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On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBd patients

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World Journal of Gastroenterology 2005年第35期11卷 5540-5544页

作者： Nanne KH de boer Luc JJ derijks Lennard PL Gilissen daniel W Hommes Leopold GJB Engels Sybrand Y de boer Gijsbertus den Hartog Piet m Hooymans Anja BU m(?)kelburg Barend d Westerveld Anton HJ Naber Chris JJ mulder dirk J de Jong department of Gastroenterology and Hepatology VU University medical Centre Amsterdam The Netherlands department of Clinical Pharmacy maxima medical Centre Veldhoven The Netherlands department of Gastroenterology and Hepatology Academic Hospital Maastricht The Netherlands department of Gastroenterology and Hepatology Academic medical Centre Amsterdam The Netherlands department of Gastroenterology and Hepatology maasland Hospital Sittard The Netherlands department of Gastroenterology and Hepatology Rijnstate Hospital Arnhem The Netherlands department of Clinical Pharmacy maasland Hospital Sittard The Netherlands department of Gastroenterology and Hepatology Isala Clinics Location Sophia Zwolle The Netherlands department of Gastroenterology and Hepatology Radboud University Nijmegen medical Centre The Netherlands

AIm: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-mP) intolerant inflammatory bowel disease (IBd) patients over a treatment period of at least 1 ***: database ***: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had ***: The majority of AZA or 6-mP-intolerant IBd patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.

关键词： 6-Thioguanine Azathioprine 6-mercaptopurine Crohn's disease Ulcerative colitis Side effects Tolerance Safety

How small could a pup sound？ The physical bases of signaling body size in harbor seals

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Current Zoology 2017年第4期63卷 457-465页

作者： Andrea RAVIGNANI Stephanie GROSS maxime GARCIA Ana RUBIO-GARCIA Bart de boer Veterinary & Research department Sealcentre Pieterburen Hoofdstraat 94a Pieterburen AG 9968 The Netherlands Artificial Intelligence Laboratory Vrije Universiteit Brussel Pleinlaan 2 Brussels 1050 Belgium Language and Cognition department Max Planck Institute for Psycholinguistics Wundtlaan 1 Nijmegen XD 6525 The Netherlands Institute for Terrestrial and Aquatic Wildlife Research University of Veterinary Medicine Hannover Foundation Werftstrasse 6 Buesum 25761 Germany ENES Lab/Neuro-PSI CNRS UMR9197 University of Lyon/Saint Etienne 23 rue Paul Michelon 42023 Saint-Etienne cedex 2 France

Vocal communication is a crucial aspect of animal behavior. The mechanism which most mam- mals use to vocalize relies on three anatomical components. First, air overpressure is generated in- side the lower vocal tract. Second, as the airstream goes through the glottis, sound is produced via vocal fold vibration. Third, this sound is further filtered by the geometry and length of the upper vocal tract. Evidence from mammalian anatomy and bioacoustics suggests that some of these three components may covary with an animal＇s body size. The framework provided by acoustic al- Iometry suggests that, because vocal tract length （VTL） is more strongly constrained by the growth of the body than vocal fold length （VFL）, VTL generates more reliable acoustic cues to an animal＇s size. This hypothesis is often tested acoustically but rarely anatomically, especially in pinnipeds. Here, we test the anatomical bases of the acoustic allometry hypothesis in harbor seal pups Phoca vitulina. We dissected and measured vocal tract, vocal folds, and other anatomical features of 15 harbor seals post-mortem. We found that, while VTL correlates with body size, VFL does not. This suggests that, while body growth puts anatomical constraints on how vocalizations are filtered by harbor seals＇ vocal tract, no such constraints appear to exist on vocal folds, at least during puppy- hood. It is particularly interesting to find anatomical constraints on harbor seals＇ vocal tracts, the same anatomical region partially enabling pups to produce individually distinctive vocalizations.

关键词： acoustic allometry honest signaling larynx pinniped vocal tract.

modular operation of microfluidic chips for highly parallelized cell culture and liquid dosing via a fluidic circuit board

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microsystems & Nanoengineering 2020年第1期6卷 106-121页

作者： A.R.Vollertsen d.de boer S.dekker B.A.m.Wesselink R.Haverkate H.S.Rho R.J.Boom m.Skolimowski m.Blom R.Passier A.van den Berg A.d.van der meer m.Odijk BIOS Lab on Chip Group MESA+Institute for NanotechnologyUniversity of TwenteEnschedeThe Netherlands mesoscale Chemical Systems MESA+Institute for NanotechnologyUniversity of TwenteEnschedeThe Netherlands Institute for Technology-Inspired Regenerative medicine Maastricht UniversityMaastrichtThe Netherlands micronit microtechnologies EnschedeThe Netherlands Applied Stem Cell Technologies TechMed CentreUniversity of TwenteEnschedeThe Netherlands

microfluidic systems enable automated and highly parallelized cell culture with low volumes and defined liquid *** achieve this,systems typically integrate all functions into a single,monolithic device as a“one size fits all”***,this approach limits the end users’(re)design flexibility and complicates the addition of new functions to the *** address this challenge,we propose and demonstrate a modular and standardized plug-and-play fluidic circuit board(FCB)for operating microfluidic building blocks(mFBBs),whereby both the FCB and the mFBBs contain integrated valves.A single FCB can parallelize up to three mFBBs of the same design or operate mFBBs with entirely different *** operation of the mFBBs through the FCB is fully automated and does not incur the cost of an extra external *** use this modular platform to control three microfluidic large-scale integration(mLSI)mFBBs,each of which features 64 microchambers suitable for cell culturing with high spatiotemporal *** show as a proof of principle that we can culture human umbilical vein endothelial cells(HUVECs)for multiple days in the chambers of this ***,we also use the same FCB to control an mFBB for liquid dosing with a high dynamic *** results demonstrate that mFBBs with different designs can be controlled and combined on a single *** novel modular approach to operating an automated microfluidic system for parallelized cell culture will enable greater experimental flexibility and facilitate the cooperation of different chips from different labs.

关键词： FCB operation culture

multimodal probe for optical coherence tomography epidetection and micron-scale indentation

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 64-72页

作者： L.Bartolini F.Feroldi J.J.A.Weda m.Slaman J.F.de boer d.Iannuzzi department of Physics and Astronomy Vrije Universiteit Amsterdam and LaserLab Amsterdam de Boelelaan 1081 1081HV AmsterdamThe Netherlands

We present a multimodal ferrule-top sensor designed to perform the integrated epidetection of Optical Coberence Tomognphy(OCT)depth-profiles and micron-scale indentation by all-optical *** scarning a sample under the probe,we can obtain structural crosse soction images and identify a region of interest in a nonhomogencous ***,with the same probe and setup,we can immediately target that area with a series of spherical indentation measurements,in which the applied load is known with aμN precision,the indentation depth with sub-/m precision and a maximum contact radius of 100 *** to the visualization of the internal structure of the sample,we can gain a better insi ght into the observed mechanical *** ability to impart a small,confined load,and perfomn OCT A scans at the same time,could lead to an altemative,high transverse resolution,Optical Coherence Elastography(OCE)sensor.

关键词： Optomechanical microindentation optical coherence tomography indentation multimodal sensor,epidetection

Patient involvement in lung foundation research: A seven year longitudinal case study

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Health 2013年第2期5卷 320-330页

作者： G. J. Teunissen m. A. Visse d. Laan W. I. de boer m. Rutgers T. A. Abma department of medical Humanities VU University Medical Centre EMGO+ Amsterdam The Netherlands Lung Foundation Netherlands Amersfoort The Netherlands

Patient involvement in health research is getting more accepted over the years. Until recently scientists and medical professionals were the sole assessors of quality and relevance of research proposals. In the Netherlands, as in other European and North American countries, emancipatory, political and democratic developments stimulated the emergence of patient involvement as a new “voice” in the appraisal of research. A time-series cross sectional longi-tudinal case study was used to describe and analyse a seven year period since the introduction of the patients’ perspective in the Long-fonds research cycle. Longfonds, the Lung Foundation in the Netherlands (LFN) was formerly called “Astma Fonds”. The study was conducted using an actors-interaction model against the background of the dynamics in society. The introduction of patient involvement resulted in a paradigm shift. The scientific and societal relevance of research proposals are now being reviewed by all parties in a more ef- fective and efficient way. Patients, now involved in the review procedure of research funding, are trained and equipped with an appraisal tool for societal relevance from a patients perspective. Scientific relevance and societal relevance are evaluated separately and balanced in the re- search funding application approval process. Societal relevance is being evaluated by a pa- tient advocates group. The results show how a government initiative and an approach by a patient organisation have led to more patient involvement in lung research. It requires “believers” both to initiate and continue the work and to promote the lessons learned inside and outside the patient organisation. As this depends on devoted individuals, the continuity of patient involvement remains vulnerable. This seven year study offers valuable insight in patient involvement against the background of the changeing health discourse.

关键词： Appraisal Lung Patient Participation Patient Involvement Lay Expertise medical Research Quality of Life Commitment

Amplitude analysis of the decays d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： m.Ablikim m.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger m.Berlowski m.Bertani d.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen m.L.Chen S.J.Chen S.L.Chen S.m.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.dai J.P.dai A.dbeyssi R.E.de boer d.dedovich C.Q.deng Z.Y.deng A.denig I.denysenko m.destefanis F.de mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer m.Fritsch C.d.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.m.Gersabeck B.ding X.X.ding Y.ding Y.ding J.dong L.Y.dong m.Y.dong X.dong m.C.du S.X.du Z.H.duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna m.Greco m.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo m.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.m.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche m.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia d.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin m.Q.Jing X.m.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang m.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf m.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff m.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li d.m.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li m.H.Li P.R.Li Q.m.Li Q.X.Li R.Li S.X.Li T.Li W.d.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COmSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner mongolia University Hohhot 010021China Institute of modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays d^(0)→a_(1)(1260)π,d^(0)→π(1300)π,d^(0)→ρ(770)ρ(770),and d^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of d^(0)→4πwhen used to determine the CKm angleγ(ϕ_(3))via the B^(−)→dK^(−)decay.

关键词： BESIII d^(0)meson decays amplitude analysis CP-even fraction

determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： m.Ablikim m.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger m.Berlowski m.Bertani d.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.Y.Chen m.L.Chen S.J.Chen S.L.Chen S.m.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui H.L.dai J.P.dai A.dbeyssi R.E.de boer d.dedovich C.Q.deng Z.Y.deng A.denig I.denysenko m.destefanis F.de mori B.ding X.X.ding Y.ding Y.ding J.dong L.Y.dong m.Y.dong X.dong m.C.du S.X.du Y.Y.duan Z.H.duan P.Egorov Y.H.Fan J.Fang J.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng m.Fritsch C.d.Fu J.L.Fu Y.W.Fu H.Gao X.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.m.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna m.Greco m.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo m.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han F.Hanisch X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.m.Hu J.F.Hu S.L.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia d.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin m.Q.Jing X.m.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang m.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf m.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei m.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li d.m.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li Ke Li L.J.Li L.K.Li Lei Li m.H.Li P.R.Li Q.m.Li Q.X.Li R.Li S.X.Li T.Li W.d.Li W.G.Li X.Li X.H.Li X.L.Li X.Z.Li Xi Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COmSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner mongolia University Hohhot 010021China Institute of modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

25－羟维生素d和甲状旁腺激素与高血压的相关性

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中华高血压杂志 2014年第6期22卷 587-588页

作者： van Ballegooijen AJ Kestenbaum B Sachs mC de boer IH Siscovick dS Hoofnagle AN Ix JH Visser m Brouwer IA 练桂丽叶鹏机构不详

有研究证实,维生素d缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素d缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高... 详细信息

有研究证实,维生素d缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素d缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素d和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素d[25(OH)d]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)d水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素d缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。

关键词： 25-羟维生素d 甲状旁腺激素高血压相关性维生素d缺乏肾素血管紧张素系统血管炎性反应 25(OH)d

印度尼西亚、苏里南、荷兰的宫颈癌患者中人乳头瘤病毒16型的E6、E7、L1变异型

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 56-57页

作者： de boer m.A. Peters L.A.W. Aziz m.F. 安妮 department of Pathol ogy Leiden University Medical Center Leiden Netherlands

Objective. Human papillomavirus type 16 (HPV 16) has several intratyp ic varian ts, and some are associated with enhanced oncogenic potential. For risk determin ation aswell as for future vaccine development, knowledge about variants is impo rtant. Regarding the geographical distribution of HPV variants and the lack of d ata from Indonesia and Suriname, we studied the prevalence of HPV 16 variants in cervical cancer in these high incidence countries. data were compared with The Netherlands, a low-risk country. methods. dNA samples from 74 formalin-fixed p araffin-embedded HPV 16-positive cervical carcinomas from Indonesia (Java, N = 22), Suriname (N = 25), and The Netherlands (N = 27) were amplified using prime rs specific for the E6, E7, and part of the L1 regions. Products were sequenced and analyzed. Results. A specific Javanese variant, with mutations 666A in E7 an d 6826T in L1, was found in 73%of the Indonesian samples, 56%having an additio nal mutation in the E6 open reading frame (ORF; 276G), giving the predicted amin o acid change N58S. This Javanese variant was also found in three Surinamese sam ples, which reflects what could be expected from migration of Javanese people to Surinam. Other non-European variants were identified in Indonesian, Surinamese , and dutch samples in 14%, 28%, and 19%, respectively. Conclusion. The major ity of the HPV 16-positive cervical cancers in Indonesia are caused by a specif ic intratypic variant that was rarely found before in other countries.

关键词：人乳头瘤病毒 E6 E7 L1 变异型荷兰人癌基因变异体特殊型种特异性