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Com.lem.nt-dependent neuroinflam.ation in spinal cord injury:from.pathology to therapeutic im.lications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanm.rco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian m.stroph David Gim.el Jonathan Grossberg Daniel L.Barrow m.tthew F.Gary Ali m.Alawieh Departm.nt of Neurosurgery Emory University School of MedicineAtlantaGAUSA Departm.nt of Neurology Yale UniversityNew HavenCTUSA Center for Neurotraum. Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury rem.ins a m.jor cause of disability in young adults,and beyond acute decom.ression and rehabilitation,there are no pharm.cological treatm.nts to lim.t the progression of injury and optim.ze recovery in this *** the thorough investigation of the com.lem.nt system.in triggering and propagating cerebral neuroinflam.ation,a sim.lar role for com.lem.nt in spinal neuroinflam.ation is a focus of ongoing *** this work,we survey the current literature investigating the role of com.lem.nt in spinal cord injury including the sources of com.lem.nt proteins,triggers of com.lem.nt activation,and role of effector functions in the *** study relevant data dem.nstrating the different triggers of com.lem.nt activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to dam.ge-associated m.lecular *** effector functions of com.lem.nt have been im.licated in spinal cord injury,and we critically evaluate recent studies on the dual role of com.lem.nt anaphylatoxins in spinal cord injury while em.hasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we system.tically review the different translational approaches used in preclinical m.dels of spinal cord injury and discuss the challenges for future translation into hum.n *** review em.hasizes the need for future studies to dissect the roles of different com.lem.nt pathways in the pathology of spinal cord injury,to evaluate the phases of involvem.nt of opsonins and anaphylatoxins,and to study the role of com.lem.nt in white m.tter degeneration and regeneration using translational strategies to supplem.nt genetic m.dels.

关键词： com.lem.nt neuroinflam.ation neuroplasticity regeneration spinal cord injury targeted therapy

Structure of the Ligated Ag60 Nanoparticle [{Cl@Ag12}@Ag48（dppm.12]（where dppm.bis（diphenylphosphino）m.thane）

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Chinese Journal of Chem.cal Physics 2019年第2期32卷 182-186,I0002页

作者： Athanasios Zavras Antonija m.avak m.rgarita Buzancic Jonathan m.white Vlasta Bonacic-Koutecky Richard A.J.O’Hair School of Chem.stry and Bio21 m.lecular Science and Biotechnology Institute University of Mel- bourne 30 Flemington Rd Parkville Victoria 3010 Australia Center of Excellence for Science and Technology-Integration of m.diterranean Region (STIm. at Interdisciplinary Center for Advanced Sciences and Technology (ICAST) University of Split Poljicka cesta 35 Split 21000 Croatia Chem.stry Departm.nt Humboldt University of Berlin Brook-Taylor-Strasse 2 Berlin 12489 Germany

A novel bisphosphine ligated Ag60 nanocluster,[{Cl@Ag12}@Ag48(dppm.12], has been dis-covered and characterized by X-ray crystallography. It consists of a central chloride located inside an icosahedral silver core layer, which is further encased by a second shell of 48 silver atom./ions, which are capped with 12 bis(diphenylphosphino)m.thane (dppm. ligands. Due to lack of sufficient m.terial the cluster could not be further characterized by other m.thods. DFT calculations were carried out on the cation [{Cl@Ag12}@Ag48(dppm.12]+ to determ.ne if it corresponds to a superatom.with a core count of n=58. The DFT optim.zed structure is in agreem.nt with X-ray ndings, but the low value of the HOm.-LUm. gap does not support superatom.stability.

关键词： Nanoparticle DFT calculations X-ray crystallography

FTY720,a sphingosine analog,altered placentom. histoarchitecture in ewes

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Journal of Anim.l Science and Biotechnology 2020年第2期11卷 380-392页

作者： Kathrin A.Dunlap Bryan G.white David W.Erikson m.Carey Satterfield Christiane Pfarrer Guoyao Wu Fuller W.Bazer Robert C.Burghardt Kayla J.Bayless Greg A.Johnson Departm.nt of Anim.l Science Texas A&M UniversityCollege StationTX 77843USA Okanagan College Salm.n Arm.Cam.us Salmon ArmBritish ColumbiaCanada Endocrine Technologies Core Oregon National Primate Research CenterOregon Health&Science UniversityBeavertonORUSA Departm.nt of Anatom. University of Veterinary Medicine HannoverBischofsholer Damm 1530173 HannoverGermany Departm.nt of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843USA Departm.nt of m.lecular and Cellular m.dicine Texas A&M Health Science CenterCollege StationTX 77843USA

Background:The lysosphingolipid,sphingosine-1-phosphate,is a well-described and potent pro-angiogenic ***,as well as the sphingosine phosphorylating enzym. sphingosine kinase 1,are expressed in the placentom.s of sheep and the decidua of rodents;however,a function for this signaling pathway during pregnancy has not been *** objective of this study was to investigate whether sphingosine-1-phosphate prom.ted angiogenesis within the placentom.s of pregnant *** were given daily jugular injections of FTY720(2-am.no-2[2-(−4-octylphenyl)ethyl]propate-1,3-diol hydrochloride),an S1P ***:FTY720 infusion from.days 30 to 60 of pregnancy did not alter m.ternal organ weights nor total num.er or m.ss of placentom.s,but did alter placentom. *** of caruncular crypts and cotyledonary villi was decreased,as was the relative area of cotyledonary tissue within ***,the percentage of area occupied by cotyledonary villi per unit of placentom. was increased,while the thickness of the caruncular capsule was decreased in ewes treated with ***,FTY720 infusion decreased the num.er and density of blood vessels within caruncular tissue near the placentom. capsule where the crypts em.rge from.the ***,FTY720 infusion decreased asparagine and glutam.ne in am.iotic fluid and m.thionine in allantoic fluid,and decreased the crown rum. length of day 60 ***:While m.m.ers of the sphingosine-1-phosphate signaling pathway have been characterized within the uteri and placentae of sheep and m.ce,the present study uses FTY720 to address the influence of S1P signaling on placental *** present evidence that m.dulation of the S1P signaling pathway results in the alteration of caruncular vasculature,placentom. architecture,abundance of am.no acids in allantoic and am.iotic fluids,and fetal growth during pregnancy in *** m.rked m.rphological changes in placentom. histoarchitec

关键词： Placentom. Pregnancy Sheep Sphingosine1 phosphate(S1P)

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流体力学习题详解

1992年

作者： Frank m.·怀特(Frank m. white)原

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旱地禾草和豆科牧草的产量和质量

草原与草坪 1985年第3期 23-25页

作者： Larry m. white 张明华

在评价牧草种和栽培品种时,要考虑到家畜的生产、牧草的质量和数量。假若牧草是用作成年母牛的维持饲料,那么每一种牧草的高产就最重要,即使可消化率为50％或再高一点。但是,如果牧草是用作青年母牛或阉牛的生长饲料,或者仅在母牛产犊... 详细信息

在评价牧草种和栽培品种时,要考虑到家畜的生产、牧草的质量和数量。假若牧草是用作成年母牛的维持饲料,那么每一种牧草的高产就最重要,即使可消化率为50％或再高一点。但是,如果牧草是用作青年母牛或阉牛的生长饲料,或者仅在母牛产犊前后用作附加能量饲料时,那么高质量的牧草可能就要比牧草的产量更重要。北部大平原的两个研究报告,包括了主

关键词：禾草草芦中间冰草产量沙生冰草草地雀麦变形雀麦旱地耕地质量

Epidem.ology and control of m.nkeypox outbreak in Houston,Texas

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Global Health Journal 2024年第3期8卷 133-139页

作者： Abisola m.Oladim.ji Abayom. Joseph Afe Louis Carillo Courtney Hundley Yufang Zhang Stephen Long Kirstin Short Roger Sealy Janeana white David Persse Bureau of Epidem.ology Houston Health DepartmentHoustonTX 77054USA

Background:In the 2022-2023 global outbreak,the United States and state of Texas recorded a total of 31,277 and 3,085 confirm.d m.nkeypox(m.ox)cases respectively as of Novem.er *** study aim. to investigate the dem.graphic characteristics and risk factors of m.ox outbreak in Houston and docum.nt the epidem.ologic control m.asures im.lem.nted with their ***:Houston Health Departm.nt received reports of suspected m.ox cases via electronic case reports and laboratory reports from.healthcare providers within *** were then investigated and reclassified as either positive or negative using DNA polym.rase chain reaction *** the reported cases received between m.y 2022 and January 2023 were included in this study using convenient sam.ling *** statistics using frequency distribution was used to analyze the sociodem.graphic,clinical features and travel history of the cases.A two-sided Chi-squared test was used to determ.ne association between m.ox test results and risk factors with significant level set at Pm.asures such as com.unity engagem.nt,health education,tracking and contact tracing,vaccination,referrals and laboratory sam.le logistics support were im.lem.nted by the health ***:Out of the total of 1,625 suspected persons investigated for m.ox,724(44.6%)tested *** the 724 confirm.d cases,m.le was 700(96.7%),fem.les 20(2.8%),transgender m.le 1(0.1%),transgender fem.le 3(0.4%).Age groups 30-39 years constituted 43.6%,18-29 years 27.4%,40-49 years 18.2%,50-59 years was 8%.Race distribution of positive cases was whites 43.4%,African Am.rican 38.7%,Asian 1.4%.Risk factors with Pm.le gender,age groups 30-39 years and 40-49 years,travel history to m.ox endem.c areas,recent sexual contact with known or suspected m.ox cases,hum.n im.unodeficiency virus *** as gay and bisexual were also statistically significant risk factors for m.ox inf

关键词： m.nkeypox m.ox Riskfactors Control Tecovirim.t Vaccination

Episodic uplift of the Tianshan m.untains since the late Oligocene constrained by m.gnetostratigraphy of the Jingou River section,in the southern m.rgin of the Junggar Basin,China

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Episodic uplift of the Tianshan Mountains since the late Oli...

福建紫金山矿田悦洋银多金属矿床银的赋存状态和沉淀机制

中国科学院地质与地球物理研究所2008学术年会

作者： Paul white Institute of Geology and Geophysics Chinese Academy of Sciences

[1]Thick Cenozoic sedim.nts in the southern m.rgin of the Junggar Basin accum.lated in response to the uplift and deform.tion of the Tianshan *** better constrain this m.untains’ tectonic history,we report a detailed m.gnetostratigraphic study of the Jingou River section,located in the northern piedm.nt of the Tianshan m.s.A total of 1133 sam.les were used to establish the m.gnetostratigraphy of a m.re than 3000 m.thick section from.the exposed base of the Anjihaihe Form.tion to the m.ddle of the Xiyu *** vertebrate fossil sites and a good correlation with the CK95 geom.gnetic polarity tim.scale suggest that the section was deposited from.30.5 to～4.6 m. and the age of the top of the Xiyu form.tion is～2.6 m. based on an extrapolation of the sedim.ntation *** results show that significant increases in sedim.ntation rates as well as notable changes in depositional environm.nts occurred at～26-22.5 m.,～13-11 m. and～7 m.,which represent the initial uplift of the Tianshan *** two subsequent rapid uplift *** addition,changes in sedim.ntation rates im.ly that the uplift of the Tianshan *** episodic,and relatively short,with intervals of intensified deform.tion with long periods of tectonic weakness or quiescence.

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岩石学报 2024年第3期40卷 987-1002页

作者：刘兰海陈静周涛发孙艺 white Noel C 合肥工业大学资源与环境工程学院合肥工业大学矿床成因与勘查技术研究中心(ODEC)合肥230009 安徽省矿产资源与矿山环境工程技术研究中心合肥230009 Centre of Excellence in Ore Deposits(CODES) University of TasmaniaHobart 7001

浅成低温热液矿床是世界上银矿的重要矿床类型,伴生有金铜铅锌等多种金属。银的赋存状态研究可以为矿床资源禀赋、选冶成本以及经济价值的综合评价提供重要的依据。近年来,矿物自动定量分析系统越来越多地应用到贵金属的赋存状态研究中... 详细信息

浅成低温热液矿床是世界上银矿的重要矿床类型,伴生有金铜铅锌等多种金属。银的赋存状态研究可以为矿床资源禀赋、选冶成本以及经济价值的综合评价提供重要的依据。近年来,矿物自动定量分析系统越来越多地应用到贵金属的赋存状态研究中,相比传统方法而言其能提供精确定量的矿物学信息。悦洋银多金属矿床位于福建省紫金山矿田,是典型的浅成低温热液矿床,是研究银赋存状态的理想选区。通过野外地质调查研究发现,矿体主要受控于岩性边界和断裂构造,主要矿石类型为热液角砾岩型和石英脉型。成矿作用可以分为石英-黄铁矿、石英-黄铁矿-黄铜矿、石英-银多金属、石英-碳酸盐等四个阶段,其中银在石英-银多金属阶段沉淀,可以进一步划分为石英伊利石硫化物亚阶段和石英冰长石硫化物亚阶段。本文在野外地质调查的基础上,针对不同的矿石类型使用TIm.(TESCAN Integrated m.neral Analyzer)自动矿物分析系统,结合显微镜下观察、扫描电镜和电子探针分析手段,对银的赋存形式和分布情况进行了定量化研究,根据矿物共生组合对银沉淀机制及成矿过程进行了探讨。研究结果显示,悦洋矿床中的银90%以上以独立矿物的形式存在,主要是硫化银和自然银,且粒径大多在10~50μm.间;少部分银以次显微包裹体形式存在于黄铜矿中,或以显微包裹体和类质同相形式存在于黄铁矿和闪锌矿中。成矿热液中银主要以硫氢络合物形式运移,主成矿期大量的冰长石与银矿物共生表明沸腾作用是主要的沉淀机制。

关键词：银的赋存状态矿物定量分析银的沉淀机制浅成低温热液矿床紫金山矿田

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Asym.etrical m.te preference in recently adapted white Sands and black lava populations of Sceloporus undulatus

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Current Zoology 2013年第1期59卷 20-30页

作者： Kayla m. HARDWICK Jeanne m. ROBERTSON Erica Bree ROSENBLUm Departm.nt of Biological Sciences University of Idaho Moscow ID 83844 USA Departm.nt of Biology California State University Northridge CA 91330 USA Departm.nt of Environm.ntal Science Policy and Management University of California Berkeley CA 94720 USA

Speciation can proceed rapidly when natural and sexual selection act in concert. For exam.le speciation can be ac- celerated when traits that confer a selective advantage in a particular habitat also influence m.te preference. Studying parallel but evolutionarily independent instances of ecological divergence can illum.nate the interaction between natural and sexual selection during speciation. Locally adapted populations of the eastern fence lizard Sceloporus undulatus have recently evolved in three different habitats in the Chihuahuan desert： blanched color m.rphs occur on the gypsum.dunes of white Sands, m.lanic color m.rphs occur on the Carrizozo lava flow, and brown color m.rphs occur in the surrounding desert scrubland. In addition to dif- ferences in cryptic dorsal coloration, populations also differ in the size and color of ventral patches used for social signaling. This system.therefore provides an opportunity to investigate the interplay of natural and sexual selection during rapid ecological speci- ation. We used m.te preference experim.nts to determ.ne whether locally adapted populations m.y exhibit the early stages of be- havioral reproductive isolation. We observed an asym.etrical m.te preference in this system. white Sands m.les preferentially courted local fem.les, while m.les from.dark soils and black lava populations did not exhibit a preference for local m.tes. We also found that fem.le behavior and ventral patch phenotype were associated with m.le courtship. Our results suggest that the observed preference for local m.tes evolved at white Sands, and we discuss the possible link between local adaptation and traits involved in m.te preference in this system.[Current Zoology 59 （1）： 20-30, 2013].

关键词： Eastem.fence lizard m.gic trait Ecological speciation Sexual signaling Courtship m.te preference asym.etry