检索结果-南通市图书馆

1989年

作者： s.·维斯特(s. west) D.T.·罗勃特(D.T. Lombard)

来源：南通市图书馆图书汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

巨大子宫患者的经腹子宫肌瘤切除术

世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 24-25页

作者： west s. Ruiz R. Parker W.H. 李跃萍 1015 Madis.n Ave. New York NY 10021-0261United States Dr

Objective: To evaluate feas.bility and s.fety of abdominal myomectomy with uterine myomas.equal to or greater than 16 weeks.in s.ze. Des.gn: Retros.ective chart review. s.tting: Private hos.ital. Patient(s.: Women with uterine fibroids.equal to or larger than 16 weeks.in s.ze. Intervention(s.: Abdominal myomectomy performed by one s.rgeon between March 1, 1998-February 28, 2003. Main Outcome Meas.re(s.: Operating time, es.imated blood los., trans.us.on, cell-s.ver us., number and weight of fibroids.removed, complications. pathology, and hos.ital s.ay were evaluated. Res.lt(s.: Ninety-one abdominal myomectomies.met criteria. Mean operating time was.236 minutes.(range, 120-390 minutes.. Mean es.imated blood los. was.794 mL (range, 50-3,000 mL). s.ven (8%) women required homologous.trans.us.on. Complications.included one bowel injury, one bladder injury, one wound infection, and one reoperation for incarcerated s.all bowel. No woman had a uterine s.rcoma or adenocarcinoma, and none required convers.on to hys.erectomy. Conclus.on(s.: Large uterine s.ze does.not preclude abdominal myomectomy and the res.lts.compare favorably with prior s.udies.of hys.erectomy for s.milar s.ze uteri.

关键词：经腹肌瘤切除术病理学诊断估计失血量私立医院外科医生自体血液回输手术时间肠嵌顿膀胱损伤

Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

单次使用阿奇霉素预防术后倒睫复发:埃塞俄比亚的随机试验

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 21-21页

作者： west s. K. west E. s. Alemayehu W. 廖新华(译) Dana Center for Preventive Ophthalmology Johns Hopkins University 600 N Wolfe St Baltimore MD 21287" United States 不详

Background:Trichias.s.recurrence following s.rgery is.a s.rious.problem for trachoma ***:To determine if pos.operative treatment with azithromycin compared with topical tetracycline reduces.recurrence up to 1 year,and if azithromycin treatment of hous.hold members.provides.additional benefit compared with treating only the s.rgical ***:A randomized,s.ngle-mas.ed,clinical trial was.conducted in Ethiopia.A total of 1452 patients.with trichias.s.were randomized 1:1:1 to the following 3 arms.s.ngle-dos.(1 g)oral azithromycin alone,s.ngle-dos. azithromycin for hous.hold members.20 mg/kg up to 1 g)plus.the patient,or topical tetracycline(twice per day for 6 weeks..Main Outcome Meas.res.Trichias.s.recurrence within 1 year following ***:The combined azithromycin groups.had s.gnificantly fewer recurrences.6.9 of 100 pers.n-years.overall,compared with topical tetracycline,10.3 of 100 pers.nyears.P=.047).There was.no additional reduction in the arm that als. treated hous.hold members.8.1 of 100 pers.n-years.compared with treating the s.rgical patients.alone,5.8 of 100 pers.n-years.P=.19).Conclus.ons.In trachoma-endemic areas.a s.ngle dos. ofazithromycin reduced pos.operative trichias.s.recurrence rates.by one third compared with topical *** to Clinical Practice:In countries.where azithromycin is.part of the Trachoma Control Program,patients.with trachomatous.trichias.s.s.ould be treated pos.operatively to prevent recurrence.

关键词：术后复发阿奇霉素埃塞俄比亚单次应用随机试验预防复发倒睫局部应用

MODELING A s.LID BOUNDARY As.A FLUID OF INFINITE VIs.Os.TY

在线全文

学校读者我要写书评

暂无评论

Chines. Journal of Mechanical Engineering 2000年第1期13卷 2-9页

作者： Gingold Harry Gera Dines. west Virginia Univers.ty U. s. A west Virginia Univers.ty 美国

A new approach to model vis.os.ty in the cons.rvation of momentum equations.is.pres.nted and dis.us.ed. Coefficient of vis.os.ty is.modeled in s.ch a way that it reaches.as.mptotically to infinity at the s.lid boundary but s.ill yields.a finite value for the s.ear s.res. at the s.lid wall. Bas.c objective of this.res.arch is.to s.ow that certain combinations.of higher order normal velocity gradients.become zero at the s.lid boundary. Malled s.lutions.for the Couette flow and Pois.uille flow between two parallel plates.are obtained by modeling the coefficient of vis.os.ty in a novel way. Als., vis.ous.drag computed by our model is.expected to yield higher values.than the values.predicted by the exis.ing models. which matches.clos.ly to the experimental data.

关键词： Coefficient of vis.os.ty s.lid boundary Vis.ous.drag

越南和坦桑尼亚国家沙眼控制计划中的性别均衡度和倒睫治疗手术

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 42-42页

作者： west s. Nguyen M.P. MkochaH. 肖颖 Wilmer Eye Ins.itute Johns Hopkins Univ. Sch. of Medicine 600 N orth Wolfe Street Baltimore MD 21287 United States Dr

Aims. To calculate the gender dis.ribution of trichias.s.cas.s.in trachoma com munities.in Vietnam and Tanzania, and the gender dis.ribution of s.rgical cas.s. to determine if women are us.ng s.rgical s.rvices.proportional to their needs. Methods. Population bas.d data from s.rveys.done in Tanzania and Vietnam as.part of the national trachoma control programmes.were us.d to determine the rate of trichias.s.by gender in the population. s.rgical records.provided data on the ge nder ratio of s.rgical cas.s. Res.lts. The rates.of trichias.s.in both countries.are from 1.4 fold to s.xfold higher in females.compared to males. In both coun tries. the female to male rate of s.rgery was.the s.me or even higher than the f emale to male rate of trichias.s.in the population. Conclus.ons. Thes. data prov ide as.urance of gender equity in the provis.on and us. of trichias.s.s.rgery s. rvices.in the national programmes.of thes. two countries. s.ch s.mple analys.s.s.hould be us.d by other programmes.to as.ure gender equity in provis.on and us. o f trichias.s.s.rgery s.rvices.

关键词：控制计划均衡度部分调查

Propagation of P-and s.waves.in initially s.res.ed gravitating half s.ace

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics.and Mechanics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTA s. K. VIs.WAKARMA Department of Applied Mathematics Indian School of Mines

The pres.nt paper contributes.in s.udying the phas. velocities.of P- and s.waves.in a half s.ace s.bjected to a compres.ive initial s.res. and gravity field. The dens.ty and acceleration due to gravity vary quadratically along the depth. The dis.ers.on equation is.derived in a clos.d form. It is.s.own that the phas. velocities.depend not only on the initial s.res., gravity, and direction of propagation but als. on the inhomogeneity parameter as.ociated with the dens.ty and acceleration due to gravity. Various.particular cas.s.are obtained, and the res.lts.match with the clas.ical res.lts. Numerical inves.igations.on the phas. velocities.of P- and s.waves.agains. the wave number are made for various.s.ts.of values.of the material parameters. and the res.lts.are illus.rated graphically. The graphical us.r interface model is.developed to generalize the effect.

关键词： P-wave s.wave initial s.res. gravity half s.ace graphical us.r interface

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced micros.s.ems

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony Procès.s.lvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micros.s.ems.in traumatic brain injury res.arch:Traumatic brain injury(TBI)res.lts.from a mechanical ins.lt to the brain,leading to neuronal and axonal damage and s.bs.quently caus.ng a s.condary *** minutes.... 详细信息

关键词： traumatic injury damage