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Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease:A controversial issue

World journal of Gastroenterology 2014年第23期20卷 7325-7338页

作者： wilhelmus j kwanten Wim Martinet Peter P Michielsen Sven M Francque Laboratory of Experimental Medicine and Paediatrics University of Antwerp2000 AntwerpProvince of AntwerpBelgium Laboratory of Physiopharmacology University of Antwerp2000 AntwerpProvince of AntwerpBelgium Department of Gastroenterology Hepatology Antwerp University HospitalB-2650 EdegemProvince of AntwerpBelgium

Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to *** potential role of autophagy in disease is increasingly recognised and investigated in the last *** it is commonly accepted that autophagy plays a role in the hepatic lipid ***,dysfunction of autophagy may be an underlying cause of non-alcoholic fatty liver ***,controversy of the exact role of autophagy in the lipid metabolism exists:some publications report a lipolytic function of autophagy,whereas others claim a lipogenic *** review aims to give an update of the present knowledge on autophagy in the hepatic lipid metabolism,hepatic insulin resistance,steatohepatitis and hepatic fibrogenesis.

关键词： Non-alcoholic fatty liver disease Non-alcoholic fatty liver disease Steatohepatitis Non-alcoholic steatohepatitis Autophagy Lipophagy Lipid metabolism

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The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment

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Cellular & Molecular Immunology 2020年第6期17卷 653-655页

作者： Lambertus P.van den Heuvel Nicole C.A.j.van de Kar Caroline Duineveld Andrei Sarlea Thea j.A.M.van der Velden wilhelmus T.B.Liebrand Sanne van Kraaij Camilla Schjalm Romy Bouwmeester jack F.M.Wetzels Tom E.Mollnes Elena B.Volokhina Department of Pediatric Nephrology Amalia Children’s Hospital Radboud University Medical CenterRadboud Institute for Molecular Life SciencesNijmegenThe Netherlands Department of Laboratory Medicine Radboud University Medical CenterRadboud Institute for Molecular Life SciencesNijmegenThe Netherlands Department of Pediatrics University Hospitals LeuvenLeuvenBelgium Department of Nephrology Radboud University Medical CenterRadboud Institute for Health SciencesNijmegenThe Netherlands Department of Immunology Oslo University Hospital and University of OsloOsloNorway Research Laboratory Nordland HospitalBodøand K.G.Jebsen TRECUniversity of TromsøTromsøNorway Center of Molecular Inflammation Research Norwegian University of Science and TechnologyTrondheimNorway

Dear Editors,Eculizumab is a therapeutic complement C5 inhibitor approved for the treatment of atypical hemolytic uremic syndrome(aHUS),paroxysmal nocturnal proteinuria(PNH),generalized myasthenia gravis and neuromyelitis optica spectrum *** dosing of eculizumab is important to ensure complete complement *** activity is often monitored by measuring either formation of the C5 activation product C5b-9 in vitro using an ELISA,independent of red blood cells,or by hemolytic assays measuring hemoglobin release from *** approaches allow analysis of complement activation via the classical(CP)and alternative(AP)pathways.

关键词： hemolytic rabbit gravis

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Surgery in (pre)malignant celiac disease

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World journal of Gastroenterology 2015年第43期21卷 12403-12409页

作者： jolanda MW van de Water Petula Nijeboer Laura R de Baaij jessy Zegers Gerd Bouma Otto j Visser Donald L van der Peet Chris jj Mulder wilhelmus jHj Meijerink Department of Gastroenterology and Hepatology Coeliac Center AmsterdamVU University Medical Center Department of Haematology Coeliac Center AmsterdamVU University Medical Center Department of Surgery Coeliac Center Amsterdam VU University Medical Center

AIM: To report the outcome of surgery in patients with(pre)malignant conditions of celiac disease(CD) and the impact on ***: A total of 40 patients with(pre)malignant conditions of CD,ulcerative jejunitis(n = 5) and enteropathy associated T-cell lymphoma(EATL)(n = 35),who underwent surgery between 2002 and 2013 were retrospectively evaluated. Data on indications,operative procedure,post-operative morbidity and mortali ty,adjuvant therapy and overal l survival(OS) were collected. Eleven patients with EATL who underwent chemotherapy without resection were included as a control group for survival analysis. Patients were followed-up every three months during the first year and at 6-mo intervals ***: Mean age at resection was 62 years. The majority of patients(63%) underwent elective laparotomy. Functional stenosis(n = 1 3) and perforation(n = 12) were the major indications for surgery. In 70% of patients radical resection wasperformed. Early postoperative complications,mainly due to leakage or sepsis,occurred in 14/40(35%) of patients. Eight patients required reoperation. More patients who underwent resection in the acute setting(n = 3,20%) died compared to patients treated in the elective setting. With a median follow-up of 20 mo,seven patients(18%) required reoperation due to long-term complications. Significantly more patients who underwent acute surgery could not be treated with adjuvant chemotherapy. Patients who first underwent surgical resection showed significantly better OS than patients who received chemotherapy without ***: Although the complication rate is high,the preferred first step of treatment in(pre)malignant CD consists of local resection as early as possible to improve survival.

关键词： Enteropathy associated T-cell lymphoma Ulcerative

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真菌性角膜炎合并细菌感染的患病率及波谱分析

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 30-30页

作者： Pate j.C. jones D.B wilhelmus K.R. 王文军 Sid W Richardson Ocular Microbiology Laboratory Department of Ophthalmology Baylor College of Medicine 6565 Fannin Street Houston TX 77030 United States

Aims: To estimate the propensity of keratomycosis for parallel or secondary bacterial infection and to explore affinities among fungal and bacterial co-isolates. Methods: A retrospective review of laboratory records over 24 years yielded 152 episodes of culture positive fungal keratitis. After collating 65 corneal specimens having bacterial co-isolates, polymicrobial co-infection was defined as detection of concordant bacteria on smear and culture or on two or more different media. Results: 30 (20% ) keratomycoses met laboratory criteria for polymicrobial infection. The risk of bacterial co-infection was 3.2 (95% confi-dence interval, 1.7 to 5.8) times greater with yeast keratitis than with filamentous fungal keratitis. Conclusions: Bacterial coinfection occasionally complicates fungal keratitis, particularly candidiasis.

关键词：真菌性角膜炎合并细菌感染波谱分析真菌性角膜病继发细菌感染细菌混合感染细胞涂片类细菌

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