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重力坝-地基体系的简化地震分析

世界地震工程 1987年第4期 22-24+41页

作者： T.Yagawa m.wieland 祁建华

前言以前通常使用Westergaard提出的方法计算和设计混凝土重力坝,其中由惯性力和动水压力组成的地震力是作为静力与静水压力和重力等迭加。直到最近,采用有限元方法对水坝的动力分析作了大量的研究。其中一些研究,动力分析包括了考虑可... 详细信息

前言以前通常使用Westergaard提出的方法计算和设计混凝土重力坝,其中由惯性力和动水压力组成的地震力是作为静力与静水压力和重力等迭加。直到最近,采用有限元方法对水坝的动力分析作了大量的研究。其中一些研究,动力分析包括了考虑可压缩库水的动水压力的相互作用和结构与地基的相互作用。从这些研究明显可见,在大型水坝的技术设计阶段,尤其在高地震活动区必须采用动力分析计算,同时考虑坝体柔性的动水压力相互作用是明显的,水的压缩性是不能忽略的。并且也

关键词：刚性地基重力坝地震分析

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干法纺丝工艺模拟

国际纺织导报 2021年第4期49卷 8-10页

作者： W.Arne R.Wegener m.wieland 李婷(译) 于俊荣(校) Fraunhofer工业数学研究所德国不详

干法纺丝是一种重要的化学纤维工业化生产工艺,用于仅能借助于溶剂进行纺丝的聚合物。在其常用工艺中,聚合物溶液通过由数百个毛细管组成的纺丝组件挤出到气室中,经溶剂蒸发而固化成纤维。纺丝工艺对于得到高质量且性能均匀的纤维至关... 详细信息

干法纺丝是一种重要的化学纤维工业化生产工艺,用于仅能借助于溶剂进行纺丝的聚合物。在其常用工艺中,聚合物溶液通过由数百个毛细管组成的纺丝组件挤出到气室中,经溶剂蒸发而固化成纤维。纺丝工艺对于得到高质量且性能均匀的纤维至关重要。采用试错法进行工业化规模的干法纺丝工艺的试验设计通常很困难且成本昂贵。因此,Fraunhofer工业数学研究所(ITWm)开发了一种仿真框架用以模拟此类过程并进行虚拟设计。为了证明该概念的可行性,以醋酸纤维素丙酮混合物为例进行了研究。为了验证该模型和仿真框架,采用简化设置将单根纤维的计算结果与复杂的3维(3D)仿真结果进行了比较,结果表明它们有较好的一致性。

关键词：干法纺丝模拟建模

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

内皮唾液酸蛋白通过调节血管平滑肌细胞表型重建,促进动脉粥样硬化

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中华高血压杂志 2017年第2期25卷 162-162页

作者：刘莉叶鹏 Hasanov Z Ruckdeschel T Knig C mogler C Kapel SS Korn C Spegg C Eichwald V wieland m Appak S Augustin HG

动脉粥样硬化是全球主要的致死原因,血管平滑肌细胞（vascular smooth muscle cells,VSmC）在动脉粥样硬化的发病中起关键作用。内皮唾液酸蛋白（CD248）已被认为是间质细胞系细胞（包括肿瘤相关周细胞、肌成纤维细胞间质和活化的VSmC... 详细信息

动脉粥样硬化是全球主要的致死原因,血管平滑肌细胞（vascular smooth muscle cells,VSmC）在动脉粥样硬化的发病中起关键作用。内皮唾液酸蛋白（CD248）已被认为是间质细胞系细胞（包括肿瘤相关周细胞、肌成纤维细胞间质和活化的VSmC）的激活标记物。因此,研究人员假设VSmC表达的内皮唾液酸蛋白可以功能性地参与动脉粥样硬化的发病。方法与结果：

关键词：血管平滑肌细胞表型动脉粥样硬化唾液酸蛋白内皮重建调节白通细胞间质

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

CO_(2)Plume Geothermal(CPG)Systems for Combined Heat and Power Production:an Evaluation of Various Plant Configurations

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Journal of Thermal Science 2022年第5期31卷 1266-1278页

作者： SCHIFFLECHNER Christopher wieland Christoph SPLIETHOFF Hartmut Chair of Energy Systems TUM School of Engineering and DesignTechnical University of Munich85747 GarchingGermany

CO_(2) Plume Geothermal(CPG)systems are a promising concept for utilising petrothermal resources in the context of a future carbon capture utilisation and sequestration *** geothermal energy has a tremendous worldwide potential for decarbonising both the power and heating *** paper investigates three potential CPG configurations for combined heating and power generation(CHP).The present work examines scenarios with reservoir depths of 4 km and 5 km,as well as required district heating system(DHS)supply temperatures of 70℃ and 90℃.The results reveal that a two-staged serial CHP concept eventuates in the highest achievable net power *** a thermosiphon system,the relative net power reduction by the CHP option compared with a sole power generation system is significantly lower than for a pumped *** net power reduction for pumped systems lies between 62.6%and 22.9%.For a thermosiphon system with a depth of 5 km and a required DHS supply temperature of 70℃,the achievable net power by the most beneficial CHP option is even 9.2%higher than for sole power generation *** second law efficiency for the sole power generation concepts are in a range between 33.0%and 43.0%.The second law efficiency can increase up to 63.0%in the case of a CHP ***,the combined heat and power generation can significantly increase the overall second law efficiency of a CPG *** evaluation of the achievable revenues demonstrates that a CHP application might improve the economic performance of both thermosiphon and pumped CPG ***,the minimum heat revenue required for compensating the power reduction increases with higher electricity *** summary,the results of this work provide valuable insights for the potential development of CPG systems for CHP applications and their economic feasibility.

关键词： deep geothermal energy combined heat and power generation CO_(2)plume geothermal systems petrothermal resources carbon capture utilisation and storage

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death