-in-valve PVr in the surgical *** hybrid patient expired 11 months post ***:A systematic approach to PVr utilizing all approaches in pre-defined order of preference leads to consistent outcomes in a wide variety of anatomic *** PVr may be accomplished in the majority of *** necessary,hybrid off-pump rVOT plication with transcatheter PVr avoids the need for cardiopulmonary bypass.

关键词： Transcatheter pulmonary valve replacement adult congenital heart disease congenital heart disease

The pervasive effects of lighting environments on sensory drive in bluefin killifish： an investigation into male/male competition, female choice, and predation

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Current Zoology 2018年第4期64卷 499-512页

作者： Lisa D. MITCHEM Shannon STANIS Nicholas M. SUTTON Zachary turner rebecca C. FULLEr School of Integrative Biology University of Illinois Urbana IL 61801 USA Department of Biology University of Virginia Charlottesville VA 22904 USA Department of Mathematics University of Illinois Urbana IL 61801 USA

Sensory drive predicts that the conditions under which signaling takes place have large effects on signals, sensory systems, and behavior. The coupling of an ecological genetics approach with sen sory drive has been fruitful. An ecological genetics approach compares populations that experi ence different environments and asks whether population differences are adaptive and are the result of genetic and/or environmental variation. The multifaceted effects of signaling environ ments are wellexemplified by the bluefin killifish. In this system, males with blue anal fins are abundant in tanninstained swamps that lack UV/blue light but are absent in clear springs where UV/blue light is abundant. Past work indicates that lighting environments shape genetic and envir onmental variation in color patterns, visual systems, and behavior. Less is known about the select ive forces creating the across population correlations between UV/blue light and the abundance of blue males. Here, we present three new experiments that investigate the roles of lighting environ ments on male competition, female mate choice, and predation. We found strong effects of lighting environments on male competition where blue males were more likely to emerge as dominant in teastained water than in clear water. Our preliminary study on predation indicated that blue males may be less susceptible to predation in teastained water than in clear water. However, there was little evidence for female preferences favoring blue males. The resulting pattern is one where the effects of lighting environments on genetic variation and phenotypic plasticity match the direction of selection and favor the expression of blue males in swamps.

关键词： Lucania goodei adaptive plasticity intrasexual selection male competition private communication predation

头皮屑产生与角质功能障碍(第一部分：微生物和头皮屑)

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临床皮肤科杂志 2013年第5期42卷 321-324页

作者： Graham A.turner Michael Hoptroff Clive r.Harding 联合利华Port Sunlight研发中心 BebinglonMerseysideUK 英国CH63 3JW

典型头皮屑是指头皮表面粘着的薄片状瘙痒性皮屑,据不完全统计,全球青春期后一半以上的人群被头皮屑所困扰。关于头皮屑的病因是多因素的,但马拉色菌的定植、皮脂分泌和个体易感性是最重要的3个因素。共生酵母菌马拉色菌的定植对头皮屑... 详细信息

典型头皮屑是指头皮表面粘着的薄片状瘙痒性皮屑,据不完全统计,全球青春期后一半以上的人群被头皮屑所困扰。关于头皮屑的病因是多因素的,但马拉色菌的定植、皮脂分泌和个体易感性是最重要的3个因素。共生酵母菌马拉色菌的定植对头皮屑的形成有重要作用,但马拉色菌同时存在于健康头皮上,这一点说明该菌不是导致头皮屑形成的惟一原因。

关键词：头皮屑马拉色菌角质层头皮脂肪酸

A Finite Element Model to Investigate the Impact of Torch Angle on an Autogenous TIG Welding Process

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World Journal of Engineering and Technology 2017年第4期5卷 743-753页

作者： richard turner PrISM² research Group School of Metallurgy & Materials University of Birmingham Birmingham UK

A numerical modelling activity was completed to explore the impact that the angle θ created by the torch from the vertical had upon the thermal and mechanical predictions for a T-joint autogenous TIG welded component. A parametric system of 9 models was set-up to simulate the effects of varying the angle θ by a small, potentially unnoticeable amount to a manual operator. The variations ranged from -8° to +8° away from a nominal default position of torch. The numerical models were created and computed using specialist welding simulation software Sysweld, and pre/post-processing software Visual Environment (both owned by ESI Group). The resulting weakly-coupled thermal and mechanical analyses illustrated a small deflection of angle that the weld bead was penetrating in to the T-joint, consistent with the variation in torch angle, and a negligible variation in peak temperature of 1.8%. The mechanical results however demonstrated a more significant output, namely that the distortion observed upon the vertical plate within the T-joint was predicted to increase by over 50% as result of this small shift in the welding torch angle. However, other mechanical predictions for plastic strain, Von Mises residual stress and distortion on the horizontal plate, were all suggesting only very minor sensitivity (typically less than 5%) to the torch angle variation. However, the predictions for vertical plate distortions demonstrate how difficult a manual TIG operation can be to perform with sufficient process control and repeatability, due to the significant impact that human operator-induced variation has upon some of the mechanical outputs.

关键词： Arc Welding Distortion Von Mises residual Stress Plastic Strain

The Animistic Turn:Implications for the Anthropology of the Anima

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宗教人类学 2015年第1期 3-17页

作者： Edith turner 美国弗吉尼亚大学人类学系

In the anthropology of the 1950’s if researchers"went native",it might doom them *** turner and I spent two and a half years among the Ndembu of *** people believed in spirits,and like many researchers we merely stud... 详细信息

关键词：精神现象宗教人类发展现状

The Effects of a Unilateral Strength and Power Training Intervention on Inter-Limb Asymmetry and Physical Performance in Male Amateur Soccer Players

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Journal of Science in Sport and Exercise 2023年第4期5卷 328-339页

作者： Francesco Bettariga Luca Maestroni Luca Martorelli Paul Jarvis Anthony turner Chris Bishop StudioErre Via della Badia1825127 Brescia(BS)Italy School of Medical and Health Sciences Edith Cowan UniversityJoondalupAustralia School of Science and Technology London Sport InstituteMiddlesex UniversityGreenlands LaneLondonUK reAct Via Madonna della Neve 2424121 BergamoBGItaly

The aims of this study were(a)to investigate the effects of a unilateral training program in reducing inter-limb asymmetry in male soccer players;(b)to explore such effects on measures of physical performance and unilateral inter-limb ***-four soccer players,randomly assigned to a 6-week unilateral strength and power training(UNI)(n=12)or a control group(CON)(n=12),performed single countermovement jump(SLCMJ),single leg broad jump(SLBJ),single leg drop jump(SLDJ),10-m sprint,and 505 change of direction(COD)speed *** jump scores revealed small to large improve-ments in SLCMJ,SLBJ,and SLDJ reactive strength index(rSI)(g=0.46 to 1.66)in the UNI group,whereas negligible changes were found in the CON group(g=−0.31 to 0.33).Asymmetry indexes showed a moderate significant reduction in the SLDJ(rSI)and in the SLDJ stiffness(K)(g=1.00 to 1.11)in the UNI *** between-group comparison indicated a significant change in the SLDJ(rSI)and in the SLDJ(K)(g=1.01 to 1.07)in favour of the UNI ***,a unilateral training program seems to be able to reduce between-limb imbalances and foster improvements in jump performance,without any detrimental effects on linear or COD speed *** the importance of these physical characteristics for soccer,it is suggested that unilateral strength and power training are incorporated into strength training routines for players of all levels.

关键词： Inter-limb asymmetry Training program intervention Between-limb differences resistance training Plyometrics Football Physical performance

Comparison of a Manual and an Automated Tracking Method for Tibetan Plateau Vortices

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Advances in Atmospheric Sciences 2018年第8期35卷 69-84页

作者： Julia CUrIO Yongren CHEN reinhard SCHIEMANN Andrew G. turner Kai Chi WONG Kevin HODGES Yueqing LI NCAS-Climate University of Reading Reading RG6 6BB UK Department of Meteorology University of Reading Reading RG6 6BB UK Institute of Plateau Meteorology China Meteorological Administration Chengdu 610072 China Heavy rain and Drought-Flood Disasters in Plateau and Basin Key Laboratory of Sichuan Province Chengdu 610072 China

Tibetan Plateau vortices （TPVs） are mesoscale cyclones originating over the Tibetan Plateau （TP） dnring the extended summer season （April-September）. Most TPVs stay on the TP, but a small number can move off the TP to the east. TPVs are known to be one of the main precipitation-bearing systems on the TP and moving-off TPVs have been associated with heavy precipitation and flooding downstream of the TP （e.g., in Sichuan province or over the Yangtze river Valley）. Identifying and tracking TPVs is difficult because of their comparatively small horizontal extent （400-800 kin） and the limited availability of soundings over the TP, which in turn constitutes a challenge for short-term predictions of TPV-related impacts and for the climatological study of TPVs. In this study, （i） manual tracking （MT） results using radiosonde data from a network over and downstream of the TP are compared with （ii） results obtained by an automated tracking （AT） algorithm applied to ErA-Interim data. Ten MT-TPV cases are selected based on method （i） and matched to and compared with the corresponding AT-TPVs identified with method （ii）. Conversely, ten AT-TPVs are selected and compared with the corresponding MT-TPVs. In general, the comparison shows good results in cases where the underlying data are in good agreement, but considerable differences are also seen in some cases and explained in terms of differences in the tracking methods, data availability/coverage and disagreement between sounding and ErA-Interim data. recommendations are given for future efforts in TPV detection and tracking, including in an operational weather forecasting context.

关键词： Tibetan Plateau Vortices Yearbook of TPVs TrACK mesoscale cyclones manual tracking automated tracking