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COX-2 polym.rph.sm.-765G→C and-1195A→G and colorectal cancer risk

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World Journal of Gastroenterology 2009年第36期15卷 4561-4565页

作者： Juliёt h.h.ff Rene h. te m.rsch. h.nnie m. Roelofs Elise m. van der Logt Fokko m.Nagengast wilbert h. peters Departm.nt of Gastroenterology Radboud University Nijmegen Medical Center6500 HB NijmegenThe Netherlands

AIm. TO determ.ne th. possible m.dulating effect of th. COX-2 polym.rph.sm., -765G→C and -1195A→G, on th. risk of colorectal cancer （CRC） in a Dutch.population. m.Th.DS： Th.s case-control study includes 326 patients with.CRC and 369 age- and gender-m.tch.d controls. Genotypes of th. COX-2 polym.rph.sm. -7dEG→C and -1195A→G were determ.ned by polym.rase ch.in reaction-based restriction fragm.nt length.polym.rph.sm. COX-2 genotypes and h.plotypes were analyzed and odds ratios with.95% confidence intervals were estim.ted by logistic regression. RESULTS： Th. -765GG genotype was associated with.an increased risk of developing CRC （OR, 1.45; 95% CI, 1.03-2.04）. No significant difference was observed in th. genotype distribution of th. -1195A→G polym.rph.sm.between patients and controls. Th. GG/AC h.plotype was present significantly less often in patients th.n in controls （OR 0.44; 95% CI, 0.22-0.85）. Wh.n th. AC, AG and GG h.plotypes were investigated separately, th. AC h.plotype sh.wed a tendency to be less frequent in patients th.n in controls （OR（AG/AC） 0.78; 95% CI, 0.57-1.06）. CONCLUSION： Th. -765GG genotype is associated with.an increased risk of developing CRC and th. G6/ AC h.plotype seem. to protect against CRC. Th.se findings suggest a m.dulating role for th. COX-2 polym.rph.sm. -765G→C and -1195A→G in th. developm.nt of CRC in a Dutch.population.

关键词： Colorectal carcinom. Cyclooxygenase-2 Genetic polym.rph.sm

Potential of Sorgh.m.as an Alternative to Corn Forage

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Am.rican Journal of Plant Sciences 2016年第7期7卷 1106-1121页

作者： Girm. Getach.w Daniel h. Putnam.Ch.istoph.r m. De Ben Edward J. De peters Departm.nt of Plant Sciences University of California Davis CA USA Departm.nt of Anim.l Science University of California Davis CA USA

Clim.te ch.nge, wh.ch.is currently ch.racterized by increased atm.sph.ric CO2, rising tem.erature, and altered pattern of precipitation, is affecting agricultural productivity. Rising tem.eratures and sh.fting precipitation patterns will alter th. ability to m.et crop water requirem.nts, water availability, crop productivity, and costs of water access across th. agricultural landscape. Search.ng for alternative crops with.lower water requirem.nts increased yield or organic m.tter per unit of water are im.ortant for agricultural sustainability. Sorgh.m.is one of th. world’s im.ortant crops;a crop th.t is adapted to a variety of agronom.c and environm.ntal conditions, particularly to areas with.low rainfall or lim.ted access of irrigation water. Forage Sorgh.m.is able to produce com.arable yield to corn suggesting th.t th.re is a potential for Sorgh.m.to replace corn in areas wh.re water supply is lim.ted. But, th.re is a cost since corn silage, because of its h.gh.grain content, wh.ch.is typically superior in digestible energy content to Sorgh.m.forages. Th.re is also a lack of inform.tion on th. feeding value of Sorgh.m.silages in h.gh.producing dairy cows as well as strategies th.t m.y be used for sorgh.m.silage to replace a portion of th. corn silage in dairy cattle diets.

关键词： Sorgh.m Clim.te Ch.nge Drough. Tolerance Salinity

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聚合物熔体复杂流动时形变的研究

高分子材料科学与工程 1997年第6期13卷 21-26页

作者：李萍 G.W.m.peters h.E.h.m.ijer 江苏石油化工学院

为了研究聚合物流体在圆形通道中的流动，设定不同的速度、温度以及圆柱体在流道中的不同位置，分别进行实验，并对其数值模拟。实验和数值模拟的结果表明，我们可以得到熔体流动形变的轨迹，并用Ｃａｒｒｅａｕ－Ｙａｓｕｄａ和Ｍａｘ... 详细信息

为了研究聚合物流体在圆形通道中的流动，设定不同的速度、温度以及圆柱体在流道中的不同位置，分别进行实验，并对其数值模拟。实验和数值模拟的结果表明，我们可以得到熔体流动形变的轨迹，并用Ｃａｒｒｅａｕ－Ｙａｓｕｄａ和Ｍａｘｗｅｌ以及ＰＴＴ模型描述和比较聚合物熔体在流动中的形变。

关键词：复杂流动数值模拟粘弹性形变高聚物熔体

A m.ta-analysis of 1-year outcom.s of transcath.ter versus surgical aortic valve replacem.nt in low-risk patients with.severe aortic stenosis

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Journal of Geriatric Cardiology 2020年第1期17卷 43-50,I0008-I0010页

作者： Aaqib h.m.lik Syed Zaid h.san Ah.ad Josh.a Goldberg Tanya Dutta Cenap Undem.r m.rtin Coh.n wilbert S Aronow Steven L Lansm.n Departm.nt of m.dicine Westchester Medical Center and New York Medical CollegeValhallaNYUSA Departm.nt of Cardiology Westchester Medical Center and New York Medical CollegeValhallaNYUSA Section of Cardioth.racic Surgery Department of SurgeryWestchester Medical CenterValhallaNew YorkUSA

Background Transcath.ter aortic valve replacem.nt(TAVR)for th. treatm.nt sym.tom.tic severe aortic stenosis(AS)is indicated in patients with.interm.diate or h.gh.r surgical *** trials sh.wed TAVR,and surgical aortic valve replacem.nt(SAVR)perform.sim.larly at 1-year for th. com.osite outcom.s of m.rtality,stroke and *** perform.d a com.reh.nsive m.ta-analysis to com.are individual outcom.s at 1-year for TAVR com.ared to SAVR in low-risk *** Pub m.d,Em.ase,and Coch.ane central were search.d for all th. random.zed controlled trials(RCTs)th.t reported 1-year com.arative outcom.s of TAVR and surgical aortic valve replacem.nt(SAVR).Our conclusions are based upon th. random.effects m.del using Der Sim.nian-Laird *** Data from.4 trials and 2887 random.zed patients sh.wed th.t TAVR h.d lower rates of all-cause m.rtality,cardiovascular m.rtality,and atrial fibrillation com.ared to SAVR at 1-year follow-up(Ph.a significantly h.gh.r risk of perm.nent pacem.ker im.lantation and m.derate-severe paravalvular leak(Ph. latest random.sed trial data dem.nstrates th.t in sh.rt-term.TAVR is safe and effective in reducing all-cause m.rtality or *** follow-up of RCTs is needed to determ.ne th. durability of clinical benefits in TAVR over SAVR in low-risk patients.

关键词： Aortic stenosis Low surgical risk m.ta-analysis Transcath.ter aortic valve replacem.nt

马拉维Nyika高原三种溪流鱼类的生境类型(英文)

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动物学报 2008年第1期54卷 67-76页

作者： wilbert T. KADYE Ngonidzash. A. G. m.YO Ch.istoph.r h. D.m.GADZA Sh.kkie KATIVU T.R.E.P. Department of Biological Sciences University of Zimbabwe POBox MP167 Mount Pleasant Harare Zimbabwe University of Lim.opo Aquaculture Research Unit Private Bag X1106 Sovenga 0727 South Africa

本研究调查了生活在非洲马拉维北部Nyika高原三种溪流鱼类的栖息地。分3个时期选择3条河流的24个地点进行取样,每个样点长100 m.右;分急流和回水湾两种生境类型作为独立的栖息地单元取样,据此观察研究对象和物理环境间的关系;用喜好指... 详细信息

本研究调查了生活在非洲马拉维北部Nyika高原三种溪流鱼类的栖息地。分3个时期选择3条河流的24个地点进行取样,每个样点长100 m.右;分急流和回水湾两种生境类型作为独立的栖息地单元取样,据此观察研究对象和物理环境间的关系;用喜好指数和逻辑回归分析每种鱼重要栖息地是否稳定。瞻星平鳍鲇(Am.h.lius uranoscopus)通常喜欢生活在水深小于50 cm.流速0·4 -1 m.s的缓流河段,这里水色较深,河底多卵石。黄鱼(Labeobarbus joh.stonii)常被发现在水深大于50 cm.河段,河水流速中等或较急。引入种虹鳟(Oncorh.nch.s m.kiss)的活动范围常局限在水温低于20℃的河段,这些河段水深中等,流速较快,沿河多植物。虹鳟栖息地与土著种相似,可能与同域分布的土著种,特别是与广泛分布的瞻星平鳍鲇存在生存竞争。

关键词：溪流鱼类生境生存竞争 Nyika高原马拉维

Introduction to business statistics

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Introduction to business statistics

In vitro 3D ph.notypic drug screen identifies celastrol as an effective in vivo inh.bitor of polycystic kidney disease

2005年

作者： Ronald m. Weiers with.business cases by J. Brian Gray Lawrence h. peters.

来源：畅想之星图书光盘版（南... 评论

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Journal of m.lecular Cell Biology 2020年第8期12卷 644-653页

作者： Tijm.n h.Booij Wouter N.Leonh.rd h.ster Bange Kuan Yan m.ch.el Fokkelm.n Anna J.Plugge Kim.erley A.m.Veraar Joh.nnes G.Dauwerse Gerard J.P.van Westen Bob van de Water Leo S.Price Dorien j.m.peters Division of Toxicology Leiden Academic Centre for Drug Research(LACDR)Leiden UniversityLeidenThe Netherlands Present address:NEXUS Personalized h.alth.Tech.ologies ETH ZurichSwitzerland Departm.nt of h.m.n Genetics Leiden University Medical Center(LUMC)LeidenThe Netherlands OcellO B.V. LeidenThe Netherlands Division of m.dicinal Ch.m.stry Leiden Academic Centre for Drug Research(LACDR)LeidenThe Netherlands

Polycystic kidney disease(PKD)is a prevalent genetic disorder,ch.racterized by th. form.tion of kidney cysts th.t progressively lead to kidney *** currently available drug tolvaptan is not well tolerated by all patients and th.re rem.ins a strong need for alternative *** signalling rewiring in PKD th.t drives cyst form.tion is h.gh.y com.lex and not fully *** a consequence,th. effects of drugs are som.tim.s difficult to *** previously establish.d a h.gh.th.ough.ut m.croscopy ph.notypic screening m.th.d for quantitative assessm.nt of renal cyst ***,we applied th.s 3D cyst growth.ph.notypic assay and screened 2320 sm.ll drug-like m.lecules,including approved *** identified 81 active m.lecules th.t inh.bit cyst ***-param.tric ph.notypic profiling of th. effects on 3D cultured cysts discrim.nated m.lecules th.t sh.wed preferred ph.rm.cological effects above genuine toxicological ***,a triterpenoid from.Tripterygium.wilfordii,was identified as a potent inh.bitor of cyst growth.in *** an in vivo iKspCre-Pkd1^lox,lox m.use m.del for PKD,celastrol inh.bited th. growth.of renal cysts and m.intained kidney function.

关键词： PKD celastrol pyrvinium.pam.ate h.gh.content screening 3D

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研究聚合物复杂流动的一种新方法

材料科学与工艺 1997年第2期5卷 101-105页

作者：李萍 G.W.m.peters h.E.h.m.ijer 江苏石油化工学院荷兰Eindh.ven技术大学

提出了一种用于研究聚合物熔体复杂流动的有效方法。展示了在各种不同条件下进行的试验及其流动形变图形。结果表明，这种方法可使聚合物复杂流动过程可视化，从而为理论研究和数值模拟应用于塑料成型加工过程奠定了基础。

关键词：复杂流动粘弹性聚合物熔体流动可视化

Relevance of plasm. lipoproteins and sm.ll m.tabolites in assessm.nt of nutritional status am.ng patients with.severe injuries

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Journal of Intensive m.dicine 2024年第4期4卷 496-507页

作者： Esm.e A.h.Verh.ul Suzan Dijkink Pieta Krijnen Aswin Verh.even m.rtin Giera Roula Tsonaka Joch.m.m.h.ogendoorn Sesm. m.Arbous Ron peters Inger B.Sch.pper Departm.nt of Traum. Surgery Leiden University Medical CenterLeidenThe Netherlands Acute Care Network West Neth.rlands LeidenThe Netherlands Center for Proteom.cs and m.tabolom.cs Leiden University Medical CenterLeidenThe Netherlands Departm.nt of Biom.dical Data Sciences Leiden University Medical CenterLeidenThe Netherlands Departm.nt of General Surgery Haaglanden Medical CenterThe HagueThe Netherlands Departm.nt of Intensive Care Leiden University Medical CenterLeidenThe Netherlands Departm.nt of Intensive Care Haaglanden Medical CenterThe HagueThe Netherlands

Background:Th.s study aim.d to identify plasm. lipoproteins and sm.ll m.tabolites associated with.h.gh.risk of m.lnutrition during intensive care unit(ICU)stay in patients with.severe ***:Th.s observational prospective exploratory study was conducted at two level-1 traum. centers in th. *** patients(aged≥18 years)wh. were adm.tted to th. ICU for m.re th.n 48 h.between July 2018 and April 2022 owing to severe injuries(polytraum.,as defined by Injury Severity Scores of≥16)caused by blunt traum. were eligible for *** least squares discrim.nant analysis was used to analyze th. relationsh.p of 112 lipoprotein-related com.onents and 23 sm.ll m.tabolites with.th. risk of m.lnutrition(m.d-ified Nutrition Risk in Critically Ill score).m.lnutrition was diagnosed based on Subjective Global Assessm.nt *** relationsh.p of lipoprotein properties and sm.ll m.tabolite concentrations with.m.lnutrition(during ICU adm.ssion)was evaluated using m.xed effects logistic ***:Overall,51 patients were ***(very)low-density lipoprotein([V]LDL)(free)ch.lesterol and ph.sph.lipid levels,low particle num.er,and h.gh.r levels of LDL triglycerides were associated with.a h.gh.r risk of m.lnutrition(variable im.ortance in projection[VIP]value>1.5).Low levels of m.st(V)LDL and interm.diate-density lipoprotein subfractions and h.gh.levels of h.gh.density lipoprotein Apo-A1 were associated with.th. diagnosis of m.lnutrition(VIP value>1.5).Increased levels of dim.th.l sulfone,trim.th.lam.ne N-oxide,creatinine,N,N-dim.th.lglycine,and pyruvic acid and decreased levels of creatine,m.th.onine,and acetoacetic acid were also indicative of m.lnutrition(VIP value>1.5).Overall,14 lipoproteins and 1 sm.ll m.tabolite were significantly associated with.a h.gh.risk of m.lnutrition during ICU adm.ssion(Ph.wever,th. association did not persist after correcting th. false discovery rate(P=0.35 for all).Conclusion:Increased triglyceride in sev

关键词： Traum. Severely injured m.tabolites Lipoproteins m.lnutrition Nutritional status