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N-Propionylmannosamine:using biochemical glycoengineering to promote peripheral nerve regeneration

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Neural Regeneration Research 2015年第12期10卷 1947-1948页

作者： Georgios Koulaxouzidis werner Reutter Christian Witzel Department of Plastic and Hand Surgery University of Freiburg Medical Center Institut für Laboratoriumsmedizin Klinische Chemie und Pathobiochemie Charité-Universit?tsmedizin (Freie Universit?t Berlin) Plastic and Reconstructive Surgery Charité-Universit?tsmedizin Berlin

The peripheral nervous system,in contrast to the central nervous system,is capable of spontaneous ***,nerve reconstruction in the peripheral nervous system remains a major challenge,as the functional outcomes followin... 详细信息

关键词： N-Propionylmannosamine Figure Man ST UDP acid

Bridging large gaps in the injured spinal cord: mechanical and biochemical tissue adaptation

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Neural Regeneration Research 2016年第10期11卷 1572-1574页

作者： Veronica Estrada Hans werner Müller Molecular Neurobiology Laboratory Department of Neurology Heinrich-Heine-University Medical Center Düsseldorf

Incidence and consequences of spinal cord injuries： World- wide, every year 250,000-500,000 people suffer from spinal cord injury （SCI; ***, 2013）. Traumatic lesions of the spinal cord lead to primary and secondary injury mechanisms, which result in axon damage, loss of signal conduction, demyelination of axons and long-lasting deficits in motor and sensory func- tion. The extent of the damage and the subsequent functional loss depend on the spinal level and the severity of the primary injury. Furthermore, pathophysiological and pathomorpholog- ical responses in acute and chronic SCI share similar but also different requirements for treatment.

关键词： Bridging large gaps in the injured spinal cord SCI

A robust feature extraction approach based on an auditory model for classification of speech and expressiveness

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Journal of Central South University 2012年第2期19卷 504-510页

作者：孙颖 V.werner 张雪英 College of Information Engineering Taiyuan University of Technology Department Electronic and Informatics Laboratory for Digital Speech and Audio ProcessingVrije Universiteit Brussel

Based on an auditory model, the zero-crossings with maximal Teager energy operator (ZCMT) feature extraction approach was described, and then applied to speech and emotion recognition. Three kinds of experiments were carried out. The first kind consists of isolated word recognition experiments in neutral (non-emotional) speech. The results show that the ZCMT approach effectively improves the recognition accuracy by 3.47% in average compared with the Teager energy operator (TEO). Thus, ZCMT feature can be considered as a noise-robust feature for speech recognition. The second kind consists of mono-lingual emotion recognition experiments by using the Taiyuan University of Technology (TYUT) and the Berlin databases. As the average recognition rate of ZCMT approach is 82.19%, the results indicate that the ZCMT features can characterize speech emotions in an effective way. The third kind consists of cross-lingual experiments with three languages. As the accuracy of ZCMT approach only reduced by 1.45%, the results indicate that the ZCMT features can characterize emotions in a language independent way.

关键词： speech recognition emotion recognition zero-crossings Teager energy operator speech database

Three-dimensional Wentzel-Kramers-Brillouin approach for the simulation of scanning tunneling microscopy and spectroscopy

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Frontiers of physics 2014年第6期9卷 711-747页

作者： Krisztian Palotas Gabor Mandi werner A. Hofer Department of Theoretical Physics Budapest University of Technology and Economics and Condensed Matter Research Group of the Hungarian Academy of Sciences Budafoki dt 8. H-1111 Budapest Hungary Department of Theoretical Physics Budapest University of Technology and Economics Budafoki ut 8. H-1111 Budapest Hungary Surface Science Research Centre University of Liverpool L69 3BX Liverpool UK

We review the recently dew, loped three-dinmnsional （3D） atom-superposition approach for simulating scanning tunneling microscopy （STM） and spectroscopy （STS） based on ab initio electronic structure data. In the method, contributions from individual electron tunneling transitions between the tip apex atom and each of the sample surface atoms are summed up assuming tile one-dimensional （1D） Wentzel-Kramers--Brillouin （WKB） approximation in all these transitions. This 3D WKB tun- neling model is extremely suitable to simulate spin-polarized STM and STS on surfaces exhibiting a complex noncollinear magnetic structure, i.e., without a global spin quantization axis, at very low computational cost. The tip electronic structure from first principles can also be incorporated into the model, that is often assumed to be constant in energy in the vast majority of the related literature, which couht lead to a misinterpretation of experimental findings. Using this approach,we highlight some of tile electron tunneling features on a prototype frustrated hexagonal antiferro- magnetic Cr monolayer oil Ag（lll） surface. We obtain useful theoretical insights into tile simulated quantities that is expected to help the correct evaluation of experimental results. By extending the method to incorporate a simple orbital dependent electron tunneling transmission, we reinvestigate the bias voltage- and tip-dependent contrast inversion effect on the W（110） surface. STM images cal- culated using this orbital dependent model agree reasonably well with Tersoff-Hamann and Bardeen results. The computational efficiency of the model is remarkable as the k-point samplings of the surface and tip Brillouin zones do not affect the computational time, in contrast to the Bardeen method. In a certain case we obtain a relative computational time gain of 8500 compared to the Bardeen calculation, without the loss of quality. We discuss the advantages and limitations of tile 3D WKB method, and show further ways

关键词： electron tunneling STM STS WKB tunneling transmission spin polarization metal surfaces contrast inversion

Neural network learns physical rules for copolymer translocation through amphiphilic barriers

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npj Computational Materials 2020年第1期6卷 1039-1046页

作者： Marco werner Yachong Guo Vladimir A.Baulin Institute Theory of Polymers Leibniz-Institut für Polymerforschung Dresden e.V.Hohe Straße 601069 DresdenGermany Departament d’Enginyeria Química Universitat Rovira i Virgili26 Av.dels Paisos Catalans43007 TarragonaSpain Kuang Yaming Honors School Nanjing University22 Hankou Road210093 NanjingChina

Recent developments in computer processing power lead to new paradigms of how problems in many-body physics and especially polymer physics can be *** processors can be exploited to generate millions of molecular configurations in complex environments at a second,and concomitant free-energy landscapes can be *** that are complete in terms of polymer sequences and architecture form a powerful training basis for cross-checking and verifying machine learning-based *** employ an exhaustive enumeration of polymer sequence space to benchmark the prediction made by a neural *** our example,we consider the translocation time of a copolymer through a lipid membrane as a function of its sequence of hydrophilic and hydrophobic ***,we demonstrate that massively parallel Rosenbluth sampling for all possible sequences of a polymer allows for meaningful dynamic interpretation in terms of the mean first escape times through the ***,we train a multi-layer neural network on logarithmic translocation times and show by the reduction of the training set to a narrow window of translocation times that the neural network develops an internal representation of the physical rules for sequencecontrolled diffusion *** on the narrow training set,the network result approximates the order of magnitude of translocation times in a window that is several orders of magnitude wider than the training *** investigate how prediction accuracy depends on the distance of unexplored sequences from the training window.

关键词： neural network narrow

Multiple von Meyenburg complexes mimicking diffuse liver metastases from esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2006年第26期12卷 4250-4252页

作者： Stefan Fritz Thilo Hackert Hendrik Blaker werner Hartwig Lutz Schneider Markus W Buchler Jens werner Departments of General and Visceral Surgery University of Heidelberg Germany Departments of Pathology University of Heidelberg Germany

Von Meyenburg complexes are benign liver lesions consisting of adenomatous bile duct proliferates. We present two patients suffering from esophageal cancer accompanied by the occurrence of yon Meyenburg complexes. Preoperative computerized tomography （CT） of the liver had not shown these lesions. In one of the patients, diffuse nodular manifestation was found in both liver lobes, mimicking diffuse hepatic metastases. Intraoperative frozen section revealed the benign nature of the lesions in both cases. The patients underwent esophageal resection without complications. To the best of our knowledge, the coincidence of von Meyenburg complexes and esophageal cancer has never been reported before. This uncommon entity should be taken into consideration as a differential diagnosis of liver lesions in malignancies. It underlines the importance of intraoperative frozen section for liver lesions of unknown origin.

关键词： Von Meyenburg complexes Bile duct hamartomas Esophageal carcinoma Liver metastasis

Projected Elliptical Distributions

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Acta Mathematicae Applicatae Sinica 2005年第2期21卷 285-294页

作者： Winfried Stute Uwe werner Institute of Mathematics University of Giessen Arndtstr. 2 D-35392 Giessen GermanyInstitute of Mathematics University of Giessen Arndtstr. 2 D-35392 Giessen Germany

Abstract We introduce a new parametrization of elliptically contoured densities and study the associated family of projected (circular) distributions. In particular we investigate the trigonometric moments and some co... 详细信息

关键词： Elliptically contoured distributions projection circular random variables trigonometric moments convolution

Contemporary perspective on endogenous myocardial regeneration

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World Journal of Stem Cells 2015年第5期7卷 793-805页

作者： Dejan Milasinovic werner Mohl Department of Cardiology Clinical Centre of Serbia Department of Cardiac Surgery Medical University of Vienna

Considering the complex nature of the adult heart, it is no wonder that innate regenerative processes, while maintaining adequate cardiac function, fall short in myocardial jeopardy. In spite of these enchaininglimitations, cardiac rejuvenation occurs as well as restricted regeneration. In this review, the background as well as potential mechanisms of endogenous myocardial regeneration are summarized. We present and analyze the available evidence in three subsequent steps. First, we examine the experimental research data that provide insights into the mechanisms and origins of the replicating cardiac myocytes, including cell populations referred to as cardiac progenitor cells(i.e., c-kit+ cells). Second, we describe the role of clinical settings such as acute or chronic myocardial ischemia, as initiators of pathways of endogenous myocardial regeneration. Third, the hitherto conducted clinical studies that examined different approaches of initiating endogenous myocardial regeneration in failing human hearts are analyzed. In conclusion, we present the evidence in support of the notion that regaining cardiac function beyond cellular replacement of dysfunctional myocardium via initiation of innate regenerative pathways could create a new perspective and a paradigm change in heart failure therapeutics. Reinitiating cardiac morphogenesis by reintroducing developmental pathways in the adult failing heart might provide a feasible way of tissue regeneration. Based on our hypothesis "embryonic recall", we present first supporting evidence on regenerative impulses in the myocardium, as induced by developmental processes.

关键词： Cardiac regeneration Cardiac development Embryonic recall Pressure-controlled intermittentcoronary sinus occlusion Heart failure Myocardialinfarction

Investigation of gas concentration cell based on LiSiPO electrolyte and Li_2CO_3,Au electrode

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Chinese Science Bulletin 2009年第8期54卷 1334-1339页

作者： ZHU YongMing CHU WingFong WEPPNER werner Faculty of Engineering Christian-Albrechts University Kaiserstrasse 2 D-24143 Kiel Germany Faculty of Chemical Engineering Harbin Institute of Technology at Weihai Weihai 264209 China

Solid lithium ion conducting electrochemical cells using LiSiPO as solid electrolyte and Li2CO3 mixed with Au as electrodes were prepared and employed as chemical sensors for the detection of CO2 *** EMF of the cell depends on the concentration of CO2 in air according to the partial pressure dependence of Nernst's law in the investigated range from 100 to 2000 ppm over the temperature range from 473 K to 673 K.

关键词：固体电解质气体浓度碳酸锂金电极细胞基础 CO2气体传感器检测