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论原生林的定义及判定标准

内蒙古林业科技 1991年第3期17卷 45-46,F003页

作者： Hunt.,ml 苏晓梅

前扣带皮质向伏隔核的输入控制疼痛和镇痛的社交转移

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中国疼痛医学杂志 2022年第1期28卷 4-6页

作者： Smith ml Asada N Malenka RC 华肖肖(译) 张玲(校) 不详同济大学医学院

共情是体验他人的感觉和情感状态,是社交中的重要组成部分。该研究发现小鼠疼痛和吗啡镇痛可以通过短暂的社会接触转移到旁观者身上。光遗传学操控实验表明前扣带皮质(ACC)及其到伏隔核(NAc)的投射选择性地参与疼痛和镇痛的社会转移。... 详细信息

共情是体验他人的感觉和情感状态,是社交中的重要组成部分。该研究发现小鼠疼痛和吗啡镇痛可以通过短暂的社会接触转移到旁观者身上。光遗传学操控实验表明前扣带皮质(ACC)及其到伏隔核(NAc)的投射选择性地参与疼痛和镇痛的社会转移。相比之下,恐惧的社会转移则不需要ACC到NAc的输入,而是依赖于ACC至基底外侧杏仁核(BLA)的投射。这些发现表明ACC与人类共情反应密切相关,并通过不同的下游靶点介导不同形式的共情行为。

关键词：吗啡镇痛伏隔核前扣带皮质共情输入控制光遗传学情感状态疼痛

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创伤弹道学：常见错误概念综述

国外医学（军事医学分册） 1989年第2期6卷 88-91页

作者： Fack.,ml 王正国

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老年人有关的皮肤改变:表现及临床意义

国外医学（皮肤性病学分册） 1989年第4期15卷 227-230页

作者： Richey ml 罗挺

引起老年人皮肤改变的原因有环境(如日光、风)、内脏疾病(如糖尿病、动脉粥样硬化)及正常的衰老。老年人皮肤的结构和功能皮肤的结构和功能密切相关。

关键词：老年人皮肤干燥病老化

STUDIES　OF　THE　INTERACTION　BETWEEN　METALLOPORPHyRINS　OF　TMPyP－3　AND　SINGLE－STRANDED　DNA　ON　NC　MEMBRANE

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Chinese Chemical Letters 1995年第2期6卷 123-126页

作者： Chen, y Li, yZ Chang, WB Ci, yX Beijing Univ Dept Chem Beijing 100871 Peoples R China

We report here a fast staining method for single-stranded DNA fixed on nitrocellulose membrane using M-meso-letra(3-N-methylpyridyl)-porphrin (M-TMPyP, M: Mn3, Fe3, Pt3). The optimal staining solution consists of 54-108 μg/ml M-TMPyP in 25～200 mmol/l. phosphate buffer solution (pH 5.0～8.0).When DNA dot on NC membrane is treated with the staining solution at room temperature for 1～2 minutes with continuous stirring, it turns to brown-yellow.10pg per dot of single-stranded DNA is visible. It is a useful tool to sludy the DNA blotting, and for recognition of the special bands of DNA in a complete electrophoretogram of DNA blot. The staining mechanism is also *** staining techniques of DNA play a important role in DNA blotting,display of DNA elcctophoretogram and location of the special DNA band from *** R.J. Fiel and co-workers[1] reported that meso-tetra(4-N-methylpyridyl) porphyrin can intercalale in calf thymus DNA. the intercalation between TMPyP-4 and DNA in solution has been intensively investigated by several groups[2～8],but none of them concerned with the interaction of metalloporphyrin and filterbound DNA. In this report, the use of M-TMPyP as a fast and sensitive staining reagent for single-strand DNA on NC membrane is described.

关键词： NC MEMBRANE BETWEEN AND DNA

Leveraging generative adversarial networks to create realistic scanning transmission electron microscopy images

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npj Computational Materials 2023年第1期9卷 1492-1500页

作者： Abid Khan Chia-Hao Lee Pinshane y.Huang Bryan K.Clark Department of Physics University of Illinois Urbana-ChampaignUrbanaIL 61801USA Department of Materials Science and Engineering University of Illinois Urbana-ChampaignUrbanaIL 61801USA Materials Research Laboratory University of Illinois Urbana-ChampaignUrbanaIL 61801USA Institute for Condensed Matter Theory and IQUIST and NCSA Center for Artificial Intelligence Innovation University of Illinois Urbana-ChampaignUrbanaIL 61801USA

The rise of automation and machine learning(ml)in electron microscopy has the potential to revolutionize materials research through autonomous data collection and processing.A significant challenge lies in developing ml models that rapidly generalize to large data sets under varying experimental *** address this by employing a cycle generative adversarial network(CycleGAN)with a reciprocal space discriminator,which augments simulated data with realistic spatial frequency *** allows the CycleGAN to generate images nearly indistinguishable from real data and provide labels for ml *** showcase our approach by training a fully convolutional network(FCN)to identify single atom defects in a 4.5 million atom data set,collected using automated acquisition in an aberration-corrected scanning transmission electron microscope(STEM).Our method produces adaptable FCNs that can adjust to dynamically changing experimental variables with minimal intervention,marking a crucial step towards fully autonomous harnessing of microscopy big data.

关键词： autonomous adjust network

Fibroblast Growth Factor 19 Induced Changes in Non-malignant Cholangiocytes

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 909-916页

作者： Jiaqi yang David Sontag Sam Kung Gerald y.Minuk Section of Hepatology Department of MedicineRady College of MedicineUniversity of ManitobaWinnipegManitobaCanada Department of Immunology Rady College of MedicineUniversity of ManitobaWinnipegManitobaCanada Department of Pharmacology and Therapeutics Rady College of MedicineUniversity of ManitobaWinnipegManitobaCanada

Background and Aims:Fibroblast growth factor(FGF)19 has been implicated in the pathogenesis of murine hepatocellular *** it plays a role in the development or course of human cholangiocarcinoma remains to be *** aim of this study was to determine whether prolonged exposure to FGF19 results in the transformation of non-malignant human cholangiocytes into cells with malignant ***:Human SV-40 transfected non-malignant H69 cholangiocytes were cultured with FGF19(0-50 ng/ml)for 6 weeks,followed by 6 weeks with medium *** proliferation,invasion,stem cell surface markers,oncofetoprotein expression,state of differentiation,epithelial-mesenchymal transition(EMT)and interleukin(IL)-6 expression were documented at various time intervals throughout the 12-week ***:FGF19 exposure was associated with significant increases in cell proliferation,de-differentiation,EMT and IL-6 ***,each of these effects returned to baseline or control values during the 6-week FGF19 free follow-up *** remaining cell properties remained ***:Six weeks of FGF19 exposure did not result in the acquisition of permanent malignant features in non-malignant,human cholangiocytes.

关键词： Fibroblast growth factor 19 Cholangiocytes Cholangiocarcinoma Farnisoid x receptor Obetcholic acid

Artificial intelligence in gastroenterology: A state-of-the-art review

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World Journal of Gastroenterology 2021年第40期27卷 6794-6824页

作者： Paul T Kröner Megan ml Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong Division of Gastroenterology and Hepatology Mayo ClinicJacksonvilleFL 32224United States Cancer Center Amsterdam Department of Gastroenterology and HepatologyAmsterdam UMCLocation AMCAmsterdam 1105The Netherlands The Hasso Plattner Institute for Digital Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Gastroenterology and Hepatology Leiden University Medical CenterAmsterdam 2300The Netherlands Division of Gastroenterology and Hepatology Sheikh Shakhbout Medical CityAbu Dhabi 11001United Arab Emirates Section of Gastroenterology and Hepatology Michael E.DeBakey VA Medical Center and Baylor College of MedicineHoustonTX 77030United States Section of Health Services Research Michael E.DeBakey VA Medical Center and Baylor College of MedicineHoustonTX 77030United States Section of Cardiology Michael E.DeBakey VA Medical CenterHoustonTX 77030United States

The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical *** field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an *** clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic *** objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field.

关键词： Artificial intelligence Machine learning Deep learning Clinical applications Gastroenterology

Audit Firm Size Effects in China’s Emerging Audit Markets

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Audit Firm Size Effects in China’s Emerging Audit Markets